Best Operating Grants for Nonprofits in North Carolina

The Ryan White HIV/AIDS Program Part C Capacity Development Program aims to enhance the capabilities of community-based organizations, focusing on improving health outcomes and decreasing HIV transmission. This initiative supports individuals who have not yet accessed regular HIV care, emphasizing innovative care solutions and infrastructure development to address these critical needs.

The AIDS Drug Assistance Program (ADAP) Emergency Relief Funds aim to provide essential funding to states and territories. This initiative focuses on preventing, reducing, or eliminating waiting lists for ADAP services, ensuring timely access to necessary medications and support for individuals living with HIV/AIDS. This program addresses critical funding shortfalls, enhancing the healthcare infrastructure and improving health outcomes in affected communities.

The Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement aims to enhance the effectiveness of HIV prevention and care planning for RWHAP Parts A and B recipients. Through the provision of training, tools, and technical assistance, this initiative seeks to optimize resource allocation and strengthen the overall system of HIV care and treatment, ultimately improving health outcomes for those affected by HIV.

The Friends Foundation for the Aging Grant supports innovative and impactful programs aimed at addressing the needs of older adults, particularly within underserved populations. This Quaker foundation prioritizes collaboration and sustainability in its funding efforts. Eligible applicants must be 501(c)(3) public charities focused on enhancing the quality of life for aging individuals. Grants are typically awarded for one year and target organizations that align with the foundation's mission and values.

The Senator Harold "Potch" Wheeler Memorial Scholarship, managed by the Community Foundation of Whitley County, honors the legacy of a dedicated public servant. This competitive scholarship is available annually to high school seniors from Whitley County who plan to pursue college education in public service or within the Indiana Department of Natural Resources. Recipients are chosen based on their embodiment of the ideals and character traits exemplified by Senator Wheeler.

The Atlantic Salmon Federation Olin Fellowships support individuals aiming to enhance their knowledge and skills in salmon conservation and management. These fellowships are available annually for various pursuits, including research and graduate studies, without the requirement of being enrolled in a degree program. Eligible applicants must be legal residents of the U.S. or Canada, and the fellowships can be conducted at accredited institutions or active management programs.

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story – Joest, Brian H. Memorial Fund

Brian Henry Joest was born in Lagrange, Indiana in 1957. He grew up on the Atwood family farm that was settled by his ancestors in the mid-1800s. Now a historical Hoosier Homestead, the Atwood Farm provided him with all the outdoor activities possible for a farm boy in northern Indiana. Brian’s love of nature and the outdoors continued throughout his life. After high school, he attended Glen Oaks Community College and then Purdue University, where he earned a Bachelor of Science degree in Agricultural Economics

For decades, Brian went on annual backcountry camping and canoeing trips across the US and Canada. He paddled some of the most beautiful rivers in North America. He took a road trip to remote northern Alaska. He camped out on an active volcano in Guatemala. He explored most of the US National Parks. In his later years, his travels were less rustic but still adventurous as he and his wife, Cindy, checked off many items on his bucket list. They traveled to Paris, Rome, Florence, the Amalfi Coast of Italy, Ireland, and all around the US and Canada.

Brian began his professional career with management positions at Many Glacier Hotel at Glacier National Park in Montana; the Grand Hotel on Mackinac Island, Michigan; the Mountain View Grand Resort in New Hampshire; and Copper Mountain Ski Resort in Colorado. He also worked for Marriott Corporation where he opened new hotels across the Midwest.

Upon the birth of his first child, Brian moved his young family back to Lagrange County so his children could grow up on the Atwood Farm near their family. Brian worked for Life Care Center of Lagrange, was a substitute teacher for the Lakeland School District, and worked for fifteen years for East Noble School Corporation, most recently as an Instructional Assistant for high school students with special needs.

Brian enjoyed doing things for other people and took so much joy in their happiness. His career choices reflected his servant’s heart. He loved working in the hospitality industry and being able to make someone else’s vacation more memorable. He helped the patients and their families at Life Care Center. He spent years making a difference for students in our local schools.

Brian experienced first-hand the unique challenges faced by the families of individuals with special needs. He was a father, stepfather, and step-grandfather to children with different disabilities. He understood the difficulties of navigating support systems and knew there are gaps in these systems that result in unmet needs. At the end of his life, while he was fighting cancer, Brian dreamed of being able to return to the classroom to help special needs students. This was not to be. In 2022, his family created this fund in his honor with the intent of continuing his dream to help improve the lives of individuals with special needs.

The MIND Prize, funded by The Pershing Square Foundation, supports innovative research to combat neurodegenerative diseases like Alzheimer's. It empowers early-to-mid-career investigators to explore unconventional approaches and fosters collaboration across disciplines. Each winner receives $250,000 annually for three years, promoting advancements in neuroscience and creating a unique network for researchers. The initiative aims to enhance our understanding of brain health and tackle pressing societal challenges.

The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.

The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.

The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.

The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.

The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.

Troutville Volunteer Fire Department Scholarship Fund

Fund provides higher educational scholarship assistance to deserving students.

Amount

• $1,000+
• non-renewable

The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.

The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.

The Women's Club of Grand Haven Grant, established in 2001, offers scholarships to non-traditional students from the Tri-Cities seeking further education. Funded through community efforts such as an annual Used Book Sale, this grant prioritizes financial need and is open to applicants residing in Northern Ottawa County or those who graduated from local school districts. Preference is given to female applicants aged 21 and older, supporting educational advancement for those whose academic journeys have been interrupted.

The Syringe Service Program Grant, offered by The Comer Family Foundation, aims to enhance harm reduction initiatives by funding syringe access programs across the U.S. These programs provide sterile syringes, education, and support services to mitigate the risks associated with drug use, including HIV and hepatitis transmission. Priority is given to organizations in underserved areas and those led by marginalized communities. Grants are available for operational costs, program development, and staff training, with a focus on sustainability and local partnerships.

The Longleaf Fund Grant supports capital projects aimed at enhancing the lives of at-risk children and youth across the Carolinas. Focusing on building accessible play spaces, promoting educational technology, and improving environments for children with disabilities, this grant encourages community engagement and collaboration. Eligible projects must be completed within 12-18 months and demonstrate significant community support. The fund prioritizes initiatives that address the needs of vulnerable populations and can secure additional funding.

The Single Ventricle Research Fund (SVRF) offers annual grants aimed at enhancing research and care for individuals with single ventricle heart defects. With awards of up to $600,000, the SVRF encourages innovative projects that align with the Additional Ventures Research Roadmap. This initiative not only supports novel treatments but also fosters collaboration across disciplines to address critical challenges in single ventricle heart disease management.

Reader’s Digest Partners for Sight Foundation

The Reader’s Digest Partners for Sight Foundation is a philanthropic organization dedicated to improving the lives of individuals who are blind or visually impaired by fostering independence and self-sufficiency. Its mission is to support programs that help people with vision loss lead independent, productive lives, while its vision is an accessible and inclusive world where individuals have the tools, resources, and opportunities to fully participate in society.

The Foundation’s funding priorities focus on supporting nonprofit organizations and initiatives that provide education, training, and rehabilitation services, assistive technology innovations, vision care and access to aids, and capacity building for professionals serving the visually impaired community. It also invests in programs that enhance employment opportunities, promote independence, and improve service delivery systems for people with vision loss, emphasizing practical, community-based solutions and long-term impact.

Small Discretionary Grants

The Reader’s Digest Partners for Sight Foundation (RDPFS) Track #3 Small Discretionary Grants provide flexible, year-round funding for smaller-scale initiatives that support individuals who are blind or visually impaired. Grant requests are accepted on a rolling basis and awarded at the discretion of the Executive Director. Awards are made until available funds are exhausted, allowing the Foundation to respond to timely or emerging needs.

The Reader’s Digest Partners for Sight Foundation offers Single Program Grants to support impactful programs for individuals who are blind or visually impaired. These grants, ranging from $25,000 to $50,000, prioritize initiatives that enhance independence and service delivery. Eligible organizations must be US 501(c)(3) non-profits, and unsolicited proposals are not accepted. The foundation emphasizes community-based solutions and invites qualified applicants to submit a Letter of Inquiry followed by a full proposal.

The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.

The upcoming National Institute of Mental Health (NIMH) funding opportunity aims to explore the effects of HIV immunotherapies on central nervous system (CNS) outcomes. It seeks to identify mechanisms, benefits, and risks associated with these therapies, focusing on overcoming CNS-specific barriers. The initiative encourages collaborations to develop strategies for achieving sustained virologic remission and improving neurological outcomes for individuals with HIV, particularly targeting neurotoxicity and neuroinflammation.

The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.