Best Unrestricted Grants for Nonprofits in Colorado

The Grief Reach Cycle 3 grant offers $15,000 to U.S.-based 501(c)(3) nonprofits dedicated to supporting grieving children and youth. This funding aims to enhance organizational capacity through strategic planning, volunteer engagement, and collaborative partnerships. Organizations must demonstrate a commitment to providing direct services and align their projects with the grant's focus areas. This competitive opportunity seeks to empower underserved communities by expanding access to vital grief support services.

The Varghese Summersett Autism Scholarship aims to support children diagnosed with autism who require financial assistance for educational or recreational opportunities. Offered by Varghese Summersett, this scholarship reflects the commitment to enhancing the quality of life for autistic children. It can be utilized for camps, tutoring, or educational tools to help them thrive. This initiative is particularly meaningful, as several members of the legal team have personal connections to autism, underscoring their dedication to this cause.

The National Book Fund (NBF) offers grants to support adult education and literacy programs across the U.S. by providing New Readers Press materials. Grants typically range from $500 to $2,000, with applications considered for higher amounts if justified. Eligible applicants must have a defined project and use materials directly with learners. Priority is given to nonprofit organizations providing free literacy instruction. Note that individuals and lending libraries are not eligible for funding.

The Logan Nainoa Fujimoto Memorial Scholarship, established in 2005, supports students pursuing Automotive Technology at the Universal Technical Institute or community colleges in Hawaii. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and be residents of Hawaii. Preference is given to past recipients and those attending the Universal Technical Institute. This scholarship honors the legacy of Logan Nainoa Fujimoto, encouraging academic and vocational excellence in the automotive field.

The BJA FY 2026 Byrne State Crisis Intervention Formula Program aims to enhance state crisis intervention court proceedings and related initiatives. Funded by the U.S. Department of Justice, the program focuses on addressing public safety challenges such as violent crime, human trafficking, and the opioid crisis. Grants will support the development of mental health courts, drug courts, and extreme risk protection order programs, providing critical resources to improve community safety and support law enforcement efforts.

The LUNGevity VA Research Scholar Award supports innovative lung cancer research within the Department of Veterans Affairs, with a focus on early detection and treatment methods relevant to veterans. The maximum award is $100,000, distributed over two years, contingent upon satisfactory progress. Applications are now open for the 2025 cycle, with funding aimed at improving outcomes and developing individualized treatment strategies, including targeted therapies and immunotherapies.

The Indian Land Tenure Foundation's Economic Opportunity Grant aims to empower American Indian nations by enhancing their control over reservation lands. This initiative addresses historical challenges in land ownership and economic development, providing essential resources and tools for communities to manage land effectively. By focusing on land acquisition and productive land use, the Foundation supports sustainable growth and cultural preservation, ultimately fostering economic self-sufficiency among Indigenous populations.

This Funding Opportunity Announcement (FOA) aims to advance the identification and evaluation of candidate biomarkers for neurological and neuromuscular disorders. By facilitating the clinical development of neurotherapeutics, the FOA encourages research that includes both animal studies and preliminary human evaluations. The ultimate goal is to produce biomarkers ready for rigorous analytical and clinical validation, enhancing the effectiveness of treatments in clinical practice.

The HVAC Skills Lab Grant aims to refurbish existing plumbing and HVAC skills labs in middle and high schools across the U.S. and Canada. With a focus on preparing students for vital trade careers, the grant provides $10,000 in equipment to enhance hands-on learning. This initiative supports schools with technical training resources, promoting the growth of skilled labor in these essential fields. Schools that have not received a Skills Lab award in the past 24 months are eligible to apply.

The Innovation in Behavioral Health (IBH) Model (the “Model”) is an eight-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs).The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to eight state Medicaid agencies (SMAs) to participate in the Model. Implementation will begin in January 2025 and end in December 2032. The Model will have an eight-year performance period, which will be comprised of a three-year Pre-Implementation Period along with a five-year Implementation Period. Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the eight years. 

The Kayla Marie Adsit Memorial Foundation Fund, established in 2009 by the Community Foundation of Northern Colorado, aims to enhance music education for Poudre School District students. It supports financially disadvantaged students and non-profits, ensuring equal access to quality music programs. Grants, capped at $500 per semester, fund essential resources like instruments, uniforms, and music supplies, prioritizing projects that benefit low-income and special needs students, fostering a thriving musical community in Fort Collins.

The Ultra-Rare Gene-based Therapy (URGenT) Network Resource Access program provides critical support to researchers by offering access to contract research organizations and subject matter experts. This funding opportunity aims to facilitate nonclinical therapeutic development efforts, helping investigators navigate the complexities of manufacturing and planning. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the proposal deadline.

The Institutional Training Programs to Advance Translational Research on Alzheimer's Disease and AD-Related Dementias aim to cultivate a diverse workforce skilled in translational research. This initiative supports predoctoral and postdoctoral researchers from various educational backgrounds, including data science and clinical research. By fostering interdisciplinary training, the program equips trainees with essential knowledge in disease biology and drug discovery, ultimately enhancing the research capabilities for Alzheimer's and related dementias.

The NIA Academic Leadership Career Award (K07) provides funding for established investigators to strengthen research capacity in aging and Alzheimer's Disease. The program supports the development of educational infrastructure, mentorship, and career development activities. Key deadlines for applications include February 12, June 12, and October 12 from 2025 to 2027. This award is specifically for research not involving independent clinical trials, allowing applicants to gain experience in trials led by others.

The Intervention Research to Improve Native American Health (R34) aims to support research that enhances health interventions for Native American populations. This includes studying the efficacy of health promotion and disease prevention strategies, culturally informed treatments, and addressing existing health disparities. The initiative encourages community-based solutions that are sustainable and adaptable to various Native American tribes. Key deadlines for grant applications are set for October 2025 and 2026, with additional dates for AIDS-related proposals.

The Intervention Research to Improve Native American Health initiative aims to enhance health outcomes in Native American communities through innovative research. This program supports studies focused on health promotion, disease prevention, and culturally informed treatment strategies. Key deadlines for grant applications are October 21, 2025, and January 7, 2026. By addressing health disparities and leveraging community strengths, the initiative fosters sustainable interventions tailored to specific cultural contexts.

The Healthy Lifestyles in Youth program, funded by the Indian Health Service, aims to empower Tribes and Tribal Organizations to deliver essential public health services. This new cohort of NPHR awards supports initiatives that foster healthier lifestyles among youth in Indigenous communities, addressing critical health disparities and promoting well-being through culturally relevant programs and services.

The NewSchools Learning Differences Grant Program aims to enhance educational opportunities for students who learn differently, particularly those affected by poverty and racism. The program invests in innovative solutions and models that support personalized education for these students, ensuring they have access to quality instruction and belonging within school communities. With a focus on equity, it seeks ideas that align with its core investment areas and addresses the needs of marginalized learners.

The Combined Pilot Research Grants by the Plastic Surgery Foundation and ACAPS aim to fund innovative pilot research projects in academic plastic surgery, focusing on education and global health. Grants of up to $15,000 are available for one-year projects. Applicants must hold a relevant degree, be affiliated with a U.S. or Canadian institution, and have ties to ACAPS. This initiative encourages pioneering research that addresses significant questions in the field, promoting the development of surgeon scientists.

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss

This award aims to support young investigators in clinical studies relevant to age-related cognitive decline and memory loss. The award also recognizes the importance of rigorous training in clinical research and encourages young investigators to seek opportunities to establish future careers in the area of human cognitive aging.

Please Note: The focus should NOT be on a neurodegenerative dementia (e.g., Alzheimer’s disease); however, proposals that focus on the combined study of cognitive aging and neurodegenerative cognitive changes may be considered.

For the purpose of this scholarship, research is defined as patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance identification of age-related cognitive decline and memory changes. These may include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health outcomes research. Disease-related studies not directly involving humans are also encouraged if the primary goal is the development of therapies, diagnostic tests, or tools to mitigate age-related cognitive decline and memory loss.

The Lisa and Douglas Goldman Fund, established in 1992, supports charitable organizations that enhance society, focusing on democracy and civil liberties. The fund prioritizes projects that ensure equal citizen participation in the democratic process and protect civil liberties, especially those implemented nationally or across multiple states. It operates by invitation only and emphasizes flexible, informed grantmaking to qualified projects that align with its mission and values.

The Food and Farm Communications Fund's Wildseed Grants program supports grassroots organizations in the U.S. that aim to bring transformative change to food and agricultural systems. With grants ranging from $20,000 to $50,000 for one year, and up to $75,000 for two years, the program emphasizes strategic communications, community engagement, and racial equity. Eligible organizations must demonstrate alignment with the Fund’s mission and have a revenue of less than $3 million.

The Frank and Audrey Senn, Sr. Memorial Scholarship Fund, established by the Community Foundation of Central Georgia, honors the legacy of Frank and Audrey Senn, lifelong supporters of education and community service. This scholarship aims to assist members of Trinity United Methodist Church in Newberry, SC, with their pursuit of higher education, offering at least $1,000 annually for up to four years. Eligible applicants must demonstrate academic commitment and community engagement.

The Preventing Violence Affecting Young Lives (PREVAYL 2.0) initiative aims to provide multiyear funding for state and local health departments to implement violence prevention strategies for adolescents and young adults. Key focuses include enhancing data-driven decision-making, building capacity for evidence-based strategies, integrating youth mental health support, fostering multisector collaborations, and prioritizing the prevention of various forms of violence, ensuring comprehensive support for youth development.

The Dr. and Mrs. W.C. Culp Student Research Grant supports medical students conducting summer research projects in interventional radiology. With funding of up to $6,000, the grant aims to inspire innovative research ideas and foster advancements in patient care. Eligible applicants include undergraduates and medical students in MD, DO, or PhD programs, including DACA recipients. A designated project advisor is required to guide the student throughout the research process.

The CAPTRUST Scholarship offers five $2,000 awards to undergraduate students with a GPA of 3.7 or higher, supporting their educational journey. Applications are open for the Spring 2025 semester, and only the first 2,500 eligible submissions will be considered. To apply, students must submit essays for four specified categories, each not exceeding 200 words, totaling a maximum of 800 words. This initiative reinforces CAPTRUST's commitment to empowering future professionals.

The We Raise Foundation's Emerging Leader Grant supports individuals aged 20-35 at Christian organizations developing innovative programs addressing poverty, violence, and inequality. With a total of $15,000 over two years, the grant allocates $10,000 for program support and $5,000 for leadership development, including coaching and conferences. This initiative aims to foster impactful leaders who inspire, communicate effectively, and engage deeply with their communities, ultimately creating lasting change.