Best Large Grants for Nonprofit Organizations in Maine

The Alzheimer's Disease Programs Initiative (ADPI) aims to foster the development of dementia-capable community health worker programs within the National Aging Network. This initiative, supported by the US HHS: Administration for Community Living (ACL), seeks to enhance dementia screening, reduce barriers to care, and improve access to essential services for individuals with dementia and their caregivers. By integrating community health workers into aging services, the program aspires to elevate the quality of life for those affected.

The Cheerful Giver Scholarship, provided by the Community Foundation of the Central Blue Ridge, offers over $300,000 in financial support to students in the Greater Augusta County area pursuing health care-related education. This need-based scholarship is open to high school seniors, current college students, and adult learners, with a preference for those entering the nursing profession. The foundation aims to enhance community well-being through educational opportunities.

The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.

The HEAL Initiative aims to identify new druggable targets for pain within the understudied proteome. This funding opportunity invites applications for pilot projects that generate preliminary data and tools for exploring these targets. The initiative seeks to enhance research on understudied proteins related to pain management, providing essential funding for biochemical and biological work. This NOFO is part of the NIH's broader effort to develop novel medications that address various aspects of opioid addiction and its consequences.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5419 - Crossing the Divide – Best Practices for Addressing Local and Privately-Owned Lateral Sewer Issues

Grant Information

To provide water resource recovery facilities (WRRFs) and collection system operators with an interactive manual of practice for implementing inflow and infiltration (I&I) and obstruction management programs with a focus on municipal and privately owned lateral sewers in complex legal, regulatory, and multi-jurisdictional environments.

The DARRP Restoration Implementation Grants aim to enhance marine and coastal habitat restoration through collaboration between NOAA and non-federal partners. These grants address oil spills and hazardous substance releases by supporting restoration activities authorized under various environmental laws. Eligible applicants will implement projects that promote sustainable fisheries, recover endangered species, and boost local economies. Through careful planning and evaluation, recipients will contribute to effective restoration strategies that align with NOAA's mission and the needs of coastal communities.

The GLS Campus Suicide Prevention program aims to enhance behavioral health services for college students, addressing critical issues such as suicide, depression, and substance use disorders. By fostering a culture of help-seeking and reducing stigma, this initiative ensures that at-risk students receive timely intervention and support. The program represents a vital investment in the mental well-being of students, promoting a healthier campus environment through evidence-based strategies and comprehensive public health approaches.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

The HIV Prevention and Alcohol R61/R33 funding opportunity aims to advance innovative HIV prevention strategies through a phased research approach. The R61 phase focuses on developing and pilot testing interventions, addressing key implementation questions for diverse populations. Following successful milestones, the R33 phase expands testing of these interventions and explores their effectiveness and sustainability, particularly in relation to alcohol use and related health issues.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.

The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.

The Confluence Grant Program, initiated by the Conservation Alliance in 2021, aims to strengthen partnerships with historically racially excluded groups. It awards four grants of $100,000 over two years to support projects that protect or restore natural places. The program emphasizes building meaningful relationships and sharing resources, ensuring that funded projects center on solutions led by impacted communities. By fostering collaboration and addressing funding gaps, the program enhances the conservation landscape for diverse voices.

The Zero Suicide Initiative aims to enhance suicide prevention within Indian health systems by implementing the Zero Suicide framework. This program focuses on culturally informed strategies to empower Tribal health systems, fostering leadership, workforce development, and effective suicide risk identification. It emphasizes timely engagement and evidence-based treatment, ensuring continuity of care and quality improvement, ultimately enhancing outcomes for American Indian and Alaska Native individuals at risk for suicide.

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Sadie Jones Fund

The original focus of the Sadie Jones Fund was to provide for vision and hearing needs for individual children in Lyon and Chase counties. While the purpose has expanded, individual children are still eligible to receive assistance.

The Sustainable Forests and Communities Grant aims to foster environmentally and economically sustainable forest communities in the U.S., particularly where the Weyerhaeuser Family has interests. It prioritizes projects enhancing the environment, economy, and community through sustainable practices. Eligible organizations must be 501(c)(3) tax-exempt entities operating in forested areas, focusing on integrated approaches that value forest ecosystem services. This initiative encourages local job creation, sustainable economic activities, and innovative partnerships to achieve sustainability goals.

The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.

The Alpha Gamma Delta Foundation provides grants aimed at combating hunger in the U.S. and Canada, focusing on direct food assistance, food rescue, and nutrition education. Eligible organizations can receive up to $10,000 in funding, with an average grant size of $5,000. Since its inception, the Foundation has awarded over $2 million to support local food programs, ensuring communities have access to essential resources and assistance for those in need.

The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5433 - Optimizing Membrane Biofouling Control in Potable Water Reuse Treatment Trains

Grant Information

Main Objective: Evaluate alternative biofouling control chemicals and operational strategies to optimize performance across the potable reuse treatment train while maintaining treatment performance and finished-water quality. Supporting objectives include:

• Identify and assess alternative biofouling control chemicals and operational strategies that can reduce membrane fouling and differential pressure, reduce cleaning frequencies, minimize degradation of ultraviolet transmittance (UVT), and reduce lifecycle cost.
• Evaluate treatment-train performance impacts, including effects on membrane system performance, membrane lifespan, UVT, and ultraviolet advanced oxidation processes (UV-AOP) performance and energy demand, finished-water quality, and concentrate management.
• Quantify lifecycle benefits and tradeoffs associated with selected strategies, including energy and chemical consumption, membrane replacement and cleaning frequency, monitoring and reporting requirements, operator safety and chemical handling, environmental considerations, and capital/operating and maintenance costs.

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

• Sudden cardiac arrest/resuscitation science
• Cardiovascular Kidney Metabolic Syndrome
• Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Breast Cancer Screening & Prevention Initiative

The Breast Cancer Screening & Prevention Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to lifesaving breast cancer screening and prevention services for uninsured and medically underserved. Through this initiative, the NAFC will provide $30,000 grants to members to establish or strengthen breast cancer screening programs in alignment with evidence-based guidelines from the U.S. Preventive Services Task Force and the American Cancer Society. Funding will support activities such as improving patient identification and referral systems, increasing access to mammography services through partnerships or mobile units, strengthening staffing and technology capacity, and providing patient education and case management to ensure follow-through with recommended screenings. By enhancing early detection and preventive care, the initiative seeks to reduce barriers to care and improve health outcomes for women who might otherwise go without critical cancer screening services.

The Ann W. Dooley Advancement Scholarship supports individuals aged 18-25 with intellectual disabilities who reside in Boone, Ogle, Stephenson, or Winnebago County. This scholarship encourages empowerment through education, enabling recipients to enhance their life skills for employment and independence. Established in memory of Ann Dooley, a dedicated educator, this scholarship honors her legacy of service and commitment to helping others. Applicants must provide verification of their disability and enrollment in a post-secondary program.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.

The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.