Best Grants for New Nonprofits in Colorado

The National Cancer Institute (NCI) invites applications for transformative research in cancer biology and oncology through nanotechnology. This funding opportunity aims to address significant challenges by exploring the interactions of nanomaterials with biological systems. Projects should focus on utilizing nanoparticles and devices for targeted cancer therapies and enhancing diagnostic capabilities. Successful proposals will contribute to the foundational knowledge necessary for future nanotechnology-based interventions in cancer treatment.

Committee of 100 Academic Scholarship

Awards:

• One time award of $5,000.

The CHEERS Open Period 2 initiative invites white papers from researchers in various technical fields, focusing on projects that align with the objectives of the Continuing Enabling, Enhancing, Restoring, and Sustaining (CHEERS) MAA. This funding opportunity, backed by the US DOD's Air Force Materiel Command, is aimed at advancing national defense capabilities through innovative research and development in areas such as ordnance, telecommunications, and medical supplies.

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.

The Patient-Centered Outcomes Research Institute (PCORI) Funding Announcement aims to enhance methods for conducting patient-centered comparative clinical effectiveness research. This initiative seeks to address critical methodological gaps, focusing on improving the use of artificial intelligence in clinical research, study design, data research networks, and ethical protections in patient-centered CER. With a budget of up to $750,000, successful proposals will contribute to the quality and strength of evidence generated in CER studies.

The Patient-Centered Outcomes Research Institute (PCORI) is offering funding up to $750,000 for studies aimed at addressing critical methodological gaps in patient-centered comparative clinical effectiveness research. This initiative focuses on enhancing the quality of evidence in clinical research by prioritizing areas such as artificial intelligence, study design improvements, support for data research networks, and ethical considerations. Successful proposals will contribute to advancing research methodologies and improving patient outcomes.

The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.

The Eleanor Campbell Charitable Fund offers competitive scholarships to high school seniors and current college students from the Deering, Hillsborough, and Weare areas. With a history of over $900,000 awarded, the fund emphasizes academic achievement, financial need, and community involvement. Scholarships are available for full-time post-secondary education, with the potential for renewal based on continued eligibility. Announcements of winners occur during high school graduation ceremonies, ensuring recognition of their hard work and dedication.

Dr. Jill Biden Scholarship - Biden Breast Health Initiative

Essay:

• Why have you chosen a career in health care or education, and why do you feel it is important to encourage others to adopt a healthy lifestyle?

Awards:

• One time award of $2,500; one award per county. 

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The Dairy Health, Efficiency & Resource Dynamics Initiative Grant seeks innovative research proposals to enhance animal health, economic viability, and environmental outcomes in the U.S. dairy industry. A partnership between FFAR, Dairy Management Inc., and Zoetis, this initiative aims to explore the interconnections between dairy health, welfare, economics, and environmental sustainability, addressing critical gaps in understanding the impacts of improved animal health on dairy production.

Self-Defense Grants for MMIR Day

Facilitators, educators, organizers — May 5th is the Day of Awareness for Missing & Murdered Indigenous Women, Girls and Relatives. In honor of that day, we are offering mini grants to host a self-defense workshop for Indigenous girls and gender-expansive youth.

Why self-defense?

• Native women are murdered at 10x the national rate
• 84% experience violence in their lifetime
• Over 5,700 Native girls go missing each year

We also name the invisible crisis:

• Indigenous people from Mexico & Central America (Maya, Nahua, Zapotec, Mixtec, Lenca, and others) living in the U.S. face detention, deportation, and disappearances that are rarely counted in MMIR data.
• When a Tzotzil 18 year old like Royer Perez Jimenez dies in ICE custody, the silence is deafening.

Self-defense must include all Indigenous relatives.

XCNC has:

• $500 mini grants for stipends, space, supplies, and translation.

What we ask:

• Plan a workshop between May 5–31, 2026, rooted in community care.

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

Peter and Huberdina Weller Scholarship

• Graduating senior, graduating early college student, or current college student from a high school within the greater Community Foundation service area
• Enrolling/enrolled at an accredited post-secondary school within the United States
• Financial need (must submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• GPA of 3.0 or greater
• Intention to pursue educational opportunities and a career in horticulture or the biological sciences with an emphasis on botany
• All other qualifications being equal, tie-breaking consideration will be given to students of color
• Previous recipients of the award are encouraged to reapply.

The GoodRx Helps Community Catalyst Grants support community-led nonprofits dedicated to enhancing health and well-being for under-resourced groups. This funding aims to improve healthcare access, education, and essential services, addressing systemic barriers faced by these communities. Eligible organizations must demonstrate a commitment to community empowerment and possess a minimum annual operating budget of $250K. This initiative underscores the importance of fostering sustainable health improvements through targeted, inclusive support.

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Awards

Lifetime Achievement Award

The Lifetime Achievement Award recognizes individuals whose lifelong contributions have profoundly advanced the understanding, support, and application of intelligence.

Details

This prestigious honor highlights transformative contributions that have reshaped how intelligence is studied, taught, and applied in real-world settings.

Award Components

Recipients of the Lifetime Achievement Award receive:

• Permanent recognition as a distinguished leader in the field of intelligence.
• A $2,500 monetary award in honor of their exceptional achievements.
• A commemorative trophy celebrating their lasting impact on the field.

The Pop Culture Collaborative offers Major Grants to support initiatives that promote long-term narrative change and social justice through pop culture. Targeting U.S.-based nonprofits, for-profits, and individuals, these grants aim to engage mass audiences in transformative experiences. With a focus on communities often marginalized, the Collaborative's efforts are designed to foster a pluralistic society where everyone belongs. Grants range from $20,000 to $200,000, depending on project scope and duration, with applications reviewed biannually.

The Digital Wish Donation Program, initiated by Mobile Beacon, aims to provide affordable high-speed Internet access to K-12 schools, colleges, and libraries. For just $10 a month, participating institutions can receive donated mobile hotspots and discounted tablets, enabling them to enhance digital literacy and connectivity among underserved students. This initiative not only breaks down barriers to access but also fosters educational equality, ensuring that all learners have the tools they need to succeed in the digital age.

The OpenAI A People-First AI Fund supports U.S.-based nonprofits with 501(c)(3) status, focusing on AI literacy, community innovation, and economic opportunity. It aims to enhance public understanding of AI, promote participatory design in AI applications by communities, and expand access to meaningful work through inclusive practices. Organizations at all stages of AI adoption are encouraged to apply, especially those addressing the needs of traditionally marginalized populations. This initiative emphasizes equitable distribution of AI benefits.

Confederated Tribes of Siletz Indians

The Confederated Tribes of Siletz Indians is a sovereign nation and has three main branches of government – Judicial, Executive, and Legislative. One of our most important resources is our people.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

Arthur S. Bensell Memorial Scholarship

Arthur S. Bensell was an educator, civic leader, Tribal Council member and Tribal Chairman. He spent many years in service to his community and Tribe as Mayor of the City of Siletz and tribal leader.

Art attended Ohio State University and graduated from Heidelberg College in 1934. During his career with the Bureau of Indian Affairs, he served as a teacher, principal and reservation principal in Minnesota, Alaska and North Dakota. Upon returning to Siletz, Art became involved in tribal business affairs and served many years on the Tribe’s Education Committee and always strived for better educational opportunities for Tribal members.

A memorial scholarship fund was established through the Confederated Tribes of Siletz Indians to honor and award Tribal members in education. The $1000 scholarship is administered by the Tribal Education Committee and strengthened by various fund raising activities throughout the year.

The AAAS Early Career Award for Public Engagement with Science recognizes outstanding early-career scientists and engineers for their significant contributions to public engagement in science. Established in 2010, the award includes a $5,000 prize, a plaque, and recognition at the AAAS Annual Meeting. Eligible nominees must be actively conducting research in STEM fields and demonstrate engagement beyond their job responsibilities, with one awardee chosen annually.

The AOAP Swim Lesson Grant aims to enhance drowning prevention by providing financial support to aquatic facilities for swim lessons and life jackets. With a minimum allocation of $10,000 annually, the program seeks to offer at least 100 free lessons to low-income participants and distribute 500 life jackets each year. It encourages non-profit organizations to apply, ensuring a focus on education and safety in aquatic environments. This grant represents a significant step towards making swimming accessible and safe for all.

The Paul Purcell "Kids Win!" Annual Baird Education Grant honors the legacy of former Baird CEO Paul E. Purcell, who dedicated his life to educational causes. Established in 2020, this grant supports 501(c)(3) organizations that ensure all children, regardless of circumstances, have access to quality education. Funded by Baird and its associates, it prioritizes programs serving diverse and underserved populations, embodying Purcell's belief that every child deserves the opportunity to succeed.

Every Battle Creek area resident shall have the resources to access post-secondary education and training.

Your dreams matter — and we want to help you achieve them. Whether you’re a graduating high school senior, an adult returning to school, or a graduate student pursuing advanced education, we’re here to support you by opening doors to opportunity.

Beyond tuition, many funds support total cost of attendance — books, fees, equipment, and in some cases childcare or transportation.

Checks are made payable to the educational institution indicated on the follow-up and mailed directly to the educational institution. Checks are typically mailed in early August.

Ronald Clark McDaniel Memorial Scholarship Fund

To honor the life and legacy of Ronald Clark "Ron" McDaniel, family and friends established the Ronald Clark McDaniel Memorial Scholarship Fund in 2008. Ron, born in Harlan, Kentucky, moved to Battle Creek, Michigan at the age of 5. He was involved in the National Honor Society, Boys State, played baseball and football and graduated in the top ten of his class at Pennfield High School. He then served in the United States Air Force obtaining presidential awards and honors before he made his home back in Battle Creek. Ron managed to balance his commitment and love for his family and sports while exhibiting an unequaled work ethic, often working 7 days a week, at the same company for 38 years. This fund was established to carry on his value of education. He believed that all young adults should participate in extra-curricular activities in or outside of school while focusing on education. Most of all Ron McDaniel believed education was the key to success. Scholarships in memory of Ron will be awarded to graduating seniors who have participated in high school athletics and are seeking educational opportunities in teaching/education.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The NIA Research and Entrepreneurial Development Immersion (REDI) program aims to support early-career scientists transitioning to industry through the Entrepreneurial Small Business Transition Award. This initiative fosters entrepreneurial skills while enabling small business concerns to hire postdoctoral fellows and early-stage researchers, enhancing their research capabilities. Focused on mentoring and training, the program is designed to ensure that participants develop essential skills for successful careers in entrepreneurship and scientific development.

Excellence in Medicine Awards

The AMA Foundation’s Excellence in Medicine Awards honor physicians and medical advocates who exemplify the highest values of the profession—volunteerism, community engagement, leadership, and service to underserved populations. Each recipient is recognized at a ceremony during the AMA Annual Meeting in Chicago and receives a $2,500 grant honorarium directed to a nonprofit health organization of their choice. Since 2005, more than 100 honorees have been celebrated through this program, with over $250,000 awarded to strengthen community health and advance equitable care nationwide. 

Excellence in Medicine Awards- Dr. Edmond and Rima Cabbabe Dedication to the Profession Award

Honors physicians who are committed to expanding knowledge through teaching, conducting research and publishing. Other qualifying virtues include leadership, volunteerism and philanthropic activities in medical and other civic organizations.

Made possible by Edmond Cabbabe, MD, and Rima Cabbabe