Best Large Grants for Nonprofit Organizations in New York

Agog Open Call: Climate Futures + Immersive Media

This open call supports immersive media projects that help people better understand and respond to climate challenges and imagine what a better world could be.

We are looking for projects that use immersive technologies—including smart glasses, augmented reality, spatial sound, and mixed reality—to create more engaging, experiential forms of climate storytelling and civic participation.

The open call will support projects across a range of stages and formats, from early ideas to more developed work. What matters most is a compelling story or experience, a clear sense of purpose, and a thoughtful approach to bringing the work to life.

Grants may be awarded in denominations ranging from $25,000 to $200,000. In addition to funding, selected projects may receive mentorship, advisor support, and opportunities for partnership and distribution.

The Tommy Wells Foundation Grant supports youth aged 4-18 in music and hockey programs by providing financial assistance. As a 501(c)(3) nonprofit, the Foundation raises funds to honor Tommy Wells' legacy. Organizations in the greater Nashville, TN area are preferred for funding. The TWF encourages applicants to request funds for those who will benefit most, ensuring accountability by requiring confirmation of fund usage within a year.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Jeryl Salmond II Memorial Scholarship ($1,700)

This renewable scholarship is available to students who are pursuing a career in the Mental Health field. 

The Howard and Beverly Murray Memorial Scholarship, offered by the Community Foundation of North Central Washington, honors high-achieving students pursuing education in math and science. Eligible applicants must be graduating seniors from Chelan or Douglas high schools with a minimum GPA of 3.4. This scholarship aims to support students who demonstrate a commitment to their academic pursuits in fields like mathematics, physics, and chemistry, ensuring they have the resources needed to succeed in further education.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Jacqueline M. Miller Scholarship ($1,700)

This non-renewable scholarship is for high school seniors graduating from a high school in Fairfield County, South Carolina. 

The Anna Hudson Erbacher Scholarship, funded by the Schenectady Foundation, supports aspiring teachers in Schenectady County with a total award of $10,000, disbursed in annual installments. This scholarship aims to assist high school seniors pursuing education-related degrees, emphasizing academic performance and financial need. Applications are now open, with winners announced in May. The foundation has a rich history of community support, having invested over $32 million since its inception in 1963.

The Ruth D. Frick Ames Scholarship, established by Robert Ames to honor his wife, supports students pursuing a nursing degree. Managed by the South Dakota Community Foundation, this scholarship aims to ease the financial burden for those aged 18-32 with a GPA of 2.9 or higher. Applicants should demonstrate financial need, strong academic performance, and community involvement. This initiative reflects Ruth's legacy of compassion, service, and commitment to helping others in the nursing field.

The Schenectady STEM Scholarship, managed by the Schenectady Foundation, offers $10,000 scholarships in four annual installments to graduating seniors of Schenectady City School District pursuing STEM careers. This initiative aims to inspire future innovators and strengthen the community by supporting education in science, technology, engineering, and mathematics. With a focus on equitable access, the foundation plans to invest $2 million in grants and scholarships in 2025, enhancing opportunities for local students.

The Cullen Foundation's Supplemental Academic Program (SAP) supports educational initiatives for underserved PreK-12 students in Erie County, NY. Focused on enhancing access and academic outcomes, the program funds evidence-based academic programs that directly benefit economically disadvantaged students. Interested organizations must meet specific eligibility criteria and demonstrate a strong fit with the foundation's goals. For detailed guidelines and funding levels, applicants should refer to the provided resources and ensure alignment with the foundation's focus areas.

Anita Tarr Turk Fund for Breast Cancer Research

The Anita Tarr Turk Fund for Breast Cancer Research was established in October 2011 as an endowed field of interest fund. Its purpose is to distribute grants annually to one or more charitable, educational or scientific organizations conducting top-level research searching for the cause of, and cure for, breast cancer.

Anita Tarr Turk encouraged the Community Foundation for Monterey (CFMC)’s board to consider grants to the Susan G. Komen Breast Cancer Foundation, Damon Runyon Cancer Research Foundation and the California Breast Cancer Research Program. The Fund may also consider proposals from organizations conducting similar research. Due to the narrow field of interest and suggested organizations in the fund’s establishing documents, organizations are invited to share research projects for CFMC to consider.

Grant Amount

• $60,000/year

The Combined Pilot Research Grants from the Plastic Surgery Foundation and the American Society for Peripheral Nerve support innovative research in peripheral nerve surgery. Aiming to enhance scientific knowledge and clinical practices, these grants fund preliminary projects with a maximum of $15,000 for one year. Eligible applicants include those with doctoral degrees or those in relevant clinical positions, encouraging new collaborations and research initiatives to advance the field.

The Genentech Foundation supports innovative projects that address systemic inequities in healthcare. They fund tax-exempt organizations, including public charities and governmental entities, located in the U.S. Grant requests must be submitted at least 60 days before the project start date. Notably, projects must align with Genentech's commitment to advancing health equity and diversity in the medical workforce. Applications for funding will be accepted starting January 2, 2026, after a temporary closure.

Early Career Talent Development General Application

The UNCF Student Professional Development Programs (SPDP) Department works closely with some of the nation’s leading corporations and foundations to shape and execute internship programs, including both stand-alone internship programs and internship-and-scholarship programs

The UNCF Student Professional Development Programs (SPDP) Department works closely with some of the nation’s leading corporations and foundations to shape and execute internship programs, including both stand-alone internship programs and internship-and-scholarship programs with two goals – 

• To help companies build a more diverse workforce; 
• To provide diverse students with the preparation they need to succeed in college, familiarize themselves with professional career paths, and prepare to be competitive candidates for internships and future employers after graduation.

UNCF’s SPDP partners include The Walt Disney Company, Toyota, Papa Johns, United Health Foundation, Wells Fargo, and the Walton Family Foundation. We currently serve over 1500 students annually through internship, leadership, and professional development services.

The UNCF Student Professional Development Programs (SPDP) offer career readiness, success coaching, and paid summer and semester internships to college students. Students participating in SPDP will be exposed to career pathways and opportunities and have access to leadership and personal development training. 

SPDP students will:

• Prepare to navigate from college to early-stage careers
• Enhance professional experiences through meaningful internships
• Develop stronger project management skills
• Improve networking and communication skills
• Strengthen interviewing techniques 

Currently, the SPDP is sourcing candidates to fill for summer 2026 internships!! The Early Career Talent Development General Application is used to establish an applicant pool of potentially eligible students for these ongoing internship/student professional development opportunities that are published/unpublished. Internship or professional development opportunities using the Early Career Talent Development General Application, are restricted to students who are enrolled full time at an accredited institution within the U.S. during the 2025-2026 academic year. 

The Project Lifesaver International Grant by the Alzheimer’s Foundation of America aims to fund programs that prevent wandering and enhance public safety for individuals with dementia-related illnesses. This grant supports public safety agencies that are members of AFA and Project Lifesaver International, focusing on essential training, supplies, and community outreach. Grants are awarded biannually, promoting better care and safety for individuals living with Alzheimer’s disease and related dementias.

The Anne & Irving Brodsky Innovation Grant, offered by the Alzheimer's Foundation of America, provides $25,000 to support innovative programs that enhance the lives of individuals affected by Alzheimer's disease and related conditions. This grant is exclusively available to AFA nonprofit member organizations, with funding directed towards essential program expenses such as staff training, administrative costs, and necessary supplies. The initiative aims to foster advancements in care and support for families dealing with Alzheimer's.

The AHRF Birtman Grant provides up to $75,000 for one year of research focused on hearing and balance disorders related to the inner ear. This grant encourages both basic and clinical studies, covering direct costs such as staff salaries and research equipment. Applicants must hold relevant advanced degrees and be affiliated with a U.S. university or hospital. An alternative budget option of $50,000 is available, enhancing eligibility for Regular grants if not awarded the Birtman Grant.

The Northfield Bank Foundation, established in 2007, supports non-profit organizations in Staten Island, Brooklyn, and Central New Jersey. It focuses on enhancing education, health services, youth programs, and community projects. Eligible applicants must have 501(c)(3) status and demonstrate financial need. The foundation does not fund political organizations or individual endeavors except for scholarships. Grants support both program initiatives and facility improvements, ensuring a positive impact on local communities.

The Klingenstein Third Generation Foundation's 'Transformation of Mental Health Care Program' seeks innovative research into improving mental health care access for children and adolescents, particularly from under-resourced backgrounds. Applications are invited for studies that build on promising pilot work, focusing on scalable delivery models and technology use. Eligible applicants are academic researchers based in the U.S. who can demonstrate rigorous research capabilities. The foundation plans to award up to two grants of $100,000 each year for two years.

Ginger D. Schroder Cattaraugus County Legislative District 2 Scholarship

The Ginger D. Schroder Legislative District 2 Scholarship is given to a graduating high school student residing in Cattaraugus County Legislative District 2 who will pursue a trade degree or 2-or 4-year college degree.

Northern Chautauqua Community Foundation

Vision: We envision a vibrant, prosperous northern Chautauqua community, rich in opportunity today and tomorrow.

Our Mission

To realize our vision we focus on:

• strategic and responsive grant making
• encouraging local philanthropy and building permanent endowments for the future
• actively serving as a community leader and partner for the benefit and enrichment in our community.

Scholarships

Northern Chautauqua Community Foundation proudly manages over 200 individual scholarship funds,

Terence J. Centner Agricultural and Environmental 4-H Scholarship

The Terence J. Centner Agricultural and Environmental 4-H Scholarship benefits student that participated in 4-H for a minimum of 3 years and completed an outstanding agricultural or environmental project.

This fund is established in memory of Harry E. and Mary Ellen Centner to honor their dedication and hard work on their family farm in the Town of Dunkirk and their leadership activities in the Chautauqua County 4-H Program.

The MNAF Linda Knauff Clinical Practice Project Grant supports Minnesota Nurses Association members in conducting research that aligns with MNA's organizational goals. It promotes best practices through literature reviews, workgroup convening, policy development, and quality improvement initiatives. Applicants must be MNA members engaged in direct patient care, complete their projects within two years, and submit periodic reports. Preference is given to first-time applicants whose projects meet quality standards.

The MNA Associate Member Scholarships provide financial assistance to MNA associate members who are typically undergraduate nursing students. Offered by the Minnesota Nurses Association Foundation, these scholarships aim to support the professional development and educational goals of nursing students, contributing to the advancement of the nursing profession and ensuring access to quality healthcare for all. Eligible candidates include MNA members, their dependents, and veterans, fostering a commitment to nursing excellence.

The Mary Eliza Mahoney Scholarships, offered by the Minnesota Nurses Association Foundation (MNAF), provide financial support to nursing students, members of healthcare unions, their dependents, and veterans. Each scholarship awards $2,500 per semester for a maximum of four semesters, totaling up to $10,000. This initiative aims to enhance nursing education and promote the professional growth of future nurses, ensuring access to quality healthcare for all.

Northern Chautauqua Community Foundation

Vision: We envision a vibrant, prosperous northern Chautauqua community, rich in opportunity today and tomorrow.

Our Mission

To realize our vision we focus on:

• strategic and responsive grant making
• encouraging local philanthropy and building permanent endowments for the future
• actively serving as a community leader and partner for the benefit and enrichment in our community.

Scholarships

Northern Chautauqua Community Foundation proudly manages over 200 individual scholarship funds,

Matthew Hazelton Memorial Scholarship for Law Enforcement

The Matthew Hazelton Memorial Scholarship for Law Enforcement supports students in northern Chautauqua who wish to pursue a career in law enforcement or criminal justice.

The Innovations in Alzheimer’s Caregiving Awards, overseen by the Family Caregiver Alliance, recognize organizations that enhance support for family caregivers of individuals with Alzheimer’s disease. These awards highlight innovative approaches in three categories: Creative Expression, Increasing Access and Reducing Stigma, and Public Policy. Each award is valued at $20,000, and applicants must be non-profit organizations, government agencies, or universities operating within the U.S. that focus on the needs of unpaid caregivers.

The DGF Fellows program is a year-long New York City-based intensive for professional dramatists who are looking to develop their existing work at the next level of their careers. The Fellows program is a free program hosted by the Dramatists Guild Foundation, designed to eliminate historical barriers of entry for many emerging dramatists.

This cohort of playwrights, composers, lyricists, librettists, and bookwriters will work together under the guidance and leadership of prominent program chairs to develop their current work in pursuit of further development and production.

This year, the program will work as an accelerator program for dramatists with existing works still in their revision process. Within the structure of the program is a uniquely successful format of partnering playwrights and musical theater writers during the learning process. Fellows who are selected will receive a $5,000 scholarship, access to career resources, and the opportunity to partner with several arts organizations.

Additionally, the program provides its Fellows with one-on-one mentoring from accomplished professionals in the field who help them hone their process, find their unique voice, and revise and edit existing work ready for development. At the end of the program, each Fellow will have an opportunity to participate in a presentation of their work for top theater professionals.

The National Institute of Neurological Disorders and Stroke (NINDS) aims to support innovative research for validating therapeutic targets in Alzheimer's Disease-Related Dementias (ADRD). This initiative focuses on overcoming barriers in treatment development by ensuring well-validated targets linked to disease mechanisms. By employing a phased award mechanism, NINDS seeks to enhance the rigor of target validation, facilitating the transition from basic discoveries to clinical applications, ultimately accelerating the development of effective therapeutic strategies.