Best Private Grants for Nonprofits in North Carolina

The Never Lose Hoop Fund, established by JC and Joni Hulls, provides grants to support families affected by cancer. The fund aims to enhance the quality of life for children and their families through shared experiences, such as family camps and outdoor activities. Grants are available for those currently battling cancer or who have lost an immediate family member to cancer within the last two years. This initiative helps families create lasting memories and find joy during difficult times.

The Trails Capacity Program, previously known as the Trail Fund Grant, aims to enhance community capacity for trail maintenance, research, and stewardship training across the nation. The program focuses on supporting non-Forest Service Federal lands, as well as state and local areas, fostering inclusivity and improved user behavior. By collaborating with diverse trail partners, it seeks to ensure effective stewardship and sustainable trail management, ultimately promoting public access and enjoyment of America's natural landscapes.

The Hillman Emergent Innovation Grant offers $50,000 for 12-18 months to support innovative nursing-driven interventions for underserved populations facing health care access barriers, including racial minorities and low-income individuals. It encourages fresh, early-stage ideas targeting serious illness and end-of-life care challenges. By fostering community engagement and interdisciplinary collaboration, the program aims to transform care delivery in diverse settings, ensuring equitable health services for all.

Casey's Cash for Classrooms Grants support K-12 public and nonprofit private schools through funding for physical improvements, material needs, teacher support, and community engagement. In 2025, $900,000 was awarded across 80 grants, allowing schools to enhance their learning environments. With a commitment to community engagement, Casey's has donated $15 million since 2019, emphasizing their dedication to making life better for communities and guests. Grants range from $3,000 to $50,000, with funds required to be used within 12 months.

The CFHC: Fletcher Community Grants, managed by the Community Foundation of Henderson County, supports cultural, educational, historic, and civic enrichment in Fletcher. Established in 1990, these grants are intended for specific projects that foster collaboration among nonprofits, enhancing community well-being. Eligible applicants include 501(c)(3) organizations, while grants are not available for ongoing support or individual scholarships. The fund encourages proposals that demonstrate broad community impact and sustainability.

The Youth Incentive Award, established by the Coleopterists Society, encourages students in grades 7-12 to explore the fascinating world of beetles. Annually, up to $1200 is awarded, with two grants of $400 and $800 for junior and senior categories, respectively. Recipients also receive a subscription to The Coleopterists Bulletin. The program aims to promote beetle studies, develop essential life skills, and provide financial support for educational projects, fostering a passion for entomology among youth.

The John Lennon Endowed Scholarship, established by Yoko Ono to honor John Lennon, supports students attending UNCF member institutions. This initiative addresses financial need and promotes education among African American youth. With over $65 million awarded annually, UNCF empowers thousands of students, advocating for minority education and community engagement. Eligible applicants must have a minimum GPA of 3.0, complete a FAFSA, and demonstrate unmet financial need. This scholarship plays a crucial role in fostering future leaders.

The Ross Merrill Award for Outstanding Commitment to the Preservation and Care of Collections recognizes North American institutions demonstrating exceptional dedication to conservation. This award highlights organizations that engage in significant outreach, involve conservation professionals, and show a commitment to community education regarding the importance of preserving cultural heritage. While no monetary prize accompanies the award, it serves as a prestigious acknowledgment of exemplary conservation efforts. Nominations are encouraged from both inside and outside organizations.

The AAS Northeast Asia Council (NEAC) Distinguished Speakers Bureau Grant invites applications from U.S. and Canadian colleges to host distinguished scholars for public lectures on Japan and Korea. This program, initiated in 2011, aims to foster engagement with early career scholars and enhance East Asian studies. Grants cover honoraria of $500 and additional funding for in-person events, promoting accessibility and academic collaboration. Institutions are encouraged to apply every three years, ensuring support for smaller programs in Asian studies.

The Willis C. Helm Charitable Trust, established in 1954, focuses on supporting organizations that work on juvenile delinquency and the development of boys from broken homes. It provides annual grants averaging between $5,000 and $15,000, with a total giving of around $60,000 for five grants each year. Eligible organizations must be 501(c)(3) exempt and preferably located in Minnesota. Applications are accepted year-round, with a deadline of March 31 for annual review.

The Biocodex Microbiota Foundation invites early career researchers in the microbiome field from U.S. institutions to apply for the 2024 grant. This initiative focuses on groundbreaking research into gut microbiota's role in human health and disease, particularly in areas like circadian rhythms and metabolic disorders. The grant supports operational costs, allowing for innovative projects aimed at fostering independent research careers in microbiota studies.

The Student Research Fellowship Awards program provides financial support of up to $2,500 for students conducting research on Inflammatory Bowel Disease (IBD) for a minimum of 10 weeks. Aimed at undergraduate, medical, and graduate students, the initiative encourages research interest in IBD. Up to 16 awards are available, and research must be conducted under a qualified mentor at an accredited institution, ensuring a professional academic environment for the study of this critical health issue.

The CAO Legislative Crisis Grant, funded by the National Education Association Staff Organization, is designed to support affiliates in creating and refining student-centered initiatives. Grants can be utilized for contract campaigns, new program development, or enhancing existing practices to improve sustainable learning conditions. This opportunity is exclusive to affiliates, ensuring a focused approach to advocacy and collective bargaining efforts that benefit students.

The Orthopaedic Physical Therapy Research Grant, funded by the Foundation for Physical Therapy Research, aims to support innovative research that optimizes movement and enhances societal health. With a commitment to addressing health disparities, the foundation will award $40,000 for one or two years to promising researchers. This initiative not only strengthens the physical therapy profession but also contributes to the growing evidence base that underscores the value of physical therapy in various healthcare settings.

The Child Well-Being Grant Program, established by the Doris Duke Foundation, focuses on promoting the healthy development of children and preventing abuse. With a commitment to addressing systemic inequities, the program supports initiatives that strengthen social service systems and foster partnerships to enhance access to services. It prioritizes funding for projects that encourage community-based interventions and the development of future leaders dedicated to improving child welfare, ensuring all children have the opportunity to thrive in safe and supportive environments.

The Sherry Wagner-Henry Board Fellowship, initiated by the United States Institute for Theatre Technology (USITT), offers a unique opportunity for emerging leaders in the theatre and entertainment industry. This 12-18 month program connects Fellows with experienced board members to enhance their professional skills. Participants gain access to board resources, attend meetings, and receive support for conferences, all valued at approximately $3,000 to $3,500. Ideal for individuals with 2-5 years of experience, this Fellowship fosters growth and leadership in nonprofit governance.

The Innovations for Healthy Living program invites eligible U.S. small businesses to apply for SBIR grants aimed at improving minority health and eliminating health disparities. The initiative encourages innovative proposals for effective, affordable, and culturally acceptable solutions. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent recommended 30 days prior to submission. This funding opportunity supports projects that address health challenges faced by underserved populations.

The Morton Gould Young Composer Awards, presented by The ASCAP Foundation, support emerging composers under 30 by recognizing their original concert music. This prestigious award honors Morton Gould's legacy and offers monetary prizes to recipients. Eligible entrants must be U.S. citizens or permanent residents, aged at least 13, and can submit one original work. Previous winners of three or more awards are ineligible, ensuring a fair opportunity for new talents.

The Henry Luce Foundation's Asia: Responsive Grants program supports initiatives that enhance understanding of East and Southeast Asia. With a focus on academic research, cultural exchange, and public education, the program seeks to promote collaboration between American and Asian institutions. Grants are awarded primarily to U.S.-based non-profits, fostering innovative teaching, resource development, and policy engagement, while prioritizing projects that bridge diverse disciplines and geographic divides.

The Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42) program invites small business concerns to develop innovative technologies aimed at enhancing minority health and addressing health disparities. This initiative emphasizes the creation of effective, affordable, and culturally acceptable solutions for NIH-defined populations. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent encouraged 30 days prior to submission.

The Stephen Schwartz Musical Theatre Teacher of the Year Award, presented by The ASCAP Foundation and the Educational Theatre Association, recognizes outstanding middle and high school musical theatre teachers. Awarded annually, the recipient, selected by a panel of experts, will receive a $5,000 prize and be honored at the EdTA Theatre Education Conference in Minneapolis, MN. This prestigious award highlights the significant impact of dedicated educators in shaping the future of musical theatre.

The T.E.A.L. Research Grant supports innovative ovarian cancer research initiatives aligned with the mission of the Tell Every Amazing Lady About Ovarian Cancer Foundation. Designed for researchers affiliated with 501(c)3 not-for-profit institutions in the U.S., the grant aims to enhance women's health awareness and education regarding ovarian cancer. While the application period for 2025 is currently closed, interested parties should anticipate further updates in spring 2026.

The AES Infrastructure Grant, offered by the American Epilepsy Society, provides up to $50,000 to support the development of national or international multicenter research programs. This funding is intended for organizational planning sessions, infrastructure development, and pilot projects, facilitating future investments from other organizations. These grants are available annually in the spring, enabling researchers to enhance their collaborative efforts.

The Bayer Fund: Food & Nutrition Grant supports high-quality programs that combat malnutrition and improve access to nutritious foods, particularly for underserved communities and families with young children. Eligible organizations include 501(c)(3) nonprofits and government units. The fund prioritizes long-term behavioral change towards healthy eating and nutrition, with grants typically not exceeding 25% of an organization's operating budget. International requests start at $25,000, fostering sustainable food security and education initiatives.

The PCC Rapid Response Grants provide support for cultural initiatives that aim to shape narratives during critical cultural moments. These grants prioritize projects that engage communities of color, immigrants, refugees, and other marginalized groups, focusing on intersectionality, gender justice, and social equity. Eligible projects include pop culture campaigns, research, and public spectacles that respond to urgent political and cultural events, aiming to reach mass audiences and disrupt harmful narratives.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

• Identification treatment responsive biomarkers
• Assess clinical measures and improve that enhance clinical trial readiness
• Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.