Best Aleutians East Borough Grants for Nonprofits in Alaska

The Educational Theatre Foundation (ETF) is offering the Shrek the Musical Jr. Pilot Grant, providing three no-cost licenses for schools. This innovative bilingual adaptation allows actors to perform in either American English or Latin American Spanish, enhancing accessibility and engagement. The initiative promotes educational theatre by supporting high schools with active Thespian troupes across the United States. By collaborating with Music Theatre International, ETF aims to refine the script and deliver a unique theatrical experience that fosters community and creativity.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

EdTA Membership Grant

Theatre matters.

It belongs in our classrooms and communities – now more than ever. Yet the role of the theatre educator has become increasingly complex, and financial support is often uncertain or even eliminated.

To help meet this moment, the Educational Theatre Foundation is proud to introduce the EdTA Membership Grant.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Educator & Program Grants

Giving school theatre programs a boost

The Thespian Growth & Excellence Fund is committed to supporting the ongoing development of theatre programs and the pursuit of excellence for educators, students, schools, and communities by offering a number of grants that assist in EdTA membership, teacher support, and programmatic resources for theatre in schools.

By the end of 2024, the Thespian Growth and Excellence Fund has awarded 349 grants to 276 schools, totaling $286,167 in assistance provided to school theatre programs, many at schools with Title 1 designations.

Educator Support ($500)

Can be used for professional development for theatre educators that would benefit their students, including coursework, EdTA’s Theatre Education Conference registration fees, and related travel expenses.

The Educational Theatre Foundation (EdTA) offers the Thespian Growth & Excellence Grants to support production expenses for school theatre programs. Grants of up to $1,000 can cover essential costs such as licensing fees, rentals, sets, and costumes. With a commitment to enhancing educational theatre, EdTA prioritizes applications based on demonstrated need, particularly for Title 1 schools, helping to foster creativity and collaboration in diverse educational settings.

The EdTA Thespian Growth & Excellence Grants support theatre programs by providing financial assistance for troupe expenses, including travel to professional productions and participation in state conferences. Founded by the Educational Theatre Foundation, these grants aim to enhance educational theatre access and representation. By the end of 2024, 349 grants totaling over $286,000 will have been awarded, benefiting schools with Title 1 designations and empowering students and educators in their creative pursuits.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Educator & Program Grants

Giving school theatre programs a boost

The Thespian Growth & Excellence Fund is committed to supporting the ongoing development of theatre programs and the pursuit of excellence for educators, students, schools, and communities by offering a number of grants that assist in EdTA membership, teacher support, and programmatic resources for theatre in schools.

By the end of 2024, the Thespian Growth and Excellence Fund has awarded 349 grants to 276 schools, totaling $286,167 in assistance provided to school theatre programs, many at schools with Title 1 designations.

Equipment Upgrade (up to $5,000)

Can be awarded to help school theatre programs with large technical purchases that upgrade the resources available for theatrical use, such as lighting and sound equipment.

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

• Creating Safe Communities
  • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
  • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

• Creating Strong Communities
  • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
  • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
  • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
• Additional Community Commitments
  • United Way: Employee donation matching in all markets.
  • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
  • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.

Dick & Judy Hoyt Inclusion Grant

The Doug Flutie, Jr. Foundation for Autism is excited to collaborate with the Hoyt Foundation for the Dick and Judy Hoyt Grant for Inclusion. Our joint effort is driven by a shared vision of fostering a society where individuals with autism and other disabilities are embraced and valued within their communities. In tribute to the pioneering spirit of Dick and Judy Hoyt, we will be distributing $50,000 through this community grant to support people with autism and other disabilities. Successful ways grant funds can be used: 

• Side-by-side participation with non-disabled peers in a swim program, the grant provides a private lifeguard to allow individualized support to ensure an inclusive experience.
• Grant provides the purchase of a racing chair to allow an individual with a disability to run in races with non-disabled peers.
• Competitive horseback riding supported by the grant to purchase specialized equipment to allow a rider to compete against non-disabled peers.
• Grant provides the purchase of an adaptive ski prosthetic to allow an individual to participate side by side with non-disabled peers on their high school ski teams.
• Participation in dance training and competitions to allow a student with a disability to compete in a dance competition with non-disabled peers, grant lessons, and staff to assist in dance training.
• Grant provides a mobile stand to allow a student with a disability to participate side by side with non-disabled peers in the college marching band. 

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Resident Research Award

Provides residents and fellows an opportunity to attend and present their scientific research at the SIR Annual Scientific Meeting. The intent is to expose young researchers who wish to further their careers in interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Research Scientist Award

Recognizes the contributions and accomplishments of PhD scientists and engineers at all levels of training for their basic and preclinical research on the topic of interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Dr. Gary J. Becker Young Investigator Award

Promotes excellence in academic research for members early in their careers. This award honors the founding editor of the Journal of Vascular and Interventional Radiology (JVIR) and recognizes the importance of the young investigator in developing interventional solutions for the future.

About

In 1990, SIR Foundation established the Dr. Gary J. Becker Young Investigator Award as a way to recognize promising young practitioners of interventional radiology early in their careers and encourage their pursuit of academic careers. Each year, the author of the most outstanding clinical science research paper submitted receives this distinguished award.

Award

$3,000 honorarium along with complimentary registration to the SIR Annual Scientific Meeting.

The award will be presented during the SIR Foundation Awards Ceremony at the SIR Annual Scientific Meeting.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Dr. Constantin Cope Medical Student Research Award

Introduces interested medical students to the greater interventional radiology community at the SIR Annual Scientific Meeting. Recognizes the student author of an accepted abstract that best honors the spirit of inventiveness and scientific purity.

Award

Up to two recipients will receive complimentary registration and a travel award of up to $1,000.

Dr. Barry T. Katzen Master Clinician Award

Honors an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field and who has also made a demonstrable impact at their institution or practice as a result.

About

The Dr. Barry T. Katzen Master Clinician Award seeks to honor an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field as well as who has made a demonstrable impact at their institution or practice as a result. This award recognizes individuals who have made significant contributions to enhancing patient outcomes and advancing the reputation and practice of interventional radiology through their hard work, commitment and, most importantly, clinical practice. The award is being given in the name of Barry T. Katzen, MD, FSIR, who pioneered clinical practice for IR in 1976 and became a vocal advocate, champion and example for colleagues of the importance of IR being a clinical discipline for advancement of the specialty.

The recipient will receive:

• Complimentary annual meeting registration
• Recognition during the SIR Annual Scientific Meeting

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Excellence in Innovation Award

Fund compelling, novel ideas that lead to improved health outcomes in IR.

About

Interventional radiologists create and introduce novel, minimally invasive procedures and devices that help solve some of our toughest medical challenges. To continue this rich history of innovation in IR, the purpose of this award is to fund compelling, novel ideas that lead to improved health outcomes in IR.

Innovation, for this purpose, is broadly defined as any use of emerging methods, new devices, new procedures or new technologies, such as artificial intelligence and nanotechnology, that display an exceptional degree of potential for transforming and advancing the specialty of interventional radiology.

The Annual Meeting Research Award Committee selects one recipient for this award each year.

The recipient will receive:

• Complimentary annual meeting registration
• Travel stipend up to $1,000
• The opportunity to present their research as well as meet peers, network with senior scientists and participate in learning opportunities at the SIR Annual Scientific Meeting
• Recognition during the SIR Annual Scientific Meeting

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Artificial Intelligence in Communication Sciences and Disorders Research Grant

About

The American Speech-Language-Hearing Foundation (ASHFoundation) invites investigators to submit proposals for up to four research grants ranging from $25,000 to $50,000. The Artificial Intelligence in Communication Sciences and Disorders Research Grant (AI in CSD Research Grant) supports interdisciplinary studies that advance the ethical, clinically and scientifically grounded application and integration of artificial intelligence (AI) into communication sciences and disorders (CSD) practice and service delivery. Funding may be applied to one- or two-year studies.

Specific Objectives of the Funding Opportunity

As part of this initiative, the ASHFoundation invites proposals that implement AI technologies to transform clinical practice, education, and research in CSD. Proposals that are submitted under this funding opportunity must meet the following:

• Include interdisciplinary research teams that integrate clinicians and AI researchers,
• Address clinically relevant questions or have a clear translational potential, and
• Cover one or more of the following priority areas: AI-driven assessment and diagnosis; personalized and adaptive interventions; equitable access to care; data infrastructure for predictive analytics; technology innovation; prevention for public health; and ethical standards for AI integration.

The State Pilot Program for Treatment for Pregnant and Postpartum Women aims to enhance the state's capacity to deliver integrated and evidence-based services for substance use disorders and maternal mental health. The initiative focuses on supporting pregnant and postpartum women and their families, ensuring they receive comprehensive care tailored to their unique needs. Funded by the Substance Abuse and Mental Health Services Administration, this program is a vital step toward improving health outcomes for vulnerable populations.

The Assisted Outpatient Treatment (AOT) program aims to support adults with serious mental illness (SMI) by facilitating community-based treatment. Funded by the US HHS's Substance Abuse and Mental Health Services Administration (SAMHSA), the initiative encourages collaboration with civil courts and community partners. Recipients will implement AOT to ensure that eligible individuals receive necessary support, thereby enhancing their mental health outcomes and promoting recovery.

The Building Communities of Recovery program aims to enhance access to long-term recovery support for individuals facing substance use disorders and co-occurring mental health issues. By empowering organizations to mobilize community resources, this initiative fosters a collaborative environment that promotes sustained recovery. Funded by the Substance Abuse and Mental Health Services Administration, the program emphasizes the importance of community connections in the recovery process, ensuring that individuals receive the support they need to thrive.

American Psychiatric Association Foundation

There is no health without mental health. The APA Foundation is working in your community to provide the support and resources we all need to prioritize mental wellbeing where you live, learn, work, worship, and play.

Backed by the medical expertise of the APA and industry-leading strategic partners, we administer community-changing programs, public education campaigns, grants, and awards aimed at increasing mental health literacy, connecting individuals to needed care, and shifting attitudes toward mental health.

Our Mission is to promote the mental health and well-being of individuals and communities. Our Vision is a mentally healthy nation for all – where we live, learn, work, worship, and play.

Diversity Leadership Fellowship

The Diversity Leadership Fellowship identifies and motivates minority psychiatry residents or those interested in minority and vulnerable populations to become well equipped to teach, administer, and provide culturally competent, evidence based mental health and substance abuse services to diverse minority groups and at-risk populations. These populations include—but are not limited to—American Indians/Native Alaskans, Asian Americans/Native Hawaiians/Native Pacific Islanders, Blacks/African Americans, Hispanics/Latinos, LGBTQ, and religious minorities. Program Benefits:

• Sponsorship to attend a minimum of four APA meetings:
  • Two APA Annual Meetings
  • Two Fellowship Forums
• Develop leadership skills in the field of psychiatry and advance understanding of the life experiences of racial ethnic minority communities
• Gain an understanding of APA/APAF Governance through observation and service on an APA Council, Committee, or APAF initiative
• Have the opportunity to sit on the APAF Board of Directors as a non-voting member (one Diversity Leadership fellow allowed)
• Cultivate a professional network with psychiatrists interested in minority mental health and services through exclusive events and engagements with APA leaders. Establish relationships and peer-mentorship with a diverse group of resident fellows with similar career interests and goals

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Investigator Sponsored Studies Program

Alkermes seeks to support research designed and conducted by independent clinicians and scientists through our Investigator Sponsored Studies (ISS) program. Alkermes may occasionally announce a Request for Proposals (RFP) for research in clinical areas where gaps in data have been identified. 

The ISS research Alkermes supports must be based in the United States and is typically conducted by experienced researchers who have an established history of successfully completing research with independent funding. Alkermes can provide its marketed products to the ISS programs it supports. In addition, there may be financial support available, but please note that study budgets cannot exceed $300,000 (inclusive of overhead).

• ISS Areas of Interest
  • Sleep Disorders
  • Schizophrenia & Bipolar I Disorder
  • Schizophrenia

The ASPECT program, initiated by the DOE, aims to bolster the U.S. energy future by enhancing domestic critical mineral supply chains and developing innovative chemical technologies. This Notice of Funding Opportunity (NOFO) invites proposals for research and pre-pilot testing of technologies that convert alternative and waste feedstocks into valuable chemicals. By offering distinct pathways for technologies at various stages of development, the program seeks to advance solutions that contribute to sustainable energy practices and promote resource efficiency.

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Pathways APN Research Awards

The Alkermes Pathways Advanced Practice Nurse (APN) Research Awards™ program is designed to empower the advanced practice nursing community by offering funding opportunities that recognize their vital role in evidence-based care and the advancement of mental health research.

The Alkermes Pathways APN Research Awards provide opportunities for individual grants of up to $10,000 per project for licensed psychiatric-mental health nurse practitioners who are actively engaged in clinical, academic, and/or community health settings and are committed to advancing research in schizophrenia or bipolar I disorder.

Interface Health Foundation

Interface Health Foundation is a non-profit, 501c3 tax-exempt organization driven by a collective vision of positive change. In healthcare industry policy, understanding the intricate dynamics of funding and its impact on public access, quality, and cost remains paramount. IHF is dedicated to advancing analysis and research into the crossroads of healthcare industry policy, structural frameworks and affordability.

At IHF, our mission is clear: to empower and support student-led research endeavors that shed light on critical healthcare policy and structural issues affecting the public. Through our initiatives, we seek to foster a deeper understanding of the complex dynamics shaping the healthcare landscape.

Interface Health Foundation: Research Grant

Healthcare administrative grant award opportunities are highly competitive and allow candidates to stand out as they enter the job market. Through this IHF grant award, you will get the opportunity to pull together research and content on topics that aren't fully studied or publicized. Depending on the grant topic, some grantees will also have access to a preceptor who is an executive leader in the healthcare field. The preceptor will serve as a valuable resource to the grantee during the development of the research paper and beyond.

An example of a research topic is the impact of legislated acute care nurse staffing levels on the following: nursing professional job satisfaction, the patient experience, and the standard nursing quality indicators as part of nursing Magnet status accreditation.

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.