Blueprint Medtech: Small Business Translator (U44 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

Next predicted deadline: Oct 18, 2023 (Full proposal)

Later predicted deadlines: Jan 24, 2024 (Letter of inquiry), Feb 24, 2024 (Full proposal), May 20, 2024 (Letter of inquiry), Jun 20, 2024 (Full proposal)

Grant amount: Up to US $5,500,000

Funding uses: Research, Project / Program

Location of project: Anywhere in the world

Location of residency: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico, Virgin Islands Show all

Overview:

NOTE: All applications are due by 5:00 PM local time of applicant organization.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from Small Business Concerns (SBCs) to pursue translational activities and limited-size clinical studies to advance the development of therapeutic and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and effective nesting, design verification and validation activities leading to submission of an Investigational Device Exemption (IDE) to the FDA or Institutional Review Board (IRB) application for a Non-Significant Risk (NSR) study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use.

This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress. Participants in Blueprint MedTech receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants to receive assistance with specialty areas including regulatory, reimbursement, intellectual property, commercialization, and strategic partnerships. Participants can also augment their project with NIH contract research organizations that specialize in large animal testing, sterilization testing, biocompatibility assessment, manufacturing, and medical monitoring. SBCs developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this FOA or any of the companion opportunities. 

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