Best Large Grants for Nonprofit Organizations in New York

The NIA — Neighbors in Action program, initiated in 2025, aims to empower community-driven projects in Rochester. With grants ranging from $250 to $10,000, it invites neighborhood associations, block clubs, and community organizations to apply. Established to revitalize local neighborhoods, NIA promotes resident engagement and action. Since its inception, it has funded numerous initiatives to enhance community connections and foster collaboration among residents, striving for a more connected and vibrant Rochester.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

The NIH Support for Conferences and Scientific Meetings (R13) grant aims to facilitate high-quality conferences that contribute to public health and the scientific missions of NIH Institutes and Centers. Key application deadlines range from April 2024 to January 2027, providing vital opportunities for researchers to gather and share knowledge. This grant is particularly focused on enhancing the impact of scientific dialogue in critical health areas.

The Paul G. and Miriam B. Mattern Fund Grant, established in 2012, honors the legacy of Paul and Miriam Mattern, dedicated volunteers from Walton, NY. The fund supports projects that enhance the cultural and social well-being of the community, providing grants up to $5,000 annually to qualified non-profit organizations. Matching grants are encouraged, and various types of support, including capital and program funding, are available to strengthen community initiatives.

The Hamer Foundation

Our Mission:

The mission of The Hamer Foundation is to provide support to nonprofit organizations within a 100-mile radius of State College PA in the following areas: 

• Environmental Support – 50% of donations 
• Community Support – 35% of donations 
• Educational Support – 15% of donations 

This funding opportunity invites applications for Testing Centers focused on evaluating somatic cell genome editing technologies for translational applications. These centers will provide essential resources and testing services to researchers, ensuring the efficacy and safety of novel genome editing methods. By developing innovative in vivo and in vitro models, the centers aim to enhance scientific rigor and reproducibility in biomedical research, ultimately supporting the advancement of therapeutics for human diseases.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

This funding opportunity from the NIH encourages groundbreaking research to enhance, develop, and preserve animal models and related biological materials for studies impacting human health. The program seeks innovative methodologies that can improve the diagnosis and management of diseases affecting animal use in biomedical research. Projects must demonstrate relevance across multiple NIH Institutes to align with broader research goals, emphasizing diverse body systems and disease categories.

The Kenneth A. Scott Charitable Trust Grants focus on enhancing the quality of life for companion animals and native wildlife. This private foundation supports innovative projects that go beyond basic care, ensuring the well-being of homeless and abused animals. Eligible organizations must have a 501(c)(3) status and be located in specific states, including Ohio and parts of Indiana and Michigan. The Trust emphasizes humane treatment and sustainable funding for animal welfare initiatives.

The Friends of Loutit Library Fund Scholarship, established by the Friends of Loutit Library in 2005, aims to assist students pursuing an advanced degree in Library Science. This scholarship is open to individuals who either reside or have resided in the Tri-Cities area of Northern Ottawa County. Financial need is not a consideration, ensuring that all eligible students can apply for this essential educational support from the Grand Haven Area Community Foundation.

The Limited Competition Small Grant Program for ORIP SERCA K01 Recipients provides funding to early-stage veterinary scientists to enhance their research capabilities and transition to independent investigator status. This initiative addresses challenges faced by these researchers, including reliance on funding from senior investigators. Grants support pilot studies, secondary data analysis, and development of research methodologies, aiming to foster independence within a two-year timeframe without funding clinical trials.

Society of Teachers of Family Medicine (STFM) 

Founded in 1967, the Society of Teachers of Family Medicine (STFM) is a national community of academic leaders committed to developing an accomplished family medicine workforce, prepared to serve as the foundation of America’s health care system. Our members include physicians, PAs, nurse practitioners, behavioral health specialists, researchers, pharmacists, nurses and other health care professionals, health system executives, administrators, coordinators, fellows, residents, students, and others involved in the education of family physicians. 

STFM Faculty for Tomorrow Resident Scholarship

The STFM Faculty for Tomorrow Resident Scholarship provides family medicine residents with the opportunity to attend the full-day Faculty for Tomorrow Workshop for Residents and the STFM Annual Spring Conference. This program is supported by the STFM Foundation and in part by Mary Nolan Hall, MD. 

The STFM Foundation supports multiple scholarships to cover registration fees for residents to attend the full-day Faculty for Tomorrow Workshop for Residents and the STFM Annual Spring Conference.Scholarship recipients are chosen based on essays they have written to answer the questions "Why are you interested in teaching family medicine?" and "How do you think you can make a difference in the future of family medicine?"

Society of Teachers of Family Medicine (STFM) 

Founded in 1967, the Society of Teachers of Family Medicine (STFM) is a national community of academic leaders committed to developing an accomplished family medicine workforce, prepared to serve as the foundation of America’s health care system. Our members include physicians, PAs, nurse practitioners, behavioral health specialists, researchers, pharmacists, nurses and other health care professionals, health system executives, administrators, coordinators, fellows, residents, students, and others involved in the education of family physicians. 

STFM Excellence in Education Award

Designed to honor outstanding teachers, the STFM Excellence in Education Award recognizes an STFM member who has demonstrated excellence in teaching, curriculum development, mentoring, research, or leadership in education at regional or national levels. Nominees must have sustained involvement in family medicine education.

The selection is made by the STFM Nominations Committee and approved by the STFM Board of Directors. Nominations are ranked based on the:

• Contributions recognized at the home institution
• Regional/national impact of nominee's activities
• Sustained involvement in family medicine education

Nominees must be STFM members. Members of the Nominations Committee are not eligible to receive the award while serving on the Committee.

About AWS

We Move Welding Forward

Founded in 1919, the American Welding Society is a nonprofit organization with a global mission: to advance the science, technology, and application of welding and allied joining and cutting processes worldwide, including brazing, soldering, and thermal spraying.

By fostering knowledge, embracing change, and providing real-world opportunities through scholarships, fellowships, and workforce development, AWS provides the tools to help members succeed—and to inspire future generations of welding professionals.

Counselor and Fellow Awards

The AWS Counselor and Fellow Awards celebrate members for distinguished organizational leadership and notable contributions to welding science and technology.

Counselor Awards

The American Welding Society, in 1999, established the honor of Counselor of the Society to recognize members for a career of distinguished organizational leadership that has enhanced the image and impact of the welding industry. The first class of Counselors was inducted at the 2001 AWS Show.

Election as a Counselor of the Society is demonstrated as evidenced by:

• Leadership of or within an organization that has made a substantial contribution to the welding industry.
• The individual’s organization shall have shown an ongoing commitment to the industry, as evidenced by support of participation of its employees in industry activities.
• Leadership of or within an organization that has made a substantial contribution to training and vocational education in the welding industry.
  • The individual’s organization shall have shown an ongoing commitment to the industry, as evidenced by support of participation of its employees in industry activities.
  • This recognition is selected by the AWS Counselor Committee based on specific criteria at least 16 months in advance of FABTECH.
  • Nominations must be submitted through the online nomination portal by June 1st.
  • Nominations are reviewed/selected at the fall Counselors Committee meeting, with final approval the following year at the spring Districts Council meeting.

A maximum of 5 Counselors are selected each year, as determined by the Counselors selection committee.

VCA Charities is dedicated to enhancing pet ownership by offering Disaster Relief Grants to support animal welfare organizations impacted by natural disasters. These grants provide funding for essential veterinary care, pet supplies, temporary shelter, and transportation costs for rescued animals. Prioritizing immediate relief, VCA Charities also assesses preparedness requests at year-end. The program aims to alleviate the suffering of pets and ensure they remain in loving homes during crises, addressing both urgent and long-term needs in affected communities.

About AWS

We Move Welding Forward

Founded in 1919, the American Welding Society is a nonprofit organization with a global mission: to advance the science, technology, and application of welding and allied joining and cutting processes worldwide, including brazing, soldering, and thermal spraying.

By fostering knowledge, embracing change, and providing real-world opportunities through scholarships, fellowships, and workforce development, AWS provides the tools to help members succeed—and to inspire future generations of welding professionals.

Counselor and Fellow Awards

The AWS Counselor and Fellow Awards celebrate members for distinguished organizational leadership and notable contributions to welding science and technology.

Fellow Awards

The American Welding Society, in 1990, established the honor of Fellow of the Society to recognize members for distinguished contributions to welding science and technology, and for promoting and sustaining the professional stature of the field. The first class of Fellows was inducted at the 1991 AWS Show.

AWS Fellow candidates are expected to have demonstrated impactful contributions through research, teaching, leadership, or service. Election as a Fellow of the Society is based on the outstanding accomplishments and technical impact of the individual. These accomplishments will have advanced the science, technology and application of welding, as evidenced by:

• Sustained service and performance in the advancement of welding science and technology
• Publication of papers, articles, and books, which enhance knowledge of welding
• Innovation and development of welding technology
• Society and Section contributions
• Professional recognition

The Michigan Animal Health Foundation offers research and education grants to enhance animal health and welfare. Since 1977, these grants have supported nearly 50 projects aimed at improving veterinary care and medical techniques. Eligibility varies, with specific criteria for research grants, while educational grants have no restrictions. Researchers and educators alike can benefit from this funding, which plays a vital role in advancing animal health initiatives.

The IATSE Local 161 Hardship Relief Fund provides emergency financial assistance to performing arts and entertainment professionals facing unexpected critical needs. This support helps cover essential living expenses, including healthcare, housing, and utilities, thereby preventing eviction or service shut-offs. Members in good standing for at least two years may apply, ensuring that those in the most urgent situations receive timely help from the Entertainment Community Fund.

The Two-Year College Biology Teaching Award, sponsored by the National Association of Biology Teachers (NABT), recognizes outstanding biology educators in two-year colleges who implement innovative teaching techniques. This award highlights the importance of culturally responsive pedagogies that foster equity and inclusion in various learning environments. Recipients receive a $500 travel honorarium, a recognition plaque, and one year of complimentary NABT membership, supporting their professional development and commitment to enhancing biology education.

The National Endowment for the Arts (NEA) offers Grants for Arts Projects (GAP) to support diverse arts initiatives that enhance public engagement and education. These grants aim to improve community well-being through the arts and are open to all organizations, regardless of size or location. Applicants are encouraged to align their projects with NEA funding priorities, fostering creativity across various disciplines such as music, theater, and visual arts.

The Lots of Compassion Grant, supported by KidsGardening and Mrs. Meyer’s Clean Day, aims to transform vacant urban lots into thriving community gardens. By providing $20,000 to each of the 10 selected grantees, the initiative focuses on empowering under-resourced communities, fostering social connections, and enhancing mental health. The grant prioritizes organizations that involve diverse participants and demonstrate significant community impact, ensuring that the gardens not only flourish but also cultivate kindness and compassion.