Best Operating Grants for Nonprofits in Delaware

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

Sodexo Stop Hunger Foundation

The Sodexo Stop Hunger Foundation goes beyond food aid to create lasting change. Through innovative programs, strategic partnerships and volunteer action, Stop Hunger tackles the root causes of food insecurity.

In 2025, Sodexo Stop Hunger Foundation and the Hunger Center awarded grants to 131 programs representing 118 communities in 37 states plus the District of Columbia. Collectively, these programs provided an estimated 22,000 backpacks full of shelf-stable food items for students to take home for the weekend or holidays when school meals are not served.

Since 2006, the Sodexo Stop Hunger Foundation has been a driving force behind weekend and holiday hunger relief for students across the U.S. Through support of food backpack programs, the Foundation partners with local food banks and schools to discreetly provide K-12 students with backpacks filled with nutritious, shelf-stable meals. These backpacks are distributed in safe, familiar settings – typically on the last school day before a weekend or school break – ensuring that all children who rely on free or reduced-price school meals don’t go hungry when school is out.

K-12 Backpack Grant

The K-12 Backpack Grant is an initiative launched by the Sodexo Stop Hunger Foundation and administered in partnership with the Congressional Hunger Center to support community backpack programs. Grants of $1,000 will be issued to community organizations with established backpack feeding programs that provide students with shelf-stable, nutritious meals when school is out of session.

The Trout and Salmon Foundation Grant offers matching funds up to $5,000 to support projects aimed at restoring and enhancing trout and salmon habitats in North America. Established in 1969, the foundation prioritizes partnerships with local watershed organizations focused on habitat improvement. Grants are provided for projects that physically restore streams and fisheries, with on-site labor recognized in certain cases. The foundation seeks to diversify funding across various watersheds and regions, ensuring a broad impact in conservation efforts.

The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.

The Yamaha Outdoor Access Initiative supports outdoor enthusiasts and promotes responsible use of off-highway vehicles (OHVs). Its mission includes educating the public on land use and wildlife conservation while protecting access to public lands. Applications are accepted quarterly from nonprofit organizations and community groups focused on land stewardship and access improvements, ensuring a safe and sustainable outdoor experience for all.

The Research Foundation of the American Society of Colon and Rectal Surgeons offers a Career Development Award to support early career investigators in colorectal surgery. With a funding of $75,000 per year for two years, this award emphasizes mentorship and career growth. Applicants must be within five years of their first faculty position and demonstrate innovative research in colon and rectal diseases. The award aims to enhance academic careers while fostering advancements in surgical techniques.

The Robert and Joan Dircks Foundation Grant Program supports non-profit organizations in New Jersey that provide opportunities for disadvantaged individuals. With grants ranging from $1,000 to $15,000, the foundation focuses on innovative programs that solve critical issues rather than operational needs. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code. The foundation does not fund political activities, cultural projects, or operating budgets, ensuring resources directly benefit those in need.

The NIHCM Foundation is seeking innovative research proposals that address critical issues in U.S. health care, particularly focusing on drug pricing, provider consolidation, health care delivery, chronic disease management, and the role of artificial intelligence. Projects should aim to improve affordability and quality of care. We welcome submissions from a variety of researchers and organizations, with a preference for studies that can be completed within one year.

The ASTR Targeted Research Area Grant supports projects by scholars focusing on under-represented areas in theatre, dance, and performance studies. This includes research on Asian, African, Latin American, and Middle Eastern disciplines, as well as pre-1900 studies and essential translations. The grant, offering up to $3000, encourages recipients to publish their findings and collaborate with Theatre Survey editors. Eligibility extends to scholars with terminal degrees and graduate students, provided they are ASTR members.

The Cameron Award supports field research on native rodents across the Americas, encouraging studies in ecology, behavior, physiology, and conservation. It is available to students in MS or PhD programs and postdoctoral researchers in the U.S. Applicants must be ASM members. Funds cover supplies, equipment, and travel, but not salaries or meeting travel. The award aims to enhance understanding of rodent ecology and their impact on ecosystems.

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The Robotic Research Grant, offered by the American Society of Colon and Rectal Surgeons, provides up to $150,000 over two years for innovative research in colorectal surgery and robotics. Emphasizing education, health equity, and novel techniques, the grant supports projects conducted in the U.S. or Canada, with a focus on scientific rigor. Applications must be submitted by ASCRS members who are principal investigators, ensuring alignment with ethical research standards.

The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.

The Research Foundation of the ASCRS offers the Limited Project Grant to support innovative research in colon and rectal surgery. With funding up to $25,000 for one year, this grant aims to foster investigator-initiated, hypothesis-driven projects conducted in the U.S. or Canada. Successful applicants may secure further funding from national agencies. ASCRS membership is required for principal investigators, ensuring a dedicated approach to advancing colorectal health and surgical techniques.

The Eugene Salvati, MD, Limited Project Grant, offered by the Research Foundation of the American Society of Colon and Rectal Surgeons, supports clinical research in colorectal surgery. This grant aims to honor Dr. Salvati's legacy by funding innovative projects that improve patient care. With a maximum funding of $25,000 for one year, it emphasizes investigator-initiated research conducted within the U.S. or Canada, encouraging collaboration among ASCRS members and adherence to ethical review board protocols.

The NIDA Mentored Clinical Scientist Development Program Award aims to foster research independence in clinician scientists by providing intensive supervised research training and career development in the field of substance use and substance use disorder. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submission for this essential funding opportunity.

The MMUF Dissertation Grant, funded by the Mellon Foundation, supports doctoral candidates who are alumni of the Mellon Mays Undergraduate Fellowship. This grant aids scholars in completing their dissertations, ensuring diverse perspectives are represented in academia. With up to $30,000 for a 12-month period, the program encourages candidates to secure additional funding from their institutions. The initiative aims to bolster access to education and foster understanding among varied backgrounds, ultimately enhancing the academic landscape.

The General Surgery Resident Research Initiation Grant aims to engage General Surgery Residents in research related to colorectal diseases. With an annual funding of $20,000, this grant supports both clinical and laboratory-based research. It is geared towards residents or recent graduates of approved General Surgery programs, prioritizing those with aspirations in Colon and Rectal Surgery. This initiative fosters innovative research to enhance patient care and surgical techniques in the field.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5426 - Investigation of Non-Point Sources of PFAS in Sewersheds and Potential Mitigation Strategies

Grant Information

Evaluate the impact of non-point or dispersed sources of per- and polyfluoroalkyl substances (PFAS) in the sewershed (including PFAS-contaminated groundwater infiltration) on PFAS mass loading to wastewater treatment plants.

Assess how PFAS loading from non-point or dispersed sources of PFAS in the sewershed may affect treatment efficiency and reuse water quality.

Improve understanding of PFAS precursor contributions.

Identify potential strategies to mitigate PFAS loading from non-point or disbursed sources of PFAS in the sewershed.

The Richard King Mellon Foundation invites innovative proposals that align with their 2021-2030 Strategic Plan, aiming to invest over $1.2 billion to enhance opportunities in southwestern Pennsylvania. Their funding focuses on conservation, economic development, economic mobility, health and well-being, organizational effectiveness, and social-impact investments. The General Application offers flexibility without deadlines, allowing for a variety of support types, including project-specific and general operating funding, aimed at enriching community vitality and environmental stewardship.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5411 - Practical Playbook for Adaptive Utility Capital Improvement Planning Under Deep Uncertainty

Grant Information

• Assess current utility practices for incorporating adaptive or flexible decision making into capital improvement planning (CIP) at the portfolio or programmatic level.
• Identify where deep uncertainty most affects CIP decision points, including investment areas prone to lock-in or points of no return.
• Document the institutional processes, frameworks, and governance structures that have enabled utilities to embed adaptive and flexible investment strategies.
• Quantify how adaptive capital strategies compare to traditional CIP approaches in terms of lifecycle costs, rate stability, financial risk exposure, and avoided or deferred capital investments across a range of plausible future conditions.
• Establish practical criteria to help utilities determine which types of capital investments are well suited for adaptive approaches.
• Develop a practitioner-focused playbook that equips utilities to apply adaptive CIP in practice, including case studies, decision trees, trigger points, vulnerability assessment tools, financial and risk insights, and governance guidance.
• Produce tiered recommendations that allow utilities to adopt adaptive CIP practices incrementally.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Medication Therapy Management (MTM) Initiative

The Medication Therapy Management (MTM) Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to improve medication access, adherence, and patient understanding among uninsured and medically underserved populations. Individuals without health insurance often face significant barriers to obtaining prescription medications and receiving the counseling necessary to manage chronic conditions effectively. Through this initiative, NAFC will provide $30,000 grants to member free and charitable clinics and pharmacies to establish or expand Medication Therapy Management programs aligned with recommendations from the American Pharmacists Association. Funding will support activities such as staff certification in MTM, development of standardized protocols, and patient education to help individuals better understand their medications, manage side effects, and support overall treatment plans. By strengthening pharmacist-led care and improving communication between providers and patients, this initiative seeks to enhance medication adherence, improve chronic disease management, and advance better health outcomes for vulnerable patient populations.

The BTCF: Simple Gifts Fund Grant supports young artists aged 13-19 in the Berkshire Taconic region, providing financial assistance for summer enrichment programs in the arts. Established in 1998 in memory of folk singer Bill Crofut, the fund aims to empower youth through small grants that can cover costs for tuition, art supplies, or living expenses. The grant fosters creativity and personal growth, ensuring that young individuals have opportunities to pursue their passions.

The Goldberg, Joseph and Ruth Scholarship, offered by the Beatrice Educational Foundation, aims to support students pursuing medical professions, such as nursing, dental, and physical therapy. Established in 1987, the Foundation provides over $55,000 annually in scholarships to Beatrice High School seniors. Eligible applicants must be in the top quarter of their class and complete the application independently. This scholarship is part of the Foundation's commitment to enhancing educational opportunities in the Beatrice School District.

The Lifetime Contribution to the AAAAI and Allergy/Immunology Specialty Award honors individuals who have made significant and enduring contributions to the AAAAI and the allergy/immunology field. Awardees are recognized for exemplary service, leadership in professional organizations, impactful research, and mentorship of trainees. This prestigious accolade underscores the recipient's dedication to advancing the specialty and improving patient care, emphasizing the importance of community engagement and leadership in the field.

The Lazarus Family Scholarship in Bioethics and Humanities, offered by the AMA Foundation, supports students engaged in bioethics or the humanities, including art, music, and literature. This scholarship aims to foster the next generation of physician leaders by providing financial assistance to those who are committed to advancing health equity and community service. By recognizing diverse fields of study, it emphasizes the importance of interdisciplinary approaches in medicine and the humanities.