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Best Operating Grants for Nonprofits in Iowa

Find the perfect Operating grants for nonprofits in Iowa on Instrumentl. 10,000+ Operating grants for nonprofits in Iowa in the United States.

10,000+

Available grants

$2.56B

Total funding

$5K

Median grant

10,000+ grants
$2.56B total
$5K median

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9,583 Results based on applied filters

HIV/AIDS Clinical Trials Network Clinical Trials Units

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for Clinical Trials Units (CTUs) as part of its effort to combat HIV/AIDS. This initiative aims to support innovative clinical trials and implementation research to improve prevention and treatment strategies. With a focus on both domestic and international research sites, CTUs will play a crucial role in addressing the HIV epidemic and enhancing participant recruitment and retention. This funding opportunity is authorized under the Public Health Service Act.
HIV / AIDS

HIV/AIDS Clinical Trials Network Laboratory Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for up to four Clinical Trials Network Laboratory Centers (LCs). These LCs will support HIV prevention and treatment strategies by providing necessary laboratory infrastructure and technologies for clinical trials. They will ensure rigorous laboratory testing and oversight, enhance sample integrity, and utilize advanced data management systems to meet evolving demands in HIV research and testing.
HIV / AIDS

Melanoma: Established Investigator Award

Melanoma Research Foundation
Private
United States
Up to US $125,000
The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

Career Development Award Program RFP- New Application

Melanoma Research Foundation
Private
United States
Up to US $50,000
The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

HIV/AIDS Clinical Trials Network Leadership and Operations Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is calling for applications for four Leadership and Operations Centers (LOCs) as part of its HIV/AIDS Clinical Trials Network initiative. These LOCs will guide research on HIV therapeutics, prevention, and treatment strategies across diverse populations. The initiative aims to enhance evidence-based practices and improve health outcomes for individuals affected by HIV, ultimately contributing to the goal of ending the HIV epidemic.
HIV / AIDS

Accelerating Research and Development of Next Generation Malaria Vaccines Against Malaria – A Model for Mosquito-Borne Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID is focused on advancing the research and development of next-generation malaria vaccines, aiming to leverage innovative vaccine design techniques. This initiative not only aims to enhance malaria prevention but also serves as a model for combating other mosquito-borne diseases. By utilizing cutting-edge methods such as structure-based immunogen design and combination vaccines, the program seeks to significantly reduce both parasite infection rates and the overall disease burden associated with malaria.
Malaria Tropical Diseases

Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement -- Cycle 1 2026

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $22,000,000
The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.
Addiction & Substance Use Disorders Mental Health & Psychiatric Diseases Cardiovascular Diseases & Systems +2 more

Cynthia and Alan Baran Fine Arts and Music Scholarship Fund

Community Foundation of Middle Tennessee
Private
United States
Unspecified amount
The Cynthia and Alan Baran Fine Arts and Music Scholarship Fund, established by passionate artists Cynthia and Alan Baran, aims to support young individuals pursuing their dreams in visual arts and music. This fund, administered by the Community Foundation of Middle Tennessee, offers scholarships to rising college students majoring in Fine Arts or Music, emphasizing the importance of creativity and academic achievement. With a commitment to fostering talent, this initiative empowers future generations to thrive in the arts.
Education - High School Academic Scholarship Programs Fine Art +2 more

Encompass Health Therapy Grant

Encompass Health Corporation
Corporate
Puerto Rico, United States
Up to US $75,000
The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.
Medical Rehabilitation Home Health Care Health Care Access & Delivery +3 more

HIV Prevention NOVA 2026

Gilead Sciences, Inc.
Corporate
United States
Unspecified amount

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

HIV / AIDS

Geoff Richter Performing Arts Award

Foundation For Jewish Philanthropies
Private
United States
US $2,000

Our Mission

Empower donors to fulfill their passions and dreams by establishing charitable vehicles designed to create a positive and enduring impact on Jewish Buffalo, Western New York and the World.

Geoff Richter Performing Arts Award

The Geoff Richter Performing Arts Award Committee announces the availability of an Award up to $2,000! The GRPAA was founded in memory of Geoff Richter, Western New York Musician and Educator of the Arts.

About Geoff Richter

A native of Eden, New York, Geoff received his Bachelor of Music degree with a Performer’s Certificate in trumpet and a Master’s with a Performers Fellowship, from the Eastman School of Music.

Geoff played trumpet professionally with the Rochester, San Antonio, and Buffalo Philharmonic Orchestras and Niagara Falls, Binghamton, Chautauqua, Orchard Park, Clarence, Cheektowaga, and Amherst Symphony Orchestras. He co-founded the Buffalo Brass Quintet, the Buffalo Niagara Concert Band, and The Frankfurters, an internationally known Bavarian show band. He also acted as the summer/pops conductor of the Erie County Wind Ensemble and the Amherst Symphony Orchestra.

After retiring from a long career at Williamsville North High School, Geoff started working part time as director of the orchestra for musicals at St. Joseph Collegiate Institute. He also worked with the Mount Saint Mary Academy band and recruited and directed the orchestra for the annual school musical.

Performing Arts Education - Higher Education Music +2 more

Neonatal Research Initiative- RFP

Little Giraffe Foundation
Private
United States
US $5,000 - US $10,000
The Little Giraffe Foundation is dedicated to supporting neonatal health through research grants ranging from $5,000 to $10,000. Since 2011, they have provided substantial resources to hospitals and institutions, focusing on both immediate and long-term health challenges faced by premature infants. Eligible applicants include scientists and healthcare professionals from U.S.-based institutions. The foundation aims to advance research in biological processes, genetics, clinical studies, and more, improving outcomes for vulnerable populations.
Obstetrics & Neonatal Care

Little Giraffe Foundation: NICU Support Grants

Little Giraffe Foundation
Private
United States
Up to US $2,000
The Little Giraffe Foundation, a national non-profit based in Chicago, provides NICU Support Grants ranging from $100 to $1,000. Since 2011, they have positively impacted countless families by delivering over 32,000 gift bags and funding essential research. These grants aim to enhance the experience for parents and patients in neonatal intensive care units, supporting initiatives like holiday gift bags and resources for bonding with babies. Applications are welcomed from eligible U.S.-based institutions.
Obstetrics & Neonatal Care

Women's Club of Grand Haven Grant

Grand Haven Area Community Foundation
Private
United States
Unspecified amount
The Women's Club of Grand Haven Grant, established in 2001, offers scholarships to non-traditional students from the Tri-Cities seeking further education. Funded through community efforts such as an annual Used Book Sale, this grant prioritizes financial need and is open to applicants residing in Northern Ottawa County or those who graduated from local school districts. Preference is given to female applicants aged 21 and older, supporting educational advancement for those whose academic journeys have been interrupted.
Education - Higher Education Educational Access & Equity Adult Education +3 more

USADPLC Dry Pea & Lentil Council Grant Opportunity

USA Dry Pea & Lentil Council
Private
United States
US $16,000 - US $75,000
The USA Dry Pea and Lentil Council (USADPLC) invites research proposals for pulse crops, focusing on breeding, nutrition, crop management, and product development for the 2023-24 fiscal year. Projects should adopt a transdisciplinary approach to tackle complex challenges, with average awards around $30,000. Researchers are encouraged to leverage industry funding for matching grants. Note that equipment purchases over $10,000 are not eligible. Compliance with specific proposal guidelines is essential.
Agricultural Crops Agricultural Economics Agricultural Pest Management +1 more

Elevance Health Foundation: Food as Medicine Grant

Elevance Health Foundation
Corporate
United States
Unspecified amount
The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.
Food Security Nutrition & Healthy Eating Chronic Illnesses

Bob Skiera Memorial Fund Building Bridges Initiative and John P. White Grant Program

Tree Fund
Association/Society
United States
US $5,000 - US $30,000
The Bob Skiera Memorial Fund Building Bridges Initiative Grant Program supports urban forestry research and collaboration. With a maximum award of $30,000, it aims to enhance communication between arborists, urban foresters, and various professionals. The program welcomes proposals that explore the benefits of urban forests, policy implementation, and ecosystem services. This initiative honors Bob Skiera's legacy, fostering trust and cooperation within the urban planning community for sustainable urban forestry practices.
Forestry

1954 Project - Luminary Award

Cleveland Avenue Foundation for Education Group
Corporate
United States
US $1,000,000
The 1954 Project - Luminary Award seeks visionary nonprofit leaders dedicated to advancing educational equity for Black students. Awardees receive $1 million in funding, leadership development, and networking opportunities. The selection prioritizes leaders demonstrating strategic vision, community commitment, adaptability, and collaborative spirit. Applicants must align with one of three impact areas: Innovation in Teaching and Learning, Diversity in Education, or Pathways to Economic Mobility, ensuring their initiatives foster systemic change and uplift marginalized communities.
Educational Access & Equity Education System Policy & Reform Teacher Development & Training +3 more

Bezos Scholars Program

Bezos Family Foundation
Private
United States
More than US $1,000
The Bezos Scholars Program, supported by the Bezos Family Foundation, is a transformative, no-cost leadership development initiative designed for high school juniors. Each year, selected scholars from the U.S. and Africa engage in a year-long program, developing leadership skills through civic engagement and community projects. Participants receive personalized college advising, funding for their projects, and an all-expenses-paid trip to the Aspen Ideas Festival, fostering a diverse community of changemakers committed to making a difference.
Academic Scholarship Programs Educational Access & Equity Youth Development & Leadership +2 more

Jack Feldt Ambucs Memorial Scholarship

Grand Haven Area Community Foundation
Private
United States
Unspecified amount
The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.
Education - Higher Education Educational Access & Equity Physical Therapy +2 more

Mentored Quantitative Research Development Award (Parent K25 Independent Basic Experimental Studies with Humans Required) (353711)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Mentored Quantitative Research Development Award (K25) aims to engage skilled professionals in NIH-relevant research, enhancing their expertise in addressing health-related issues. This award supports individuals with backgrounds in quantitative sciences and engineering, providing them with dedicated time for supervised research and study. Key application deadlines span from June 2024 to February 2027, emphasizing the program's commitment to fostering innovative research in health and disease.
Engineering Mathematics Chemistry +8 more

Alliance for Innovation on Maternal Health (AIM) Capacity Program

Health Resources and Services Administration
Federal Government
American Samoa, Guam +4 more
Up to US $230,000
The Alliance for Innovation on Maternal Health (AIM) Capacity Program aims to enhance the capacity of state, territorial, and Tribal entities in the U.S. to implement and sustain AIM Patient Safety Bundles. By promoting evidence-based maternal safety practices, the program strives to improve the quality of maternity care, enhance maternal health outcomes, and significantly reduce preventable maternal mortality and severe morbidity.
Maternal And Perinatal Health Patient Safety

Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding (363415)

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $200,000
The Ryan White HIV/AIDS Program Part D provides supplemental funding aimed at enhancing the infrastructure and capacity of organizations to deliver high-quality, family-centered HIV care services. This initiative focuses on two key areas: HIV Care Innovation and Infrastructure Development, ensuring improved access to essential services for women, infants, children, and youth affected by HIV.
HIV / AIDS

Ryan White HIV/AIDS Program Part B AIDS Drug Assistance Program Training and Technical Assistance

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The Ryan White HIV/AIDS Program Part B AIDS Drug Assistance Program Training and Technical Assistance aims to enhance the capacity of ADAPs. By providing essential tools and expert guidance, the program seeks to improve health outcomes for individuals living with HIV in an evolving healthcare landscape. This initiative is funded by the US HHS through the Health Resources & Services Administration, ensuring support and resources are effectively allocated to meet the needs of vulnerable populations.
HIV / AIDS

Operating Grants for Nonprofits in Iowa Highlights

Looking for operating grants for nonprofits in Iowa?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Iowa recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Iowa

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Operating grants for nonprofits in Iowa grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Operating grants for nonprofits in Iowa over $25K in average grant size

37 Operating grants for nonprofits in Iowa over $50K in average grant size

33 Operating grants for nonprofits in Iowa supporting general operating expenses

100+ Operating grants for nonprofits in Iowa supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Health & Medicine

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Iowa?

Most grants are due in the first quarter.

Q1
30.7%
Q2
24.4%
Q3
22.2%
Q4
22.7%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Iowa?

Grants are most commonly $18,750.

$500 $500 Min.
$18,750 $18.8 K Median
$195,866 $195.9 K Average
$3,000,000 $3 M Max.

Average Grant Size

What's the typical amount funded for Iowa?

Grants are most commonly $82,635.

$82,635

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Iowa year over year?

In 2024, funders in Iowa awarded a total of 28,032 grants.

2022 25,336

2023 26,582

2024 28,032

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Iowa given out in Iowa, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in Iowa changing over time?

Funding has increased by 9.41%.

2022 $2,079,026,768

2023 $2,108,613,200
1.42%

2024 $2,307,128,111
9.41%

Iowa Counties That Receive the Most Funding

How does grant funding vary by county?

Polk County, Story County, and Johnson County receive the most funding.

County Total Grant Funding in 2024
Polk County $545,560,005
Story County $266,280,101
Johnson County $184,865,698
Linn County $166,016,288
Boone County $155,314,892