Best Operating Grants for Nonprofits in Pennsylvania

The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.

The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.

The National Institute of Neurological Disorders and Stroke (NINDS) aims to support innovative research for validating therapeutic targets in Alzheimer's Disease-Related Dementias (ADRD). This initiative focuses on overcoming barriers in treatment development by ensuring well-validated targets linked to disease mechanisms. By employing a phased award mechanism, NINDS seeks to enhance the rigor of target validation, facilitating the transition from basic discoveries to clinical applications, ultimately accelerating the development of effective therapeutic strategies.

The Pizza Hut Foundation is offering scholarships for students demonstrating financial need and community leadership. Eligible applicants must be U.S. residents aged 17-26, enrolled in accredited post-secondary education for Spring 2026, and maintain a minimum GPA of 2.5. Scholarship amounts range from $500 to $5,000, with distribution to be made in Spring 2026. The application period runs from July 8 to September 5, 2025, with notifications for recipients by November 17, 2025.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

George F. and Asha W. McMillan Scholarship

This scholarship is to provide financial support to an individual in order for him or her to receive a degree in Christian education or related studies or to advance his or her Christian vocation.

This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.

The Nowak Fellowship, part of Reinvestment Fund, supports pre-graduate school fellows aspiring to careers in community economic development. This initiative honors the legacy of Jeremy Nowak, the founding Executive Director, by addressing barriers faced by communities in accessing essential resources. Through this fellowship, Reinvestment Fund aims to empower new leaders and foster sustainable growth in underserved areas across the country.

The Lydia Fisher Warner Memorial Trust Grant supports hospitals in Philadelphia and its vicinity, established through the will of Ms. Warner in memory of her family. This perpetual trust ensures that the income generated will benefit the community for years to come. With an average grant size of $2,500 to $15,000, the trust typically awards around six grants annually. Eligible organizations must be 501(c)(3) exempt entities, focusing on improving healthcare access in the region.

The Ruth D. Frick Ames Scholarship, established by Robert Ames to honor his wife, supports students pursuing a nursing degree. Managed by the South Dakota Community Foundation, this scholarship aims to ease the financial burden for those aged 18-32 with a GPA of 2.9 or higher. Applicants should demonstrate financial need, strong academic performance, and community involvement. This initiative reflects Ruth's legacy of compassion, service, and commitment to helping others in the nursing field.

The MNA Associate Member Scholarships provide financial assistance to MNA associate members who are typically undergraduate nursing students. Offered by the Minnesota Nurses Association Foundation, these scholarships aim to support the professional development and educational goals of nursing students, contributing to the advancement of the nursing profession and ensuring access to quality healthcare for all. Eligible candidates include MNA members, their dependents, and veterans, fostering a commitment to nursing excellence.

The Ida W. Browning Trust Grant aims to enhance educational experiences for young people through audio-visual technology. With a mission focused on promoting religious and character-building initiatives, this trust supports eligible organizations in Harrisburg, PA, that qualify as 501(c)(3) entities. Grants typically range from $500 to $15,000, emphasizing partnerships with Sunday Schools, Churches, and youth organizations to foster Christian character development.

The Karl A. Bickel and Madira Bickel Journalistic Scholarship Fund Grant supports journalism students at accredited colleges and universities. Established under Karl A. Bickel's Last Will and Testament, it awards approximately $40,000 annually. Eligible organizations must have journalism programs and qualify as 501(c)(3) exempt entities. While there are no geographical restrictions, preference is given to institutions in Florida. The fund is administered by Wells Fargo Bank, ensuring that deserving students receive necessary financial support.

The Lancaster Equity Fund Grant offers up to $5,000 to support individuals from Black, Indigenous, and Immigrant communities in Lancaster. This grant aims to alleviate costs related to project execution, from self-compensation to logistical challenges. The Equity Council, in partnership with the Lancaster County Community Foundation, is dedicated to fostering systemic change by empowering BIPOC communities to take an active role in addressing societal issues. This initiative is a valuable opportunity for both seasoned and emerging leaders.

The MNAF Linda Knauff Clinical Practice Project Grant supports Minnesota Nurses Association members in conducting research that aligns with MNA's organizational goals. It promotes best practices through literature reviews, workgroup convening, policy development, and quality improvement initiatives. Applicants must be MNA members engaged in direct patient care, complete their projects within two years, and submit periodic reports. Preference is given to first-time applicants whose projects meet quality standards.

The Anna B. Glauser Trust Grants provide financial support to organizations aiding physically handicapped individuals, particularly blind residents in Delaware County, PA. Established in memory of Willis K. Glauser, the trust awards 1-2 grants annually, ranging from $2,500 to $5,000. Eligible organizations must be 501(c)(3) certified, while funding for salaries is typically excluded. This initiative reflects Anna Glauser's lifelong commitment to assisting the visually impaired community.

Angell Family Scholarship

The Angell Family Scholarship is for graduating high school seniors that attended Linton-Stockton, White River Valley, Dugger Union, or Sullivan High School. This scholarship is intended for students pursuing a one- or two-year vocational or occupational degree at Vincennes University or Ivy Tech which will lead directly to employment once completed. (Students seeking four-year degree paths should view other scholarship options offered by the Foundation.) The Angell Family Scholarship Fund was established in 1998 to provide scholarships for graduating high school seniors that reside in the Angell family (former) business marketing area in Greene and Sullivan counties.

The William C. Risser Charitable Trust Grants support mental health research, particularly in Schizophrenia. This private foundation assists 501(c)(3) nonprofit organizations across the U.S. with grants typically ranging from $25,000 to $55,000. Administered by Wells Fargo, the Trust awards 1-2 grants annually, focusing on program support for scientific and educational research. Eligible organizations must meet IRS exemption requirements.

The Pediatric Cancer Research Foundation (PCRF) offers Donor Designated Grant Programs aimed at funding innovative projects addressing childhood cancer. These grants support researchers dedicated to finding cures, enhancing treatment, and improving care. With an annual commitment to extraordinary researchers, PCRF ensures funds are directed towards promising advances in prevention and treatment. Since 1982, PCRF has raised over $51 million, significantly impacting survival rates and striving to eliminate childhood cancer through collaborative efforts and cutting-edge research.

The Delta Scholarship aims to support college-bound minority students in San Diego County who are dedicated to pursuing higher education. Established in memory of Jim Lewis, a passionate community leader, this scholarship offers up to $10,000 per student annually for four years, based on financial need. Eligible applicants must be graduating high school seniors with a minimum GPA of 3.0, planning to attend an accredited college or university.

The Community Assets Grant aims to revitalize neighborhoods in Erie County by improving parks, fields, and trails to foster healthier lifestyles and equitable access to recreational opportunities. This initiative addresses declining physical activity and rising health issues like heart disease, while supporting economic growth through local tourism and community engagement. By investing in these assets, Erie County enhances its unique cultural and social fabric, ensuring residents benefit from improved public spaces and increased community satisfaction.

The Ross Wagner Foundation Scholarship offers significant financial support for students pursuing degrees in various engineering fields, including civil, mechanical, and electrical engineering. With awards up to $25,000 annually, students can receive up to $100,000 over four years. Applicants must maintain a B average, work in engineering labs, and be enrolled in top-ranked engineering schools in the U.S. and Canada. This scholarship honors Ross Wagner's legacy, promoting excellence in engineering education.

The Journalism & Media Grant aims to promote inclusive narratives and accurate media that engage communities in democratic processes. It supports U.S.-based nonprofit organizations focused on professional reporting, multimedia storytelling, and civic media. The grant addresses barriers to media participation and fosters innovation in journalism, providing essential infrastructure for a diverse media landscape. While unsolicited proposals are not accepted, organizations can share ideas through a Letter of Inquiry (LOI).

The TTP Bridge Program aims to enhance the safety and accessibility of bridges in Tribal communities, addressing the urgent need for infrastructure improvements. With aging bridges affecting economic development and children's transportation, this program allows federally recognized Indian Tribes to apply for funding for planning, construction, and rehabilitation of bridges. By focusing on TTP bridges in poor condition, the initiative seeks to strengthen economic foundations and ensure better connectivity with markets, benefiting both families and communities.

The MASOT Conney W. Berger Jr. Memorial Graduate Student Award, established in honor of a dedicated toxicologist, supports doctoral students in toxicology/pharmacology. Eligible candidates must present at the MASOT meeting and meet specific criteria, including GPA requirements and MASOT membership. This award, valued at $500, encourages academic excellence and is made possible through the generous support of SafeBridge Consultants, Inc.

The Cultural Capital Fellowship offers $10,000 grants to Native artists and culture bearers dedicated to community outreach and cultural preservation. This fellowship strengthens the Collective Spirit of First Peoples artists, emphasizing the importance of passing on ancestral knowledge and maintaining cultural sharing. Eligible applicants must have strong ties to their Native community and be committed to sustaining cultural practices. The fellowship aims to support those who promote generosity, wisdom, and integrity within their communities.

The Jennifer Easton Community Spirit Award honors Native artists who have dedicated their lives to sharing cultural knowledge and ancestral gifts. With a grant of $50,000, this award supports artists deeply rooted in their communities, fostering healing and resilience. Nominations are open for practicing artists across various mediums, including music, dance, and storytelling, ensuring the continuation of Indigenous traditions and the enrichment of Native culture.