Best Large Grants for Nonprofit Organizations in District of Columbia

The Public Art Building Communities (PABC) grant program, offered by the DC Commission on the Arts & Humanities, aims to support artists and organizations in creating new public art installations. Projects must be accessible to the public and can be either temporary or permanent, with specific guidelines regarding maintenance and sustainability. Applicants must engage with the local Advisory Neighborhood Commission to secure support and promote community involvement in the project's design and execution.

The TYLENOL Future Care Scholarship supports students pursuing healthcare careers, continuing a 30-year tradition of helping those dedicated to caring for others. Eligible applicants must be U.S. residents, graduate students or seniors enrolling in graduate school for the 2024-25 academic year, and provide proof of enrollment in an accredited healthcare program. Scholarships cover tuition, fees, and necessary supplies, ensuring that future healthcare professionals receive the support they need.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Special Presenter Initiatives Grants, offered by the Mid Atlantic Arts Foundation in partnership with various local arts organizations, aim to support the presentation of professional performing artists at small and mid-size community venues. This initiative encourages projects that feature touring artists and includes community engagement activities, fostering meaningful interactions between artists and local audiences. The program seeks to enhance the cultural landscape of the participating jurisdictions through diverse and innovative performances.

L3Harris Technologies collaborates with Project Lead The Way (PLTW) to ignite interest in STEM among PreK-12 students. This initiative provides grants for schools to implement PLTW Gateway programs starting in the 2025-2026 academic year. Eligible public and charter schools in specific counties will receive a total of $20,000 over two years to support the development of innovative educational programs. This partnership aims to empower future generations and foster skills essential for the aerospace and defense industries.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The DC Mayor’s Scholars Undergraduate Program provides need-based funding for District of Columbia residents pursuing their first associate or bachelor’s degree at select colleges. As a last-dollar award, it helps cover tuition gaps after other financial aid. Eligible applicants must have been DC residents for at least a year, maintain satisfactory academic progress, and have household incomes below 300% of the federal poverty guidelines. Funding caps are $4,000 annually, with limits on total awards.

Program Purpose

The purpose of Locally Appropriated Funds is to meet the needs of crime victims, to engage the community regarding the social problems related to crime, and to prevent crime. These services support victims through their recovery process, as well as assist them with all stages of the criminal justice process. Victim assistance includes services such as, but not limited to, crisis intervention, case management, counseling, emergency and transitional housing, criminal justice support, and advocacy. Prevention and outreach activities may include such programs as community engagement activities, media campaigns, use of technology, focus groups, or culturally and linguistically appropriate training and engagement.

The National Institute on Drug Abuse is funding pilot and feasibility studies aimed at preparing for substance use and HIV prevention research trials. The program encourages innovative interventions for substance use disorders and HIV eradication, focusing on stakeholder collaboration and practical application. Projects may include assessment of service models, intervention development, and community engagement. This initiative is designed to fill critical research gaps and enhance partnerships, although applications are not currently being accepted.

The Folger Institute Long-term Fellowship offers a $70,000 stipend for one academic year to support scholars conducting research on early modern humanities using the Folger's extensive collections. Open to international scholars, applicants must hold a Ph.D. and may propose flexible research schedules, including virtual months. This fellowship encourages projects that enhance understanding of Shakespeare and the cultural history of the early modern world, promoting inclusive histories and addressing inequities.

District Department of Transportation

The District Department of Transportation (DDOT) was established by The District Department of Transportation Establishment Act of 2002 as a cabinet-level agency responsible for the management of transportation infrastructure and operations (D.C. Law 14-137 [2002]).

Every day, over 1,000 members of the DDOT team work tirelessly to ensure that the District’s roads are safe, reliable , and easy to navigate for the millions of residents, commuters, and visitors who use the transportation network each year.

Mission: The District Department of Transportation’s mission is to equitably deliver a safe, sustainable and reliable multimodal transportation network for all residents and visitors of the District of Columbia. 

National Electric Vehicle Infrastructure (NEVI) Program Funding Round #1

The District Department of Transportation (DDOT) invites organizations, businesses, and District of Columbia property owners to apply for a competitive grant to design, install, operate, and maintain federally compliant Direct Current (DC) fast charging stations. Under the National Electric Vehicle Infrastructure (NEVI) Formula Program, DDOT is receiving $16.7 million over five (5) years to invest in electric vehicle (EV) charging infrastructure throughout the District of Columbia (District) in accordance with the program’s guidance, specifications, and requirements. These first round of stations must be withing one (1) travel-mile of federally designated Alternative Fuel Corridors (AFCs) for the District to achieve fully built out status. The District currently has six (6) AFCs. 

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Jean Dreyfus Lectureship for Undergraduate Institutions Grant provides a $25,000 award to facilitate a visit by a notable researcher in the chemical sciences to undergraduate institutions. It includes funding for summer research fellowships for two students and requires the researcher to deliver accessible lectures to the public. This initiative honors Jean Dreyfus's legacy and supports the engagement of undergraduates in scientific research and discourse.

The Day-End Dough-Nation® Program by Panera Bread exemplifies community generosity through the donation of unsold bakery products to local charities. This impactful initiative supports various organizations that distribute food to those in need, including shelters, health centers, and youth programs. By partnering with thousands of non-profits nationwide, Panera Bread not only reduces food waste but also plays a crucial role in addressing hunger and promoting equality within communities.

The Housing for Everyone Grant Competition, part of the 2026 Initiative, aims to support eviction prevention in low-to moderate-income communities. This 20th annual initiative recognizes the destabilizing impact of eviction and displacement on families, which leads to job loss, school disruptions, and health issues. By funding innovative organizations, the competition seeks to provide stability for renters, enabling them to stay in their homes and communities.

The DC Oral History - Beyond the Archive Grants provide funding for community organizations and individuals to create public humanities projects utilizing existing oral history collections. These projects should focus on themes relevant to Washington, DC, and benefit its residents. Possible outcomes include exhibitions, performances, written research, and educational curricula, all aimed at showcasing the unique stories of the city’s diverse communities.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

The Rock Spring Congregational United Church of Christ SAM Grant supports organizations that align with its mission as a Just Peace and Open and Affirming Congregation. Grants, ranging from $500 to $5,000, are available for general operating support or special projects. Eligible organizations are those that meet basic human needs and can engage Rock Spring volunteers, primarily in the Metropolitan Washington, D.C. area, and those in alignment with the values of the United Church of Christ.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

Detroit HBCU Scholarship Endowment

This generous Detroit HBCU Scholarship provides need-based awards to support students who are in one of the eligible zip codes of Detroit.

The purpose of the Detroit HBCU Scholarship Endowment Fund is to provide 1 (one) annual, renewable, and need-based scholarships up to $5,000 (five-thousand dollars) to students graduating from a high school with a Detroit address or students transferring from a metro-Detroit community college to attend a partner HBCU.

The William C. Seitz Senior Fellowships at the National Gallery of Art support research on modern and contemporary art. Designed for scholars with a PhD or equivalent professional experience, these fellowships provide a stipend of $50,000, office space, and access to the Gallery's extensive resources. Eligible candidates can reapply after five years, and all must demonstrate proficiency in two languages besides English. This prestigious program fosters a vibrant community of art scholars.

The Veterans Assistance & Service Dog Funding Program, established by the Cornelia T. Bailey Foundation, aims to support 501(c)(3) nonprofit organizations serving veterans. This initiative enhances services like healthcare, housing, and employment support, while also facilitating the provision of service dogs for veterans facing disabilities. Applications for 2025 are closed, but interested organizations can check back in January 2026. Grants will empower nonprofits to better assist veterans in their transition to civilian life.

The Helen Wardman Naselli Memorial Fund Grant, established in 1990, supports organizations dedicated to aiding elderly individuals in need. The foundation prioritizes funding for charities in the Washington, DC area that provide care and relief for the aged. Eligible organizations must be tax-exempt under the Internal Revenue Code. However, larger charitable organizations reliant on public appeals and grants for individuals or capital projects are ineligible for funding.

L3Harris Technologies is collaborating with Project Lead The Way (PLTW) to expand STEM education for PreK-12 students. This initiative aims to inspire young learners through enhanced PLTW programs starting in the 2025-2026 academic year. Eligible schools, including public and charter institutions in specified counties, can receive grants of $5,000 to support program expansion. The focus is on providing resources for new modules, teacher training, and ensuring access for diverse and economically challenged communities.

The American Agri-Women Gail McPherson Fly-In Scholarship honors a founding member of AAW, supporting members to attend the annual Fly-In in Washington, DC. This scholarship is open to any AAW member, while applicants who have attended a previous Fly-In are ineligible. The initiative promotes leadership and engagement among agricultural women, fostering a community dedicated to advocacy and education.