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Best Operating Grants for Nonprofits in Pennsylvania

Find the perfect Operating grants for nonprofits in Pennsylvania on Instrumentl. 10,000+ Operating grants for nonprofits in Pennsylvania in the United States.

10,000+

Available grants

$2.66B

Total funding

$5K

Median grant

10,000+ grants
$2.66B total
$5K median

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10,268 Results based on applied filters

Core Research Grants: Future of Work

Russell Sage Foundation
Private
United States
Up to US $200,000
The Future of Work program by the Russell Sage Foundation investigates the decline in quality of low-wage jobs in the U.S. It explores factors such as outsourcing, immigration, union decline, and technological changes. Current research focuses on minimum wage impacts, offshoring effects, and job search behaviors influencing employment outcomes, particularly for women and minorities in the post-recession labor market. This grant aims to enhance understanding of these critical issues affecting low-education workers.
Employment Services Workers’ Rights

Betsy & Ryan Colwell Mentorship Scholarships for Women in Thoracic Surgery

The Thoracic Surgery Foundation
Private
Canada, Mexico +1 more
Up to US $2,500
The Betsy & Ryan Colwell Mentorship Scholarships for Women in Thoracic Surgery support early-career female cardiothoracic surgeons by facilitating mentor relationships and networking opportunities at the WTS Annual Conference. Each scholarship, valued at $2,500, covers conference registration, lodging, and travel expenses. Two scholarships will be awarded annually starting in 2025, aiming to empower women in a specialty where they are underrepresented and help them navigate their challenging career path.
Cardiovascular Diseases & Systems Surgery

Advancing Research Careers (ARC) Predoctoral to Postdoctoral Transition Award to Promote Diversity (F99/K00 - Clinical Trial Not Allowed) (357177)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Advancing Research Careers (ARC) Predoctoral to Postdoctoral Transition Award (F99/K00) supports late-stage graduate students from diverse backgrounds in transitioning to postdoctoral positions. This phased award aims to facilitate doctoral dissertation completion and subsequent career development in biomedical research. Participants will engage in mentoring, networking, and professional development activities, preparing them for impactful careers that often require postdoctoral training. Key deadlines for applications span from February 2025 to January 2028.
Diversity, Equity & Inclusion Medical Education & Professional Training Biology +1 more

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $800,000
The HEAL Initiative Whole Joint Health Program aims to advance research on the biological mechanisms of joint pain by exploring the interactions of various tissues within the joint. This innovative program will support clinical studies that focus on non-pharmacological interventions to enhance healing and improve quality of life for individuals suffering from chronic joint pain. By fostering a comprehensive understanding of joint health, the initiative aligns with the NIH's broader goals to reduce chronic pain and opioid dependency.
Musculoskeletal Diseases Orthopedics

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
Unspecified amount
The NARMS Cooperative Agreement Program aims to enhance antibiotic resistance surveillance in retail food specimens, building on the National Antimicrobial Resistance Monitoring System initiated by the FDA in 1996. This program seeks to improve detection of antibiotic-resistant bacteria in food commodities and expand sampling sites. By strengthening monitoring efforts, it aims to protect public health and achieve measurable outcomes aligned with NARMS objectives, contributing to national efforts against antibiotic resistance.
Veterinary Science & Services Animal Food & Drug Safety

Puffin Foundation: Annual Artist Grant Program - Odd Year Focus

Puffin Foundation Ltd
Private
United States
Up to US $3,500
The Puffin Foundation's Annual Artist Grant Program, focused on odd years, supports individual artists and non-profit organizations in the genres of video/film and theater. Grants, typically around $1,750, aim to uplift marginalized voices in the arts. Applicants must be U.S. citizens or permanent residents with an SSN. The program excludes proposals in other disciplines and projects involving AI. This initiative prioritizes diverse artistic expression and aims to maximize funding impact for those with limited financial resources.
Theater Media Arts

USF: Youth Learn-to-Swim Grant

Usa Swimming Foundation
Private
United States
Unspecified amount
The USA Swimming Foundation's Youth Learn-to-Swim Grant aims to increase access to swim lessons for children across the nation. By providing funding to swim lesson programs, the foundation ensures that financial barriers do not prevent children from learning this vital life skill. Grants can be used for free or reduced-cost lessons, addressing the needs of underserved communities and promoting safety through swimming education.
Swimming Diversity, Equity & Inclusion

Laura Wesolowski Scholarship

Scranton Area Foundation Inc
Private
United States
Unspecified amount

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a graduating high school senior who is a current employee of a McDonald’s restaurant located in Northeastern Pennsylvania.

Education - Higher Education Educational Access & Equity

Extramural Discovery Science Accelerator Award

American Cancer Society
Association/Society
United States
Up to US $75,000
The Extramural Discovery Science Accelerator Award supports the commercialization of ongoing cancer research projects, focusing on experiments that facilitate technology validation and de-risking. Applications are accepted on a rolling basis, with a budget of up to $75,000 for one year. This award encourages independent investigators at any career stage to advance their technologies, with a strong emphasis on commercial viability and collaboration within a learning community.
Cancer / Oncology Medical Technology, Devices, and Equipment

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

Northeastern Pennsylvania Health Care Foundation Nursing Scholarship

Scranton Area Foundation Inc
Private
United States
Unspecified amount

Scranton Area Community Foundation

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

Scholarships

We are honored to be the stewards of over 90 scholarship funds established by philanthropically-minded individuals in our community. Generous donors entrust us to connect them to dynamic students to provide financial resources for their education through scholarships. Our donors establish scholarship funds with criteria they wish to be met by applicants. Our scholarship committee considers the criteria, evaluates the submitted applications, and chooses the best candidates for each scholarship.

Northeastern Pennsylvania Health Care Foundation Nursing Scholarship

This scholarship is awarded to individuals seeking financial support to obtain a certification or degree in the nursing field, including a Certified Nursing Assistant (CNA), Licensed Practical Nurse (LPN), or a Registered Nurse (RN), Bachelor’s of Science in Nursing (BSN), or nurse educator.

Education - Higher Education Nursing

Judy Tomes Duffy Music Education Scholarship

Scranton Area Foundation Inc
Private
United States
Unspecified amount

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

Judy’s altrusim, devotion to the betterment of education and the community, combined with her great love of music are the pillars on which this scholarship is based.

Music Education Education - Higher Education

Joseph J. Costa Memorial Scholarship

Scranton Area Foundation Inc
Private
Lackawanna County, Pennsylvania
Unspecified amount

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a Lackawanna Junior College student who is selected by the school and demonstrates characteristics of academic achievement, good citizenship and service to others, and leadership.

Education - Higher Education Youth Development & Leadership

James F. Swift Scholarship

Scranton Area Foundation Inc
Private
United States
US $6,000 - US $24,000

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to graduating seniors from Lackawanna County high schools who plan to continue their education in a college or university program. This $6,000 scholarship, renewable for up to three years (for a total of $24,000), is offered each year for full-time study at an accredited two- or four-year college or university of the student’s choice. 20 students will be selected annually for this award.

The James F. Swift Scholarship Fund has awarded over $5.5 million since 2008, benefitting 360 local students.

Created in 2002 through a gift by Mr. James F. Swift to the Scranton Area Community Foundation, the James F. Swift Scholarship Fund provides support for higher education for students graduating from high schools in Lackawanna County. Following Mr. Swift’s death in 2006, the Scranton Area Community Foundation gratefully received a significant gift from his estate to the scholarship fund, which has allowed a great number of students from Lackawanna County the opportunity to pursue their academic and professional goals through higher education.

Education - Higher Education Educational Access & Equity

The Saturday Club’s Grant Fund Program

The Saturday Club
Private
Bucks County, Pennsylvania, Chester County, Pennsylvania +3 more
Unspecified amount
The Saturday Club’s Grant Fund Program supports local charitable organizations that enhance the lives of women, children, and families in Greater Philadelphia. Funded through member fundraising efforts, the program opens for applications in November with a deadline in early January. Eligible non-profits must be 501(c)(3) or 501(c)(4) and focus on specific projects. Grants are awarded annually in April, with prior year budgets required for applicants.
Youth Services Family Services Women & Girl Services

William J. Wolf Memorial Scholarship Fund

Pittsburgh Foundation
Private
Allegheny County, Pennsylvania
Up to US $16,000
The William J. Wolf Memorial Scholarship Fund, established at the Pittsburgh Foundation, honors the legacy of William J. Wolf, a dedicated community member who wished to support future generations. This scholarship assists undergraduate and graduate students from Allegheny County, PA, who demonstrate financial need and maintain a minimum GPA of 2.0. Preference is given to those who incorporate Lutheran teachings into their worldview, ensuring a meaningful impact on their education and community.
Education - Higher Education College Success / Persistence

William Dale Murphy Memorial Scholarship Fund

Pittsburgh Foundation
Private
Allegheny County, Pennsylvania
Up to US $2,500
The William Dale Murphy Memorial Scholarship Fund, established by the Pittsburgh Foundation, provides financial assistance to dependent children of Conrail employees pursuing education at accredited colleges or universities. Created to honor the legacy of community leadership by Charles McKinley, this fund aims to support students in achieving their academic goals while promoting equity and opportunity in southwestern Pennsylvania. Eligible applicants must demonstrate financial need and maintain a minimum GPA of 2.0.
Education - Higher Education College Success / Persistence

Kathryn Giarratani Scholarship Fund of the Western PA Herb Society

Pittsburgh Foundation
Private
Allegheny County, Pennsylvania
US $1,000
The Kathryn Giarratani Scholarship Fund, established by the Western PA Unit of The Herb Society of America through the Pittsburgh Foundation, offers scholarships to students pursuing degrees in horticulture, botany, or related fields. Founded in 1945, the Pittsburgh Foundation supports local educational initiatives aimed at fostering community development. Eligible applicants must maintain a minimum GPA of 3.0 and preferably be residents of Western Pennsylvania, ensuring support for local talent in environmental sciences.
Education - Higher Education College Success / Persistence

Leadership Development Grants

Presbyterian Women In The Presbyterian Church Usa Inc
Private
American Samoa, Guam +4 more
Up to US $500
The Leadership Development Grants empower women in the PC(USA) to enhance their leadership skills through educational opportunities. This initiative fosters personal growth and active participation within the Presbyterian Women community, ultimately strengthening the church's mission. Eligible women can apply for grants to attend various leadership events, ensuring that they can contribute effectively to the church's goals while developing their unique gifts and talents.
Women & Girl Services Presbyterianism

Teaching the Bible Grant

Presbyterian Mission Agency
Private
United States
Up to US $10,000
The Teaching the Bible Grant, offered by the Presbyterian Mission Agency, supports Presbyterian-related schools, colleges, and universities in enhancing biblical education. Grants of up to $10,000 are available for initiatives such as lecture series, Bible studies, and new curriculum development. This funding not only encourages academic engagement but also fosters community learning experiences, allowing students to explore and reflect on their faith collectively. Applications are accepted quarterly, with deadlines on the first Friday of March, June, and September.
Religious / Theological Education Presbyterianism

Wyeth Foundation for American Art Grant - Organization

Wyeth Foundation For American Art
Private
United States
US $5,000 - US $25,000
The Wyeth Foundation for American Art aims to promote the study and appreciation of historic American art through financial support for research, conservation, and innovative exhibitions. Grants typically range from $5,000 to $25,000 and are awarded to non-profit organizations. The foundation emphasizes the importance of scholarship and excellence in American art, while not funding projects focusing solely on art from the last three decades.
American Art Art Conservation

Excellence in LGBTQ Health Award

American Medical Association Foundation
Private
United States
US $2,500

Excellence in Medicine Awards

The AMA Foundation’s Excellence in Medicine Awards honor physicians and medical advocates who exemplify the highest values of the profession—volunteerism, community engagement, leadership, and service to underserved populations. Each recipient is recognized at a ceremony during the AMA Annual Meeting in Chicago and receives a $2,500 grant honorarium directed to a nonprofit health organization of their choice. Since 2005, more than 100 honorees have been celebrated through this program, with over $250,000 awarded to strengthen community health and advance equitable care nationwide. 

Excellence in LGBTQ Health Award

Honors physicians, residents/fellows and final-year medical students that have demonstrated outstanding work, innovation and leadership in LGBTQ policy, advocacy, patient care, academics (teaching and research), workforce diversity and/or health care administration.

Sexuality & LGBTQIA+ Rights LGBTQIA+ Services

Excellence in Medicine Awards- Pride in the Profession Award

American Medical Association Foundation
Private
United States
US $2,500

Excellence in Medicine Awards

The AMA Foundation’s Excellence in Medicine Awards honor physicians and medical advocates who exemplify the highest values of the profession—volunteerism, community engagement, leadership, and service to underserved populations. Each recipient is recognized at a ceremony during the AMA Annual Meeting in Chicago and receives a $2,500 grant honorarium directed to a nonprofit health organization of their choice. Since 2005, more than 100 honorees have been celebrated through this program, with over $250,000 awarded to strengthen community health and advance equitable care nationwide. 

Excellence in Medicine Awards- Pride in the Profession Award

Honors physicians who aid underserved populations in the U.S.

Minority Services Health Disparities & Social Determinants of Health

Condie Nursing Scholarship Fund

Pittsburgh Foundation
Private
United States
US $1,000

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

Condie Nursing Scholarship Fund

The Condie Nursing Scholarship Fund was created at The Pittsburgh Foundation to provide scholarships for both traditional and nontraditional students to begin or advance their nursing careers at a 2-or 4-year college or university.

Award Type: Single Year Award.

Education - Higher Education Nursing

Performing Arts Global Exchange Grant

Mid Atlantic Arts Foundation
Private
American Samoa, Guam +4 more
US $1,500 - US $8,000
The Performing Arts Global Exchange Grant (PAGE) fosters international performing arts in the U.S., promoting cultural understanding through diverse programming. It offers support to nonprofit presenters who engage artists from a curated roster, focusing on underrepresented regions like Morocco and South Africa. Grants require public performances and community interaction, emphasizing outreach to underserved areas. PAGE is supported by Mid Atlantic Arts and the National Endowment for the Arts, aiming to enhance accessibility to global artistic expressions.
Performing Arts Artist Residencies

Scott F. Hirsh Memorial Nursing Scholarship

Pittsburgh Foundation
Private
United States
Up to US $1,000

The Pittsburgh Foundation provides scholarship opportunities for students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four–year universities, graduate schools, and career/technical schools.

Scott F. Hirsh Memorial Nursing Scholarship

The Scott F. Hirsh Memorial Nursing Scholarship was established at The Pittsburgh Foundation in memory/honor of Scott F. Hirsh to provide two scholarships for high school seniors in the Baldwin, Whitehall, Keystone Oaks, and Brentwood communities who plan to attend a 4-year college or university in a nursing program.

  • Average Award: Up to $1,000
  • Award Type: Single-Year Award
Education - Higher Education Nursing

Operating Grants for Nonprofits in Pennsylvania Highlights

Looking for operating grants for nonprofits in Pennsylvania?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Pennsylvania recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Pennsylvania

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

300+ Operating grants for nonprofits in Pennsylvania grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

100+ Operating grants for nonprofits in Pennsylvania over $25K in average grant size

88 Operating grants for nonprofits in Pennsylvania over $50K in average grant size

45 Operating grants for nonprofits in Pennsylvania supporting general operating expenses

300+ Operating grants for nonprofits in Pennsylvania supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

1,000+ Grants on Instrumentl focused on Education - K through 12

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Pennsylvania?

Most grants are due in the second quarter.

Q1
27.0%
Q2
28.4%
Q3
23.4%
Q4
21.2%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Pennsylvania?

Grants are most commonly $28,750.

$500 $500 Min.
$28,750 $28.8 K Median
$465,890 $465.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Pennsylvania?

Grants are most commonly $120,832.

$120,832

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Pennsylvania year over year?

In 2024, funders in Pennsylvania awarded a total of 114,767 grants.

2022 101,760

2023 105,380

2024 114,767

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Pennsylvania given out in Pennsylvania, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in Pennsylvania changing over time?

Funding has increased by 39.90%.

2022 $9,486,595,381

2023 $9,869,112,363
4.03%

2024 $13,806,751,647
39.90%

Pennsylvania Counties That Receive the Most Funding

How does grant funding vary by county?

Montgomery County, Philadelphia County, and Allegheny County receive the most funding.

County Total Grant Funding in 2024
Montgomery County $11,058,341,664
Philadelphia County $2,487,099,923
Allegheny County $1,915,534,930
Chester County $846,675,579
Centre County $563,407,306