Best Operating Grants for Nonprofits in Delaware

The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.

The Agriculture Innovation Center Grant Program aims to support Agriculture Innovation Centers by providing grants that facilitate technical assistance to agricultural producers. This initiative focuses on enhancing the marketing of value-added agricultural products, ultimately fostering growth in the agricultural sector. Funded by the USDA's Rural Business-Cooperative Service, this program is designed to empower producers and promote innovation in agricultural practices.

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

• deploying capital quickly, 
• funding high-risk, high-reward ideas, 
• bringing new perspectives into a field, 
• encouraging collaboration, and 
• leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

• inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
• empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

The Tick-borne Pathogen Award, sponsored by Bay Area Lyme Foundation, offers $150,000 to support innovative research on non-Borrelia tick-borne pathogens. This grant aims to attract scientific talent to explore co-infections with Lyme disease and other related infections. Eligible candidates include researchers from academia or the private sector at the post-doctoral level or higher, with a focus on improving diagnostics and therapies for tick-borne diseases. Applications must present a viable proof-of-concept project.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5429 - Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs

Project Objectives

• Survey and characterize dissolved organic nitrogen and phosphorus (DON/DOP) concentrations and speciation across North American wastewater facilities, including but not limited to influent, secondary effluent, tertiary effluent, digester supernatant, thermal hydrolysis process (THP) centrate, autothermal thermophilic digestion (ATAD) sidestreams, and dewatering recycle streams.
• Understand the dynamics of DON/DOP in effluent, including quantifying the bioavailable fraction of DON/DOP in different relevant process streams, evaluating their transformation into nitrogenous disinfection by-product (N-DBP) precursors, determining bio-uptake rates representative of receiving water conditions, and measuring the timescale for biodegradation in receiving waters.

The PennHOSA Foundation Scholarship promotes healthcare careers by providing scholarships to HOSA student members in Pennsylvania. It aims to enhance compassionate care delivery and community needs. Additionally, the Helen Heidelbaugh Aspire Award is given to one student focusing on community service. Eligible applicants must be HOSA members and enrolled in accredited healthcare programs, demonstrating financial need. This scholarship is a one-time award, reinforcing the commitment to future healthcare professionals.

The Avant Garde Award supports innovative research on HIV and substance use disorders, encouraging creative scientists to explore high-risk, high-reward approaches. While applications are not currently being accepted, this initiative by the National Institute on Drug Abuse (NIDA) aims to stimulate collaborations and impactful research. Early-stage investigators are particularly encouraged to consider this opportunity as they develop their proposals for future funding. The program uses the DP1 activity code, fostering transformative advancements in biomedical and behavioral science.

The CDC's National Center for Injury Prevention and Control invites research proposals aimed at reducing suicide and interpersonal violence among youth aged 10 to 24. This funding opportunity encourages the evaluation of pre-existing primary prevention strategies that have not yet been rigorously assessed. Proposed approaches may include community programs and policies designed to enhance social connectedness, mitigate harmful online behaviors, and address technology-facilitated interpersonal violence.

The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.

The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.

Mr. Holland’s Opus Foundation

Who knew that a movie made 30 years ago would become the catalyst for the creation of a namesake non-profit, changing the lives of hundreds of thousands of kids by giving them access to learn and play music in school – keeping music education alive and strong across the country?

Mr. Holland’s Opus Foundation was inspired by the acclaimed motion picture Mr. Holland’s Opus, the story of the profound effect a dedicated music teacher had on generations of students. Michael Kamen, who wrote the score for the film, started the foundation in 1996 as his commitment to the future of music education.

The Foundation donates high-quality musical instruments to deserving, under-funded music programs, and provides an array of support services to school districts. By increasing the school’s inventory of quality, playable instruments, music teachers are given the tools they need to deliver a quality music education to students who want to learn. In collaboration with committed school districts, the Foundation’s investments are strategically placed as part of a K–12 district-wide plan to achieve positive and lasting results. Generations of students will benefit.

Instrument Grants

Mr. Holland’s Opus Foundation donates musical instruments to schools nationwide with a focus on increasing student access to music education programs in low-income communities.

Mr. Holland’s Opus Foundation grants consist of musical instruments and equipment only; no cash grants are provided. Our team handles sourcing, ordering, and delivering the instruments. As part of the application process, we work with the teacher to assess the program’s needs to determine the appropriate instruments and equipment. Note that only student model instruments are provided, and the brand is at the Foundation’s discretion.

The Indigenous Scholarships: Arts Fund facilitates artistic development for Aboriginal Australian, Torres Strait Islander, Native American, Alaskan Native, and Native Hawaiian artists. Offering up to $5,000, it supports projects in each other's countries, with applications due in March and September. Since 2002, over $1 million has been awarded to more than 500 artists, fostering cultural exchange and growth in the arts between Australia and the USA.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.

The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.

The Steven Scott Quinn Scholarship Fund, established by the Stark Community Foundation, aims to support Stark County, Ohio residents pursuing higher education in fields such as culinary arts, hospitality, nursing, nutrition, physical therapy, and occupational therapy. This initiative reflects the Foundation's long-standing commitment to enhancing the community through philanthropy and addressing diverse educational needs since its inception in 1963.

The State Pilot Program for Treatment for Pregnant and Postpartum Women aims to enhance the state's capacity to deliver integrated and evidence-based services for substance use disorders and maternal mental health. The initiative focuses on supporting pregnant and postpartum women and their families, ensuring they receive comprehensive care tailored to their unique needs. Funded by the Substance Abuse and Mental Health Services Administration, this program is a vital step toward improving health outcomes for vulnerable populations.

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Investigator Sponsored Studies Program

Alkermes seeks to support research designed and conducted by independent clinicians and scientists through our Investigator Sponsored Studies (ISS) program. Alkermes may occasionally announce a Request for Proposals (RFP) for research in clinical areas where gaps in data have been identified. 

The ISS research Alkermes supports must be based in the United States and is typically conducted by experienced researchers who have an established history of successfully completing research with independent funding. Alkermes can provide its marketed products to the ISS programs it supports. In addition, there may be financial support available, but please note that study budgets cannot exceed $300,000 (inclusive of overhead).

• ISS Areas of Interest
  • Sleep Disorders
  • Schizophrenia & Bipolar I Disorder
  • Schizophrenia

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

The Gospel Fest Music Arts Scholarship, established by Vicki Hill of WTLZ-FM, aims to support Saginaw County students pursuing degrees in Musical Arts. This initiative is part of a larger effort by the Saginaw Community Foundation to enhance local education through scholarships and grants. The annual Gospel Fest, attracting up to 2,000 attendees, serves as a vibrant community event promoting peace and cultural unity through music, showcasing both local and national talent.

Who We Are - CAP Foundation

Mission

Our mission is to improve people’s health by:

• Developing tomorrow’s pathology leaders through awards for advanced training, research, and education.
• Mobilizing pathologists to expand health equity in medically underserved communities within the US and globally.

Vision

Our vision is that pathologists are equipped to bridge health disparities and enhance outcomes globally.

CAP Foundation History

For over 50 years, the CAP Foundation has granted millions of dollars to support pathology education, research, training, and travel grants, with the purpose to:

• Enhance the role of the pathologist in the provision of medical care.
• Advance pathology through the education of the medical community.
• Encourage the clinical application of research developments.

Our Core Values

• Advancement: We are committed to pushing the boundaries of pathology and patient care through scholarships, grants, and educational programs.
• Collaboration: Through effective partnerships, we significantly enhance our capacity to fulfill our mission.
• Excellence: We are dedicated to achieving the highest standards in pathology education, research, and community service.
• Service: Service reflects our core mission of improving health equity by providing access to healthcare and pathology expertise, particularly in underserved communities.

Presidential Pathology Scholarship

This scholarship allows the sitting CAP President to personally support educational creativity, expand awareness of pathology, and connect communities through the CAP Foundation’s mission to develop tomorrow’s pathology leaders. This scholarship is established in honor of each sitting CAP President, as a commitment to the CAP Foundation’s efforts to advance the specialty by supporting creative projects that encourage interest in or expand the reach of pathology. Up to two scholarships will be supported each year. Ranging from $500-$1,500 per awardee, to be used toward the selected project(s).

Each year the sitting CAP President will select a focus area to support based on at least one of the CAP Foundation’s Five (5) Pillars. CAP Foundation Five Pillars:

• Global: Expands global pathology access, capacity, training, and equity.
• Future Leaders: Builds pipeline through learning, leadership, mentorship, and awards.
• Ethics, Research, Innovation: Advances ethical practice, discovery, innovation, and diagnostic excellence.
• Advanced Training: Delivers specialized skills through grants, workshops, and roundtables.
• Community Engagement: Increases visibility and connection with patients, partners, and the public.

The NEA Federal Rescue Implementation Network Grant provides up to $100,000 per year for two years to state affiliates for hiring a coordinator to implement the American Rescue Plan in support of public education. This funding is specifically for backfilling a position that must remain filled for at least ninety days, ensuring effective oversight of federal recovery initiatives within the affiliate.

The NASPGHAN Foundation Abbott Advanced Fellowship in Pediatric Nutrition offers up to $75,000 for one year of advanced training in pediatric nutrition for members of NASPGHAN. This fellowship aims to enhance pediatric nutrition expertise by supporting a well-defined clinical experience and focused research project. Eligible applicants must be MDs or DOs and members in good standing, with a preference for those seeking training at different institutions. This initiative addresses the increasing importance of pediatric nutrition in child health.

The Measurement and Evaluation Graduate Student Award, offered by SHAPE America, aims to support graduate students specializing in psychomotor measurement and evaluation. This scholarship assists with professional expenses, ensuring candidates can focus on their studies. Eligible applicants must be current SHAPE America members and pursuing relevant master's or doctoral degrees. The award prioritizes those who have completed their first year of study, promoting excellence in health and physical education across the U.S.

Brave Beginnings Grants, under the Will Rogers Motion Picture Pioneers Foundation, focus on enhancing neonatal care by providing vital equipment to hospitals. Since 2006, the program has awarded approximately $1 million annually to Neonatal Intensive Care Units (NICUs) across the U.S. Following a suspension due to COVID-19, the 2026 grant cycle is now open, with applications due by February 13, 2026. This initiative aims to ensure the availability of lifesaving equipment for newborns in critical need.

The Ag Health and Safety Grants, awarded by CHS and the CHS Foundation, aim to enhance agricultural safety and foster community well-being. These grants focus on educating youth and farmers about agricultural hazards, providing training for rural professionals, and developing essential safety guidelines. With a commitment to improving safety standards, the program has benefitted over 32,000 youth and supported more than 450 communities through safety initiatives and equipment, ensuring a safer future for all involved in agriculture.