Best Seed Grants for Nonprofits in American Samoa

The Systems-Based Approaches to Improve Patient Safety program aims to enhance patient safety by prioritizing healthcare worker safety and well-being. By focusing on systemic improvements, this initiative seeks to create a safer healthcare environment, recognizing that worker safety is integral to patient safety. The funding opportunity encourages innovative proposals that bring new insights from healthcare professionals, ultimately supporting AHRQ's mission to strengthen the patient safety movement.

The Water Resources Research Act Program National Competitive Grants FY2026, administered by the U.S. Geological Survey, aims to support innovative research initiatives at Water Resources Research Institutes across the U.S. and its territories. These grants facilitate essential studies on water management, addressing critical water resource challenges while promoting collaboration among states. This program seeks to enhance the understanding of water issues, ultimately contributing to sustainable management practices and informed decision-making in water resource policy.

The Health and Health Care Disparities grant aims to support innovative research that addresses the health challenges faced by individuals with disabilities, particularly in communities experiencing health disparities. Key application deadlines span from February 2024 to October 2026. This funding opportunity invites research proposals that explore the underlying factors affecting the health and well-being of these populations, promoting interventions that can lead to significant improvements in health equity.

The State Biomonitoring Cooperative Agreement aims to enhance public health laboratories' ability to conduct biomonitoring and assess human exposure to environmental chemicals. This funding opportunity emphasizes community investigations, state-level studies, and emerging chemicals not covered in the National Exposure Report. By improving laboratory capacity and fostering collaboration, the initiative seeks to identify harmful exposures and evaluate intervention effectiveness over a three-year period.

The Telehealth Nutrition Services Network Grant Program, funded by the Health Resources and Services Administration, aims to enhance access to quality health care through innovative telehealth nutrition services. This program focuses on preventing and managing chronic diseases by leveraging telehealth technology, ensuring that individuals receive essential nutrition guidance remotely. With a commitment to improving health outcomes, this initiative will significantly benefit communities seeking better access to healthcare resources.

The Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program aims to foster the development of American Indian and Alaska Native scientists by funding eligible Tribal Entities. This initiative focuses on creating effective training and mentoring activities for individuals pursuing doctoral degrees in biomedical research. Ultimately, it seeks to enhance the capability of researchers to address health disparities within AI/AN communities, ensuring culturally appropriate and ethically responsible research practices.

This funding opportunity invites applications for investigator-initiated clinical trials focused on complementary and integrative health interventions delivered remotely or via mobile health technologies. The trials must be fully powered, with no in-person contact, and require justification for this approach. Preliminary data on feasibility and safety must be provided, alongside evidence of clinical benefit. A Plan for Enhancing Diverse Perspectives is mandatory for submission. Key deadlines range from February 2024 to June 2026.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Advancing Equity Through Oral Health Funds, initiated by CareQuest Institute, seeks to transform oral health systems by supporting projects that dismantle disparities faced by marginalized communities. The program encourages organizations to propose innovative solutions that enhance access to dental care, engage community voices, and promote policies that ensure equitable health outcomes for all. This initiative aims to create a more integrated and accessible healthcare system, particularly for historically underserved populations.

This funding opportunity supports research aimed at improving health among Native American populations by developing, adapting, and testing interventions. It addresses significant health disparities and seeks culturally informed solutions. The initiative encourages research that informs intervention strategies tailored to community needs, focusing on sustainability and scalability. The program is vital for enhancing health equity and resilience in Native American communities, ultimately aiming to reduce morbidity and mortality through effective health interventions.

This funding opportunity announcement aims to enhance health interventions for Native American populations. It supports research to develop, adapt, and test culturally informed health promotion and disease prevention strategies. The initiative addresses significant health disparities faced by these communities, emphasizing sustainable and adaptable solutions. Researchers are encouraged to build on community strengths and resilience, focusing on effective dissemination and integration of interventions. The program welcomes applications targeting diverse Native American groups, including Alaska Natives and Native Hawaiians.

The Intervention Research to Improve Native American Health (R21 Clinical Trials Optional) aims to support exploratory studies focused on enhancing health outcomes within Native American populations. This initiative encourages research that addresses critical health disparities, tests new interventions, and develops culturally appropriate solutions to improve health and well-being. Applications are encouraged to include community-driven research, addressing unique sociopolitical and environmental challenges faced by these populations, ultimately aiming to reduce morbidity and mortality.

The OJJDP FY 2026 Strengthening Internet Crimes Against Children (ICAC) program aims to enhance the technological investigative capacity of ICAC task forces nationwide. Through this funding opportunity, the program will support the development and refinement of investigative tools and methods to combat child sexual abuse material, exploitation, and trafficking. The deadline for application submission is November 5, 2026, at 8:59 p.m. ET, emphasizing the urgency of addressing these critical issues.

The Hershey Heartwarming Young Heroes GYSD Grant supports youth-led projects for Youth Service Month and Global Youth Service Day. Open to U.S. and Canadian youth aged 5-25, grants of $250 or $500 are available, depending on volunteer engagement. Projects should address community needs and foster inclusivity among diverse youth volunteers. Successful applications will partner with local organizations and focus on relationship-building. A total of $50,000 in grants will be awarded, encouraging meaningful community service.

The NIH grant focuses on elucidating the role of transporters in key perinatal barriers such as the placenta and blood-brain barrier. By establishing a multi-barrier transport network, the initiative aims to enhance understanding of maternal and infant health regarding nutrient and medication transport. This research will create essential resources and standards, fostering future studies on perinatal exposure and intervention strategies. Ultimately, it aims to advance knowledge in pediatric pharmacology and neurodevelopment.

The NIA Predoctoral Fellowship Award aims to enhance diversity in the translational research workforce focusing on Alzheimer's disease and related dementias. This funding opportunity supports promising predoctoral candidates from underrepresented backgrounds, fostering their research training and skills in various aspects of AD/ADRD. By encouraging interdisciplinary teamwork, the program seeks to develop a diverse workforce capable of contributing significantly to the prevention, treatment, and management of these conditions.

The BRAIN Initiative aims to foster innovation in the development of next-generation devices for recording and modulating the human central nervous system. This funding opportunity encourages clinical studies and translational research to create advanced therapeutic and diagnostic devices for neurological disorders. Applicants are advised to submit Letters of Intent 60 days before the proposal deadline. This initiative emphasizes milestones and collaboration with NIH staff throughout the project.

The NIA Postdoctoral Fellowship Award aims to enhance diversity in the translational research workforce for Alzheimer's disease and related dementias (AD/ADRD). This fellowship supports promising candidates from diverse backgrounds in developing essential translational research skills. The program emphasizes interdisciplinary approaches to treatment, prevention, and early detection of AD/ADRD while providing research experience under the guidance of mentors in clinical trials, fostering a diverse and effective research community.

The Comprehensive Housing Counseling (CHC) and Housing Counseling Training (HCT) NOFO (FY2026) aims to support HUD-approved housing counseling agencies. These agencies provide essential guidance to tenants and homeowners regarding property maintenance, financial management, and literacy. This initiative plays a crucial role in helping individuals secure sustainable homeownership or affordable rentals, while also serving as a safeguard against housing scams and discrimination, connecting clients to various housing resources.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The NIA Expanding Research in AD/ADRD Summer Research Education Program supports the recruitment of early-stage investigators and aims to provide hands-on research experiences in Alzheimer's Disease and related dementias. Targeting high school students, undergraduates, and science teachers, the program enhances STEM education through authentic research opportunities and educational activities. By fostering early exposure to research, it aims to stimulate interest in AD/ADRD careers and address workforce shortages in this critical field.

The CDC's initiative, 'Holistic and Evidence-Informed Wellness for STI Prevention', addresses the significant public health burden of STIs in the U.S. by promoting a comprehensive approach that emphasizes healthy choices and relationships. By supporting a coalition of sexual health experts, the program aims to enhance STI prevention through strategic resource allocation and the dissemination of high-quality, evidence-based materials, targeting priority groups most affected by STIs. This holistic strategy seeks to reduce STI morbidity and improve overall sexual health.

The Advanced Rehabilitation Research Training (ARRT) Program aims to enhance the research capabilities of individuals with advanced degrees, focusing on disability and rehabilitation research related to employment outcomes. Funded by the US HHS Administration for Community Living, this grant offers a 36-month project period, supporting multidisciplinary training for researchers, including those with disabilities, to contribute to high-quality research in the field.

The NIH Blueprint for Neuroscience Research Network aims to enhance foundational research on human consciousness, addressing critical biomedical issues such as coma and dementia. By fostering a collaborative framework among 14 NIH institutes, the initiative seeks to improve diagnosis and treatment of neurological disorders through interdisciplinary approaches. Key objectives include detecting consciousness in minimally responsive patients, enhancing understanding of sleep disorders, and exploring new methodologies. This effort will ultimately strengthen U.S. leadership in neuroscience and improve patient outcomes.

The NHLBI is set to release a NOFO aimed at enhancing an international research platform for cardiac surgery. This initiative will integrate various research areas, including mechanistic science and implementation science, to advance innovative techniques and improve health outcomes for adults with cardiovascular disease. Furthermore, the platform will serve to train future clinical trialists. Potential applicants are encouraged to start forming collaborations and preparing their proposals, as applications are not yet being solicited.