Best Large Grants for Nonprofit Organizations in District of Columbia

The Visions – Projects + Events Grant, administered by HumanitiesDC, invites DC-based nonprofit organizations to create innovative public humanities programs. By supporting projects that engage with the community through documentaries, events, and educational initiatives, this grant fosters creative interpretations of humanities scholarship. Eligible applicants must demonstrate a connection to Washington, DC, and incorporate relevant expertise in their projects. This funding opportunity encourages collaboration and accessibility, enriching the cultural landscape of the District.

The Arts and Humanities Education Project Grant Program (AHEP) supports non-profit organizations in the District of Columbia to enhance student engagement in arts and humanities. AHEP aims to provide high-quality experiences that bolster academic achievement and strengthen the role of arts education. This competitive grant is open to projects of various sizes, focusing on in-school, out-of-school, professional development, and older adult initiatives, fostering a rich cultural landscape.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Extension Risk Management Education (ERME) Competitive Grants: Exploratory Projects aim to enhance agricultural producers' economic viability through innovative risk management education. Funded by the University of Delaware, these grants offer up to $10,000 for projects that address emerging risk topics or support producer workshops. With an 18-month duration from April 2026 to September 2027, this initiative encourages the development of new educational approaches to better serve the needs of farmers and ranchers.

Foundation for Children with Intellectual and Developmental Disabilities

The FCIDD was founded for the purpose of providing support to organizations that serve individuals with intellectual and developmental disabilities.

Mission Statement: The Foundation supports organizations which enhance the lives of persons with intellectual and developmental disabilities by promoting research, projects, education and advocacy. 

Nonprofit Project Grants

The Foundation for Children with Intellectual and Developmental Disabilities (FCIDD) funds 501(c)(3) organizations working with individuals with intellectual and developmental disabilities of all ages, primarily in the states of Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, New York, New Jersey, Pennsylvania, Ohio, West Virginia, Delaware, Maryland, the District of Columbia, and Virginia. 

Funding Priorities

• Grants will be awarded for the purpose of primarily benefiting, including, or increasing accessibility for individuals with intellectual or development disabilities.
• Grants may be awarded for scholarships or training personnel in the care and education of individuals with developmental and/or intellectual disabilities. 
• Grants shall mainly be distributed to a Charity whose primary purpose or whose project is to support individuals with intellectual or developmental disabilities. A Charity which has a project to benefit individuals with developmental or intellectual disabilities based on financial need shall be awarded the grant money based upon its own objective criteria and without any special preference to members of Civitan or members of their family.

Grant Categories

A grant application typically fits into one of the following categories: Accessibility & Engagement; Educational Spaces; Program Area Improvements; Outreach and Education 

Accessibility & Engagement

For museums, parks, other public spaces without a specific I/DD focus wanting to make property or equipment improvements and additions to better include visitors with I/DD.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

The Sara E. and Bruce B. Collette Postdoctoral Fellowship in Systematic Ichthyology, funded by the Smithsonian Institution, supports postdoctoral research in collections-based systematic ichthyology. Established in 2017, this fellowship aims to foster the next generation of researchers through access to the National Museum of Natural History's extensive collections. Awardees receive a stipend of $62,000 annually, as well as allowances for research, travel, and health insurance, making it a prestigious opportunity for scholars in the field.

The SpartanNash Foundation Grant supports nonprofit organizations focused on Hunger, Heroes, and Hope. Eligible applicants must be 501(c)(3) organizations located within a 30-mile radius of SpartanNash facilities. The Foundation ensures that every dollar raised directly benefits partner organizations, with a commitment to community impact. Grants are not available for ineligible entities, including those outside the radius or not aligned with the Foundation's mission. Since its inception in 2015, the Foundation has positively influenced local communities.

The Arthur Molella Distinguished Fellowship, endowed by The Lemelson Foundation, supports senior scholars in technology and innovation studies at the Smithsonian Institution. Eligible candidates include experienced authors and scholars from various related fields. The fellowship offers flexible funding of $35,000 for sabbaticals, short visits, or residencies, encouraging research that highlights diverse inventors and innovations. The program fosters participation in museum activities and provides necessary support for non-US citizens.

Department of Behavioral Health

The Department of Behavioral Health provides prevention, intervention and treatment services and supports for children, youth and adults with mental and/or substance use disorders including emergency psychiatric care and community-based outpatient and residential services.

DBH serves eligible adults, children and youth and their families through a network of community based providers and unique government delivered services. It operates Saint Elizabeths Hospital—the District’s inpatient psychiatric facility.

Hospital -Based Peers Support Services

The Government of the District of Columbia, Department of Behavioral Health, Adult Services Administration is soliciting applications from qualified organizations to implement the Hospital-Based Peer Support Services program under the District of Columbia Opioid Response (DCOR) grant. The DCOR grant, guided by LIVE.LONG.DC.(LLDC), is focused on increasing access to medications for opioid use disorder (MOUD) treatment, reducing unmet treatment needs, and reducing opioid overdose-related deaths in the District of Columbia through the provision of prevention, harm reduction, treatment, and recovery support services (RSS) to individuals with stimulant use disorder (STUD) and opioid use disorder (OUD).

Target Population

The target population is individuals who have OUD and/or STUD that receive care in a participating hospital within the District of Columbia. Individuals may be in the hospital ED or an inpatient unit for OUD/STUD-related reasons (e.g., overdose or injection-related infection) or for any other reason. 

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Rosendin Foundation Annual Grant provides financial support to community-focused 501(c)(3) non-profit organizations across various states, aiding initiatives in emotional, occupational, and nutritional health. Grants can reach up to $50,000 and are geared towards organizations that positively impact their communities. However, the foundation does not fund discriminatory practices, political efforts, or religiously affiliated projects, ensuring that support is directed towards inclusive and impactful community services.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

FY26 McKinney-Vento Homeless Assistance

The Office of the State Superintendent of Education (OSSE) will issue a Request for Applications for the fiscal year 2027 (FY27) McKinney-Vento Homeless Assistance Grant Program (MKV) for eligible Local Educational Agencies (LEAs) in the District of Columbia. Authorized under Title VII-B of the McKinney-Vento Homeless Assistance Act, Section 726, as amended, the purpose of this grant is to facilitate the enrollment, attendance, and success in school of homeless children and youth.

Length of Award:

The grant award period will be from October 1, 2026, or the date of the award if awards are made after this date, through September 30, 2027. LEAs must commit to obligate all grant funds awarded under this competition (RFA# GD0-MKV-FY2027) by September 30, 2027. Awards may be continued for a maximum of one additional year. Continuation awards are based on availability of funds; recipient’s implementation and/or operation of the program as submitted in the application; recipient’s demonstration that substantial progress has been made toward meeting the objectives set forth in the approved application, based on ongoing monitoring and review of the recipient’s reports; compliance with District and federal laws, regulations, and guidance; and appropriate expenditure of funds throughout each grant award period. All awards will be reviewed annually for consideration of continued funding.

Available Funding for Award:

A total of at least Three Hundred Thousand Dollars and Zero Cents ($300,000.00) in grant funds are available for award. District of Columbia LEAs shall use the funds to address the educational and related needs of homeless children and youth in DC. LEAs, with or without this funding, must ensure that children and youth experiencing homelessness have equal access to the same free, appropriate public education, including public preschool education, as provided to other children and youth. OSSE anticipates awarding 3-6 subgrants based on the highest-ranking applications. Grant funds shall only be used to support activities authorized by relevant statutes and regulations and that are included in the applicant’s submission.

The Consolidated Justice Grants RFA, administered by the District of Columbia Office of Victim Services and Justice Grants (OVSJG), aims to enhance public safety and improve the justice system for crime victims and their families. This initiative provides vital funding to local programs addressing violent crime and criminal justice issues, ensuring compliance with federal and local regulations. By fostering a comprehensive network of support, OVSJG strives to create effective systems of care for the community.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

The WAVForce Incentives Project aims to enhance the availability of wheelchair accessible vehicles (WAVs) in Washington, D.C., by incentivizing drivers and fostering partnerships within the for-hire industry. This initiative, backed by the District of Columbia Department of For-Hire Vehicles, seeks to ensure 24/7 WAV service availability while promoting self-sustainability through strategic collaborations. By dedicating significant funding towards driver incentives, the project intends to improve operational capacity and service quality for the community.

The Department of Employment Services (DOES) connects District of Columbia (District) residents, job seekers, and employers to opportunities and resources that empower fair, safe, and effective working communities. DOES provides a range of programs and services to jobseekers, including job development, job search assistance, self-directed job search, vocational training, apprenticeship, unemployment insurance, transitional employment, and referrals to supportive services and educational programs.

DOES, Office of Workforce & Federal Programs Out-of-School Youth Program (OSY) provides occupational skills training, career awareness counseling, work readiness modules, basic education, GED preparation, supported internship experiences, vocational skills training, and pre-apprenticeship. Out-of-School programs serve young adults ages 16 - 24 who are no longer attending secondary or post-secondary school. It is a training vehicle that assists youth in achieving short and long term educational and employability goals through relevant occupational skills training and guidance.

OSY Pre-Apprenticeship Grant

Purpose

The goal of OSY Pre-Apprenticeship grant is to equip out-of-school youth ages 16 – 24 in Washington, DC with pathways to high-demand careers through traditional and nontraditional industry-aligned training, stackable credentials, and unsubsidized job placement. This structured program, up to 16-weeks in length, provides participants who are actively seeking unsubsidized employment with the opportunities to build career readiness, strengthen both technical & workplace skills, as well as gain exposure to the workforce. Program providers are responsible for delivering comprehensive career readiness training, recruiting and maintaining partnerships with pre-apprenticeship employer host sites, and facilitating participant placement and matching appropriate work experiences in the following industries. The goal is to prepare participants for entry into a registered Apprenticeship program or direct placement into unsubsidized employment within the pre-apprenticeship scope, while maintaining and creating sustainable pathways to longterm career success.

Washington State Department of Commerce

The Washington State Department of Commerce’s mission is to strengthen communities in Washington. We are the lead state agency charged with enhancing and promoting sustainable community and economic vitality in Washington. We administer a diverse portfolio of more than 100 programs and several state boards and commissions, all focused on helping communities achieve positive growth.

Early Learning Facilities (ELF) Public School District & Tribal Compact Schools Program

Program Purpose

The Early Learning Facilities (ELF) program supports Washington’s commitment of developing additional high quality early learning opportunities for children from low-income households. The Early Learning Facilities (ELF) Program goal is to expand Early Childhood Education and Assistance Program (ECEAP) and Working Connections Child Care (WCCC) availability for children from income-qualified.

This competitive grant process is to assist public school district and tribal compact school child care providers to remodel, purchase, or construct early learning facilities and classrooms to create more early learning opportunities for children from income-qualified households. 

This funding round is specifically for the following:

• Public School Districts
• Tribal Compact Schools

All entities identified in RCW 43.31.575 including Private Schools and Schools not affiliated with a Public School District, are invited to apply for the Eligible Organizations competitive grant funding round.

The Emeril Lagasse Foundation offers Community Grants aimed at supporting 501c3 non-profit organizations that focus on culinary, nutrition, and arts education, with an emphasis on life skills development. Grants are available to organizations in communities where the foundation operates, including Greater New Orleans, Austin, and Southern California. Eligible applicants must demonstrate a commitment to inclusivity and align with the foundation's vision of empowering youth to reach their full potential.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

National Federation of the Blind Scholarships

All other scholarships proudly carry the name National Federation of the Blind. Our members acknowledge academic excellence and leadership in making these awards.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Kurzweil Foundation and Ray Kurzweil

The Kurzweil Foundation and Ray Kurzweil contribute to each recipient’s award, and provide each finalist with a commemorative plaque in both print and Braille. Ray Kurzweil is a long-time friend of the Federation and deserves our special recognition.

Equitable Food Access Initiative: Produce Incentives

The total funding amount of $2,100,000 is anticipated for one (1) award for the first budget period. 

The mission of DC Health is to promote and protect the health, safety, and quality of life of residents, visitors, and those doing business in the District of Columbia. The agency is responsible for identifying health risks; educating the public; preventing and controlling diseases, injuries, and exposure to environmental hazards; promoting effective community collaborations; and optimizing equitable access to community resources.

The Community Health Administration (CHA) within DC Health works to prevent the leading causes of death, protect and promote the health of mothers and children, and eliminate racial and ethnic health disparities. CHA’s approach targets multiple factors that influence health through evidence-based programs, policies, and systems change.

The purpose of this funding is to attract qualified applicants to implement evidence-based or evidence-informed strategies to increase food access and improve food environments for District residents with lower incomes through farmers’ market produce incentives.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Jesse and Hertha Adams Charitable Trust Scholarship

The Jesse and Hertha Adams Trust Scholarship is made available for those individuals who wish to achieve their dreams. Success is acknowledged through hard work and the effort you put forth. And the Jesse and Hertha Adams Scholarship acknowledges both. In addition to funding this named scholarship, the trust generously contributes to our program travel expenditures for our winners and many of our National Federation of the Blind other scholarships.