Best Operating Grants for Nonprofits in Iowa

The Indian Housing Block Grant Competitive Program (IHBG-COMP) for FY 2026 offers competitive grants to eligible recipients under NAHASDA. This program aims to support affordable housing initiatives benefiting low-income Tribal families, enhancing their living conditions and community well-being. Funded by the US HUD's Office of Public and Indian Housing, the IHBG-COMP encourages the development of sustainable housing solutions within Native American communities.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

Hogg Foundation for Mental Health

The Hogg Foundation for Mental Health was established in 1940 at The University of Texas at Austin by the children of Texas Governor James Hogg. For over a quarter of a century, the Hogg Foundation was guided by the passion and insight of the Governor’s daughter, Miss Ima Hogg, who actively promoted the foundation and encouraged its staff to pursue a bold, new vision. Today the Hogg Foundation is based at The University of Texas at Austin Steve Hicks School of Social Work and is funded through an endowment created by gifts from the Hogg family and managed by The University of Texas/Texas A&M Investment Management Company.

The Hogg Foundation is inspired by Ima Hogg’s vision for a Texas that supports and promotes mental health, resilience, and well-being. Miss Ima was ahead of her time in believing that mental health was just as important as physical health. She believed all people should have access to community-based resources to support mental well-being and live fulfilling lives, and she championed supports in everyday environments like schools, workplaces, places of worship, and homes.

Stephany June Bryan: Bold Spirit of Achievement Scholarship

The Hogg Foundation for Mental Health is offering ten $5,000 scholarships in honor of Stephany June Bryan to individuals facing personal and financial barriers to achieving their educational or career goals due to the impact of living with a mental health challenge and/or supporting a loved one with a mental health challenge.

You do not need to be enrolled in a program at the time you submit your application. However, you will need to provide enrollment verification and/or a certificate of completion when/if it is awarded.

The Native Forward Direct Scholarship supports American Indian and Alaska Native students by providing mid-year funding opportunities to alleviate educational costs. With over 50 years of experience, Native Forward has empowered more than 22,000 students from diverse backgrounds. This scholarship recognizes the limited access these students face in higher education and aims to enhance their academic journeys while fostering community engagement and mentorship through a strong alumni network.

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

The Louis Stokes Alliances for Minority Participation (LSAMP) Bridge to Doctorate Scholars Program, funded by the National Science Foundation, aims to recruit and retain minority graduate students in STEM fields. This program offers significant benefits, including a $32,000 annual stipend and $12,000 educational allowance for two years, fostering a supportive community through monthly dinners for Indigenous graduate students. Eligible applicants must be U.S. citizens, identify as American Indian or Alaska Native, and have participated in an LSAMP program.

The Sundance Collab's Cultural Impact Residency, honoring Michael Latt, is a six-month online program supporting early-career, underrepresented storytellers focused on social impact. Running from March to August 2026, it offers mentorship, feedback sessions, and resources to eight selected fellows in screenwriting, directing, and documentary filmmaking. This opportunity is designed for works-in-progress, fostering a supportive creative community to inspire and develop impactful narratives.

The Clark and Ruby Baker Foundation Grant aims to support charitable organizations that align with the philanthropic mission of the Baker family, focusing on Methodist-affiliated educational institutions, aid for disadvantaged children, and assistance for the sick in Georgia. The Foundation considers funding for construction projects of educational and medical facilities, ensuring that grants are awarded to meet specific community needs and promote long-term benefits.

The Leonard Litz LGBTQ+ Foundation, via its TransPLUS Resource Center, supports transgender, gender-nonconforming, non-binary, and intersex individuals. By providing grants and resources, the Foundation aims to address urgent needs in healthcare, housing, and legal services while fostering community connections. They build peer-support networks, publish updates, and support initiatives to empower TGNCNBI individuals and their allies, ensuring that marginalized voices are heard and uplifted.

The John H. and Ruby M. Laurie Charitable Scholarship offers a $1,000 scholarship to graduating seniors from Camdenton High School with a minimum GPA of 3.5. This renewable scholarship supports students enrolled in accredited colleges or vocational schools, encouraging academic achievement. Preference is given to those pursuing a Business degree. This initiative aims to enhance community welfare through educational support and resource development, fostering future leaders in the region.

The ScotiaRISE initiative by Scotiabank aims to foster economic resilience among disadvantaged groups over ten years, with a budget of $500 million. By focusing on enhancing educational opportunities, facilitating employment for newcomers, and removing barriers to career advancement, ScotiaRISE seeks to create a more inclusive society. This program highlights the importance of collective efforts in supporting individuals and communities to thrive, ensuring everyone has the chance to rise above challenges and contribute positively to their environments.

The Gilbert M and Martha H Hitchcock FoundationThe Gilbert M and Martha H Hitchcock Foundation is one of the oldest private, continuously run family foundations in Omaha, Nebraska, with more than 80 years serving the greater metro Omaha and Council Bluffs area with philanthropic support. From the start, the foundation matched the Hitchcocks' passions: supporting local journalism and the hard-working youth who delivered it, supporting religious institutions, promoting Omaha's growth, and providing care to the sick and elderly. In time, its focus has expanded to include private and higher education, the arts, conservation and animal welfare, preserving history, and social service organizations serving the greater Omaha and Council Bluffs area.

The Fair Housing Initiatives Program (FHIP) aims to combat discriminatory housing practices through funding provided to various organizations. Established by Congress in 1988 and made permanent in 1992, FHIP supports entities that educate the public and enforce fair housing rights. The program offers competitive grants across four initiatives, including the Private Enforcement Initiative, which enables national non-profit organizations to investigate violations and uphold fair housing laws effectively.

The EMF EMRA Resident Research Grant, funded by the Society for Academic Emergency Medicine Foundation, aims to enhance research in emergency medicine by providing up to $10,000 for residents in accredited programs. This grant promotes the development of future researchers, improves patient care, and supports effective health policy through rigorous scientific inquiry. Eligible applicants must be ACGME-approved residents and secure a faculty preceptor's support, ensuring a robust educational experience in research methodologies.

The ABPN Dorthea Juul, PhD, Education Research Award offers up to $100,000 for research projects aligned with the ABPN's mission of enhancing lifelong learning and certification standards for psychiatrists and neurologists. Two awards each in psychiatry and neurology are available annually, with projects lasting up to two years. Eligible applicants must hold faculty appointments or have confirmed offers, comply with conflict of interest policies, and, if MDs or DOs, maintain ABPN certification and licensure.

The Alkermes Pathways Research Awards program aims to foster research in neuroscience, specifically targeting schizophrenia and bipolar disorder. With grants up to $100,000, it supports early-career investigators exploring critical areas, including sleep and circadian disturbances related to these conditions. This initiative addresses the urgent need for innovative solutions in mental health research, empowering the next generation of scientists to make impactful contributions in understanding and treating these complex disorders.

Okoboji Foundation

The Okoboji Foundation was started in 1988, by a group of dedicated lovers of The Lakes Region who wished to improve the quality of life of those who call this area home.

Originally named the University of Okoboji Foundation, Berkley Bedell served as the first Board Chairman.  In 2006, the foundation changed its name to the Okoboji Foundation to establish the organization as a Community Foundation. Over $5.24 million has been granted to more than 80 different nonprofit agencies located around The Lakes since its inception and preserving the stories that make Iowa Great Lakes a place of local legends.

Today, the Okoboji Foundation is the center point of giving for vital capital projects. Current funding priorities focus on arts & culture, economic development, lake quality & environment, and outdoor experiences & recreation. It’s through the generosity of donors that the Okoboji Foundation continues to make a positive, lasting impact in the Lakes community.

Areas of Focus

We fund projects in the Iowa Great Lakes Region that align with one or more of the following:

• Arts & Culture – Enriching community life and sustaining nostalgia and legacy for residents and visitors.
• Outdoor Recreation – Expanding opportunities for active, healthy lifestyles.
• Lake Quality & Environment – Protecting and sustaining our lakes and natural resources

What We Fund

We fund VITAL CAPITAL PROJECTS, such as buildings, equipment, or physical property that will be available for many years of use in our Lakes communities. We want to help develop communities where people want to live, work, visit, and play

Projects should be visible, available to a large portion of the public, and have a long lasting impact in the Iowa Great Lakes region.

Professional signage must be included on structures or property funded by Foundation grants. The Okoboji Foundation will provide official logos and style guidelines for signage.

Funding Levels

There are two categories of funding: Leadership Grants and Community Needs Grants.

Community Needs Grants

Grant requests under $25,000 will be considered by the Youth In Philanthropy student led committee. Any unfunded grants in this category will then be reviewed by the Okoboji Foundation grant committee. Projects should be completed and request reimbursement with receipts totaling amount of grant award within one year of the award notification.

Okoboji Foundation

The Okoboji Foundation was started in 1988, by a group of dedicated lovers of The Lakes Region who wished to improve the quality of life of those who call this area home.

Originally named the University of Okoboji Foundation, Berkley Bedell served as the first Board Chairman.  In 2006, the foundation changed its name to the Okoboji Foundation to establish the organization as a Community Foundation. Over $5.24 million has been granted to more than 80 different nonprofit agencies located around The Lakes since its inception and preserving the stories that make Iowa Great Lakes a place of local legends.

Today, the Okoboji Foundation is the center point of giving for vital capital projects. Current funding priorities focus on arts & culture, economic development, lake quality & environment, and outdoor experiences & recreation. It’s through the generosity of donors that the Okoboji Foundation continues to make a positive, lasting impact in the Lakes community.

Areas of Focus

We fund projects in the Iowa Great Lakes Region that align with one or more of the following:

• Arts & Culture – Enriching community life and sustaining nostalgia and legacy for residents and visitors.
• Outdoor Recreation – Expanding opportunities for active, healthy lifestyles.
• Lake Quality & Environment – Protecting and sustaining our lakes and natural resources

What We Fund

We fund VITAL CAPITAL PROJECTS, such as buildings, equipment, or physical property that will be available for many years of use in our Lakes communities. We want to help develop communities where people want to live, work, visit, and play

Projects should be visible, available to a large portion of the public, and have a long lasting impact in the Iowa Great Lakes region.

Professional signage must be included on structures or property funded by Foundation grants. The Okoboji Foundation will provide official logos and style guidelines for signage.

Funding Levels

There are two categories of funding: Leadership Grants and Community Needs Grants.

Leadership Grants

Grant requests of $25,000 or more will be reviewed by the Okoboji Foundation grants committee. The committee may request an in person follow-up presentation by the nonprofit. Projects should be completed and request reimbursement with receipts totaling amount of grant award within three years of the award notification.

The Daland Fellowships in Clinical Investigation, awarded by the American Philosophical Society, support research in clinical medicine across various fields, including internal medicine and psychiatry. Each fellowship provides $40,000 annually for up to two years, contingent on satisfactory progress. Eligible candidates include those with recent M.D. or Ph.D. degrees, and applicants must conduct research under a scientific advisor in the U.S. Preference is given to those with limited postdoctoral training.

Danny Did Foundation

The Danny Did Foundation is a not-for-profit corporation organized in the state of Illinois and recognized by the Internal Revenue Service as a 501©(3) tax-exempt organization. 

Founded by Chicagoans Mike and Mariann Stanton in January 2010 after the death of their four-year-old son Danny, the Danny Did Foundation works toward its mission to prevent deaths caused by seizures with these main goals in mind: advancing public awareness of Sudden Unexpected Death in Epilepsy (SUDEP), enhancing SUDEP education and disclosure between medical professionals and families afflicted by seizures, and the mainstreaming of seizure detection and prediction devices that may assist in preventing seizure-related deaths.

Danny Did Foundation Hardship Grant

The Danny Did Foundation (“Foundation”) strives to assist individuals and families living with seizures. With an approved Request for Funding, the Foundation will provide monetary funding to the Grantee so they may gain access to a particular device or technology (“Device”) that the Grantee, in collaboration with the Grantee’s medical providers and professionals, independently deem appropriate. This money shall be defined as “Funds” and the spending of any Funds shall be at the sole discretion of the Grantee. The Foundation does not direct, limit, participate, or manage the decision-making or purchase of any specific Device.

While no Device has been proven to prevent epilepsy-related mortality (including SUDEP), the Danny Did Foundation is devoted to seeking out resources that may assist families living with epilepsy.

Hardship Grant: I am unable to make a purchase for the epilepsy related resource I seek therefore I am requesting a hardship grant. If I am approved for funding, I agree to provide a receipt for the resource I purchase to the Danny Did Foundation within 14 days of receiving the grant check, or I will return the funds to the Danny Did Foundation. 

The Isabelle Rowe Nursing Scholarship supports non-traditional students aged 21 and older from the Fox Valley and Waupaca areas pursuing nursing degrees. Established in 2007 by Julian Rowe in honor of his wife, Isabelle, this fund provides non-renewable scholarships of $2,000 for 4-year colleges and $1,000 for 2-year institutions. Applicants must maintain a minimum GPA of 2.5, have work experience in healthcare, and demonstrate financial need, with opportunities to reapply annually.

Syndax Pharmaceuticals, Inc.

At Syndax, we are determined to realize a future in which people with cancer live longer and better than ever before. We believe that it takes a community to build a great medicine, and that is why we are working to set the new standard for developing medicines in the field of oncology – one that revolves around collaboration, shared learning, and excellence.

Syndax’s mission is to obtain regulatory approval and commercialize drugs that extend and improve the lives of cancer patients by drawing on the newest scientific research and advances, collaborating with determined problem solvers, and identifying value in overlooked aspects of science.

Educational Funding

At Syndax, we are committed to the goal of supporting objective, balanced and scientifically rigorous education that furthers improvements in science, medicine, and patient care. We accomplish this goal, in part, by providing grants for independent medical education (IME) programs. These can include live, online, and/or enduring programs that educate healthcare providers (HCPs), patients, or caregivers. Programs that are funded via Syndax medical education grants must be primarily dedicated, in both effort and time, to medical, health or scientific topics that are objective, balanced, unbiased, and scientifically rigorous. Medical education grants must never be made with the intent to directly or indirectly reward, influence or encourage the recipient to prescribe, purchase, sell or arrange for any Syndax product.

Shawnee Fine Arts Club Scholarship

Provides a scholarship to graduating seniors of Shawnee High School, Liberty Academy, or home-schooled residents of Shawnee, Oklahoma with a minimum cumulative GPA of 2.7. Student must be accepted into the university of their choice, majoring in music, visual arts, dance, or drama.

The R. Don Cowan Music & Performing Arts Scholarship, administered by the East Texas Communities Foundation, supports students pursuing studies in music and performing arts, including musical theater and dance. Applicants must be graduating seniors or current college students from Smith County, with no specific financial need requirement. This scholarship is available for one year and allows recipients to major in any subject while continuing their performing arts education.

The Ruth M. Cogan Foundation Trust Fund, established by the Stark Community Foundation, supports students from Stark County, Ohio pursuing college education in music. This fund aims to help graduating seniors or current college students who demonstrate a passion for music and embody the spiritual qualities exemplified by Ruth. Since 1963, the Foundation has evolved from a grantmaker to a community leader, transforming lives through philanthropy.

The NIDCD Research Career Enhancement Award for Established Investigators (K18) supports seasoned researchers in enhancing their skills to advance their studies related to hearing, balance, taste, smell, voice, speech, and language sciences. The program encourages the acquisition of new methodologies and approaches to answer critical questions in these fields. Key deadlines for applications span from June 2024 to February 2027, providing ample opportunity for interested investigators.

The Heiser Program for Research in Leprosy, established by Dr. Victor G. Heiser, focuses on innovative biomedical research to combat leprosy. Since 1975, it has funded over 200 grants totaling more than $20 million, supporting early-career researchers and significant projects. The program aims to enhance diagnostic tools, improve treatments, and implement effective surveillance strategies. With a dedicated Scientific Advisory Committee, it ensures rigorous proposal reviews and fosters collaboration among grantees, ultimately advancing leprosy elimination efforts.