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The National Cancer Institute invites applications for the validation of biomarkers and assays for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation of assays, emphasizing the importance of human samples. The program encourages multi-disciplinary collaboration and aims to enhance the performance and reproducibility of cancer assays across clinical laboratories. Applications are due by 5:00 PM local time during the designated deadlines each year.

The Affordable Housing and Supportive Services Demonstration (AHSSD) aims to enhance housing stability and well-being for American citizens residing in affordable housing. By funding Community Action Agencies and tribes, the initiative fosters public welfare engagement and service enrollment. The program addresses diverse needs, offering referrals, case management, and direct services in education, childcare, mental health, and more, ultimately supporting economic mobility and reducing dependency among vulnerable populations.

The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.

The HEAL Initiative aims to develop non-addictive therapeutics for pain management through small molecules and biologics. This funding opportunity supports preclinical optimization, facilitating the transition of promising candidates to clinical trials. Important proposal deadlines span from January 2024 to January 2027, with optional Letters of Intent encouraged 30 days prior. The program emphasizes collaboration with NIH staff to ensure thorough project planning and monitoring, aiming to revolutionize pain treatment while ensuring safety and efficacy.

The National Fish and Wildlife Foundation (NFWF) invites proposals for the Bats for the Future Fund RFP to combat white-nose syndrome (WNS) affecting bat populations in North America. This initiative seeks to advance treatments, implement management strategies, and support research that enhances bat survival and recovery. A match of 50% of the grant amount is preferred, aimed at fostering innovative conservation efforts and collaboration among stakeholders to ensure the future of affected bat species.

The Blueprint Neurotherapeutics Network (BPN) invites small businesses to apply for funding to advance small molecule drug discovery and development projects for nervous system disorders. This program supports research through disease-specific assays and partnerships with NIH-funded consultants. Key deadlines for application submissions span from February 2024 to August 2026. BPN ensures institutions retain IP rights for developed drug candidates, facilitating control over patent negotiations.

The Fiscal Year 2026 National Incident Management System (NIMS) Cooperative Agreement aims to enhance the operational capabilities of the Emergency Management Assistance Compact (EMAC) for effective disaster response. It focuses on closing funding gaps, fostering collaboration among federal and non-federal partners, and improving resource coordination during emergencies. This initiative supports the DHS's goals of building national resilience and enhancing first responder training, ensuring swift and effective responses to various threats and disasters.

The National Estuarine Research Reserve System (NERRS) Land Acquisition and Construction Program for Fiscal Year 2026, funded by NOAA, aims to enhance research and education by supporting land acquisition and construction projects. With approximately $8.5 million available, the program prioritizes strategic expansions of Reserve boundaries and facility enhancements, ensuring sustainable design standards. Funding will support 5-20 projects over 12-36 months, with potential extensions for complex projects, contingent on available funds and negotiations.

The Recordings at Risk Grant, administered by CLIR, supports the preservation of rare audio and audiovisual media of scholarly value through digital reformatting. With funding from The Andrew W. Mellon Foundation, the program aims to award $6.75 million across twelve competitions, offering grants between $10,000 and $50,000. It encourages U.S. nonprofit institutions to preserve vulnerable media, helping them to develop strategies for effective digital reformatting and promoting best preservation practices.

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

The National Institute on Deafness and Other Communication Disorders (NIDCD) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) are seeking innovative research applications for non-invasive imaging technologies to study the human olfactory system. This initiative emphasizes the need for advanced multimodal imaging techniques to enhance diagnostic capabilities for olfactory disorders, addressing challenges posed by the system's unique anatomical features. Collaboration among experts is encouraged to foster impactful research developments.

The Kenneth Rainin Foundation seeks to promote innovative research in Inflammatory Bowel Disease (IBD) by encouraging diverse perspectives from early career investigators and those underrepresented in science. The Innovator Awards do not require preliminary data and are evaluated based on the potential for innovation and scientific merit. Eligible researchers must hold advanced degrees and can apply for funding through their home institutions, fostering groundbreaking ideas that can transform IBD treatment and prevention.

This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.

This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.

PetSmart Charities' Adoption Prep Grants aim to support organizations that facilitate the adoption of homeless pets through in-store programs. Eligible partners must demonstrate a commitment to increasing adoptions, with grants reaching up to $75,000 in the U.S. and $40,000 in Canada. The funding can be utilized for vaccinations, spay/neuter services, staffing, and volunteer support. This initiative focuses on building sustainable adoption programs that break down barriers to pet adoption.

The FY26 Community Policing Development program, administered by the U.S. Department of Justice's COPS Office, aims to enhance community policing through innovative strategies and resources. Funding is available for developing law enforcement products that promote effective practices and training programs to ensure law enforcement agencies can implement common sense policing. The initiative supports a safe environment by advancing crime prevention and improving community-police relationships, with applications due by August 31, 2026.

The National Cancer Institute (NCI) invites applications for innovative technologies aimed at cancer research and clinical care. This funding opportunity supports early-stage projects focused on proof-of-concept studies to assess the feasibility of new methods and tools. Applications should demonstrate significant technical innovation, targeting advancements in cancer biology, early detection, clinical diagnosis, treatment, and epidemiology. Technologies may include novel analysis platforms, imaging technologies, and biospecimen processing innovations, with a focus on cancer applications.

The National Cancer Institute (NCI) invites applications for the R33 grant aimed at advancing emerging technologies in cancer research. This funding opportunity seeks projects that demonstrate significant progress in technology development, focusing on cancer biology, early detection, and clinical diagnosis. Eligible proposals must showcase innovative methodologies that enhance research capabilities, with a strong emphasis on technical validation and broad applicability in cancer applications.

The Clinical and Translational Science Award (CTSA) Program invites applications to enhance clinical and translational science through innovative partnerships and research programs. This initiative aims to accelerate the delivery of treatments to diverse populations by improving clinical research efficiency, creating national resources for public health responses, and providing training for clinical research professionals. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the full proposal deadline.

The NIA Advanced Postdoctoral Career Transition Awards aim to enhance diversity in the translational research workforce for Alzheimer's disease and related dementias (AD/ADRD). This initiative supports early career researchers from diverse backgrounds in acquiring essential research skills applicable to various AD/ADRD studies. The goal is to cultivate a more diverse pool of researchers capable of leading interdisciplinary approaches in treatment, prevention, and management of AD/ADRD. Notably, independent clinical trials are not permitted under this award.

The National Cancer Institute (NCI) is seeking applications for studies that explore how bariatric surgery influences cancer risk, emphasizing the need for innovative research in this area. This funding opportunity encourages the participation of researchers who focus on the long-term impacts of bariatric surgery beyond weight loss and diabetes, addressing critical gaps in understanding the disease mechanisms involved. Key deadlines for application submissions span from February 2025 to October 2027.

The National Cancer Institute (NCI) invites applications for studies on mechanisms by which bariatric surgery influences cancer risk. This funding opportunity encourages exploration beyond short-term outcomes like weight loss and diabetes. The goal is to support innovative proof of concept studies, emphasizing feasibility without prior development in the literature. Unpublished data is not allowed, but references from preprints with a DOI are acceptable. Deadlines for applications span from February 2025 to November 2027.

The Interdisciplinary Transportation Law and Policy Technology Training Program aims to enhance the skills of policymakers and legal professionals in adapting to rapid advancements in transportation technology, including AI and automated vehicles. This initiative will allocate $600,000 to develop a comprehensive training curriculum, including a week-long course for support staff and a semester-long program for law students. The project will be executed over a 24-month period, targeting University Transportation Centers and their consortia.

The PreventSA Incubator aims to reduce sexual assault rates in the U.S. by 70% by 2050 through innovative solutions. This six-month program offers $50,000 in funding, mentorship, and community support for technology or social media ideas targeting high-school-aged youth (ages 14-18). It seeks projects that prevent peer-on-peer sexual assault and can launch by April 2026. Applicants must focus on direct engagement with high-risk youth and adapt successful interventions from other countries.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.