Best Large Grants for Nonprofit Organizations in Connecticut

The National Institute on Aging (NIA) is inviting applications for the Alzheimer's Drug-Development Program (U01 Clinical Trial Optional). This initiative seeks to support pre-clinical and early-stage clinical development of innovative drug candidates aimed at preventing Alzheimer's disease or treating its symptoms. The program encourages collaboration among researchers and aims to enhance the therapeutic pipeline for AD through targeted approaches. This notice allows potential applicants time to prepare robust projects.

The Mabel M. Witmer Scholarship Fund, managed by The Foundation for Enhancing Communities, supports students pursuing education in trade or technical schools. This fund aims to assist residents of Cumberland or Franklin County with financial need, especially those who have relevant work experience in their chosen field. By investing in education and skills development, the scholarship contributes to community empowerment and long-term economic growth in South Central Pennsylvania.

The SOT Undergraduate Research Award supports outstanding undergraduate students presenting original toxicology research at the SOT Annual Meeting. Awardees receive recognition, complimentary registration, lodging, and travel funding up to $800. This award encourages students to pursue graduate studies in toxicology or related fields and includes mentorship opportunities during the meeting, fostering their academic and professional growth.

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Franklin Hines Scholarship ($3,600)

This renewable scholarship is available to students who are graduating seniors from one of the following high schools: Hartsville High School, Darlington High School, Lamar High School, or McBee High School. 

The College Life Protected Graduate Research Grant supports research that enhances the value of higher education. Focused on systemic risks, it invites proposals on topics like mental health's impact on student success, campus safety compliance, and the effects of medical withdrawals. The grant is open to individuals in postsecondary education, who can re-apply regardless of prior submissions, promoting continued exploration of these critical issues.

The John Lennon Endowed Scholarship, established by Yoko Ono to honor John Lennon, supports students attending UNCF member institutions. This initiative addresses financial need and promotes education among African American youth. With over $65 million awarded annually, UNCF empowers thousands of students, advocating for minority education and community engagement. Eligible applicants must have a minimum GPA of 3.0, complete a FAFSA, and demonstrate unmet financial need. This scholarship plays a crucial role in fostering future leaders.

The Walters Services, Inc. Fabe & Beverly Walters Scholarship Fund, established by The Foundation for Enhancing Communities, aims to alleviate the financial burden of higher education for children and spouses of employees under 26. This scholarship supports full-time or part-time students, emphasizing academic achievement, community volunteerism, financial need, and an essay submission. The initiative embodies core values of love, integrity, and teamwork, fostering educational opportunities for future generations.

Ginger D. Schroder Cattaraugus County Legislative District 2 Scholarship

The Ginger D. Schroder Legislative District 2 Scholarship is given to a graduating high school student residing in Cattaraugus County Legislative District 2 who will pursue a trade degree or 2-or 4-year college degree.

Gregory D. Spring Perseverance Scholarship

Established in memory of Gregory D. Spring, this scholarship is for a graduating senior from Allegany-Limestone Central School, Ellicottville Central School, Franklinville/Ten Broeck Academy, Portville Central School, Hinsdale Central School or Olean High School with a preference for a student who intends to pursue a degree or certification in a trade or technical program. 

The Undiagnosed Diseases Network (UDN) aims to enhance diagnostic excellence through multiple clinical Networks of Diagnostic Excellence (NODEs). These NODEs will operate as regional networks, leveraging partnerships with various healthcare facilities to provide participant-centered evaluations for complex conditions. They will also engage in research and training to improve diagnostic tools and strategies. This initiative encourages collaboration and aims to improve the overall experience and access for participants in need of specialized care.

The Willis C. Helm Charitable Trust, established in 1954, focuses on supporting organizations that work on juvenile delinquency and the development of boys from broken homes. It provides annual grants averaging between $5,000 and $15,000, with a total giving of around $60,000 for five grants each year. Eligible organizations must be 501(c)(3) exempt and preferably located in Minnesota. Applications are accepted year-round, with a deadline of March 31 for annual review.

Community Foundation for Northeast Florida

The Community Foundation for Northeast Florida connects people who care with causes that matter. Since 1964, we have served the citizens of Duval, St. Johns, Nassau, Baker, Clay, and Putnam counties through a range of charitable and civic activities, while helping individual donors achieve their philanthropic goals. We believe in Giving Back. Forever Forward.

Scholarships

Thanks to generous donors, The Community Foundation offers several scholarships each year that benefit students in Northeast Florida who are seeking post-secondary degrees.

Bernie G. Yvon Memorial Fund Scholarship

For High School Seniors & College Students in The Theatre/Performing Arts

The purpose of the fund is to perpetuate the legacy of Bernie G. Yvon by supporting students pursuing study in the Theatre/Performing Arts with need-based scholarships. In this tenth year (2026), amounts up to $2000 each will be available from contributions to the fund via The Community Foundation for Northeast Florida. In selecting the successful candidate(s), the review committee will consider the following:

• Knowledge of Bernie G. Yvon
• Theatre/Performing Arts potential and past experiences
• Financial need
• Academic record
• Two letters of recommendation
• GPA

Dennis Jones and Wayne Johnston Memorial Dice Run Scholarship

This fund provides a scholarship for a graduating senior from either Olean High School or Allegany-Limestone Central School who will be attending a 4-year college, with preference for a student planning to study business or business related field (i.e. accounting, finance, marketing, economics etc.)

The T.E.A.L. Research Grant supports innovative ovarian cancer research initiatives aligned with the mission of the Tell Every Amazing Lady About Ovarian Cancer Foundation. Designed for researchers affiliated with 501(c)3 not-for-profit institutions in the U.S., the grant aims to enhance women's health awareness and education regarding ovarian cancer. While the application period for 2025 is currently closed, interested parties should anticipate further updates in spring 2026.

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

Vietnam Veteran’s Moving Wall Fund

The Vietnam Veteran’s Moving Wall Fund Scholarship was established to support the children of local veterans who served in the Vietnam War or subsequent conflicts. It was created in 1990 by the Vietnam Veteran’s Moving Wall Committee using remaining funds originally raised to bring the National Vietnam Veteran’s Moving Wall Exhibit to Glen Oak Park in Peoria, Illinois. The exhibit honors the 58,126 Americans who lost their lives during the Vietnam War.

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

MidAmerica National Bank’s Employees Children Scholarship Fund

The MidAmerica National Bank’s Employees Children Scholarship Fund was established in 2005 by MidAmerica National Bank to provide scholarship support to the children of bank employees. It is open to students graduating from high school or currently enrolled in an undergraduate college or vocational program.

Ezekiel Hennessey Mitchel Scholarship Fund

The Ezekiel Hennessey Mitchel Memorial Scholarship is designated for graduating high school seniors from Benton, Polk, Lincoln, and Linn Counties pursuing careers in vocations such as the following:

• Home building trades
• Tile setting
• Carpentry
• General contracting
• Electrical
• Plumbing
• HVAC
• Welding
• Entrepreneurship and/or small business development
• Other trades defined by Benton Community Foundation

Students must attain certificates or degrees from accredited trade schools, technical schools, or community colleges. 

The Benton Community Foundation will be awarding over $132,330 this year in scholarships to graduating high school seniors from Benton County high schools.

Ruth & Julian Adams Memorial Scholarship

Ruth died in 1983, and Julian died in 2002. Both had a passion for journalism. Ruth’s daughter Shirley McDonald, and her husband Marv McDonald, established the Ruth and Julian Adams Memorial Scholarship Fund as a lasting tribute to Shirley’s parents’ memory. The fund benefits Benton County high school students pursuing careers in journalism.

Seattle Foundation

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

Patricia Fisher Endowed Scholarship

The Seattle Association of Black Journalists (SABJ) established this scholarship in honor of Patricia Fisher, a Puget Sound native, journalist, educator and role model for her support of young people and her community. Scholarships of $5,000 help students of African descent who are from or attending college in Washington and who are pursuing college careers in communications, such as print, photo, broadcast journalism or multimedia and online journalism. Scholarships are awarded based on scholastic achievement, financial need, community service and a serious interest in communications. Recipient(s) will be matched with a mentor who is a SABJ member.

The AES Infrastructure Grant, offered by the American Epilepsy Society, provides up to $50,000 to support the development of national or international multicenter research programs. This funding is intended for organizational planning sessions, infrastructure development, and pilot projects, facilitating future investments from other organizations. These grants are available annually in the spring, enabling researchers to enhance their collaborative efforts.

Ethan’s Coffee Fund Scholarship aims to support graduating seniors from Benton County pursuing degrees in STEM or philosophy, who demonstrate a minimum GPA of 3.5 and financial need. This fund honors Ethan Daley's passion for learning, encouraging students to share their unique interests and humor. Examples of suitable candidates include those with diverse experiences and a zest for life, as the scholarship seeks to foster creativity and community engagement among aspiring scholars.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

• Identification treatment responsive biomarkers
• Assess clinical measures and improve that enhance clinical trial readiness
• Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.

 Advancing Markets for Producers Grants

ALB has received a USDA AMP (Advancing Markets for Producers) grant, and we’re excited to invite sheep producers to be part of this opportunity to help grow the US sheep industry. This grant will integrate new technology and sustainable management strategies to boost productivity, open new markets, and strengthen opportunities for the next generation of producers.

Producer Program

The project will provide an opportunity for 150 sheep producers to identify production inefficiencies and to develop conservation plans. Producers will also modify management plans through technology implementation to mitigate emissions and improve their overall productivity. Enrolled producers will work with a Technical Service Provider (TSP) to establish operational plans, implement recommended changes and organize farm data to identify best management practices for productivity improvements. 

Enrollment Benefits

Producers enrolled in the program will be paid up to $23,000 to develop and implement improved sheep and land stewardship management plans. Additional enrollment benefits:

• Technical Service Provider
• Electronic livestock identification system
• Soil sampling
• NSIP ultrasound and genetic consulting services

JFS–David Rubenstein Memorial Scholarship

The JFS–David Rubenstein Memorial Scholarship, established by Dr. Robert Rubenstein and Marie Raftery, honors the memory of Dr. Robert’s son, David. The program provides financial support to students from San Diego’s Jewish community pursuing college or vocational education, and encourages them to cultivate intellectual curiosity, reflect on Jewish values, and give back to their community.

Scholarships of up to $10,000 will be awarded based on academic achievement, community involvement, and financial need.

Students are eligible to receive up to a total of four (4) years of JFS-David Rubenstein Memorial Scholarship funding, and the funding years do not have to be consecutive. Scholarships are made on a year-to-year basis and are not automatically renewed. Scholarship recipients must submit a new application and the required documentation in compliance with the application deadlines, stated herein, for each year that they seek funding.

Scholarship funds will be sent directly to the academic institution the student is attending solely for use toward qualifying academic expenses, including tuition, school-provided housing, books, school fees, or required academic supplies/equipment. Should the recipient not matriculate college by the date listed in the award, he or she agrees to forfeit the scholarship award.