Best Seed Grants for Nonprofits in American Samoa

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The NIH is announcing a funding opportunity for competitive revisions of ongoing grants to tackle unforeseen public health crises. This Urgent Competitive Revision program aims to facilitate timely responses to emerging health challenges. Once the Notice of Funding Opportunity is published, eligible applications will be directly routed to the appropriate NIH awarding component. Only submissions in response to an Urgent Guide Notice published by an NIH Institute or Center will be accepted.

The National Institute on Aging intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Coordinating Center (CC) of the Claude D. Pepper Older Americans Independence Centers (OAIC) program. The CC serves as a facilitator for OAIC site interactions and as a conduit for translating OAIC objectives and findings to both scientific and general audiences. The proposed CC must demonstrate an ability to work cooperatively with all OAIC sites and possess sufficient scientific expertise in geriatrics and related areas to serve the national coordination functions of the OAIC program. Applicants should have a demonstrated ability to coordinate multi-site projects.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

The World Trade Center Health Program K01 Award supports early-career researchers dedicated to enhancing the health of those impacted by the September 11 attacks. This award grants up to three years of mentored research and career development, focusing on the physical and mental health effects of 9/11 exposures. It encourages studies that translate scientific findings into improved clinical care and public health practices, ultimately addressing emerging health concerns and improving long-term outcomes for affected populations.

The Kids’ Chance of America: Emergency Grant Program aims to provide essential support to state organizations facing unexpected challenges in funding scholarships for children of injured workers. This initiative ensures that these children can continue their education despite unforeseen financial hardships. Grants can be utilized for scholarships, room, board, and educational fees, emphasizing the importance of maintaining educational support for deserving students during the 2023-2024 academic year.

The International Research Scientist Development Award (IRSDA) supports U.S. postdoctoral researchers and junior faculty to engage in mentored research and career development in low- and middle-income countries (LMICs). This initiative promotes collaboration with local researchers, enhancing understanding of the research environment and strengthening international networks. Recipients are expected to spend significant time at LMIC sites, ultimately aiming to develop competitive NIH research proposals and become leaders in global health.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Limited Competition: Biomedical Research Environment & Sponsored Programs Administration Development (BRE-SPAD) Program aims to enhance the research capacity of resource-limited institutions. By focusing on essential areas like biomedical research environment and sponsored programs administration, this initiative seeks to foster rigorous and reproducible biomedical research. Eligible organizations are encouraged to submit proposals addressing their specific needs, thereby expanding the pool of qualified researchers and strengthening the settings for NIH-funded research.

The RPAC Fundraising Grants, offered by the National Association of Realtors, support state and local associations in organizing fundraising events aimed at boosting RPAC contributions. These grants require a fundraising goal three times the amount requested, ensuring tangible results. The initiative emphasizes developing detailed fundraising plans that comply with state laws regarding corporate treasury funds. This program is vital for enhancing RPAC participation and advancing property ownership advocacy.

Mayo Family Foundation

The Mayo Family Foundation, founded by Simer and Vicki Mayo in 2019, is dedicated to creating a lasting impact across the globe. With a focus on eradicating food insecurity, empowering at-risk youth, and advancing women’s equality, the Foundation strives to transform lives and foster a brighter future for all.

Domestic Focus

We envision a world where concerns about the next meal, a safe place to sleep, or access to healthcare become a thing of the past. Our goal is to provide long-term solutions that will build stronger, more resilient individuals and communities.

A child at risk is less likely to transition to adulthood successfully. Our mission is to equip our youth with the tools needed for academic achievement and job readiness. These tools are key to securing a future marked by financial stability and high hopes of becoming a positive member of society.

Grant Application

The Mayo Family Foundation (MFF) is dedicated to creating a lasting impact. Its focus is on eradicating food insecurities, women’s equality issues, and empowering at-risk youth. The foundation strives to transform lives and foster a brighter future for all.

This grant has been created to provide the funding needed to make a significant impact in two key areas: combating food insecurity and empowering at-risk youth.

We believe that by supporting dedicated nonprofit organizations like yours, we can create a lasting positive impact in our community. Together, we can ensure that no one goes hungry and that every young person has the opportunity to thrive.

The Jean Dreyfus Lectureship for Undergraduate Institutions Grant provides a $25,000 award to facilitate a visit by a notable researcher in the chemical sciences to undergraduate institutions. It includes funding for summer research fellowships for two students and requires the researcher to deliver accessible lectures to the public. This initiative honors Jean Dreyfus's legacy and supports the engagement of undergraduates in scientific research and discourse.

The Mutual Self-Help Housing Technical Assistance Grants program provides essential funding to qualified organizations in the Western Pacific. These grants enable local initiatives where low-income families build their homes with peer support and technical guidance from professionals. This collaborative approach not only fosters community engagement but also empowers families to achieve homeownership in rural areas. Eligible applicants include government non-profits, federally recognized tribes, and private organizations, ensuring broad access to resources for housing development.

This initiative aims to enhance clinical and public health outcomes through innovative digital health interventions. It supports research on the development and effectiveness of tools designed for underserved settings, leveraging new technologies and analytics. By fostering collaborations between U.S. and low- and middle-income country researchers, the program emphasizes reciprocal innovation to tackle common health challenges, ultimately maximizing benefits for diverse populations.

The NIH Collaborative International Research Project aims to foster international research collaborations that align with the NIH mission. This grant encourages applications that incorporate at least one international subproject, offering oversight and tracking for NIH-funded international initiatives. Projects should leverage unique resources or populations abroad, contributing to advancements in health sciences relevant to NIH's objectives. This initiative underscores the importance of global partnerships in enhancing research capabilities and outcomes in the United States.

The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.

The National Institutes of Health (NIH) is set to announce a Notice of Funding Opportunity (NOFO) for multi-site investigator-initiated clinical trials. This initiative aims to support a range of clinical trials addressing efficacy and implementation research. The funding mechanism includes a two-phase approach (UG3/UH3), with a total award duration of up to seven years. Investigators are encouraged to prepare proposals that demonstrate scientific rationale and operational plans for these important studies.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The NIH Instrumentation Grant Program for Resource-Limited Institutions supports the acquisition of advanced scientific instruments. This initiative aims to bolster biomedical research capabilities and educational opportunities at institutions that typically receive limited NIH Research Project Grant funding. By facilitating access to modern technology, the program enhances research quality and fosters innovation in healthcare and related fields.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

This funding opportunity supports the establishment of Animal and Biological Material Resource Centers to enhance biomedical research through the provision of specialized laboratory animals and related resources. It seeks to promote scientific rigor and reproducibility by facilitating the development of new methodologies that complement traditional research. Centers must align with multiple NIH Institutes and focus on integrating innovative approaches like cell culture and computational models, fostering collaboration and advancement in human disease modeling.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

The Community Seed Donations program by Seed Savers Exchange provides seeds to schools, community gardens, and nonprofits, ensuring that these resources are freely available to those in need. In addition, they offer disaster relief seed donations for organizations affected by recent natural disasters. To qualify, applicants must be nonprofits with U.S. shipping addresses. This initiative not only supports community growth but also promotes sustainability and resilience in the face of challenges.

The KidsGardening Youth Garden Grant supports organizations in the U.S. or U.S. Territories that aim to enhance youth gardening programs. With a focus on underserved communities, the grant provides resources to develop or improve garden projects for youth aged 0-18. This initiative not only promotes educational opportunities but also fosters community engagement through gardening. Recipients receive a variety of supplies, including seeds and gardening tools, to help cultivate sustainable gardening practices.

The NIH's Investigator-Focused Award (Parent R35) aims to support research programs for investigators at all career stages, including Early Stage Investigators. This funding provides stability and freedom in research, allowing for innovative and ambitious studies without the constant pressure of securing new grants. Key benefits include flexibility in research direction, opportunities to tackle significant questions, and a greater potential for scientific breakthroughs, fostering a robust research environment.

The Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant aims to enhance clinical and translational science training by supporting programs that prepare predoctoral and postdoctoral researchers. This initiative, funded by the NIH, focuses on translating scientific discoveries into effective health interventions. Eligible institutions will be invited to apply, and only high-quality applications will be considered for funding, ensuring a robust peer-review process.

The Arthur C. Cope Postdoctoral Fellowship, awarded by the American Chemical Society, recognizes outstanding achievements in organic chemistry. This two-year fellowship provides $85,000 annually to early-career researchers, promoting innovative research in sustainable organic chemistry. Candidates, nominated by their mentors, must demonstrate excellence and a commitment to inclusivity in research. The fellowship encourages participation in ACS activities, fostering career development and collaboration within the scientific community.