Engineering Durable HIV Vaccine Responses (ENDURE) (R01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Deadline: Oct 9, 2024

Grant amount: Up to US $3,500,000

Fields of work: HIV/AIDS Vaccines

Applicant type: Nonprofit, Government Entity, Indigenous Group, For-Profit Business

Funding uses: Biomedical

Location of project: Anywhere in the world

Location of residency: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico Show all


NOTE: All applications are due by 5:00 PM local time of applicant organization. Optional but encouraged Letters of Intent are due 30 days prior to the full proposal deadline.

The purpose of this Notice of Funding Opportunity (NOFO) is to support basic and applied research to understand and improve durable immune responses to candidate HIV vaccines.

The scientific objective of this NOFO is to support hypothesis-driven research to investigate and improve the durability of immune responses to candidate vaccines for HIV prevention. NIAID’s Division of AIDS seeks applications that propose research to:

  • understand and define durable vaccine responses;
  • develop or improve methods to measure durable vaccine responses; and/or 
  • engineer more durable vaccine responses.

While vaccine durability is ideally defined in terms of protection from disease, for the purposes of this NOFO, durability consists of persistent immune responses, recall responses, and/or adaptive immune memory. Applications may include basic and applied research using human samples, and/or appropriate animal models.

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US Dept. of Health & Human Services: National Institutes of Health (NIH)

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This page was last reviewed April 26, 2024 and last updated April 26, 2024