Best Operating Grants for Nonprofits in Delaware

The Robert J. Keown Trust, established in 1934, provides financial assistance to needy Christians through grants to charitable organizations. Managed by Wells Fargo Bank N.A., the trust focuses on supporting organizations that benefit residents of Los Angeles County. Eligible organizations must be 501(c)(3) exempt. Preference is given to requests aiding needy Christians and elderly women. The trust awards an average of four grants per year, fostering community support and outreach.

Angel Post Deployment Test Program

Through a collaborative partnership with UNCF, XYZ Corporation has established a scholarship program to help STEM students get on the fast track to a rewarding career. In addition to direct financial support, Intel-sponsored scholarships offer the benefits of exposure to potential job opportunities, networking with fellow scholars, insight to other Intel scholarships, research, training opportunities, and access to Intel mentors offering support on technical, non-technical, cultural, and dissertation-related needs.

The James B and Lois R Archer Charitable Foundation offers Smaller Grants of $10,000 or less to support initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Organizations must have 501(c)(3) status and comply with eligibility criteria, including a one-year waiting period for reapplications. The foundation aims to have a significant impact on communities, especially in West Texas, while avoiding funding for specific exclusions such as endowments and fundraising events.

The James B and Lois R Archer Charitable Foundation offers Large Grants for requests exceeding $10,000. Focused on fostering positive change, the foundation supports initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Eligibility includes 501(c)(3) organizations, while restrictions apply to consecutive grant cycles and non-qualifying purposes such as endowments and fundraising events. Organizations are encouraged to apply for various projects to enhance community well-being.

The Clinical Research Training Scholarship in Parkinson's Disease, funded by the Parkinson's Foundation and the American Brain Foundation, supports young investigators in clinical studies related to Parkinson's disease. Offering $65,000 annually for two years, plus an additional $10,000 for education and research costs, this award aims to foster rigorous clinical research. Eligible applicants must have an MD, PhD, or equivalent degree and be AAN members, focusing on patient-oriented research with human subjects.

The Emergency Solutions Grant (ESG) program, managed by the Delaware State Housing Authority, provides essential funding for homelessness prevention and street outreach activities. It aims to enhance emergency shelters and reduce homelessness through rapid rehousing initiatives. Grants are available to local governments and non-profit organizations, supporting a wide range of activities to ensure safe and sanitary shelter for vulnerable populations. This program is critical in addressing homelessness in Delaware.

The NIA Expanding Research in AD/ADRD Postbaccalaureate Research Education Program aims to enhance the research workforce by providing intensive research experiences for recent graduates. This initiative supports early-stage investigators in Alzheimer's Disease and related dementias, addressing a critical shortage of researchers in the field. Participants engage in independent research, mentorship, and professional development, equipping them with skills necessary for advanced degrees and research careers in aging and dementia. The program fosters innovation and interdisciplinary collaboration essential for advancing AD/ADRD research.

The Chronic Pain Medicine Research Grant, offered by the American Society of Regional Anesthesia (ASRA) and Pain Medicine, aims to enhance research in pain medicine, guiding clinical practice and improving patient care. With a funding limit of $200,000, the grant prioritizes studies in areas such as Regional Anesthesia, Outcomes Research, and Patient Safety, encouraging innovative proposals from North American physician members of ASRA.

The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.

The Scott R. MacKenzie Foundation offers grants to support innovative genetic research aimed at advancing cures for diseases like cancer, diabetes, lung, and heart diseases. Only U.S.-based tax-exempt organizations with over five years of operation can apply. The Foundation emphasizes collaboration among research entities to enhance genome sequencing and disease detection. By funding these initiatives, they aim to foster awareness and progress in genetic research for future generations.

The AACR June L. Biedler Prize for Cancer Journalism

Prize Summary

The AACR June L. Biedler Prize for Cancer Journalism was established by the AACR in 2015 to raise awareness of the critical role that the media play in educating the public about cancer and cancer research.

Funded by a major bequest to the AACR from cancer research pioneer Dr. June L. Biedler, a scientist, mentor, and former member of the AACR Board of Directors, this prize showcases outstanding examples of cancer journalism and recognizes individual professional journalists who have produced accurate, informative, and compelling stories that enhance the public’s understanding of cancer, cancer research, cancer advocacy, or cancer policy.

The prize provides an unrestricted cash award of $5,000 and a commemorative award.

Categories

Each submission may be considered for only one category, as selected by the candidate on the application form.

Applicants may submit in any of the following categories:

Prize Acceptance

Awardees will be able to accept the prize during the AACR Annual Meeting 2027 in Orlando, April 2-7, 2027.

The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

The BioMarin Grant aims to support events, activities, and projects that enhance public health and benefit patients with rare diseases. This corporate funder focuses on scientific innovation and provides resources for organizations such as hospitals, universities, and patient advocacy groups. With an emphasis on education and community support, BioMarin encourages applications for funding throughout the year, ensuring timely assistance for eligible projects.

The Marlene and Spencer Hays Foundation Grants support tax-exempt organizations working to enhance lives through arts, healthcare, education, and youth programs. The foundation requires a Letter of Intent (LOI) from all applicants, emphasizing its mission to select grant recipients who align with its values. Grants are not available for political purposes, endowment campaigns, or organizations that discriminate based on race, gender, or religion. This framework ensures a focused impact on community betterment.

The ASTRO-AstraZeneca SCLC Therapy Challenge RFP aims to enhance research on limited-stage small cell lung cancer (LS-SCLC) through innovative combination therapies, particularly integrating immunotherapy with advanced radiation techniques. Proposals are encouraged to explore various aspects, including care patterns, treatment workflows, prognostic biomarkers, and toxicity management. The target budget for projects ranges from $175,000 to $375,000, with consideration given to higher requests based on scientific merit, fostering significant advancements in radiation oncology.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

The Bertin Family Foundation Grants support 501(c)(3) public charities that align with the foundation's mission of community strengthening and compassion. Grant requests are accepted annually from July 1 to August 31, focusing on program or project support rather than general endowment. The foundation values measurable outcomes and responsible stewardship, and gives preference to organizations with Gold or Platinum status on Candid.

Healthcare Assistance Grant

The MS Focus Healthcare Assistance Grant assists uninsured individuals with the cost of visiting their MS specialist as well as dental assistance. The grant, which can pay for one visit and one follow-up, is designed to assist those already diagnosed with MS who may need a visit to their treating physician to renew a prescription or handle other important needs. 

Applicants give MS Focus staff authorization to negotiate costs directly with the provider, and the fee is paid directly to the doctor. 

Mildred's Dream Foundation Grant provides vital support to community-based non-profit organizations focused on Education, Domestic Violence, and Physical or Mental Health Challenges. With grants up to $25,000, the foundation aims to honor Mildred's commitment to improving lives and creating a better world. Eligible organizations must be 501(c)(3) non-profits providing direct services in these areas. Notably, the foundation excludes funding for certain institutions, ensuring resources are directed to those genuinely in need.

The Frances Parker Rupert Memorial Fund for Music and the Performing Arts provides scholarships to talented students pursuing music or performing arts degrees. Established by the Community Foundation Serving Western Virginia, this fund aims to support high school seniors from specific counties, considering their potential and financial need. Applicants must demonstrate their artistic abilities and articulate how this scholarship will aid their educational goals in a two-page essay.

Improving Metastatic Prostate Cancer (mPCa) Care Through Innovative Strategies

The National Comprehensive Cancer Network® and Pfizer Global Medical Grants (Pfizer) are collaborating to offer a new grant opportunity seeking proposals for investigator-initiated research to improve mPCa care. Pfizer (hereafter, “Grantor”) is providing $1 Million in funding to support quality improvement studies to advance health care quality, the delivery of quality care, and improve health care provider performance in mPCa care. The Grantor will serve as the funding organization. Grants are available to all investigators from institutions within the United States. 

Aim

To promote the advancement of scientific knowledge, health care provider performance, and/or health care quality improvement focused on improving mPCa care.

A total of $1 Million is available to fund all projects. The intent is to fund 2-5 studies. There is a funding cap of $250,000 per study. Exceptional studies with budgets above this amount will be considered based on scientific merit and must contain a robust justification. All budgets must include line-item information and robust justification.

The EMF Family Building Grants, offered by the Expect Miracles Foundation, support young adult cancer survivors in their fertility treatment and family-building efforts. These grants are designed for applicants with a clear family-building plan and financial strategy, helping bridge the gap in costs associated with fertility preservation, assisted reproductive technologies, and related services. By prioritizing those actively engaged in their journey, the foundation aims to empower survivors to pursue their dreams of family.