Immunobiology of Xenotransplantation (U19 Clinical Trial Not Allowed) (353310)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Next deadline: Jul 10, 2024 (Letter of inquiry)

Later deadlines: Aug 9, 2024 (Full proposal)

Grant amount: Approximately US $1,300,000

Fields of work: Immune System Diseases Organ And Tissue Banks

Applicant type: Organizations

Funding uses: Research

Location of project: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico Show all

Location of residency: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico Show all

Overview:

NOTE:

  • Letter of Inquiry (Letter of Intent) - This is due 30 days prior to the application due date (due by 5:00 pm local time of applicant organization).
  • The following deadline applies to the standard grant application (due by 5:00 pm local time of applicant organization):
    • August 09, 2024
  • The following deadline applies to the Renewal/Resubmission/Revision grant application (due by 5:00 pm local time of applicant organization): 
    • August 09, 2024

Immunobiology of Xenotransplantation (U19 Clinical Trial Not Allowed) (353310)

Purpose

The purpose of this notice of funding opportunity (NOFO) is to solicit applications to participate in the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP), a multi-center program dedicated to resolving immunologic and physiologic barriers to safe and efficacious xenotransplantation using preclinical pig to nonhuman primate (NHP) or human decedent models of pancreatic islet, kidney, heart, lung, or liver xenotransplantation.

Scope and Research Objectives

The re-issue of the IXCRP will support a research program comprised of two or more research projects centered around preclinical NHP and/or human decedent models of porcine pancreatic islet, kidney, heart, lung, or liver xenotransplantation. The research objectives must address one or more of the remaining key immunologic and physiologic barriers to achieving safe and efficacious xenotransplantation, including issues affecting engraftment, survival, and function of xenografts.

Research foci may include:

  • development or optimization of the models themselves, including genetic modifications of the pig-donor to address FDA concerns, as well as refinement of surgical xenotransplantation techniques,
  • development or optimization of the immunosuppression (IS) regimen to prevent rejection and minimize toxicity,
  • characterization and resolution of physiological and immunological barriers to long-term xenograft survival, and
  • development or optimization of strategies to screen for and prevent pathogen transmission to recipients.

We've imported the main document for this grant to give you an overview. You can learn more about this opportunity by visiting the funder's website.

US Dept. of Health & Human Services: National Institutes of Health (NIH)
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This page was last reviewed April 03, 2024 and last updated April 03, 2024