Best Grants for Small Nonprofits in New York

The Zero Hunger | Zero Waste Foundation Grant supports nonprofit organizations focused on ending hunger and reducing food waste. Since its inception, the foundation has allocated over $59 million to enhance food security through innovative programs and community engagement. Eligible applicants include 501(c)(3) nonprofits addressing critical needs such as food access, nutrition education, and support for vulnerable populations. This initiative aims to create equitable food systems and ensure that no one goes hungry.

The HEAL Initiative aims to identify new druggable targets for pain within the understudied proteome. This funding opportunity invites applications for pilot projects that generate preliminary data and tools for exploring these targets. The initiative seeks to enhance research on understudied proteins related to pain management, providing essential funding for biochemical and biological work. This NOFO is part of the NIH's broader effort to develop novel medications that address various aspects of opioid addiction and its consequences.

The Carl and Marilynn Thoma Foundation offers Special Project Funding to support innovative initiatives in the arts, particularly in under-resourced areas. This grant encourages collaborative projects that enhance community engagement and education, focusing on art exhibitions and scholarships in the greater Texas Panhandle. By fostering leadership and creativity, the Foundation aims to empower individuals and organizations to make a lasting impact in the fields of art and art history.

The Cheerful Giver Scholarship, provided by the Community Foundation of the Central Blue Ridge, offers over $300,000 in financial support to students in the Greater Augusta County area pursuing health care-related education. This need-based scholarship is open to high school seniors, current college students, and adult learners, with a preference for those entering the nursing profession. The foundation aims to enhance community well-being through educational opportunities.

The 15 and the Mahomies Foundation Grants aim to enhance the lives of children by supporting health, wellness, and community initiatives. This private foundation seeks to fund 501(c)(3) non-profit organizations, focusing on charitable causes. Grant requests are reviewed quarterly, and applicants must meet eligibility criteria. However, the foundation does not accept applications from individuals or for non-charitable items such as autographs or game tickets.

The J.R. Simplot Company Foundation Grant supports U.S. non-profit organizations focused on art, education, youth, community, and global food and agriculture. Established in 1929, the foundation is committed to enhancing community welfare through creative cultural endeavors, educational initiatives, health services, and youth programs. Applications are reviewed quarterly, ensuring a timely response to organizations dedicated to making a positive impact in their communities.

The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.

The AAAAI Distinguished Layperson Award recognizes non-medical citizens for their significant contributions to the field of allergy, asthma, and immunology. Established by the American Academy of Allergy, Asthma & Immunology (AAAAI), this annual award honors individuals who have promoted public education, supported research, and influenced positive change in legislation related to allergies. This acknowledgment reflects the growing importance of citizen volunteers in advancing the specialty and improving patient care.

The Ella B. Cleveland Trust Grant supports charitable medical research organizations focusing on leukemia, muscular dystrophy, and cerebral palsy. Established in memory of Ella B. Cleveland, the trust prioritizes 501(c)(3) entities and has no geographic limitations, though it often funds organizations in Georgia. Applications are accepted year-round, with an average grant size of $5,000, and total annual giving ranging from $10,000 to $15,000.

The Elizabeth Furber Scholarship honors the legacy of Elizabeth Furber by providing financial assistance to American Indian and Alaska Native female graduate students. This scholarship supports students pursuing full-time degrees in various fields, including fine arts, music, and creative writing. As a need-based award, it requires applicants to demonstrate Tribal affiliation through a Tribal Eligibility Certificate. This opportunity empowers eligible students to achieve their academic goals.

The AAAAI Distinguished Service Award recognizes outstanding contributions from members of the American Academy of Allergy, Asthma & Immunology. This prestigious award honors those who have demonstrated long-standing commitment and service to the organization, focusing on their influence in advancing the field of allergy and immunology. Eligible recipients include senior members and past presidents, particularly those nearing retirement, thereby celebrating their dedication to the specialty and the patients they serve.

The AAAAI Mentorship Award honors dedicated mentors who significantly impact the careers of trainees and colleagues in the field of allergy and immunology. By supporting and guiding more than one mentee, awardees embody the core values of the American Academy of Allergy, Asthma & Immunology. This prestigious recognition highlights the importance of mentorship in fostering professional growth and advancing the specialty, benefiting both individuals and the broader medical community.

The AAAAI Travel Scholarship supports eligible professionals to attend the AAAAI Annual Meeting in Philadelphia from February 27 to March 2, 2026. This event features plenary sessions, workshops, and presentations on current research in allergy and immunology. The scholarship not only provides financial assistance but also fosters opportunities for networking and collaboration among attendees, enhancing their knowledge and experience in the field.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

The Ralph J. Torraco Scholarship for Therapy Sciences, provided by the UNICO Foundation, awards two scholarships valued at $2,500 each to full-time students pursuing degrees in Therapy Sciences, including physical therapy, occupational therapy, audiology, and speech-language pathology. Eligible candidates must be U.S. citizens with a minimum GPA of 3.0 and continue their studies in the 2026-2027 academic year. This scholarship promotes educational advancement within the community.

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

• Sudden cardiac arrest/resuscitation science
• Cardiovascular Kidney Metabolic Syndrome
• Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.

Chesapeake Watershed Investments for Landscape Defense (WILD) Program

The Chesapeake Watershed Investments for Landscape Defense (WILD) Grants Program delivered in partnership with the U.S. Fish and Wildlife Service supports efforts to improve the condition and connectivity of habitats for at risk and federally listed species.

The National Fish and Wildlife Foundation (NFWF) is committed to operating in full compliance with all applicable laws, regulations, and Executive Orders. We continuously monitor legal and regulatory developments to ensure our policies, procedures, and operations align with current federal directives. We encourage all applicants to do the same.  

The ability and extent to which NFWF is able to make awards is contingent upon receipt of funds from federal agencies and/or other funding partners. Final funding decisions will be made based on the applications received and the level and timing of funding received by NFWF.

The WILD Program Pillars are:

• Pillar 1: Restore, conserve, and connect fish and wildlife habitat
• Pillar 2: Improve water quality for fish, wildlife and people
• Pillar 3: Align the power of nature to adapt to changing landscapes
• Pillar 4: Expand access to nature and outdoor recreation for all Americans
• Pillar 5: Build partnership capacity to collaborate and coordinate actions

The Chesapeake WILD Grants Program has three distinct tracks:

• Collaborative Conservation
  • Grants of up to $200,000 will be awarded for projects that support and enhance the capacity of partnerships, networks, and other collaborative models working collaboratively to advance place-based, landscape-scale, and crossjurisdictional habitat restoration, conservation, and connectivity outcomes.
• Planning and Technical Assistance
• Implementation

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.

The Quality Improvement grant from Conquer Cancer and Pfizer aims to enhance biomarker testing and treatment practices in cancer care through innovative digital solutions. Targeting colorectal, lung, and prostate cancers, this initiative seeks proposals with measurable outcomes and strategies for sustainability. Applicants are encouraged to demonstrate how their findings can be shared across healthcare systems, ensuring broader impacts on patient care and outcomes. This collaboration reflects a commitment to improving cancer care through technology.

The Hazen and Sawyer Scholarship, valued at $10,000, is awarded annually to a graduate-level candidate dedicated to addressing critical challenges in drinking water, water reuse, and water resources. Sponsored by the American Water Works Association (AWWA), this scholarship supports students who are permanent residents of the U.S., Mexico, or Canada. Eligible funds cover tuition, books, and related educational expenses, enhancing the recipient's ability to contribute to the water industry.

The Ann W. Dooley Advancement Scholarship supports individuals aged 18-25 with intellectual disabilities who reside in Boone, Ogle, Stephenson, or Winnebago County. This scholarship encourages empowerment through education, enabling recipients to enhance their life skills for employment and independence. Established in memory of Ann Dooley, a dedicated educator, this scholarship honors her legacy of service and commitment to helping others. Applicants must provide verification of their disability and enrollment in a post-secondary program.

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting the Centers for Structural Biology of HIV and other Infectious Diseases. This solicitation will support multidisciplinary groups of scientists to determine the 3-dimensional structures of molecules and molecular complexes involved in priority infectious diseases. The effort focuses on exploring biomolecular complexes that can be targeted to make new medicines and tests to prevent or treat infections and improve human health. The centers will drive cutting-edge research and development of structural biology technologies, including high-resolution 3D structural analyses, computational molecular dynamics, functional and mechanistic characterization at the molecular and cellular level, visualization at the atomic level of molecular complexes in cells and tissues, and advanced structure-guided design of molecules to combat infectious diseases. The centers will maximize use of common resources, establish broad collaborations, and mentor future structural biology researchers. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

The Delaware River Watershed Protection Fund: Catalyst Grants, initiated in 2014 by the Open Space Institute, aims to enhance water resource management and land protection. These grants support organizations addressing climate change, environmental justice, and community resilience. Eligible applicants include not-for-profit organizations and Indigenous-led groups. Funded projects should integrate science into conservation plans, focusing on water quality and stewardship. The initiative collaborates with the William Penn Foundation to ensure sustainable water practices across the Delaware River watershed.

The Robert Silman Award, presented biennially by the James Marston Fitch Charitable Foundation, recognizes innovative proposals in the preservation, restoration, or adaptive reuse of the built environment. Open to professionals in various design fields, the award encourages originality and practical applications that advance preservation in the U.S. With a funding limit of $15,000, it seeks projects that demonstrate a clear plan for dissemination and positive community impact, especially for underrepresented groups.