Best Private Grants for Nonprofits in Guam

The Advancing Equity Through Oral Health Funds, initiated by CareQuest Institute, seeks to transform oral health systems by supporting projects that dismantle disparities faced by marginalized communities. The program encourages organizations to propose innovative solutions that enhance access to dental care, engage community voices, and promote policies that ensure equitable health outcomes for all. This initiative aims to create a more integrated and accessible healthcare system, particularly for historically underserved populations.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites applications for early phase clinical trials focused on natural products. This funding opportunity supports research into botanicals and dietary supplements that show promise based on preliminary evidence. Successful trials can receive up to six years of funding to enhance understanding of pharmacokinetics and clinical impacts. Applications must aim to optimize product delivery and explore innovative combinations with other treatment approaches.

The NCCIH Natural Product Early Phase Clinical Trial Award (R33) invites applications for early phase clinical trials of natural products like botanicals and dietary supplements. This funding aims to support studies that assess the impact of these products on target engagement and clinical outcomes. The NOFO encourages innovative designs that optimize delivery methods and investigate combinations with existing treatments. With a maximum support period of three years, the initiative seeks to translate basic science findings into practical clinical applications.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

This grant opportunity invites applications to explore the impact of Artificial Intelligence (AI) on healthcare safety. It aims to assess how innovative AI technologies can enhance patient safety and determine best practices for their safe implementation. By balancing the benefits of AI with potential risks, this initiative seeks to ensure improved healthcare delivery while safeguarding patients from harm. Applications are due by 5:00 PM local time of the applicant organization.

The NIDCD Research Fellowship for Audiologists provides clinical audiologists enrolled in Ph.D. programs with essential research training. This initiative encourages the integration of clinical and translational research, fostering strong research foundations vital for advancing audiology and hearing healthcare. Although applications are not currently being solicited, the program aims to prepare potential candidates for meaningful collaborations and impactful research projects in the biomedical, behavioral, or clinical sciences.

The Howard Fellowships, administered by the George A. and Eliza Gardner Howard Foundation, support early mid-career artists and scholars with $40,000 awards for independent projects in selected fields. This unrestricted, non-residency fellowship encourages significant creative development and public visibility through exhibitions or publications. Applicants should demonstrate a promising program of work and must currently reside in the U.S. or its territories. Ten fellowships are awarded annually, promoting artistic and intellectual advancement.

The NIJ FY 2026 Research on Gender Dysphoria and Violent Crime funding opportunity aims to support crucial research exploring the connections between gender dysphoria and violent behavior. This initiative seeks to fill gaps in empirical evidence, focusing on aspects such as prevalence rates of violent crime, post-conviction analyses, and the impact of comorbidities on violence. Researchers are encouraged to conduct retrospective data analyses to better understand these complex relationships and inform future treatment and intervention strategies.

The FY26 Reconstructive Transplant Research Program Concept Award encourages innovative research addressing critical issues in reconstructive transplantation. It supports groundbreaking concepts and untested theories, emphasizing creativity and relevance to specific focus areas. Notably, preliminary data presentation is prohibited, yet applications must demonstrate potential for interpretable results. Early-career investigators are particularly encouraged to apply, fostering new talent in this vital research field.

The NIA Expanding Research in AD/ADRD Summer Research Education Program supports the recruitment of early-stage investigators and aims to provide hands-on research experiences in Alzheimer's Disease and related dementias. Targeting high school students, undergraduates, and science teachers, the program enhances STEM education through authentic research opportunities and educational activities. By fostering early exposure to research, it aims to stimulate interest in AD/ADRD careers and address workforce shortages in this critical field.

The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.

The Rural Communities Opioid Response Program (RCORP) - Community Systems Development aims to enhance behavioral health systems in rural areas by providing funding for the development and expansion of services. This initiative supports the establishment of formalized networks to boost operational and clinical capacity, ensuring effective implementation of evidence-based substance use disorder prevention, treatment, and recovery services tailored to community needs.

The National Institute of Environmental Health Sciences (NIEHS) is launching a funding opportunity for research hubs focused on the health impacts of extreme weather. This initiative encourages multidisciplinary teams to engage with community partners on issues such as wildfire smoke and extreme heat. Emphasizing collaboration, the program aims to develop scalable solutions and measurable public health outcomes, leveraging resources and expertise across institutions to address climate-related health challenges effectively.

The Impact Aid Discretionary Construction Grant Program (84.041C) offers $19M in funding to Local Educational Agencies (LEAs) to address urgent school facility needs. This initiative supports repairs, renovations, or replacements required to maintain safe educational environments. Grants cover projects that improve accessibility in compliance with the Americans with Disabilities Act (ADA) and ensure that facilities meet health standards. The program aims to enhance learning conditions by responding effectively to emergency situations.

The Northeast Sea Grant Consortium and NOAA’s Northeast Fisheries Science Center invite proposals to explore the interactions between fishing communities and offshore wind development in the U.S. Northeast. This initiative aims to enhance understanding of community resilience and economies, while fostering collaborative research that informs decision-making. Proposals should utilize qualitative and quantitative methods and involve at least one Co-PI from the six states of the NESGC, with a requirement for a 25% non-federal match.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership (ESSSP) aims to enhance NOAA's mission through collaborative research and activities. It focuses on understanding changes in Earth's systems and their impacts on ecosystems and communities. Eligible applicants include academic institutions offering doctoral degrees in NOAA-related sciences. The total funding available is approximately $10 million, supporting initiatives that encompass research, data evaluations, and stakeholder engagement.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Health Workforce Research Center (HWRC) aims to enhance understanding of health workforce needs across various levels of governance. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative supports vital research that informs decision-makers, ensuring effective resource allocation and workforce planning to meet healthcare demands.

The 2025 Vilcek Foundation Grants aim to support nonprofit organizations that celebrate immigrant contributions to the arts and sciences. The foundation invites applications from organizations operating under U.S. IRS Section 501(c)(3) that promote diversity and inclusivity. Grants will be prioritized for new partners and those in states without prior funding. This initiative underscores the foundation's commitment to fostering appreciation for immigrant communities and their impact on society.

The Focused Technology Research and Development (R01) grant supports innovative projects aimed at developing technologies to enhance biomedical research. This funding opportunity emphasizes the creation of laboratory instruments, algorithms, and biological systems that can significantly improve research capabilities. Key deadlines for applications are set for February, June, and October of 2025 through 2027, ensuring ample time for proposal submissions. The initiative is funded by the National Institutes of Health (NIH), part of the US Department of Health and Human Services.

The National Cancer Institute (NCI) plans to issue a Notice of Funding Opportunity (NOFO) for the Paul Calabresi Career Development Award in Clinical Oncology (K12). This program aims to enhance training for clinician-scientists in cancer research, fostering their career development and collaboration with basic research scientists. It mandates diverse oncology specialties in faculty, individualized career development plans, and mentorship, supporting Scholars for up to three years to promote their research initiatives in clinical trials.

The BJA FY 2026 Rural Violent Crime Reduction Initiative aims to empower local law enforcement in rural areas to combat violent crime effectively. This funding opportunity provides resources for personnel, technology, and data analytics to enhance crime prevention strategies. Eligible applicants can utilize updated equipment and training to address specific violent crime challenges, ensuring safer communities through innovative approaches and strategic resource allocation. Applications are due by November 6, 2026.

The OJJDP FY 2026 Internet Crimes Against Children On-Line Child Protection System (ICACCOPS) funding opportunity aims to enhance and maintain critical investigative tools for child exploitation cases. ICACCOPS provides a robust IT infrastructure to support data services, network security, and management tools for law enforcement. This initiative strengthens the efforts of the national network of ICAC Task Forces, which are dedicated to combating technology-facilitated child sexual exploitation across the United States.

The National Institutes of Health (NIH) is seeking to enhance the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) through the establishment of a Clinical Coordinating Center (CCC) and Data Coordinating Center (DCC). This initiative aims to improve emergency care outcomes by supporting trials that focus on effective treatments for non-stroke neurological and cardiovascular emergencies. Although applications are not currently being solicited, this notice allows potential applicants to prepare collaborative proposals.

The Paul Calabresi Career Development Award for Clinical Oncology aims to enhance the training of clinician-scientists in clinical and translational cancer research. This funding opportunity encourages the career growth of researchers but does not permit Scholars to lead independent clinical trials. Instead, it allows participation in clinical trials under the mentorship of an experienced researcher, fostering a collaborative approach to cancer research.

The National Endowment for the Arts (NEA) offers Partnership Agreement Grants for FY 2027 to support state and regional arts agencies. These grants enhance community access to the arts and leverage federal funding to attract additional state resources. By enabling agencies to create state arts plans, the NEA fosters a collaborative approach that strengthens the arts landscape across the nation, ensuring that local needs and priorities are addressed effectively.