Best Large Grants for Nonprofit Organizations in District of Columbia

Fuel Up

We’re Fuel Up – an initiative created by America’s Dairy Farmers to help meet the needs of schools across the country when it comes to fueling healthy bodies and healthy minds.

Fuel Up is all about educators, students and partners working together to make a difference in their schools and their communities.

Fuel Up is an initiative focused on helping educators and students fuel wellness in the areas that matter most, like being mindful and staying healthy. Our educational resources, partnerships and grant/funding opportunities aim to broaden access to good nutrition and overall wellness.

School Nutrition Equipment Grants

Nutrition equipment grants are now available through GENYOUth's End Student Hunger initiative, with applications now open in the new School Wellness Portal.

K-12 schools can apply for an equipment grant to help increase students' access to, and participation in, nutritious school meals.

Overview of Fuel Up Equipment Grant

• One of two nutrition equipment kits—each valued at $2,000—is available to qualified K-12 schools to improve access to nutritious foods.

• Your application must demonstrate how the funding will increase your students’ access to and their consumption of dairy products (milk, yogurt, cheese). Your local Dairy Council can help you with ideas for how to increase dairy.

• Applications will be evaluated based on a variety of factors, including school enrollment, student reach, in-school support, school location, and the sustainability of the proposed program. Consideration will be given to schools in underserved communities whose students are most at risk for poor nutrition and childhood obesity.

• You are encouraged to contact your local Dairy Council with questions about the application process. They can be especially helpful in suggesting ways to increase dairy consumption at your school.

Schools can visit the GENYOUth School Wellness Portal to review eligibility requirements, explore equipment options, and begin an application.  

The Community Foundation of Central Wisconsin awards nearly $300,000 in annual scholarships to support Central Wisconsin students’ educational needs. 

The Community Foundation proudly supports students in Portage and Waushara counties with over $325,000 in scholarships annually, thanks to the generosity of local individuals and families. Award amounts range from $500 to $40,000, opening doors to educational opportunities.

The Community Foundation provides scholarships for a wide range of students, including high school seniors, college students, non-traditional learners, and those pursuing specific fields of study.

Ann G. Haley Scholarship

Criteria for Selection:

• Pursuing a degree in the medical field.

The Drs. James and Wanda Trefil Science Scholarship, offered by the Kosciuszko Foundation, supports undergraduate students majoring in natural sciences such as physics, biology, and chemistry. This competitive scholarship awards $5,000 and is available to U.S. citizens of Polish descent who maintain a GPA of 3.5 or higher. Applicants must be full-time students and can only receive the scholarship once, with a deadline for letters of recommendation set for March 3, 2026.

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

McLaughlin, Delbert & Mary Teaching Scholarship

This fund was established in memory of Delbert and Mary McLaughlin by their son, Bill McLaughlin to provide academic scholarships to graduating seniors of the St. Joseph School District pursing a degree in Education.

The ESA Youth Scholarship Program, by the Electronic Security Association, provides financial support to children of first responders, having awarded over $941,500 to date. Eligible applicants are high school seniors with parents who are full-time active first responders. Each scholarship winner receives $1,000 and a chance to compete for larger awards of $14,000 for first place and $5,000 for second place. Applications are welcomed from students in participating states.

The Clinical Investigator Career Development Award offered by the Lymphoma Research Foundation aims to support early-career physician researchers in developing new lymphoma therapies. With a total funding of $375,000 over three years, the program provides salary support and incidental funds for research supplies and professional development. Eligible candidates must have no more than six years of experience post-training, focusing on clinical research design and implementation to enhance their skills and career trajectory.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.

Community Foundation for Mason County, MI

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Scholarships

If you’re a high school or homeschooled senior, current college student, early college senior, or a student pursuing a master’s or doctoral degree, the Community Foundation for Mason County may have a scholarship for you.

Marlene Schoenberger Scholarship

This scholarship has been made possible by the generosity of Tamar Schoenberg, who established the Marlene Schoenberger Scholarship Fund of the Community Foundation for Mason County in memory of her mother, Marlene. This scholarship is presented to Mason County students pursuing Fine Arts and Performing Arts.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Biochemical and Molecular Characterization of Marstacimab and TFPI Pathways 

This competitive grant encompasses research aimed at elucidating molecular and cellular mechanisms underlying marstacimab-TFPI interactions, including but not limited to differential expression of tissue factor and TFPI in various tissues, binding kinetics, and other biochemical properties. Projects should seek to advance foundational understanding of these interactions through innovative approaches in biochemistry, molecular biology, and related disciplines.

Project Types and Area of Interest

Projects that will be considered for Pfizer support will focus on basic science and fundamental biological understanding of Tissue Factor Pathway Inhibitor (TFPI), anti-TFPI Monoclonal Antibodies, and marstacimab. The areas of interest may include (but are not limited to):

• Basic biology of TFPI including interactions among key regulatory proteins in the intrinsic and/or extrinsic clotting cascades (e.g. Protein S being a co-factor for both Protein C and TFPI).
• Impact of differential TFPI expression within tissues and the role of various TFPI pools/isoforms in the regulation of coagulation.
• Pharmacology resulting from concomitant therapies added to anti-TFPI

The Hillman Emergent Innovation Grant offers $50,000 for 12-18 months to support innovative nursing-driven interventions for underserved populations facing health care access barriers, including racial minorities and low-income individuals. It encourages fresh, early-stage ideas targeting serious illness and end-of-life care challenges. By fostering community engagement and interdisciplinary collaboration, the program aims to transform care delivery in diverse settings, ensuring equitable health services for all.

Delaware Art & Design Scholarship

Awards:

• One time award of $20,000. Students may reapply each year.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

• Identification treatment responsive biomarkers
• Assess clinical measures and improve that enhance clinical trial readiness
• Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

The Eleanor B. and Henry H. Stroud, M.D. Memorial Scholarship, offered by the Delaware Community Foundation, provides a one-time award of $5,000 to Delaware residents pursuing medical degrees. This scholarship emphasizes excellence, ethics, and compassion in medicine, along with financial need and academic promise. Eligible applicants can reapply for up to four annual awards, with special consideration for those demonstrating innovation in medicine. The DCF awarded a record $850,000 in scholarships to 245 students for the 2024-2025 academic year.

The Cloutier-Valenti Legacy Scholarship, funded by the Delaware Community Foundation, offers a one-time award of $1,000 to graduating seniors from selected high schools in Delaware. Eligible students must enroll in an accredited institution, demonstrate financial need, and show involvement in community activities. The scholarship aims to support students pursuing degrees in science, contributing to the foundation's mission of enhancing educational opportunities and equity in the community.

The Lucille M. Tiro Scholarship, offered by the Delaware Community Foundation, provides a one-time award of $1,000 to a graduating female senior from the Indian River School District. Applicants must demonstrate high academic achievement and financial need, with preference given to those pursuing degrees in the Arts. This scholarship is part of a broader initiative by DCF, which awarded a record $850,000 to 245 students for the 2024-2025 school year, fostering educational opportunities in Delaware.

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Webster Cornwell Scholarship

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

The Pediatric Cancer Research Foundation (PCRF) is dedicated to funding innovative research aimed at curing childhood cancer. With a focus on collaborative efforts, PCRF has contributed over $51 million since 1982, significantly improving survival rates for childhood cancers. The Translational Research Grant supports cutting-edge clinical trials and therapeutic approaches, enhancing the journey from laboratory discoveries to patient care. This initiative underscores the urgent need for effective treatments, offering hope for children diagnosed with cancer and their families.

Accreditation Sustainability Learning Community RFA

The Association of State and Territorial Health Officials (ASTHO), through the Public Health Infrastructure Grant (PHIG), is currently accepting applications for participation in a learning lab that will foster health department capacity to build a sustainable public health accreditation culture within their agencies. This opportunity is open to applicants from direct PHIG awardees at the state-, big city-, and county-level.

The John Lennon Endowed Scholarship, established by Yoko Ono to honor John Lennon, supports students attending UNCF member institutions. This initiative addresses financial need and promotes education among African American youth. With over $65 million awarded annually, UNCF empowers thousands of students, advocating for minority education and community engagement. Eligible applicants must have a minimum GPA of 3.0, complete a FAFSA, and demonstrate unmet financial need. This scholarship plays a crucial role in fostering future leaders.

Building Capacity for Communicating Impact Learning Community RFA

Learn how to communicate about Public Health Infrastructure Grant impact through a new community of practice! Through peer learning, technical assistance, and practical tools, participating teams will build strategic leadership and communications skills to more effectively translate public health achievements into compelling messages for key audiences. All directly funded PHIG recipients (big-city, county, state/territory-level governmental public health professionals) are eligible to apply.

The Pediatric Cancer Research Foundation (PCRF) offers the Emerging Investigator Fellowship Grant to support post-doctoral fellowships and clinical investigator training for promising pediatric cancer researchers. This grant aims to accelerate advancements in childhood cancer treatment by funding innovative research ideas. Applicants must have completed a minimum of two years in their fellowship or be within two years of their junior faculty role. This initiative fosters the next generation of researchers dedicated to combating childhood cancer.

The Pediatric Cancer Research Foundation (PCRF) offers Donor Designated Grant Programs aimed at funding innovative projects addressing childhood cancer. These grants support researchers dedicated to finding cures, enhancing treatment, and improving care. With an annual commitment to extraordinary researchers, PCRF ensures funds are directed towards promising advances in prevention and treatment. Since 1982, PCRF has raised over $51 million, significantly impacting survival rates and striving to eliminate childhood cancer through collaborative efforts and cutting-edge research.

Ignite Your Innovation & Entrepreneurship Ecosystem

Lead the future of innovation at your higher education institution with the Ecosystem Futures Fellowship. This fellowship is an evolution of our Course & Program Grants that focuses on scalable science, technology, engineering, and math (STEM) innovation and entrepreneurship (I&E) ecosystem solutions through the lens of environmental and social sustainability and inclusive innovation. This program offers professional development, immersive learning experiences, and a supportive community of leaders. It enhances the role of faculty and higher education leaders as ecosystem builders in partnership with industry and government.

VentureWell Ecosystem Futures Fellowship

The Ecosystem Futures Fellowship is a one-year program that aims to strengthen campus innovation and entrepreneurship. This fellowship enhances both in-class and out-of-class student engagement and institutional culture by growing ecosystem networks. Teams of two will receive $30,000 in funding—a $10,000 award and $5,000 in travel stipends for each fellow—and 12 months of immersive programming and communities of practice.

The Ecosystem Futures Fellowship is a one-year experience that supports higher education leaders in advancing science, technology, engineering, and math (STEM) innovation and entrepreneurship (I&E) ecosystem growth centered on environmental and social sustainability and inclusive innovation.

What types of projects are eligible?

Projects should focus on STEM I&E ecosystem expansion, addressing significant social, health, or environmental challenges. Your STEM I&E ecosystem growth goals might align well with the fellowship if they are similar to one of the following:

• Building out a degree pathway that incorporates I&E into STEM disciplines
• Creating or revising courses that focus on STEM I&E through a social and environmental sustainability lens—these should be courses that make connections to I&E beyond the course in order to provide more robust I&E opportunities to a diverse population of students (community-engaged learning, internships, industry partnerships, etc.)
• Connecting existing courses to campus and off-campus extracurricular and co-curricular activities
• Designing new extracurricular and co-curricular I&E activities that connect to community partners
• Working with government, industry, or other community collaborators to expand STEM I&E activities on and off campus for students and other campus collaborators
• Working with administration on campus to change policies or systems that hinder STEM I&E activities on campus (promotion and tenure requirements, tech transfer opportunities, IP policies, etc.)
• Breaking down silos on campus in order to grow connections between disciplines and learning opportunities beyond the classroom
• Strengthening research translation and innovation development opportunities that work to solve the world’s most difficult problems

What support is provided besides funding?

• Mentorship from experienced industry experts.
• Access to a resource library and a collaborative network of STEM educators and students.
• Participation in on-campus immersive experiences, communities of practice, and VentureWell’s annual conferences.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Bill Rabbit Legacy Art Scholarship

Applicant must be enrolled in an accredited, four-year, higher education institution pursuing a degree in fine arts or art education with a minimum 3.0 GPA. Accepted focuses include drawing, painting, sculpture, pottery, traditional beadwork and textiles. Three pictures of artwork must be included with application for consideration. This is a one-year scholarship reserved for Cherokee Nation and United Keetoowah Band citizens residing within the Cherokee Nation jurisdictional area.

Arizona Community Foundation

For more than four decades, the Arizona Community Foundation has worked in tandem with generous individuals, families, and organizations to address some of the biggest challenges facing our state.

Scholarships

In partnership with our generous donors, we award millions of dollars annually to help students achieve their educational goals. Through our online system, students complete one application and are matched with available scholarships, based on their eligibility requirements.

Guinn B. Burton Medical Scholarship

Guinn B. Burton established this scholarship fund in her estate trust to provide medical scholarships for disadvantaged students. 

The Irv and Irene Boersen Scholarship supports students from the Regional Synod of the Great Lakes pursuing a Master of Divinity at Western Theological Seminary. Applicants must demonstrate financial need, maintain a GPA of 3.0 or higher, and submit a FAFSA summary page. This renewable scholarship aims to cultivate future pastors and is awarded based on recommendations. It promotes educational access and community involvement, fostering a thriving environment in the Holland/Zeeland area.

Bridging the Gap Scholarship 

This scholarship was established to honor the memory of Trey Powell and Bridget Horn, who were both Veterans that lost their battle with PTSD to suicide. The Stronger Together Foundation strives to bring awareness to the large number of Veterans who face crises and ultimately commit suicide, as well as provide support to the families left behind. 

Scholarship Total Amount: $2,000.00

• (Two) $1,000.00 Scholarships will be awarded