Best Operating Grants for Nonprofits in Pennsylvania

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Schrage Family Enrichment

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

• Identification treatment responsive biomarkers
• Assess clinical measures and improve that enhance clinical trial readiness
• Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

Rapid Cancer Grants

Fast Funding for Home Cancer Care Research

We fund healthcare researchers to rapidly explore the feasibility of home infusion as a solution to the ongoing challenges of capacity shortage, site of care management, and financial toxicity in cancer care.

Traditional funding pathways for new care models are too slow to impact patients, so we’ve streamlined the process. By providing funding approvals within 14 days, we enable healthcare teams to quickly launch and evaluate home-based cancer care programs that improve access and affordability.  

What can a Rapid Cancer Grant be used for?

Projects must comprise of research investigating the feasibility, safety, or economic benefit of cancer care at home and must include delivering care to patients via an IRB approved study. IRB approval may be obtained after grant approval. Projects may include assessing suitability of home infusion, enabling access to lab draws at home, or remote care co-ordination to reduce time toxicity for patients.

If you’re a healthcare worker at an oncology practice, hospital or academic institution in the United States and are interested in continuing or launching a new home cancer care initiative, we invite you to apply for a Rapid Cancer Grant.

The National Swine Resource and Research Center (NSRRC) is a pivotal resource that enhances biomedical research by providing genetically modified models. This centralized facility reduces variability and costs for researchers, allowing them to focus on scientific discovery. NSRRC offers breeding, cryopreservation, and genotyping services, ensuring consistent access to high-quality models. By consolidating these resources, it promotes reproducibility and supports the development of innovative methodologies in research, ultimately advancing our understanding of human health and disease.

About The Children’s Heart Foundation

The Children’s Heart Foundation (CHF) is the country’s leading national organization solely dedicated to funding congenital heart defect (CHD) research. The mission of The Children’s Heart Foundation is to fund the most promising research to advance the diagnosis, treatment, and prevention of congenital heart defects. Since its inception, CHF has funded millions of dollars of CHD research across the U.S. and Canada. 

AHA/CHF Congenital Heart Defect Research Awards

The Children’s Heart Foundation partners with the American Heart Association to fund Congenital Heart Defect Research Awards. This collaborative investment of funds provides support for investigators who are actively conducting research directly related to advancing the prevention, diagnosis, and treatment of CHDs, which directly aligns with The Children's Heart Foundation's mission. 

Congenital Heart Defect Funding Opportunities

A multi-year commitment between the American Heart Association (AHA) and Children’s Heart Foundation (CHF) jointly supports Predoctoral Fellowship or Postdoctoral Fellowship investigators actively conducting basic, clinical, population, or translational congenital heart defects research.

Postdoctoral Fellowship

Purpose

To enhance the training of postdoctoral applicants who are not yet independent. The applicant must be embedded in an appropriate investigative group with the mentorship, support, and relevant scientific guidance of a research mentor. Recognizing the unique challenges that clinicians, in particular, experience in balancing research and clinical activity, this award mechanism aims to be as flexible as possible to enable applicants to develop academic careers in research alongside fulfilling clinical service commitments.

The trainee and mentor should collaboratively provide a thoughtfully planned, systematic proposal aimed at clearly answering an investigative question in cardiovascular, cerebrovascular or brain health research

• AHA research awards are limited to U.S.-based non-profit institutions, including medical, osteopathic, and dental schools, veterinary schools, schools of public health, pharmacy schools, nursing schools, universities and colleges, public and voluntary hospitals andothers that can demonstrate the ability to conduct the proposed research.

• Applicants must be AHA Professional Members at the time of proposal submission. The AHA expects all mentors associated with training/mentored research awards to maintain active AHA membership, as well.

• This award is not intended for individuals of faculty rank.

Applicants are not required to reside in the United States for any period before applying for American Heart Association funding. However, applicants must have one of the following designations at the time of proposal submission – not award start date, depending on career stage and each individual’s situation. An awardee must maintain one of the designations listed below throughout the duration of the award. Please consult with your institution’s grant officer.

• U.S. citizen
• Permanent resident
• Pending permanent resident (must have filed Form I-485 for permanent resident status and obtained an I-797C 3 Notice of Action that the application has been received by USCIS and case is pending)
• E-3 Visa - specialty occupation worker
• F-1 Visa – student (for predoctoral and postdoctoral fellows only)
• G-4 Visa - family member of an international organization employee
• H1-B Visa - temporary worker in a specialty occupation
• J-1 Visa - exchange visitor (pre- and postdoctoral fellowships only; all other awardees must obtain an H-1B or equivalent by the award activation date)
• O-1 Visa - temporary worker with extraordinary abilities in the sciences
• TN Visa - NAFTA Professional
• DACA - Deferred Action for Childhood Arrivals

About The Children’s Heart Foundation

The Children’s Heart Foundation (CHF) is the country’s leading national organization solely dedicated to funding congenital heart defect (CHD) research. The mission of The Children’s Heart Foundation is to fund the most promising research to advance the diagnosis, treatment, and prevention of congenital heart defects. Since its inception, CHF has funded millions of dollars of CHD research across the U.S. and Canada. 

AHA/CHF Congenital Heart Defect Research Awards

The Children’s Heart Foundation partners with the American Heart Association to fund Congenital Heart Defect Research Awards. This collaborative investment of funds provides support for investigators who are actively conducting research directly related to advancing the prevention, diagnosis, and treatment of CHDs, which directly aligns with The Children's Heart Foundation's mission. 

Congenital Heart Defect Funding Opportunities

A multi-year commitment between the American Heart Association (AHA) and Children’s Heart Foundation (CHF) jointly supports Predoctoral Fellowship or Postdoctoral Fellowship investigators actively conducting basic, clinical, population, or translational congenital heart defects research.

Predoctoral Fellowship

Purpose

To enhance the integrated research and clinical training of promising students who are matriculated in pre-doctoral or clinical health professional degree training programs and who intend careers as scientists, physician-scientists or other clinician-scientists, or related careers aimed at improving global cardiovascular, cerebrovascular and brain health.

• AHA research awards are limited to U.S.-based non-profit institutions, including medical, osteopathic, and dental schools, veterinary schools, schools of public health, pharmacy schools, nursing schools, universities and colleges, public and voluntary hospitals and others that can demonstrate the ability to conduct the proposed research.

• Applicants must be AHA Professional Members at the time of proposal submission. The AHA expects all mentors associated with training/mentored research awards to maintain active AHA membership, as well.

• This award is not for individuals of faculty/staff rank.

Applicants are not required to reside in the United States for any period before applying for American Heart Association funding. However, applicants must have one of the following designations at the time of proposal submission – not award start date, depending on career stage and each individual’s situation. An awardee must maintain one of the designations listed below throughout the duration of the award. Please consult with your institution’s grant officer.

• U.S. citizen
• Permanent resident
• Pending permanent resident (must have filed Form I-485 for permanent resident status and obtained an I-797C 3 Notice of Action that the application has been received by USCIS and case is pending)
• E-3 Visa - specialty occupation worker
• F-1 Visa – student (for predoctoral and postdoctoral fellows only)
• G-4 Visa - family member of an international organization employee
• H1-B Visa - temporary worker in a specialty occupation
• J-1 Visa - exchange visitor (pre- and postdoctoral fellowships only; all other awardees must obtain an H-1B or equivalent by the award activation date)
• O-1 Visa - temporary worker with extraordinary abilities in the sciences
• TN Visa - NAFTA Professional
• DACA - Deferred Action for Childhood Arrivals

The Mabel M. Witmer Scholarship Fund, managed by The Foundation for Enhancing Communities, supports students pursuing education in trade or technical schools. This fund aims to assist residents of Cumberland or Franklin County with financial need, especially those who have relevant work experience in their chosen field. By investing in education and skills development, the scholarship contributes to community empowerment and long-term economic growth in South Central Pennsylvania.

United Institute for Theatre Technology

The United States Institute for Theatre Technology (USITT) connects performing arts design and technology communities to ensure a vibrant dialog among practitioners, educators, and students.

Driven by our core values of inclusion, excellence, and responsibility, we provide mentorship programs, exhibit opportunities, grant funding, awards, and other opportunities for our members and for the entertainment industry. 

Emerging Digital Design Showcase

USITT is seeking expressions of interest from students and early-career creatives to participate in the Emerging Digital Design Showcase during the USITT26 Annual Conference & Stage Expo. Presented on the main USITT Awards Stage, this curated showcase highlights the next generation of digital and graphic designers working in performance, live events, and immersive environments.

This year’s showcase is inspired by the ocean, coastal environments, and the world beneath the surface — reflecting both the Long Beach location and the ideas of depth, motion, and interconnectedness inherent in live performance. Designers are encouraged to interpret the theme broadly rather than literally.

This showcase is not a competition; rather, it is intended as a platform for visibility, mentorship, and the celebration of emerging voices within the USITT community.

The SOT Undergraduate Research Award supports outstanding undergraduate students presenting original toxicology research at the SOT Annual Meeting. Awardees receive recognition, complimentary registration, lodging, and travel funding up to $800. This award encourages students to pursue graduate studies in toxicology or related fields and includes mentorship opportunities during the meeting, fostering their academic and professional growth.

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

Innovia Foundation

Each year, Innovia awards over $500,000 in scholarships to deserving students like you who are college-bound or pursuing vocational or technical training. Single scholarship awards range between $500 and $10,000.

Spokane Area Swimming Adam England Memorial Scholarship

Graduating high school seniors in all counties served by the Foundation are eligible to apply. Applicants must have participated in competitive swimming meets while in high school and must submit a letter of recommendation from a coach confirming participation in these swimming meets. Applicants must have a minimum 3.5 GPA and plan to enroll in post-high school program at full-time status.

The AES Infrastructure Grant, offered by the American Epilepsy Society, provides up to $50,000 to support the development of national or international multicenter research programs. This funding is intended for organizational planning sessions, infrastructure development, and pilot projects, facilitating future investments from other organizations. These grants are available annually in the spring, enabling researchers to enhance their collaborative efforts.

The National Kidney Foundation's Young Investigator Research Grant supports clinical research on kidney disease. It aims to foster innovation in patient-oriented studies, including technology development and clinical trials. Eligible applicants are junior faculty in the U.S. who have completed nephrology training. The grant provides up to $35,000 for one year, with potential renewal. Funds cover research costs, salaries, and limited travel, while prohibiting indirect costs and patient care expenses.

The Fetal, Infant, and Child Death Review Program aims to enhance the effectiveness of fetal, infant, and child death review teams across state, local, and tribal levels. By providing essential leadership and technical assistance, the program ensures standardized practices for conducting quality fatality reviews and collecting vital data. These efforts will facilitate the dissemination of findings, ultimately informing prevention strategies and improving outcomes for vulnerable populations.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Addressing Sensory Health Needs Across the Lifespan PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue the Addressing Sensory Health Needs Across the Lifespan PCORI Funding Announcement (PFA) seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects that focus on advancing care and outcomes across the lifespan for people living with sensory health conditions. Proposed CER projects should inform health decisions for people with sensory disorders, their families and care partners in the United States experiencing high burdens and practice variations in sensory health care and outcomes. 

Research Initiative Highlights

This topical PFA will solicit applications proposing to address patient-centered CER questions that will fill evidence gaps in the areas of screening, treatment, support services and interventions that address health outcomes associated with sensory conditions.

PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs). The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach.

• Increasing screening and early detection for people with sensory health conditions
• Improving treatment and care coordination for people with sensory health conditions
• Enhancing support services to improve mental health and address stigma experienced by individuals with sensory health conditions, their families and their care partners

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

The Zachary Adam Giordan-Lascari Memorial Scholarship, offered by the Community Foundation of Southern New Mexico, supports fathers pursuing physical therapy education at accredited institutes. This scholarship aims to assist students from diverse backgrounds, including those with disabilities and members of the LGBTQIA+ community. With a focus on community impact, this fund exemplifies the Foundation's commitment to enhancing educational opportunities and fostering a thriving future for recipients in Southern New Mexico.

The College Life Protected Graduate Research Grant supports research that enhances the value of higher education. Focused on systemic risks, it invites proposals on topics like mental health's impact on student success, campus safety compliance, and the effects of medical withdrawals. The grant is open to individuals in postsecondary education, who can re-apply regardless of prior submissions, promoting continued exploration of these critical issues.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

The Walters Services, Inc. Fabe & Beverly Walters Scholarship Fund, established by The Foundation for Enhancing Communities, aims to alleviate the financial burden of higher education for children and spouses of employees under 26. This scholarship supports full-time or part-time students, emphasizing academic achievement, community volunteerism, financial need, and an essay submission. The initiative embodies core values of love, integrity, and teamwork, fostering educational opportunities for future generations.

The Maternal and Child Health Encounters Networks (MCHEK) program, funded by the US HHS: Health Resources & Services Administration, aims to enhance maternal and infant health by preventing exposure to harmful substances throughout pregnancy. Through a national expert call center, it provides evidence-based guidance on medications, nutrition, and environmental factors. By translating complex scientific data into accessible information, MCHEK empowers families and healthcare providers to make informed choices that improve health outcomes.

Margaret B. Moeller Memorial Fund for Alzheimer's Home Care Companions

Grants support families in the Boyertown Area School District with members who suffer from Alzheimer's disease or other types of dementia.

The Margaret B. Moeller Fund for Alzheimer's Home Care Companions provides grants for families in the Boyertown Area School District with individuals who suffer from Alzheimer's disease or other types of dementia to obtain the services of in-home care companions, aides or other providers of respite care. Grants generally pay for several days of care for a specified period of time. The fund was created to help families who are not eligible for any other form of reimbursement for such services. Decisions are generally made within 15 days of receiving a complete application, including the referral.

The Zachary Moore Music Memorial Fund, established by The Foundation for Enhancing Communities, supports innovative music development for students from specific local schools or Lebanon Valley College. Eligible applicants must maintain a minimum 2.5 GPA and demonstrate commitment to music studies, particularly in audio engineering or creative expression. The fund aims to nurture the artistic aspirations of young musicians, reflecting the vision of Zachary Moore to inspire creativity and passion in music education.

Society of Toxicology

Founded in 1961, the Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of scientists who practice toxicology in the US and abroad. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology. SOT operates under four guiding principles:

• Serving the needs of the scientific discipline and our members to enhance human, animal, and environmental health.
• Life-long learning and intellectual scientific stimulation.
• Diversity of representation in all activities of the Society.
• Integrity.

ESS Student and Postdoctoral Travel Awards

Description

The American Chemistry Council (ACC) is pleased to sponsor two SOT Exposure Specialty Section travel awards for the upcoming 2026 Annual Meeting. Two $500 awards will be provided: one to a student and one to a postdoctoral researcher who is attending the Annual Meeting to present their work as part of the program.  

Who should apply? Any student or postdoc who is the presenting author of an abstract submitted to SOT for the Annual Meeting which indicates an application of exposure science with regards to toxicology. Abstracts will be evaluated based on the exposure assessment or methodology focus, scientific quality and significance of the research project, impact and/or novelty of the findings, written quality of the abstract, and stated need by the candidate.

Robert and Margaret Pulliam Scholarship

This scholarship was established to encourage and reward academic excellence and community service.

Award Information

6 scholarships are awarded each year. Awards will likely be between $1,400-$1,600.

Phoenix Scholarship Fund

Award Amount

Several scholarships in the range between $2,000 - $5,000 may be awarded at the scholarship committee's discretion.

Who We Are

Saginaw County is home. It is a beautiful community you’d be foolish to underestimate. We may have our challenges, but seeing its cities, villages and townships continue to grow and flourish gives us a sense of satisfaction and pride like none other.

Back in 1984, The Saginaw Community Foundation was founded to enhance the quality of life in our county by providing leadership, education, and support for philanthropy. Today, we still continue this mission of supporting the needs of our community through targeted grants, investments, and scholarships.

In addition to our grantmaking and scholarship programs, the Foundation also offers donor advised funds, which allow donors to recommend charitable grants to organizations of their choice. We also manage several endowed funds, which provide ongoing support for specific causes or organizations.

Saginaw Community Foundation is governed by a Board of Directors composed of community leaders and volunteers. A staff of professionals oversee our day-to-day operations and work with donors and community organizations to identify and address community needs.

CTE Scholarships

Dreaming of a career in welding? Maybe managing your own auto mechanics garage fuels your thoughts or you would love to become an electrician. Perhaps studying to become a chef in a culinary arts program suits your tastes.

No matter what your career path may be, there is little doubt that in recent years interest in Career and Technical Education (CTE) has grown. The increased need for workers skilled in the trades has resulted in larger numbers of students seeking out CTE programs.

Schools offering CTE encompass a wide variety of hands-on education, from HVAC to carpentry to cosmetology. In the past, financial assistance has been hard to come by for these areas of study, but that is no longer the case. Saginaw Community Foundation has several scholarship opportunities for those who have the desire to pursue CTE.

According to leading economists, not everyone needs a four-year degree. In fact, millions of good-paying jobs are opening up in the trades. And some pay better than what the average college graduate makes.

For aspiring welders, electricians, carpenters, and other valued skilled trade workers, there is great opportunity to take advantage of tailored CTE programs. The demand is massive as an estimated 3 million trade jobs in the United States remain vacant.

Our CTE scholarship awards range between $500 – $4,000 typically.

Reverend William D. Aldridge, Sr., Scholarship

The Reverend William Desmond Aldridge, the second oldest of five children, was born May 1, 1927, in Europa, Miss. The Reverend Aldridge was called to the ministry in 1944 at the age of 17. He completed three years of study at Rusk College before accepting his first pastorship in 1948. The Reverend Aldridge was named pastor of Christ Community Church on Easter Sunday in 1954, making him one of the longest-serving pastors in Saginaw County.

The Reverend Aldridge taught in the Buena Vista School District for nearly 10 years and has always placed a high priority on encouraging youth to seek academic excellence. Mary Viola “Jean” Aldridge, his wife of 50 years, was a teacher in the Buena Vista School District as well.

The Reverend Aldridge also worked at the General Motors Malleable Iron Plant and retired in 1981 after 28 years of service.