Best Large Grants for Nonprofit Organizations in District of Columbia

IRS-registered 501(c)(3) public charities serving District of Columbia residents can seek funding for programs improving lives of vulnerable and underserved people, including arts, education, community services, environment, and health, with awards of US $10,000 - US $250,000. The Morris & Gwendolyn Cafritz Foundation prioritizes comprehensive services, systemic change, and capacity building across the DC metropolitan region.

Nonprofit 501(c)(3) and 509(a) organizations can apply for McGraw Foundation’s US $2,000 - US $10,000 grants supporting education, human services, health, environmental conservation, and cultural programs. With a mission to strengthen communities, McGraw Foundation provides nonprofits with single-year operating, project, or occasional capital support; District of Columbia organizations may be eligible if they meet its geographic preferences.

Focused on community services, 501(c)(3) nonprofits in the District of Columbia can apply for Venable Foundation grants supporting general operations or projects; awards are approximately US $10,000. Organizations working in human services, legal services, education, workforce development, youth programs, health, environment, or arts and culture that serve economically disadvantaged residents may be competitive.

District of Columbia graduate students researching drinking water quality, environmental science, or public health can access funding through the American Water Works Association. This US $3,000 Dr. Philip C. Singer Scholarship supports actionable, timely research addressing current water industry challenges, and may benefit students connected to local nonprofit or public-sector water initiatives.

Nonprofit 501(c)(3) organizations serving District of Columbia residents can access funding for one-time capital, equipment, and other project needs, as well as select program or operating costs. Philip L. Graham Fund provides US $30,000 - US $75,000 grants for health and human services, education, arts and humanities, and community endeavors across the D.C. metro area.

Nonprofit 501(c)(3) organizations and schools running environmental programs in the District of Columbia can seek US $25,000 - US $100,000 for decarbonization, clean energy, and efficient resource use projects. With a mission to support sustainability, American Honda Motor provides programmatic funding where its associates live and work, including D.C.

Nonprofit 501(c)(3) organizations in the Washington, DC metro area can seek US $100,000 for high-impact projects in arts and culture, education, environment, family support, or health and wellness. Grants from Impact100 DC help District of Columbia nonprofits addressing systemic racism and structural inequity implement projects within 24 months of the award.

Nonprofit and community organizations running arts, education, environmental, or health and wellness projects or events in the District of Columbia can seek support for community initiatives from Stantec. Focused on community engagement near its office locations, Stantec invites requests for funding or other support for short- or long-term projects and community events.

Nonprofit organizations in the District of Columbia working on health, community services, environmental resilience, education, or poverty alleviation can apply for TD Charitable Foundation regional grants of more than US $5,000. Funding supports programs under Better Health, Connected Communities, Financial Security, and Vibrant Planet, with priority for diverse, historically underserved, and low-to-moderate income populations.

Nonprofit organizations serving women and children with programs like homelessness services, education, food security, health care, and anti-trafficking support in District of Columbia can apply for the Father's Table Foundation’s competitive grants, with awards up to US $750,000. Funding supports self-sufficiency, sustainability, and disaster or humanitarian relief projects with proven impact and capacity to grow.

Undergraduate-focused higher education institutions in the District of Columbia conducting biomedical research can apply for NIH Academic Research Enhancement Awards, with awards up to US $375,000. These small-scale grants support research in areas like public health, neuroscience, genetics, cancer, and HIV/AIDS while expanding research opportunities and environments for undergraduate students.

Nonprofit organizations and eligible public entities addressing education, hunger, health, disaster relief, or environmental needs in the District of Columbia can seek funding that may range from US $2,500 - US $10,000. Focused on community and environmental programs, International Paper Company Foundation prioritizes projects in communities where it operates and those involving its employees.

Nonprofit 501(c)(3) organizations in the District of Columbia working on economic opportunity, workforce readiness, entrepreneurship, or affordable housing can access funding and leadership training through the Neighborhood Builders Program. Grants from Bank of America Charitable Foundation help build nonprofit capacity via a two-year leadership development program for CEOs and emerging leaders focused on social mobility.

Nonprofit 501(c)(3) organizations in the District of Columbia can seek general operating or program support for arts, environmental, medical research, or veterans initiatives. Cornelia T Bailey Charitable Tr supports projects such as visual and performing arts for youth, environmental ingenuity, high-mortality disease research, and therapeutic programming for veterans in its active regions.

Early-career research scientists in low- or middle-income countries conducting clinical research in fields like cancer, cardiovascular disease, mental health, or environmental health can apply for the Emerging Global Leader Award, with approximately US $140,000 for mentored career development. Focused on global health, the National Institutes of Health invites eligible investigators, including those collaborating with District of Columbia nonprofits, to build independent research careers.

Early-career research scientists at academic or research institutions in eligible low- and middle-income countries can apply for the Emerging Global Leader Award from the National Institutes of Health, receiving approximately US $140,000 for mentored health research career development. District of Columbia-based U.S. mentors and partners may collaborate with LMIC investigators across diverse clinical and public health fields.

Nonprofit 501(c)(3) organizations in the District of Columbia seeking support for education-focused programs can apply for grants from the John Ben Snow Memorial Trust, typically ranging from US $5,000 - US $20,000. Funding may also support youth initiatives, arts and culture, community services, environmental education, and historic preservation projects that emphasize educational impact.

Nonprofit 501(c)(3) organizations in the District of Columbia can seek funding to support independent medical conferences, charitable events, medical education, and public education programs. With a mission to advance healthcare, Medtronic provides grants and donations to eligible health-related nonprofits; applications must be submitted at least 60 days before the funding decision or event.

Nonprofit 501(c)(3) organizations in the District of Columbia can apply for Cloudbreak Foundation’s US $5,000 - US $20,000 grants to support projects serving underprivileged children, people experiencing homelessness, and the elderly. Funding focuses on programs providing direct care or services that meet critical or basic human needs, including youth services, housing, and senior support.

The Joseph Robert Foundation Grant provides essential funding for non-profit organizations focused on the arts, animal welfare, and environmental protection. Based in Pennsylvania, the foundation prioritizes smaller local organizations in the mid-Atlantic region, offering grants typically under $10,000. It encourages innovative projects and supports first-time grant seekers, prioritizing those with limited resources. Organizations can apply for general operating support or specific project funding to further their missions and impact their communities.

Biogen Corporate Sponsorships provide funding to support congresses, events, and initiatives in exchange for tangible benefits such as marketing opportunities and recognition. Applications are reviewed on a rolling basis, and requests must be submitted 50 days in advance. Biogen considers various disease areas for sponsorship, including Alzheimer’s and Multiple Sclerosis. Approval depends on funding availability, alignment with interests, and event details, ensuring transparency for all potential sponsors.

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Full-Time Associates

Regions supports organizations important to our associates through the Regions Matching Gifts Program. This program, which is open for use for all full-time Regions associates, affiliate associates and recent retirees, allows you to make an even greater difference to your favorite charities by doubling your tax-deductible contributions to these organizations. 

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Recent Retirees

Retirees of Regions and its affiliated companies are eligible for the Matching Gift Program for up to 5 years after retirement (the gift date must be within the first 5 years of retirement). Regions will match donations of $25 or more, up to a total of $1,000 per year per retiree.

The Regions Community Affairs team will contact the organization on your behalf to verify the gift and review eligibility.

The Clif Family Foundation Open Call invites 501(c)(3) organizations to apply for grants supporting general operating costs or specific projects. With a focus on regenerative farming, food worker health, climate justice, and food access, the foundation aims to empower grassroots initiatives. Grants range from $5,000 to $50,000, with applications reviewed twice a year. Deadlines are March 1 and August 1, and announcements occur about four months post-deadline.

Bell's Brewery Small Grassroots Grants support projects focusing on water stewardship across the Great Lakes watershed. With grant amounts ranging from $500 to $5,000, eligible organizations can apply for funding to improve ecosystem health, enhance public health through better water resource management, and promote resilience against climate-related water risks. This initiative highlights Bell's commitment to environmental stewardship and community support in all 50 states and DC.

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The Competitive Graduate Research Fellowship, offered by Maryland Sea Grant, supports graduate students conducting research on critical issues affecting the Chesapeake Bay and coastal waters. This fellowship emphasizes social relevance and community engagement, particularly focusing on underserved populations. Awarded fellows receive a stipend of $34,000, tuition remission, and travel allowance. A professional mentor is required to ensure research aligns with the needs of resource managers and policy makers. Applications are encouraged from a diverse pool of candidates.