Best Seed Grants for Nonprofits in American Samoa

The National Institutes of Health (NIH) invites applications for clinical trials and ancillary studies within its funded research networks. This program supports multi-center trials, emphasizing collaborations and responsive projects. The UG3/UH3 cooperative agreement will fund an initial 2-year planning phase, with a potential 5-year implementation phase. This notice is to prepare applicants for future submissions, as applications are currently not being solicited. Prioritization will be given to studies aligned with network capabilities.

The National Cancer Institute (NCI) invites applications for the R33 grant aimed at advancing emerging technologies in cancer research. This funding opportunity seeks projects that demonstrate significant progress in technology development, focusing on cancer biology, early detection, and clinical diagnosis. Eligible proposals must showcase innovative methodologies that enhance research capabilities, with a strong emphasis on technical validation and broad applicability in cancer applications.

The National Meredith Willson Awards provide multi-year operating support to organizations using music for systemic change. The Music Man Foundation will award grants of $50,000 to $500,000 to 5-10 selected organizations in 2026, focusing on their impact through music. Eligible organizations must have 501(c)(3) status, a history of music programming, and a commitment to systemic change. Applications will be evaluated on leadership, organizational capacity, and alignment with grant criteria.

The National Cancer Institute (NCI) invites applications for innovative technologies aimed at cancer research and clinical care. This funding opportunity supports early-stage projects focused on proof-of-concept studies to assess the feasibility of new methods and tools. Applications should demonstrate significant technical innovation, targeting advancements in cancer biology, early detection, clinical diagnosis, treatment, and epidemiology. Technologies may include novel analysis platforms, imaging technologies, and biospecimen processing innovations, with a focus on cancer applications.

The NIH Specialized Center Grant (Parent P50) aims to support multidisciplinary research programs with a specific scientific theme. Applicants must include an administrative core, research projects, and at least one resource core, demonstrating collaborative impact and synergy. This funding opportunity encourages innovative approaches to address major scientific objectives, fostering long-term research initiatives aligned with the NIH's mission. Applications should emphasize how their projects interconnect to achieve goals beyond individual efforts.

The NCI Research Specialist Award (R50) supports non-tenure track scientists in cancer research who provide essential contributions within laboratories and core facilities. This award aims to enhance research careers for skilled scientists who do not seek independent investigator funding. Eligible candidates must possess an advanced degree, have at least two years of contribution to NCI-funded research, and dedicate a significant portion of their time to this work. The R50 offers salary support and travel funds to recognize and stabilize these vital roles in cancer research.

The CDC's NCIPC is seeking research proposals to tackle implementation challenges in providing linkage to care services for individuals with opioid use disorder (OUD). This initiative encourages partnerships with public health entities and local healthcare champions to create actionable, evidence-based strategies. The goal is to enhance care access and ensure comprehensive overdose prevention services are available in real-world healthcare settings, thereby improving outcomes for those at risk of opioid overdose.

The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.

The Air Force Basic Research Sciences Conference and Workshop Support program encourages proposals from U.S. institutions of higher education and nonprofit organizations for conferences and workshops that promote research and technology interchange. These events are vital for sharing recent findings and educational techniques in key scientific areas. The program specifically invites Historically Black Colleges and Universities, Minority-serving Institutions, and Tribal Colleges to participate, aiming to foster collaboration and knowledge exchange among researchers.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The NSF Core Research in Biological Sciences (BIO Core) program supports innovative research that enhances our understanding of biological systems, from molecular to biome scales. This funding opportunity encourages interdisciplinary proposals and can fund both single and multi-investigator projects. The awards will vary in scope and duration, accommodating exploratory projects and long-term commitments, depending on available funding and alignment with the program's objectives.

The NIH Director's New Innovator Award supports creative early-stage investigators pursuing innovative research with transformative potential for science relevant to the NIH mission. Applications are encouraged across all NIH-related fields, enhancing support for emerging talent. This award is part of the NIH Common Fund's High-Risk, High-Reward Research Program, which aims to cultivate groundbreaking research and foster the next generation of scientists.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR) Competitive Grants Program aims to enhance the capacity of state and local government crime laboratories for processing DNA samples. This program focuses on using DNA technology to improve forensic efficiency and implement Rapid DNA in booking stations. It targets jurisdictions with operational challenges, ensuring fair access to funding. Eligible agencies can apply for both competitive and formula CEBR funding.

The NIH Independent Scientist Award (K02) supports the development of outstanding scientists by providing three to five years of salary support and protected time for newly independent researchers. This funding opportunity is specifically for applicants proposing research that does not involve leading an independent clinical trial, allowing them to gain experience in trials led by others. Key deadlines for applications span from June 2024 to February 2027.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.

The NIH Common Fund is planning to issue a NOFO to continue the Bridge2AI program, which aims to develop AI-ready datasets and best practices for biomedical research. This next stage will leverage these datasets to address significant health challenges and foster multidisciplinary collaboration. The initiative will support 3-5 Centers focused on trustworthy AI in biomedical research, creating frameworks for reproducibility, transparency, and advancing the AI workforce in health sciences.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The NIJ FY 2026 Crime and Justice Research funding opportunity invites applications for innovative research aimed at enhancing the effectiveness of the adult criminal justice system. It comprises two main categories: one focuses on new programs and strategies to improve workforce readiness, while the other assesses the impact of the COPS De-escalation Training Program. This initiative seeks to foster safety and operational improvements within law enforcement.

The National Science Foundation (NSF) is offering funding through the Engineering (ENG) program, focusing on foundational research in civil, mechanical, and manufacturing innovation. Key areas include advanced manufacturing systems, civil infrastructure, and intelligent dynamic systems. The NSF ENG encourages innovative and transformative proposals that may not require immediate commercial outcomes. Award sizes and durations will vary based on budget availability, aiming to support long-term research advancements.

The DOE Quantum Genesis Q Competition aims to accelerate the development of fault-tolerant quantum computing capabilities essential for scientific research. This initiative invites proposals from domestic entities to create viable plans for the Quantum Genesis program, aligning with national scientific goals. The competition serves as a foundational effort to scale quantum technologies and enhance scientific workflows, fostering innovation and collaboration as the nation progresses into a new era of computational power.

The SMART FY26 Support for Adam Walsh Act Implementation Grant Program aims to enhance sex offender registration and notification practices across jurisdictions in the U.S. By supporting the implementation of the Sex Offender Registration and Notification Act (SORNA), this grant facilitates the establishment of comprehensive sex offender registries, ensuring that states, territories, and federally recognized tribes comply with federal standards. This initiative also promotes interjurisdictional information exchange and helps maintain public safety.

The NIH Independent Scientist Award (K02) aims to support the development of independent scientists and enhance their research capabilities. This award offers salary support and protected time for three to five years, specifically for those leading independent clinical trials or feasibility studies. Applicants must demonstrate a need for focused research to advance their careers. Key deadlines for applications span from June 2024 to February 2027, catering to various submission types including standard and AIDS-related grants.

The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.

Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.