Best Seed Grants for Nonprofits in American Samoa

The National Institute of Dental and Craniofacial Research (NIDCR) is set to announce a funding opportunity for clinical trials and observational studies within its Dental Primary Care Practice-Based Research Network (PBRN). This initiative aims to enhance the integration of oral and medical health by facilitating research conducted in dental practices. While applications are not currently being accepted, this notice serves to encourage collaborations that will lead to impactful projects in whole-person health.

The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.

The Cancer Health Equity Research Centers (CHERCs) initiative by the American Cancer Society aims to address health disparities by supporting research focused on social determinants affecting cancer care. This program encourages innovative projects that engage communities, enhance access, and improve outcomes across diverse populations. By fostering collaborations and promoting multidisciplinary approaches, CHERCs strive to create equitable cancer prevention and treatment solutions, ensuring that all individuals have fair opportunities for cancer care and survivorship.

The CDC has announced funding for FY 2027 to enhance state capacity in alcohol epidemiology and prevent excessive alcohol use through the NOFO CDC-RFA-DP-27-0072. This initiative aims to equip states with essential tools and knowledge for effective public health measures against excessive alcohol use, a major preventable cause of death in the U.S. The program will also provide expert technical assistance and training on effective prevention strategies over a 5-year performance period.

The Capacity Building for Global, Regional, and National Immunization Programs aims to enhance immunization efforts in key countries, focusing on the prevention and control of vaccine-preventable diseases like polio and measles. By strengthening immunization services and surveillance systems, the program will better address emerging health threats and reach under-immunized populations. Additionally, it will support sustainable practices through National Immunization Technical Advisory Groups and manage the National Stop Transmission of Polio program in Pakistan.

The U.S. Wildland Fire Service Joint Fire Science Program (JFSP) invites proposals for regional fire science exchanges across nine designated regions in the U.S. This initiative aims to promote the sharing of fire science knowledge and practices over a two-year period. Eligible applicants can focus on regions including Alaska, Appalachians, Great Basin, North Atlantic, Northern Rockies, Northwest, Oak Woodlands, Pacific Islands, and Southwest. Proposals must be specific to one region.

The FY26 Autism Research Program Career Development Award aims to support early-career investigators in conducting innovative research that can significantly impact autism. It encourages applications addressing specific areas of interest and mandates community collaboration for projects involving pilot clinical trials. Proposals must include partnerships with community members for effective planning and implementation, ensuring that the research is grounded in the needs of the autism community.

The FY26 Autism Research Program's Idea Development Award from the US DOD aims to support groundbreaking research that improves outcomes for Autistic individuals. This award encourages innovative, high-risk projects that can lead to significant advancements in autism research. Applications must address specific areas of interest or justify the importance of the research problem. A unique Partnering Principal Investigator option allows two researchers to collaborate on a single project, enhancing the potential for impactful discoveries.

The National Institute on Aging (NIA) is inviting applications for the Alzheimer's Drug-Development Program (U01 Clinical Trial Optional). This initiative seeks to support pre-clinical and early-stage clinical development of innovative drug candidates aimed at preventing Alzheimer's disease or treating its symptoms. The program encourages collaboration among researchers and aims to enhance the therapeutic pipeline for AD through targeted approaches. This notice allows potential applicants time to prepare robust projects.

The U.S. Wildland Fire Service Joint Fire Science Program is inviting proposals focusing on two main topics: understanding the drivers of changing wildfire regimes and assessing smoke impacts from prescribed fires and wildfires. Researchers are encouraged to improve forecasting models and explore scenarios that can inform management practices. Proposals should address key research needs to enhance ecological benefits and minimize air quality impacts, ensuring effective methodologies for tracking emissions and understanding their public health implications.

The FY26 Autism Research Program Clinical Trial Award aims to rapidly implement clinical trials that significantly impact autism treatment and management. Projects may range from small proof-of-concept trials to large-scale studies assessing efficacy in relevant populations. Applications are encouraged to partner experienced and early-career investigators and must include community collaborations to enhance research impact. At least one community partner is required to provide ongoing consultation throughout the project.

The BJA FY26 Body-Worn Camera Policy and Implementation Program aims to assist law enforcement agencies in acquiring body-worn cameras and establishing comprehensive BWC programs. This initiative addresses the increasing demand for reliable video evidence in criminal cases, enhancing documentation and prosecutorial outcomes. By utilizing BWCs, agencies can deter assaults on officers and protect them against false accusations, ultimately improving community trust and accountability in law enforcement practices.

The Department of the Interior's Wildland Fire Service Joint Fire Science Program (JFSP) invites proposals for the FLAMES award, aimed at master and doctoral students in wildland fire studies. This initiative enhances research relevance by connecting students with fire management practices, providing experiential learning opportunities, and fostering mentorship. Students will gain valuable insights into management and policy, preparing them for impactful careers in fire science. The program emphasizes peer-learning and professional development in the context of wildland fire management.

The National Centers for Biomedical Imaging and Bioengineering (NCBIB) program invites applications for Biomedical Technology Resource Centers (BTRCs) that develop technologies to support researchers in various biomedical fields. Key deadlines for applications include January 25, 2024, and May 25, 2024. Funding typically ranges from $600,000 to $750,000 for direct costs, with an additional $500,000 available for special-purpose equipment. This initiative is supported by the NIH.

The Women's Initiative for Screening and Health (WISH) aims to enhance women's health by increasing access to preventive services. This initiative brings together healthcare providers, academic institutions, and patient-centered organizations to improve the adoption of evidence-based guidelines for women's preventive health. By raising awareness and ensuring the guidelines are integrated into clinical practice, WISH addresses key health challenges faced by women throughout their lives.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The Kidney Precision Medicine Project (KPMP), funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), aims to enhance research on Chronic Kidney Diseases (CKDs) and Acute Kidney Injuries (AKIs). Launched in 2017, this initiative focuses on ethical collection and analysis of human kidney tissue to uncover new molecular pathways. With expanded participant recruitment efforts beginning in 2022, the KPMP seeks to advance our understanding of kidney-related health issues.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is extending the Kidney Precision Medicine Project (KPMP) for five years to enhance participant recruitment and tissue interrogation. This initiative aims to discover novel molecular pathways associated with Chronic Kidney Diseases (CKDs) and Acute Kidney Injuries (AKIs). The renewed funding will support robust longitudinal follow-ups for existing enrollees and facilitate the enrollment of new participants, ensuring comprehensive data analysis and collaboration within the research community.

The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.

The Kidney Precision Medicine Project Central Hub, funded by the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), aims to enhance our understanding of Chronic Kidney Diseases (CKDs) and Acute Kidney Injuries (AKIs). This initiative, which began in FY2017, focuses on ethically collecting and analyzing kidney biopsy tissues to uncover molecular pathways. The project was expanded in FY2022 to improve participant recruitment and tissue analysis, driving forward research in kidney health.

This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.

The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.

The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.

The National Coastal Resilience Fund (NCRF) aims to protect coastal communities through nature-based solutions, enhancing habitats while addressing the growing threats of climate change. Established in 2018, the fund focuses on restoring vital ecosystems like marshes and reefs to mitigate flooding impacts. With rising sea levels and increasing storm intensity, NCRF invests in community-led projects that foster resilience, ensuring both people and wildlife can adapt to changing environmental conditions.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

Entergy’s Open Grants Program aims to enhance community well-being through funding initiatives in arts, education, social services, and community improvement. The program prioritizes support for organizations that serve diverse populations, including children and low-income communities. Eligible entities must have 501(c)(3) status or equivalent nonprofit recognition. Applications should be submitted three months in advance, allowing ample time for review. Entergy focuses on projects that foster self-sufficiency and enrich local neighborhoods.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is announcing a Notice of Funding Opportunity (NOFO) for Diabetes Research Centers (DRCs). These centers aim to foster collaboration among diabetes researchers, enhance preclinical and clinical research, and provide access to specialized resources. Emphasis is on innovative scientific themes and collaborative projects in areas such as Immunology and Artificial Intelligence. Although applications are not currently solicited, potential applicants are encouraged to prepare for future submissions.