Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Grant amount: Up to US $2,200,000

Fields of work: Neurological Diseases & Disorders

Applicant type: For-Profit Business

Funding uses: Research

Location of project: United States

Location of residency: United States


NOTE: This grant is expiring early as per NOT-NS-23-103 and will no longer be active.

The purpose of this Program Announcement (PAR) is to enable analytical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of analytical methods for biomarker measurements, including evaluation of the detection method, its performance characteristics, and the optimal conditions that will generate reproducibility and accuracy consistent with FDA guidelines. This PAR assumes that:

  • a candidate biomarker has already been identified,
  • detection method technology has already been developed, and 
  • the research and/or clinical need and potential context of use has been identified.

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This page was last reviewed August 10, 2023 and last updated August 10, 2023