In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed) (345388)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Next deadline: May 5, 2023 (Letter of inquiry)

Later deadlines: Jun 5, 2023 (Full proposal), Sep 5, 2023 (Letter of inquiry), Oct 5, 2023 (Full proposal), May 5, 2024 (Letter of inquiry), Jun 5, 2024 (Full proposal), Sep 5, 2024 (Letter of inquiry), Oct 5, 2024 (Full proposal), May 5, 2025 (Letter of inquiry), Jun 5, 2025 (Full proposal), Sep 5, 2025 (Letter of inquiry), Oct 5, 2025 (Full proposal)

Grant amount: Up to US $499,999

Fields of work: Genetics & Genomics

Applicant type: Government Entity, Nonprofit, For-Profit Business, Indigenous Group

Funding uses: Research

Location of project: Anywhere in the world

Location of residency: Anywhere in the world


NOTE: All applications are due by 5:00 PM local time of applicant organization. 

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall, the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research.

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This page was last reviewed January 16, 2023 and last updated January 16, 2023