Best Large Grants for Nonprofit Organizations in Nebraska

The MEM Safety Grants program, offered by Missouri Employers Mutual, provides critical funding to enhance workplace safety. With one-to-one matching funds available from $500 to $10,000, it supports policyholders in acquiring necessary safety equipment. Applications are accepted year-round, with decisions made monthly. To qualify, applicants must maintain an active policy and clearly demonstrate the need for safety improvements. This initiative aims to foster safer work environments across Missouri, reflecting the company’s commitment to worker safety.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The Neil Lancaster Scholarship, established by the Nebraska Community Foundation, supports Plattsmouth high school seniors and PHS graduates who are college sophomores to seniors. This scholarship aims to empower local students to pursue higher education by providing financial assistance that may be renewable for subsequent years. The initiative reflects the foundation's commitment to fostering community growth and supporting educational opportunities, ensuring that aspiring students have the resources needed to achieve their academic goals.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Dollar General Literacy Foundation offers the DGLF Summer Reading Grants, which support the development and expansion of summer reading programs aimed at Pre-K to 12th grade students, particularly new and below-grade-level readers, including those with learning disabilities. Eligible organizations, such as nonprofits, schools, and libraries within 15 miles of a Dollar General store, can apply for grants up to $3,000 to foster literacy and education initiatives.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

The IDeA Networks of Biomedical Research Excellence (INBRE) program aims to enhance biomedical research capacity in underfunded states by fostering collaborations among research institutions. By supporting faculty research, mentoring, and student involvement, INBREs create pathways for undergraduate students to enter biomedical careers. This initiative not only promotes institutional partnerships but also strengthens research infrastructure, ultimately contributing to a more robust scientific community in IDeA states.

Through partnerships and collaboration, Lincoln Community Foundation facilitates positive change for the common good.

Since 1955, we have been privileged to be part of many wonderful legacies by connecting donor generosity to local needs. LCF serves as a faithful steward for many types of philanthropic gifts and helps donors create lasting legacies of giving. With gifts of all sizes from thousands of donors over the years, the assets of LCF have grown to more than $270 million.

Scholarships

Generous donors to Lincoln Community Foundation have established 90 scholarship funds that benefit students in Lancaster County and across the state of Nebraska. For 2025, there were 299 scholarship recipients who received awards that totaled over $606,000. 

Glenn and Dorothy Schnieber Scholarship

The Glenn and Dorothy Schnieber Scholarship was established in 2021 by their family. Glenn and Dorothy graduated from Lincoln High School in 1946. Neither of them was able to afford college. They bought a small business from Glenn’s dad and over the next 30 years they grew it into a successful wholesale food distributor, Schnieber Fine Foods. Education was always important to them. In their memory, the donors hope this scholarship will help recipients in Nebraska achieve their educational goals.

Recipients of this scholarship may renew the scholarship for the following year if they maintain a cumulative GPA of 2.8 or above, for a total of two years.

The Ashland County Wildlife Conservation League David McClure Memorial Scholarship supports graduating seniors from Ashland County high schools and alternative education programs pursuing a degree in wildlife-related fields. Applicants must maintain a GPA of 3.0 or higher and be accepted into accredited colleges or vocational programs. This scholarship fosters educational growth while promoting conservation efforts, reflecting the commitment of the Ashland County Community Foundation to enhance community development and support future leaders in wildlife conservation.

Bristol Myers Squibb Foundation Inc supports independent medical education to enhance healthcare professional competence and improve patient health outcomes. Their mission is to be a global leader in innovative medical education, focusing on evidence-based activities that address critical gaps in knowledge. By fostering excellence in healthcare, they aim to ensure measurable improvements in performance and patient outcomes across various disease areas.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

The Hirschfeld Family Foundation Grants support nonprofit organizations in Nebraska, focusing on projects that aid disadvantaged communities. Established in 1993, the foundation prefers time-limited requests over ongoing budgetary support. Priority is given to local organizations in Central and Western Nebraska that demonstrate community involvement and efficient operations. Grants are available for projects that align with the foundation's mission to promote well-being and make a meaningful difference.

Benefitting people in the places making the AI future possible

The Future is for Everyone Fund

Meta is investing directly in education, community enhancement, workforce development and sustainability projects in locations where we have a data center in the United States.

The AI future we are building is for everyone. That starts with making sure everyone in the places that are home to a Meta data center feel the benefits in their communities. We want students to have bright futures, small businesses to flourish and communities to be prosperous.

Our commitment to the communities we call home.

The Future is for Everyone Fund supports investments and programs that address local community priorities in the United States, where we have a Meta data center:

We invest in the people and shared spaces that help a community thrive. That includes the parks, trails, and gathering places where neighbors come together, the technology and access that keep them connected, and first responders - like police officers, firefighters, and paramedics — who keep our communities safe.

We support the people and organizations that power local economies - helping workers gain the skills, certifications, and hands-on experience the modern economy rewards, and backing initiatives that create jobs and give a community its character.

We fund the programs, spaces, and tools that help learners of every age discover what they're capable of - from early literacy and the arts to hands-on science, technology, and problem-solving - and we equip the educators who make it happen with the resources to bring their most ambitious lessons to life.

We invest in the long-term health of the land, water, and wildlife that make our communities home - supporting things like habitat restoration and resource conservation that connects people to the natural world.

What is the Future is for Everyone Fund?

The Future is for Everyone Fund is Meta’s $1 billion commitment to invest directly in the U.S. communities that are home to a Meta data center. The Fund supports local schools, nonprofits, and community organizations and is organized into four focus areas that reflect local priorities: Community Enhancement, Economic Vitality, Education, and Sustainability. It builds on the over $70 million in grant funding we’ve provided to our data center communities since 2011.

Project Lead The Way (PLTW) offers grants for schools to implement the PLTW Computer Science program from 2025 to 2028. Schools must provide at least one PLTW course in the first year and two courses in the second year. The total grant is $14,000, covering participation fees and training costs. Eligible institutions include public, private, and charter schools located in the U.S., with special encouragement for those serving low-income or minority-majority populations.

The Dale Jr. Foundation, founded by NASCAR driver Dale Earnhardt Jr., has raised over $8 million since 2007 to support various charities focusing on youth and underprivileged communities. The foundation emphasizes empowerment, education, wellness, hunger relief, and hope, aiming to provide resources that enhance confidence and opportunities for children facing hardships. Through fundraising efforts and partnerships with organizations like Make-A-Wish, the foundation strives to positively impact lives and foster a sense of normalcy among children in need.

The Malmsten Fund, established by Lincoln residents Carl and Salina Malmsten, provides annual gifts to retired Presbyterian pastors and their spouses in Nebraska. This fund honors the Malmsten's legacy of supporting those who served in the church, continuing their commitment even after the trust ended in 1980. Income from investments and proceeds from the sale of Clark Jeary Retirement Community further bolster this initiative, ensuring financial assistance for those in need.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

The Kessler Emergency Assistance Fund, established by the Nebraska Presbyterian Foundation in 2018, honors Dr. Silas G. Kessler's legacy of ministry. This fund provides financial support to PCUSA pastors serving or retired from Nebraska congregations within specified presbyteries. Grants aim to assist those in need, reinforcing the commitment to pastoral care and community service in Central Nebraska, Homestead, and Missouri River Valley areas.

Nature's Path's Gardens for Good program empowers communities by funding organic gardens that address food insecurity. Since 2010, it has donated $930,000 CAD to support 120 gardens. In 2023, grants of $6,500 each will be awarded to 20 gardens across the U.S. and Canada. Eligible applicants must be registered non-profits with urban organic agriculture projects that serve low-income communities, promoting sustainable practices and inclusivity.

The Presbyterian Church (USA) Grants provide financial support to Nebraska-based PCUSA congregations and organizations. Applicants can seek funding for outreach projects that enhance community ministry. With two annual grant cycles, the application process begins with a Letter of Intent, followed by a full application for approved projects. Eligible applicants must have tax-exempt status and complete a final grant report. Grants are not provided for for-profit entities, individuals, or general operating expenses.

The Greater Grand Island Community Foundation offers grants up to $10,000 to address unmet charitable needs in Hall County. Eligible organizations include 501(c)(3) entities and governmental agencies. The foundation focuses on a variety of sectors, including arts, education, health, and community enrichment. Priority is given to programs that reach underserved populations and demonstrate community engagement. Applicants must contact the foundation before proposal submission and may only apply once every 12 months.

Nebraska Humanities Council

The mission of Humanities Nebraska is to help people explore what connects us and makes us human.

There are two organizations that fall under the Humanities Nebraska umbrella — the Nebraska Humanities Council is the entity that conducts programs and makes grants. The Nebraska Foundation for the Humanities works with the Council to secure private funding and advocate for public funding at the state and federal levels to support these programs. A third organization, the Nebraska Cultural Endowment, serves as the endowment for both Humanities Nebraska and the Nebraska Arts Council, a state agency.

Sower Award in the Humanities

Humanities Nebraska presents the Sower Award in the Humanities annually to honor an individual who has made a significant contribution to the public understanding of the humanities in Nebraska. This contribution can be made through any combination of time, expertise, or resources. The selection committee will consider how nominees have helped enrich the lives of Nebraskans through the humanities: history, literature, culture, philosophy, and all the ways we explore what it means to be human.

Each year, the Sower Award in the Humanities is presented prior to the annual Governor’s Lecture in the Humanities. The award recipient must be present. In some past years the Sower Award was presented to organizations or communities; as of 2016, only individuals are eligible for nomination. Current board and staff members of Humanities Nebraska are not eligible.

Previous honorees have included:

• Talented humanities faculty who have taken the humanities to the public beyond their classroom;
• Committed volunteers dedicating their time and energy to enhancing the cultural life of Nebraska;
• Thoughtful journalists and filmmakers bringing the humanities to bear on important public issues;
• Generous philanthropists who have directed significant financial support to humanities-related programs and projects accessible by Nebraskans

Women Investing in Nebraska (WIN) provides grants to innovative projects that address urgent needs in Nebraska. Since 2011, WIN has awarded over $1.9 million to various initiatives through a member-driven process. Each fall, two grants are given, one to a University of Nebraska project and another to a nonprofit. Eligible applicants include Nebraska nonprofits with 501(c)(3) status and university departments, focusing on bold solutions to pressing issues.