Best Operating Grants for Nonprofits in Pennsylvania

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Bill Rabbit Legacy Art Scholarship

Applicant must be enrolled in an accredited, four-year, higher education institution pursuing a degree in fine arts or art education with a minimum 3.0 GPA. Accepted focuses include drawing, painting, sculpture, pottery, traditional beadwork and textiles. Three pictures of artwork must be included with application for consideration. This is a one-year scholarship reserved for Cherokee Nation and United Keetoowah Band citizens residing within the Cherokee Nation jurisdictional area.

The Pauline H. Bruce Memorial Scholarship, administered by the Northern Piedmont Community Foundation, offers $2,000 to students in Culpeper, Fauquier, Madison, and Rappahannock counties. This scholarship honors Pauline Bruce, a dedicated educator with over 40 years of service in local public schools. To qualify, applicants must demonstrate a strong desire and aptitude for success in their college education, reflecting the spirit of community and educational excellence.

The ADDF-Harrington Scholar Program aims to transform academic discoveries into effective treatments for Alzheimer’s disease and related dementias. With funding of up to $600,000 annually, this program prioritizes innovative drug targets and supports research from hit-to-lead optimization to IND-enabling studies. Eligible applicants include academic investigators with a strong potential to advance meaningful therapeutics. The program emphasizes collaboration with industry experts, making it a significant opportunity for advancing dementia research.

The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.

The Brees Dream Foundation Grant aims to enhance the lives of cancer patients while providing essential care, education, and opportunities for children and families in need. With the support of generous donors and partners, the Foundation is dedicated to advancing cancer research and offering vital resources to those facing challenges. This commitment reflects a profound dedication to improving quality of life and fostering hope in communities.

The Eagles Autism Foundation Community Grant offers funding between $5,000 and $25,000 to support local services for individuals affected by autism spectrum disorder (ASD). This initiative aims to enhance the capacity of organizations serving the ASD community, with a focus on addressing the needs of underserved populations, including non-English speakers. Eligible applicants must be registered 501(c)3 organizations in the Philadelphia area that directly benefit the autism community.

The ESA Youth Scholarship Program, by the Electronic Security Association, provides financial support to children of first responders, having awarded over $941,500 to date. Eligible applicants are high school seniors with parents who are full-time active first responders. Each scholarship winner receives $1,000 and a chance to compete for larger awards of $14,000 for first place and $5,000 for second place. Applications are welcomed from students in participating states.

The Frank M. & Eleanor R. Miese Fund Grant, administered by Bridge Builders Community Foundations, aims to support transformative programs for underprivileged children in Cooperstown and surrounding areas. The foundation promotes growth through philanthropy, ensuring resources enhance community welfare. Eligible organizations must submit a charitable designation. This grant prioritizes projects that positively impact disadvantaged youth, fostering a brighter future through dedicated support and commitment to community development.

Eleanor & James Latta Jr. Scholarship Fund

Mission Statement

In the spirit of the A. Duie Pyle company focus on supporting people in as many ways as possible, the Latta Scholarship goal is to assist the children or stepchildren of A. Duie Pyle employees to enter into or continue attending an accredited college or technical school. Applicants must be children or stepchildren of A. Duie Pyle employees, should be able to demonstrate academic success, community and/or school contribution and a solid-grasp of future professional plans.

If you are an A. Duie Pyle employee and would like your child to apply for the Latta Scholarship, full details and an application can be accessed here. For any additional questions you can reach out to pylemarketing@aduiepyle.com. or grants@chescocf.org

Background

The Eleanor & James Latta Jr. Scholarship Fund was established through donations from A. Duie Pyle, Inc. and from private donors for the benefit of children of employees of A. Duie Pyle. The fund is administered through the Chester County Community Foundation, and award winners are selected by the fund's scholarship committee, none of whom work at A. Duie Pyle.

Eleanor Pyle was Duie Pyle's daughter, and in 1942 she married James Latta, Jr. At the time, Mr. Latta was serving his country in the U.S. Army. Shortly after the wedding, Mr. Latta shipped out and served in the China-Burma-India Theater, and did not return home until April of 1945. Beginning in 1946, Jim Latta worked alongside Duie Pyle as the company continued to grow.

As Mr. Pyle's health declined in the early 1960's, Mr. Latta assumed the decision making for the future of the company. Mr. Latta led Pyle through rapid expansion, diversification, and a Teamster strike, and Pyle's resulting decertification. Throughout his leadership, Eleanor, his wife of 52 years, was by his side and involved in the company's activities. As Mr. Latta's health problems began to compound during 1985, much of the responsibility for the day to day decision making was transferred to Mr. and Mrs. Latta's three sons: Jimmy, Duie, and Peter. Mr. Latta remained a guiding force for his sons until his passing on June 16, 1995. Mrs. Latta continued as the matriarch of the company for many more years, until her passing on September 29, 2011.

The company experienced tremendous growth and solidified its identity as an outstanding place to work under the leadership of Eleanor and James Latta, Jr. They were always big proponents of education, and this scholarship fund is in memory of their tremendous contribution, and for the benefit of the employees of A. Duie Pyle, who they both so dearly respected and valued.

In 2013, shortly before his retirement, Pyle's President, Steve O'Kane, started the Eleanor & James Latta Jr. Scholarship Fund for the benefit of children of employees of A. Duie Pyle, in memory of Eleanor & James Latta Jr.

The NIGMS Institutional Biomedical Undergraduate Research Training Program aims to enhance the training of undergraduate students in biomedical research. By supporting institutions with limited NIH funding, the program provides trainees with 2–3 years of full-time research training. This initiative fosters a skilled workforce prepared for advanced biomedical degrees, addressing national health-related research needs through comprehensive educational and developmental programs.

Delaware Art & Design Scholarship

Awards:

• One time award of $20,000. Students may reapply each year.

Transportation Assistance Grant

The Transportation Assistance Grant program was established to help members of the MS community remain as independent as possible, and ensure all people with MS have the transportation necessary to get the best medical care.

The program provides funding for reasonable paratransit fees. In partnership with Lyft and Uber, the program can also provide funding for transportation to and from appointments for MS care, limited to neurologist visits and infusion centers, at no cost to the person with MS.

Chester County Estate Planning Council Scholarship Fund

The Chester County Estate Planning Council includes attorneys, trust officers, accountants, financial planners, wealth managers, investment planners, stockbrokers, insurance agents, appraisers, realtors, and nonprofit planned giving officers, as well as other specialists in related professions serving Chester County, PA.

What is Estate Planning?

Estate Planning is the process of anticipating and arranging for the protection, orderly administration, and disposition of a client’s wealth in accordance with their wishes, upon the occurrence of major events such as birth, marriage, divorce, incapacity, and death. Significant attention is paid to minimizing taxes and administration expenses. Estate planning requires knowledge of state property, probate, and trust laws; and federal and state income, gift, inheritance, estate, and generation-skipping transfer tax laws. Some estate planning areas include:

• Creating a will
• Setting up durable power of attorney
• Naming an estate executor to oversee the terms of the will
• Establishing a guardian for living dependents
• Creating/updating beneficiaries on plans such as life insurance, IRAs and 401(k)s
• Setting up trust accounts in the name of beneficiaries
• Philanthropy planning to arrange for estate gifts to charities

Guidelines

The purpose of the Chester County Estate Planning Council Scholarship Fund is to award $500 or $1,000 academic scholarships to West Chester University students entering junior or senior year, pursuing studies and considering a career in estate planning.

Additionally, the CCEPC Scholarship includes a complimentary membership to the Chester County Estate Planning Council during the student’s college years, and for two (2) years post-graduation. CCEPC’s goal is to offer students invaluable networking and learning opportunities as they pursue careers in the estate planning field.

The Eagles Autism Foundation is dedicated to enhancing autism research and care, aiming to improve the lives of individuals and families affected by Autism Spectrum Disorders. The foundation offers Postdoctoral Fellowships to support innovative research, providing $75,000 per year for two years. This initiative encourages collaboration and bridges the gap between basic science and clinical applications, fostering a culture of innovation and community engagement to address the complexities of autism.

The B Strong B Rich Fund offers financial support for Berks County residents under 30 years old who are dealing with cancer-related expenses not covered by insurance. This initiative aims to alleviate the financial burdens faced by young individuals diagnosed with cancer or in recovery, ensuring they receive the necessary assistance during a challenging time. Funded by the Berks County Community Foundation, this resource is vital for promoting health and well-being in the community.

Keith Brabant Music Scholarship Application

The Keith Brabant Music Scholarship committee is interested in finding and assisting young aspiring musicians who are willing to put in the hard work to pursue their talent, but are in need of financial help. This scholarship is to assist those with a documented financial need. Monies may be used for a broad range of music related activities (college, lessons, instruments, books, summer music camp, etc.). If the money is for lessons, instruments, or other specific items, please include information on the costs below; payment may be made directly to provider.

The Cystic Fibrosis Fund of Berks County, administered by the Berks County Community Foundation, offers financial assistance to Berks County residents diagnosed with cystic fibrosis. This fund supports individuals unable to cover essential treatment costs, ensuring they receive necessary medical care. By confirming their diagnosis and need through healthcare professionals, applicants can access funds for medical expenses and improve their quality of life. This initiative is vital for enhancing the well-being of those affected by this chronic condition.

North Central Zone Covering Jefferson and Lewis Counties "Retired Educators Helping Future Educators" In Partnership with The Northern New York Community Foundation

Scholarship Awards for 2026

Three $1,000.00 scholarships will be awarded by the North Central Zone of the Retired Educators of New York (RENY) and the Northern New York Community Foundation (NNYCF) for students residing in Jefferson and/or Lewis Counties - These are a onetime award to help students get started with their college education

Any high school senior pursuing a career in the teaching profession is eligible

• You must be a 2025-2026 high school senior
• You must be accepted into a college program starting in the Fall of 2026

The AO Spine NA Young Investigator Research Grant Award supports early-career surgeons and researchers focusing on clinically relevant spinal or spinal cord research. With funding of $20,000, this initiative encourages new investigators by providing essential start-up capital. Successful applicants are required to present their findings at the Annual AO Spine North America Fellows Forum and submit progress and final reports detailing their research outcomes. This grant aims to foster innovation and excellence in spinal care.

The Nelson Foundation's Change Champions Grant Program, initiated in 2024, aims to support organizations focused on advocacy and systems change to combat racial inequity and social injustice. Grants, ranging from $10,000 to $40,000, are awarded for two years and are dedicated to equitable school funding and enhancing teacher diversity. Open to 501c3 organizations in Pennsylvania, this program emphasizes impactful community work and has no budget restrictions.

Camillo Family Scholarship 

Benefiting dependents of Camillo Properties, Camcorp Entities, or LCI Services employees.

The Camillo Family Scholarship was created to provide dependents of employees of Camillo Companies (Camillo Holdings, LCI Services, Legend Homes, Millmark Capital, and SimplyHome) with scholarships to further their education.

This is a renewable scholarship, meaning recipients can renew the award and claim up to 4 years of funding if they meet the GPA and enrollment requirements and complete the renewal application for each academic year they plan to be enrolled.

Multiple scholarships awarded for the 2026-27 academic year. Award amount varies by college/degree type:

• 4-Year College/University - The scholarship is comprised of up to four annual awards of $5,000, for a total award of up to $20,000. The four annual awards may be received over a period of up to five years.
• 2-Year College/Trade School - The scholarship award is comprised of up to two annual awards of $2,500, for a total award of up to $5,000. The two annual awards may be received over a period of up to three years.

What can the scholarship be used for?

The scholarship will be mailed directly to the student's college to be used towards tuition, required academic fees, and/or book expenses. 

Scholarship funding cannot be distributed directly to the student. 

AD Osherman Scholarship

Benefiting first-generation students in Texas.

Funding

Four (4) scholarships awarded out:

• $3,500 for students pursuing a 4-year degree
• $2,500 for students pursuing a 2-year degree

One-time award. Previous recipients may reapply as long as all eligibility requirements are met.