Best Large Grants for Nonprofit Organizations in Connecticut

The Music Man Foundation invites eligible organizations to apply for Advocacy and Research Grants aimed at supporting systemic change in the arts sector. Organizations must demonstrate their impact on music-related systems, showcase their priorities in the field, and outline their achievements. Grants will assist with research, advocacy training, and cross-sector initiatives to enhance community vitality and promote sustainable solutions, reflecting the Foundation's commitment to fostering positive arts engagement.

The RFA-FD-23-001 funding opportunity aims to support clinical trials for orphan products targeting rare diseases. It focuses on evaluating the efficacy and safety of treatments to address unmet medical needs. By promoting innovative and collaborative trial designs, the FDA seeks to enhance the approval rates of effective therapies for rare conditions, ultimately benefiting patients and advancing drug development in this critical area.

This funding opportunity aims to enhance the development of medical products in rare diseases through innovative natural history studies. By generating high-quality data, the FDA seeks to bridge critical knowledge gaps and eliminate barriers in rare disease research. The initiative focuses on diseases with unmet needs, fostering significant impacts for those affected and facilitating the development of effective therapeutic solutions.

The CDC's initiative, 'Holistic and Evidence-Informed Wellness for STI Prevention', addresses the significant public health burden of STIs in the U.S. by promoting a comprehensive approach that emphasizes healthy choices and relationships. By supporting a coalition of sexual health experts, the program aims to enhance STI prevention through strategic resource allocation and the dissemination of high-quality, evidence-based materials, targeting priority groups most affected by STIs. This holistic strategy seeks to reduce STI morbidity and improve overall sexual health.

The National Book Fund (NBF) offers grants to support adult education and literacy programs across the U.S. by providing New Readers Press materials. Grants typically range from $500 to $2,000, with applications considered for higher amounts if justified. Eligible applicants must have a defined project and use materials directly with learners. Priority is given to nonprofit organizations providing free literacy instruction. Note that individuals and lending libraries are not eligible for funding.

The MSU Graduate Teaching Scholarships recognize the vital role graduate students play in undergraduate education by providing financial support for their teaching efforts. Eligible candidates must have a graduate teaching assistantship, complete professional development, and apply before the semester starts. Scholarships range from $250 to $1000, promoting excellence in teaching and enriching the educational experience at Montana State University.

The Native Forward Student Access Funding supports American Indian and Alaska Native students by providing financial assistance for graduate and professional examination costs. With over 50 years of experience, Native Forward has empowered more than 22,000 students across the United States. This funding not only covers exam fees but also related preparatory expenses, ensuring that students can pursue their educational goals without financial barriers. The initiative aims to enhance representation and visibility of Native scholars in higher education.

The Cystic Fibrosis Foundation's Program for Adult Care Excellence (PACE) aims to enhance adult care for cystic fibrosis patients by recruiting and training physicians. With an increasing life expectancy for CF patients, the program addresses the need for specialized adult caregivers. Physicians can apply for funding up to $38,435 per year for three years, enabling them to develop expertise in adult CF care. This initiative supports both the medical community and the CF population significantly.

Chicken & Egg Pictures Inc

Chicken & Egg Films was founded in 2005 by documentary film industry veterans Julie Parker Benello, Wendy Ettinger, and Judith Helfand. As filmmakers, teachers, funders, and impact producers, they were inspired to utilize their collective expertise to uplift the power of fellow women storytellers. Chicken & Egg was thus created to help address financial and creative challenges uniquely faced by women in the field–a model that married funding with mentorship to create not just an organization, but a growing community. 

Chicken & Egg Films shapes a more equitable and just world with the catalytic power of documentary films by providing funding, mentorship and industry access to a global community of women and gender-expansive filmmakers. 

Chicken & Egg Award

The Chicken & Egg Award recognizes women and gender-expansive filmmakers at advanced stages in their careers who are poised to reach new heights in their creative and impact trajectories across the world.

Despite progress by talented women and gender-expansive documentary filmmakers across the globe, there are often still numerous roadblocks that stand in the way of a true industry breakthrough. These barriers are often tied to gender, race, class, disability, and geography. Only a few women and gender-expansive nonfiction directors in the United States and abroad are able to work full time as independent storytellers, and few are folks of color, from working-class backgrounds, or from under-represented countries. 

There are, however, a growing number who are getting close. Each has made several films, and each is an influential leader for the issues they explore on screen. With this Award, Chicken & Egg Films is making a bold investment in these creatives and a statement about gender equity. A greater diversity of voices participating in storytelling drives change. We believe this effort is inextricably connected to elevating critical social justice, environmental, and human rights issues. 

The Chicken & Egg Award consists of a $75,000 USD cash award and a year-long mentorship program. Of the total, $50,000 is unrestricted, allowing filmmakers to decide how to use the funding to support their creative and business practices. The additional $25,000 is a grant for the project(s) the filmmaker will work on during their program year. Our in-depth mentorship program is focused on strengthening Awardees’ professional infrastructure, increasing their visibility, and fulfilling their personal and creative goals.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Grants to Individuals for Vocational Exploration

CIC is pleased to announce the first NetVUE grant program for individual projects by staff and faculty members. While NetVUE offers a number of grant programs for institutions, this new program—Grants to Individuals for Vocational Exploration—is its first program designed explicitly for individual projects by faculty members and staff at NetVUE member institutions.

Many employees at NetVUE member institutions engage and contribute to the exploration of vocation in undergraduate education through their scholarship, teaching, and practice. The NetVUE program seeks to support this work by offering them more resources to support new research and pedagogical innovation. Through the NetVUE Grants to Individuals for Vocational Exploration, CIC will offer funding and guidance to support projects that will generate artifacts or products (such as scholarly articles, course syllabi and learning activities, program designs, or other resources) that will develop and expand the existing field of scholarship, conversation, and pedagogy on vocation in undergraduate education.

This grant is intended to support innovative projects in the scholarship, pedagogy, leadership, and/or practice of vocation in undergraduate education. Proposals are welcome from both new and established scholars and practitioners. Particularly welcome are projects that seek to make vocational exploration and discernment available to all students, as well as projects that invite the NetVUE community toward fresh considerations and new frameworks in vocation as a lens for undergraduate education.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Program Development Grants

Colleges and universities that are members of NetVUE are already committed to campus activities that encourage vocational exploration by students. These institutions are making significant investments of their own resources to develop and sustain vocational exploration initiatives. In order to support NetVUE member campuses in their work, Lilly Endowment Inc. has provided funding to CIC to be used for NetVUE Program Development Grants. Many NetVUE campus leaders have observed that grants for program development at even modest levels would enable their institutions to strengthen and expand existing programs significantly.

NetVUE Program Development Grants may be requested in amounts up to $100,000 for use over two years to deepen, expand, or otherwise strengthen programs that are already underway (including those planned or initiated through recently completed NetVUE Professional Development Awards) and supported by the institution itself. A wide range of proposals that augment existing programs in vocational reflection and discernment will be considered; examples include

• mini-grants to support released time for designing or revising courses to include greater engagement with vocational reflection;
• programming that brings faculty members and administrative staff (from, for example, career services, student life, or campus ministry) into partnership for advising, mentoring, and/or experiential learning opportunities; and
• projects that integrate reflection on calling and vocational discernment into an institution’s general education requirements or into their major or minor field requirements.

The Mike Cox Internship Scholarship, established by the Duncan Aviation Family Trust, honors the late Mike Cox's legacy of mentorship. This scholarship supports students at accredited institutions who demonstrate a passion for growth and excellence. A maximum of two scholarships are awarded annually, providing $1,000 per recipient for educational expenses. Eligible candidates must be full-time students and have completed or participated in the Duncan Aviation internship program, ensuring a commitment to education and the aviation industry.

The Tribal Self Governance - Planning program provides essential support for tribes to prepare for managing healthcare services for their communities. Through the Cooperative Agreements, the Indian Health Service aims to empower tribal organizations to take charge of their health needs, facilitating a smoother transition to self-governance in healthcare. This initiative reflects a commitment to enhancing tribal autonomy and improving health outcomes, with three awards available to eligible applicants.

The Tribal Self-Governance Planning and Negotiation Cooperative Agreements are designed to assist tribes in planning and preparing to manage healthcare services for their members through the Tribal Self Governance Program. The Indian Health Service will provide three awards under this initiative, aiming to empower tribal organizations in their efforts to enhance healthcare delivery and self-determination.

The Dr. Marshall H. Layton Memorial Scholarship honors Dr. Rock's dedication to education by supporting graduating seniors from the Harrisburg School District. This one-time award aims to help students with financial need who plan to pursue higher education or trade school. Applicants must demonstrate a desire for success through an essay, reflecting Dr. Rock's lifelong commitment to fostering learning and achievement.

The Rising Investigator Supplement Grant, offered by the AASM Foundation, empowers sleep and circadian science researchers to mentor promising students and fellows facing barriers in accessing research opportunities. This grant supports innovative projects addressing critical questions in sleep health and fosters career development in the field. Eligible candidates include students and clinical fellows in various educational stages. Funding is available for up to 20% of the principal grant, capped at $50,000, for periods ranging from 8 weeks to 3 years.

The CLIMB Near Peer Mentorship Program by John Muir Health offers a year-long mentorship initiative aimed at developing family medicine learners into community-engaged providers. This program supports high school, undergraduate, and medical students by pairing them with mentors in the healthcare field. Participants engage in weekly virtual meetings and receive guidance throughout their educational journey, fostering a diverse and inclusive future in healthcare professions.

The Health Career Connection Internship, offered by John Muir Health, is a 10-week full-time program aimed at empowering underrepresented college students in healthcare. This internship provides valuable mentorship, networking opportunities, and real-world experience, focusing on diverse backgrounds. It encourages participants to explore careers in health professions, particularly those from low-income and first-generation college student backgrounds. The program is designed to inspire and motivate interns as they embark on their professional journeys.

The Mary Ellen Kowalski Memorial Scholarship honors the legacy of Mary Ellen, a dedicated educator and community member. Established by her husband in 2025, this scholarship aims to support graduating high school seniors from Marathon County pursuing post-secondary education. Applicants are evaluated on their academic achievements, extracurricular involvement, and personal challenges, ensuring that deserving students receive the financial assistance needed to succeed in their educational endeavors.

The Grief Reach Cycle 3 grant offers $15,000 to U.S.-based 501(c)(3) nonprofits dedicated to supporting grieving children and youth. This funding aims to enhance organizational capacity through strategic planning, volunteer engagement, and collaborative partnerships. Organizations must demonstrate a commitment to providing direct services and align their projects with the grant's focus areas. This competitive opportunity seeks to empower underserved communities by expanding access to vital grief support services.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Amyloidosis

Help with healthcare costs for amyloidosis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Amyloidosis is characterized by a build-up in amyloid protein in specific organs or throughout the body. It is a rare disease that affects multiple systems. Subtypes include hereditary amyloidosis, light chain amyloidosis (AL amyloidosis), and amyloid A (AA) amyloidosis (secondary amyloidosis).

The Botany in Action Fellowship Program at Phipps Conservatory and Botanical Gardens is designed for PhD students in plant-based research. It provides $6,000 for research and outreach expenses, an all-expenses paid trip for science outreach training, and opportunities to connect with the public through various outreach initiatives. This program nurtures the next generation of plant scientists committed to impactful research and educational outreach, fostering a deeper understanding of plant science.

The Sundance Institute's Native Lab Application aims to support emerging filmmakers and episodic creators from U.S.-based Native American, Native Hawaiian, Alaskan Native, and Indigenous communities, as well as Indigenous Canadian artists. This initiative nurtures independent storytelling and creativity, providing vital resources and opportunities for underrepresented voices in film. Eligible applicants must submit a narrative feature or episodic pilot script. The program will accept three U.S.-based projects and one Canada-based project, with activities held virtually and in Santa Fe, New Mexico.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Cushing’s disease or syndrome

Help with healthcare costs for Cushing's disease or syndrome

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Cushing’s Disease or Syndrome, also known as Cushing’s Syndrome, hypercortisolism and hyperadrenalism, is a condition where the pituitary gland releases high levels of the hormone cortisol. It is a rare disease that affects the endocrine system.

The Paul Drury Memorial Scholarship honors the legacy of Paul Drury, who inspired many while living with cystic fibrosis. This scholarship is aimed at siblings and children of individuals with CF, recognizing the crucial support family members provide. Eligible applicants must have a family member with CF, demonstrate academic achievement, and be enrolled in an educational program. This initiative highlights the importance of family in managing the challenges posed by cystic fibrosis.

The AOA/AOSA Opportunities in Optometry Grant program aims to promote inclusion within the optometric profession. This program offers $1,500 grants to under-represented minority students who are applying to optometry school. Eligible candidates include U.S. citizens, permanent residents, or DACA recipients who meet specific academic criteria. The initiative seeks to enhance diversity in the field and expand access to primary eye care, supporting the next generation of optometrists.

The Next Generation Undergraduate Scholarship, established by the Architects Foundation, aims to support diverse students pursuing architecture degrees. With a total award of up to $20,000, the scholarship is available to US citizens or permanent residents who are seniors in high school or second-year college students enrolled in NAAB-accredited programs. This initiative reflects a commitment to fostering inclusivity and excellence in the architectural profession, empowering future leaders to shape the built environment.