Quantifying the Impact of Environmental Toxicants on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Risk in Cohort Studies (U01 Clinical Trial Not Allowed)

This funding opportunity announcement will support research focused on major toxicants observed to be associated with elevated AD risk, and health disparities in AD-related pathologic and clinical outcomes. This funding opportunity aims to enrich existing longitudinal cohorts with measures of exposures to individual toxicants or combinations of toxicants and/or multi-omics molecular profiling that reflects the bodys response to exposure(s), support the development of multi-disciplinary teams needed for the rigorous measurement and assessment of environmental exposures at the population level and create an environmental epidemiology consortium to facilitate rapid and broad data sharing, harmonization, and integration of complex exposure data across multiple studies to enhance the opportunity for data pooling and data integration for various meta-analyses and/or comparative analyses.