Best Operating Grants for Nonprofits in Maine

The Genesis Mission by the DOE aims to transform science and energy through AI by inviting interdisciplinary teams to tackle significant challenges in energy, environment, and nuclear sectors. With multiple deadlines for FY26 Phase I and II applications, the initiative encourages leveraging diverse scientific resources to enhance R&D workflows. Successful proposals could integrate AI advancements into the American Science Cloud, fostering innovation in critical areas like advanced manufacturing and quantum information science.

The Alternative Fuel Foundation Grant aims to support educational institutions in developing programs focused on renewable energy and environmental sustainability. Grants typically range from $250 to $500, with larger amounts considered on a case-by-case basis. Eligible applicants include public or private K-12 schools and universities. The foundation encourages projects that promote alternative fuels and community involvement, with a preference for initiatives that can be completed within a year.

The NIH Mentored Research Scientist Development Award (K01) aims to support early-career researchers in the biomedical, behavioral, or clinical sciences. This program provides three to five years of protected time for intensive career development, paving the way to research independence. Various NIH Institutes leverage this award to assist individuals transitioning into new fields or re-engaging with research after personal challenges. The K01 is a vital resource for cultivating the next generation of scientific leaders.

The Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) program aims to enhance diversity in research by supporting early career investigators from underrepresented backgrounds. This initiative offers a K99/R00 career transition award for postdoctoral scholars and a UE5 cooperative agreement that provides mentorship and professional development. The program's goal is to ensure successful transitions into independent, tenure-track faculty roles in NIH mission areas, ultimately fostering a more inclusive scientific community.

The ROSES 2025: D.4 program by NASA focuses on enhancing theoretical and computational astrophysics through collaborative networks. It aims to address grand challenges in Time Domain Multi-Messenger Astrophysics by integrating diverse expertise from various fields. Researchers from U.S. institutions are encouraged to propose innovative tools for modeling complex multi-messenger phenomena, fostering interdisciplinary collaboration across academic, national laboratory, and private sectors to prepare the next generation of scientists.

Confederated Tribes of Siletz Indians

The Confederated Tribes of Siletz Indians is a sovereign nation and has three main branches of government – Judicial, Executive, and Legislative. One of our most important resources is our people.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

Arthur S. Bensell Memorial Scholarship

Arthur S. Bensell was an educator, civic leader, Tribal Council member and Tribal Chairman. He spent many years in service to his community and Tribe as Mayor of the City of Siletz and tribal leader.

Art attended Ohio State University and graduated from Heidelberg College in 1934. During his career with the Bureau of Indian Affairs, he served as a teacher, principal and reservation principal in Minnesota, Alaska and North Dakota. Upon returning to Siletz, Art became involved in tribal business affairs and served many years on the Tribe’s Education Committee and always strived for better educational opportunities for Tribal members.

A memorial scholarship fund was established through the Confederated Tribes of Siletz Indians to honor and award Tribal members in education. The $1000 scholarship is administered by the Tribal Education Committee and strengthened by various fund raising activities throughout the year.

The Society of Interventional Radiology Foundation

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Giving Circle for the Advancement of Women (GCAW) Award

Provide career development opportunities for women in interventional radiology. GCAW is dedicated to engaging all generations of women in interventional radiology through the power of community philanthropy.

The Asian Cultural Council (ACC) offers Organization Grants to arts and culture organizations in Asia and the U.S., promoting cultural exchange through travel and collaborative activities. These grants support immersive experiences, research, and access to artistic communities, fostering international dialogue and relationship-building. Organizations must be nonprofit or educational institutions, legally registered in eligible regions, and demonstrate a minimum of five years of relevant programming. ACC provides additional support to enhance project feasibility.

About Spirit of Blue

Our Vision

To become the nation’s leading supplemental provider of law enforcement safety equipment and training across the county.

Our Mission

Spirit of Blue is dedicated to the enhancement of officer safety throughout the law enforcement community by fulfilling unfunded safety equipment and training needs.

Safety Grant Program

Spirit of Blue’s primary initiative is the granting of safety equipment and training to municipal, county and state law enforcement agencies in an effort to protect their sworn personnel. 

Most grants are 100% funded, meaning that no match is required. In the majority of cases, Spirit of Blue conducts the procurement of the goods or services being granted so that the recipient agency isn’t burdened with having to negotiate prices, place orders or track delivery. Rarely, if ever, does Spirit of Blue provide cash awards. Once selected, Spirit of Blue will provide the recipient agency with an official grant award letter outlining everything that is contained in the award. The recipient agency must gain acceptance of the grant, whether on the authority of their agency head or by working with their local governing authority as their policy may dictate. There are no reporting requirements after the award of the grant, but agencies are asked to submit a photo to be used in the announcement of their grant.

Grant Application

The Spirit of Blue Safety Grant Program is designed to award equipment, or in some cases training, that will protect officers serving on duty. You should only request items that you can articulate will have a positive impact on officer safety.

About Borealis Philanthropy

Borealis Philanthropy is a philanthropic social justice intermediary that works to resource grassroots leaders and social justice movements for transformative change. We help funders expand their reach and strengthen their impact through donor collaboratives that support a variety of issues, communities, and movements. Borealis is home to nine donor collaboratives, including the Disability Inclusion Fund and Disability x Tech.

DIF x Tech Fund

For the Disability Inclusion Fund at Borealis, part of our efforts for disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. The DIF x Tech initiative, supported by the Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest, invites proposals that are working to bring about transformational change at the intersections of disability, justice, and technology

About the Disability Inclusion Fund and DIF x Tech

The Disability Inclusion Fund (DIF) supports U.S.-based groups run by and for people with disabilities to lead transformational change. The Fund is supported by donors including the Presidents’ Council on Disability Inclusion in Philanthropy, which is comprised of foundation presidents who are committed to disability inclusion as part of improving diversity, equity, and inclusion within philanthropy.

Part of the efforts of disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. This newly launched initiative is housed at the Disability Inclusion Fund (DIF) and supported by Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest. 

DIF x Tech Fund Values

All Disability x Tech award decisions will align with the DIF guiding values. The DIF guiding values are:

• Participation: Movement funding accountable to the disability rights movement. Those impacted by injustice/exclusion should be involved in strategies to advance justice/inclusion.
• Intersectionality: Acknowledging that disabled people have multiple and intersecting social and political identities that can influence their ability to have access and inclusion including race, gender identity, class, sexual orientation.
• Radical inclusion: Deeply committed to removing barriers and ensuring access so that those most affected by intersecting identities can participate, valuing lived experience.
• Leadership of those most impacted by ableism: Emphasis is given to organizations led by people subject to systemic bias and impacted by underrepresentation, particularly disabled people of color, queer, gender nonconforming and women with disabilities.
• Cross-movement solidarity: Intentional focus on collaboration and bridge- building amongst disability justice activists and across movements.
• Sustainability: Resources and tools that support the growth of grassroots disabled-led organizations, and expand operational capacities for ongoing movement building. 

What we fund

We invite proposals that are at the nexus of technology, disability rights and justice. This opportunity may be a good fit for your organization, if you are doing work in any of these areas below:

• Disabled people sharing technical skills and knowledge with others in the community.
• Disabled people leading policy, rights, and disability justice activism work related to tech. 
• Disabled people participate in all stages of the design and development of new tech that will enrich lives of people with disabilities.
• Enabling collective and equitable access to digital infrastructure. 
• Expanding the participation, leadership, and thought partnership of overlooked and under-resourced people with disabilities in all areas of the technology sector.
• Partnerships between disability-focused engineering design labs and maker spaces within schools, centers for independent living, or local nonprofit organizations.
• Permissible Policy Work:
  • We may support nonpartisan policy education and advocacy related to disability and technology. Any lobbying must remain within applicable 501(c)(3) limits and Borealis grant restrictions.

The Creation & Development Fund, administered by the National Performance Network, supports the creation and mobility of artistic works that promote racial and cultural justice. It fosters collaboration between artists and communities through financial support, enabling artists to develop meaningful relationships and present their work. The fund emphasizes equity, access, and the importance of public engagement, ensuring that diverse voices are represented while addressing systemic injustices in the arts.

Scholarships are available to graduating high school seniors. Applications are accepted from mid-November until mid-March. Scholarship award recipients will be announced at the high school awards ceremony. 

Beatrice Reynolds Memorial Scholarship

Established by the late Ira T. Reynolds in memory of his late wife to assist a Susquehanna Community School District graduate who will major in education or teacher training. Scholarship is provided in four equal installments as long as the recipient remains a student in good standing.

Steven Thayer Hopi Scholarship

This scholarship was established by the family of Steven Thayer to provide scholarship funding for young Hopi artists to develop their talents and artistic skill.

The ACS-Hach High School Chemistry Classroom Grant aims to enhance chemistry education by providing funding for innovative teaching ideas. Since its inception in 2008, over 700 teachers have benefited from grants of up to $1,800. Eligible applicants are U.S. high school chemistry educators, and the funding can be used for laboratory supplies, instructional materials, professional development, and student-led field studies, fostering a deeper understanding of chemistry.

The Safety, Security, and Privacy for Open-Source Ecosystems (Safe-OSE) program, launched by the National Science Foundation (NSF), addresses vulnerabilities in open-source products and their development infrastructure. It invites proposals to enhance safety, security, and privacy across various types of open-source ecosystems. The program aims to support initiatives that improve resilience against risks, attacks, and breaches, ensuring that OSEs can effectively manage current and future challenges.

Chautauqua Region Community Foundation

Mission: In partnership with our community, we ignite positive change and create a legacy of impact.

Scholarships

The Chautauqua Region Community Foundation annually awards more than $2 million in scholarships to students pursuing higher education, job training and certification. The Foundation hosts several different scholarship opportunities throughout the year. 

Space Camp Scholarship

Open to students (grades 4-12) or adults from Chautauqua County, NY or Warren County, PA to support the cost of attending U.S. Space Camp. 

The Ken W. Davis Foundation Grant provides essential funding to nonprofit organizations in the U.S. that align with the Foundation's mission of promoting basic human needs and education in line with Constitutional freedoms. With a minimum grant size of $2,500, the Foundation focuses on supporting human service organizations in Tarrant County, Texas, and the Permian Basin of West Texas and Southeast New Mexico, while also offering national support for grants related to Constitutional freedoms.

The ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant supports early-career scientists in radiation oncology physics research. Jointly funded by AAPM and ASTRO, this grant aims to foster innovation in the field, with up to two awards of $50,000 each available. Eligible applicants include medical physics residents and post-doctoral fellows who are active members of ASTRO and AAPM. This initiative strives to enhance the next generation of researchers, ensuring a commitment to advancing radiation oncology.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The Capacity Accelerator for Tribal Offshore Wind Engagement, launched by the U.S. Department of Energy, aims to empower Tribal Nations in offshore wind energy decision-making. This initiative offers up to $7.1 million in cash prizes and technical assistance through three phases: Capacity Needs, Capacity Development, and Engagement. Each phase is designed to support Tribes in outlining their priorities, building capacity, and implementing impactful projects in offshore wind energy.

About

Originally conceived by Dr Bruce Mesara in 1990 as a means to carry on his philanthropic efforts beyond his lifetime, the Mesara Family Foundation was re-envisioned by his two children Amy and Douglas in 2014, and received their 501(c)(3) status from the IRS in 2015. Amy and Douglas sought out the assistance of their cousins to build upon the charitable principals on their parents, aunts and uncles.

The foundation is headquartered in Kalamazoo Michigan.

Mission

The mission of the Mesara Family Foundation is to honor the philanthropic principles of the Mesara and Pauch families by supporting carefully selected organizations that share similar values. Our focus is to provide support toward education, conservation and other causes of special family interest where our funding will make a genuine difference.

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The Amy Clampitt Poet Residency Program, established by The Berkshire Taconic Community Foundation, offers a six-month residency for poets at Amy Clampitt's former home in Lenox, Massachusetts. This program aims to foster the study and promotion of poetry, providing a peaceful retreat for a poet to focus on their craft. Selected poets receive a monthly stipend of $4,000 and are encouraged to make their creative work a priority during their stay.

The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.

The Patient-Centered Outcomes Research Institute (PCORI) is offering funding up to $750,000 for studies aimed at addressing critical methodological gaps in patient-centered comparative clinical effectiveness research. This initiative focuses on enhancing the quality of evidence in clinical research by prioritizing areas such as artificial intelligence, study design improvements, support for data research networks, and ethical considerations. Successful proposals will contribute to advancing research methodologies and improving patient outcomes.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Ginny and Jim Thompson Scholarship

Selection based upon (in order of priority):

Financial need, academic ability, recommendations, and an essay, “Why is education important to me?”

Awards

• One $1,000 scholarship

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.