Best Grants for Small Nonprofits in District of Columbia

The Rotary Works Foundation Grant supports charitable projects primarily focused on children, youth, and families, emphasizing active Rotarian involvement. Grants range from $500 to $5,000, awarded prior to events. Eligible applicants include 501(c)(3) or 501(c)(1) organizations. Preference is given to projects engaging Rotarians. The application deadline is the 2nd Wednesday of each month, and all grantees must report outcomes post-project.

The Jennie K. Scaife Charitable Foundation Grant focuses on enhancing family support, women's and children's health, and animal welfare. It aims to fund programs that promote beneficial human-animal interactions and early intervention in addiction prevention. Eligible organizations must have a valid 501(c)(3) designation. Grants align with at least one of the foundation's focus areas, ensuring impactful contributions to community welfare and well-being.

The Parkinson Family Foundation Grant supports organizations focusing on Food & Water, Faith & Evangelism, and Health & Humanitarian Efforts. Applications are open year-round, with grants ranging from $1,000 to $5,000; larger requests are typically declined. Eligible applicants include schools, state governments, and 501(c)(3) nonprofits. The Foundation emphasizes selectivity and prioritizes organizations with established relationships and those promoting American ideals like freedom and justice.

The Howe Foundation, established by Thomas E. Howe in Clark County, Nevada, supports U.S. charitable organizations focused on education, medical advancements, and game hunters associations. Grants are administered by Wells Fargo Bank, with applications reviewed annually in September. Eligible organizations must be 501(c)(3) exempt under the Internal Revenue Code, ensuring support for meaningful community initiatives.

The Greenpoint Foundation Grant aims to enhance community life by supporting organizations that focus on agriculture, food security, education, and community enhancement. Established in 2022, the Foundation accepts grant applications year-round for both general operating budgets and specific projects. Priority is given to 501(c)(3) organizations and local government entities, while faith-based programs are considered on a case-by-case basis. Grant recipients must submit impact reports to ensure continued support.

The Robert W. and Martha D. Casciani Scholarship, managed by the Ashland County Community Foundation, supports graduating seniors from Ashland County high schools who have a GPA of 3.0 or higher and are pursuing degrees in Chemical or Mechanical Engineering at accredited colleges outside the county. This scholarship honors the legacy of Robert and Martha Casciani, who were committed to their community and education, encouraging future generations to achieve their academic goals.

The BIE Professional Examination Funding, provided by Native Forward Scholars Fund in partnership with BIE, offers financial assistance to support Native students in taking professional examinations, including Bar Examination funding. This award covers registration fees, preparatory course costs, and other exam-related expenses. Applicants must have graduated within one year and can only receive assistance for one exam. This initiative aims to empower Native scholars and enhance their professional visibility and opportunities.

The Tim and Sharon (Hemmeter) Buren Scholarship, managed by the Ashland County Community Foundation, supports graduating seniors and current students from Mapleton or Northwestern high schools. Eligible applicants must maintain a GPA of 3.0 and gain acceptance to an accredited college or vocational school. This scholarship encourages educational advancement, providing crucial financial assistance to both traditional and non-traditional students, thereby contributing to the community's future prosperity.

The Native American Agriculture Fund (NAAF) offers grants to support Native farmers and ranchers through business assistance, agricultural education, technical support, and advocacy services. Established from the Keepseagle v. Vilsack settlement, NAAF is committed to providing essential resources to eligible organizations, including 501(c)(3) nonprofits, educational institutions, and tribal governments. Special focuses include inflation assistance and market access, ensuring a holistic approach to agricultural support.

The Alpha Delta Kappa Xi Education Scholarship supports graduate students pursuing careers in education. This scholarship aims to recognize and foster fellowship among educators, promoting educational excellence and altruism. By providing financial assistance, it encourages aspiring educators to achieve their goals and contribute to the field of education. Eligible applicants can complete a single online application to match with multiple scholarship opportunities, streamlining the application process.

The Sundance Collab's Cultural Impact Residency, honoring Michael Latt, is a six-month online program supporting early-career, underrepresented storytellers focused on social impact. Running from March to August 2026, it offers mentorship, feedback sessions, and resources to eight selected fellows in screenwriting, directing, and documentary filmmaking. This opportunity is designed for works-in-progress, fostering a supportive creative community to inspire and develop impactful narratives.

The Child Neurology Foundation offers a Summer Scholarship for first, second, or third-year medical students interested in neurodevelopmental disabilities or child neurology. This scholarship provides $3,500 for clinical research focused on neurodevelopmental disabilities in children or young adults, conducted under the supervision of a qualified subspecialist. Applications are evaluated based on their importance, originality, and contribution to the medical student's development.

The NRF Foundation Retail Management Scholarship, in partnership with CVS Health, is designed to inspire undergraduate students to pursue careers in retail leadership. Eligible candidates can receive a $10,000 scholarship and attend the NRF Foundation Student Program in NYC in January 2026. This program provides networking opportunities with top retail executives and recruiters, along with insights into career pathways in the retail industry, making it a valuable experience for aspiring leaders.

The Robert B. Taylor Fund, managed by the San Antonio Area Foundation, supports students pursuing higher education in vocational fields or those seeking associate degrees. Available to high school seniors, college students, and adult learners, it emphasizes financial need and academic performance, specifically a minimum GPA of 2.5. Preference is given to Black or African American students and those enrolled in Alamo Community Colleges. This fund aims to enhance educational opportunities and community growth.

The Teresa and David R. Schmidt, M.D. Scholarship Fund, managed by the San Antonio Area Foundation, supports high school seniors pursuing careers in the medical field. Eligible applicants must demonstrate financial need and maintain full-time enrollment at accredited institutions. This renewable scholarship assists with tuition, fees, and books for students from specific Texas counties, fostering community growth and educational opportunities in healthcare since 1964.

The Quality of Life Grants Program, established by the Dana Reeve Foundation, aims to enhance the lives of individuals with disabilities by funding non-profit organizations. The Tier 4 Priority Impact Grants provide up to $50,000 for projects that facilitate employment and nursing home transitions, crucial for improving independence and community engagement for those living with paralysis. These grants support initiatives that ensure sustainable pathways towards gainful employment and help individuals return to their homes from nursing facilities.

The HEAL Initiative aims to address the significant overlap between chronic pain (CP) and opioid use disorder (OUD), with 40-75% of individuals affected by both. The IMPOWR project focuses on testing innovative interventions and implementation strategies to integrate care for CP and OUD across various health systems. The BEACON Center will enhance network coordination, build capacity, and develop resources to address barriers in service delivery, ultimately improving sustainability and scalability of evidence-based practices.

The C.V. Glassco Memorial Scholarship Fund honors Mr. Clarence Verbal Glassco, a dedicated community volunteer and veteran. This scholarship supports full-time students pursuing higher education or approved workforce training in Alabama. Funded by the Community Foundation of Northeast Alabama, it covers tuition, housing, and books based on available assets. Applicants are encouraged to seek additional financial resources. This initiative preserves Mr. Glassco's legacy of service and commitment to education.

The A.D. and Peggy Hewlett and Colonel David R. Inman Medical Scholarship, established by Steve Hewlett, Pam Inman, and Faye Houston, honors their parents' commitment to education and healthcare. This scholarship supports students pursuing nursing, pharmacy, or physical therapy, prioritizing applicants from Hancock, Ohio, or Daviess County, Kentucky. Applicants must demonstrate academic potential and compassion through relevant experiences. The Community Foundation of Middle Tennessee administers this fund to foster a more inclusive and thriving community.

The ANCA-Assoc Vasculitis and Granulomatosis with Polyangiitis Fund, established by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from this rare and serious condition. The fund assists with copays, premiums, and out-of-pocket expenses related to treatment, ensuring that affected individuals have access to necessary medications. With over $1.2 billion in grants awarded since 2004, the foundation has helped over 1.1 million patients access critical healthcare services.

The Hyperoxaluria Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from hyperoxaluria, a condition characterized by excessive oxalate in urine. This fund assists with prescription drug copays and insurance premiums, providing vital support for treatments. In 2024 alone, HealthWell allocated over $1.2 billion in grants, ensuring access to essential medications for those in need. The organization is committed to improving healthcare access and reducing disparities for affected individuals.

The O'Jays Scholarship Fund, established by the Stark Community Foundation, supports Stark County seniors graduating high school or residents with a GED pursuing higher education. Eligible applicants must maintain a minimum GPA of 2.5 and demonstrate financial need. This initiative reflects the Foundation's long-standing commitment to enhancing educational opportunities and addressing community challenges since its inception in 1963. The program aims to empower students to achieve their academic goals and improve their futures.

The National Park Service (NPS) invites applications for Master Cooperative Agreements from participants in the Cooperative Ecosystem Studies Units (CESU) network across various regions. This initiative fosters collaboration among federal agencies, tribes, academic institutions, and conservation organizations to enhance resource stewardship. With 390 non-federal partners and 15 federal agencies, the CESU network supports interdisciplinary projects addressing diverse environmental and cultural heritage issues. Applications are continually accepted until the announcement's closing date.

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

U.S. Small Business Administration

SBA works to ignite change and spark action so small businesses can confidently start, grow, expand, or recover. Created in 1953, the U.S. Small Business Administration (SBA) continues to help small business owners and entrepreneurs pursue the American dream. SBA is the only cabinet-level federal agency fully dedicated to small business and provides counseling, capital, and contracting expertise as the nation’s only go-to resource and voice for small businesses.

Manufacturing grants

SBA provides grants to help empower small manufacturers.

Empower To Grow (E2G) Manufacturing in America Grant

The goal of this grant is to provide workforce development in key manufacturing industries, such as timber, energy, aluminum, steel, digital, and automotive.

SBA is looking for organizations that will provide technical proficiency and essential skills, including operating machinery, quality control, welding, utilizing industrial software, and workplace safety. 

The Rod's Tire and Service Scholarship Fund, managed by the Central Kansas Community Foundation, offers $2,500 to assist graduating Marion County high school seniors pursuing higher education or vocational training. The foundation, established in 1994, focuses on enhancing community welfare through charitable giving and emphasizes support for students majoring in agricultural fields. This scholarship aims to empower local youth and strengthen the community by investing in their educational futures.

The Ruth M. Cogan Foundation Trust Fund, established by the Stark Community Foundation, supports students from Stark County, Ohio pursuing college education in music. This fund aims to help graduating seniors or current college students who demonstrate a passion for music and embody the spiritual qualities exemplified by Ruth. Since 1963, the Foundation has evolved from a grantmaker to a community leader, transforming lives through philanthropy.