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Best Unrestricted Grants for Nonprofits in North Carolina

Find the perfect Unrestricted grants for nonprofits in North Carolina on Instrumentl. 10,000+ Unrestricted grants for nonprofits in North Carolina in the United States.

10,000+

Available grants

$2.70B

Total funding

$5K

Median grant

10,000+ grants
$2.70B total
$5K median

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9,803 Results based on applied filters

Path to a Cure — Collaborative Research Grant

Cystic Fibrosis Foundation
Private
United States
Up to US $1,000,000
The Path to a Cure — Collaborative Research Grant, offered by the Cystic Fibrosis Foundation, aims to support research in developing new therapies for cystic fibrosis, particularly focusing on CFTR gene repair and replacement strategies. This program prioritizes collaborations that integrate new investigators and innovative technologies into CF research. Applicants can request up to $1,000,000 annually for three years, with proposals requiring preliminary data to demonstrate feasibility and potential impact.
Cystic Fibrosis

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed) (356717)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.
Cancer / Oncology Biomedical Imaging

David Perlman Award for Excellence in Science Journalism - News

AGU- Advancing Earth and Space Science
Private
United States
More than US $5,000
The David Perlman Award for Excellence in Science Journalism recognizes outstanding work in science news reporting. Established in 2000, this annual award honors journalists who make Earth and space science accessible to the public. Recipients receive a $5,000 prize, an engraved award, and recognition at AGU's annual meeting. Eligible nominees include journalists from any medium, excluding books, who have not won the award in the past two years. The award encourages diverse representation in science journalism.
Journalism Science Communications

Apple Crop Protection Request for Proposals

Washington Tree Fruit Research Commission
State/Local Government
United States
Unspecified amount
The Washington Tree Fruit Research Commission is inviting research proposals aimed at apple crop protection, emphasizing organic practices and pollinator protection. Key areas of focus include the management of pests like Codling Moth and Fire Blight, testing new crop protection products, enhancing soil health, and developing efficient monitoring techniques. Collaboration among institutions is encouraged, and projects should aim for practical industry applications to ensure sustainable and profitable tree fruit production.
Agricultural Crops Agricultural Pest Management Pollinator Conservation

Whole Foods Market Store Giving Program

Whole Foods Market
Corporate
Canada, United Kingdom +1 more
Unspecified amount
The Whole Foods Market Store Giving Program supports local communities by providing financial assistance to 501(c)(3) nonprofit organizations that focus on food access and environmental stewardship. This biannual program allows eligible organizations to apply via the Community Engagement Portal, although not all requests can be fulfilled due to high demand. Priority is given to those without recent funding, promoting sustainable community engagement.
Food Access & Hunger Environmental Stewardship

William F. Holmes / Frank D’Accone Dissertation Fellowship in Opera Studies

American Musicological Society Inc
Private
North America
US $25,000
The William F. Holmes / Frank D’Accone Dissertation Fellowship in Opera Studies, awarded by the American Musicological Society, supports dissertation research in opera studies for graduate students. Offering a stipend of $25,000, this fellowship is based on academic merit and aims to facilitate full-time study. Recipients may opt for a non-stipendiary award to allow more funding for others. Selection occurs in spring, with announcements made in summer.
Opera

Suzanne G. Cusick Professional Development Fund

American Musicological Society Inc
Private
United States
US $500
The Suzanne G. Cusick Professional Development Fund, offered by the American Musicological Society, provides $500 grants to support low-income scholars in music and sound studies. These grants aim to enhance professional development for independent scholars and contingent faculty who lack access to such opportunities. The fund emphasizes equitable participation, particularly for historically under-represented groups, ensuring a diverse range of recipients can benefit from this vital support.
Music Music Education

Alvin H. Johnson AMS 50 Fellowship

American Musicological Society Inc
Private
North America
US $25,000
The Alvin H. Johnson AMS 50 Fellowship supports PhD candidates in music scholarship during their final dissertation year. Awarded based on academic merit, it offers a $25,000 stipend for full-time study, with no tuition coverage. Applicants must be registered doctoral students in good standing at North American universities, having completed all requirements except the dissertation. The fellowship emphasizes timely completion, discouraging extensive employment during the term, and is non-renewable.
Music Music Education

AMS Explore Travel Grant

American Musicological Society Inc
Private
Canada, United States
US $350
The AMS Explore Travel Grant supports current or recent undergraduate students to present 10-minute papers at the 2025 AMS-SMT Joint Annual Meeting in Minneapolis. Participants will engage in cohort activities, receive constructive feedback, and enjoy a supportive conference environment. Accepted applicants will benefit from complimentary registration, a $350 travel grant, and shared lodging in the conference hotel, enhancing their academic experience and involvement in the AMS community.
Music Music Education

National Early Detection of Ovarian Cancer Research Awards

Minnesota Ovarian Cancer Alliance Inc (MOCA)
Private
United States
US $50,000 - US $100,000
The Minnesota Ovarian Cancer Alliance (MOCA) is offering grants for research focused on the early detection of ovarian cancer. With funding amounts of either $50,000 or $100,000 available, these grants support projects aimed at enhancing prevention strategies. Eligible applicants include U.S.-based researchers outside of Minnesota, and the awards will be distributed in November 2025. This initiative aims to foster innovative approaches to combat ovarian cancer effectively.
Gynecological Cancers

NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32) (358114)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32) supports rigorous biomedical research training and dissertation research for doctoral candidates in clinical, behavioral, or biomedical sciences. Funded by the NIH, this fellowship aims to enhance research capabilities and knowledge in the field of audiology. Key deadlines for applications include April 8, August 8, and December 8 for the years 2025 to 2027, ensuring timely opportunities for aspiring researchers.
Hearing Disorders & Audiology

AMD Resident Research Grant

Association of Migraine Disorders (AMD)
Association/Society
United States
Up to US $12,000
The AMD Resident Research Grant aims to foster innovative research projects related to migraine, encouraging residents to explore diverse topics that are scientifically sound. Applicants, who must be enrolled in accredited training programs, can collaborate with preceptor investigators and receive support from their institutions. The grant is open to all residents without country restrictions, promoting advancements in migraine understanding and treatment.
Neurological Diseases & Disorders Neuroscience

Alzheimer’s Association Research Grant For All (AARGA) Program

Alzheimer's Association
Private
United States
US $70,000 - US $200,000
The Alzheimer’s Association Research Grant For All (AARGA) Program supports early-career investigators in their first seven years as independent researchers. This grant aims to fund projects that develop preliminary data and test new hypotheses in Alzheimer’s and related dementia research. Areas of interest include disease mechanisms, biomarker development, and health equity. Applications are welcome from both U.S. and international researchers, fostering innovation and collaboration in the fight against dementia.
Dementia & Alzheimer’s Disease

A. O. Smith Foundation Grants

A O Smith Foundation Inc
Corporate
Bangladesh, Boone County, Kentucky +34 more
Unspecified amount
The A. O. Smith Foundation, established in 1955, provides grants to support charitable, educational, and human services organizations primarily in communities where A. O. Smith Corporation operates. With a mission focused on enhancing community well-being, the Foundation promotes education, arts, culture, and health initiatives. It encourages employees to engage in volunteerism, fostering a culture of community involvement. Notably, the Foundation does not fund politically active organizations or those primarily aiming to influence legislation.
Art & Culture Human & Social Services Health & Medicine +3 more

Autism Care Today SOS Program

AUTISM CARE TODAY
Private
United States
Up to US $5,000
The Autism Care Today SOS Program is dedicated to providing immediate assistance to families affected by autism across the United States. Established in 2005, this program addresses urgent needs for effective treatments and services for autism spectrum disorders. Unlike typical grant cycles that may take up to 12 weeks, the SOS Program prioritizes those in critical situations, ensuring timely support based on available funding. Eligibility includes a family income below $45,000 and a demonstrated immediate need for treatment.
Autism

Autism Care Today Grant

AUTISM CARE TODAY
Private
United States
Unspecified amount
The Autism Care Today Grant provides vital funding assistance to families affected by Autism Spectrum Disorders across the United States. Since its inception in 2005, it has supported over 1,562 families with more than $1.85 million in grants. The program focuses on enhancing the quality of life for children with autism through various initiatives, including safety measures, assistive technologies, and behavioral therapy funding, while also addressing the unique challenges faced by military families.
Autism

Updated National Dislocated Worker Grant Program Guidance and Application Information

US Department of Labor: Employment and Training Administration (ETA)
Federal Government
United States
US $150,000 - US $10,000,000
The Updated National Dislocated Worker Grant Program Guidance informs workforce development systems about the policies and priorities for using National Dislocated Worker Grant funds. This guidance outlines grant types, funding approaches, performance periods, cost limitations, and application requirements. It emphasizes the critical role of DWGs in supporting economic recovery, community resilience, and equitable workforce development, ensuring that these funds effectively contribute to creating good jobs and enhancing local economies.
Employment Services Workers’ Rights Disaster Relief / Humanitarian Aid

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.
Family Services Minority Services Health Disparities & Social Determinants of Health

Postdoctoral Fellowships

American Diabetes Association Inc
Private
American Samoa, Guam +4 more
US $84,008 - US $252,024
The American Diabetes Association's Postdoctoral Fellowship Awards aim to foster emerging leaders in diabetes research. With a focus on innovative research, these fellowships provide up to three years of funding, including a stipend and allowances. Eligible applicants must hold a recent advanced degree and conduct research at U.S. affiliated institutions. This initiative not only supports career development but also contributes significantly to the mission of preventing and curing diabetes.
Diabetes

AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award in Gastric Cancer

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award provides $100,000 annually for three years to early-career faculty dedicated to gastric cancer research. Eligible candidates must have an MD, PhD, or equivalent and a full-time faculty position in North America. The award supports research in various areas related to gastric cancer, ensuring a minimum of 50% time commitment to the project, thus fostering independent careers in digestive diseases.
Gastrointestinal Cancers

CLRA Research Grant Program

Childrens Leukemia Research Assn Inc
Private
United States
Up to US $30,000
The CLRA Research Grant Program, led by the Children’s Leukemia Research Association, focuses on funding innovative research aimed at uncovering the causes of leukemia and improving treatment options. Grants totaling $30,000 are awarded to U.S.-based researchers, with the intention of advancing scientific understanding and ultimately finding a cure. The program has made significant contributions to the high cure rates for childhood leukemia, showcasing the importance of continued research in this field.
Leukemia

NIMH Career Transition Award for Tenure-Track Intramural Investigators (K22 Independent Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The NIMH Career Transition Award (K22) supports tenure-track intramural investigators at NIMH in their transition to independent research faculty positions. This program aims to foster innovative research in mental health, encouraging applicants with a strong record of research excellence. Key deadlines for applications vary, including those for standard and renewal submissions, emphasizing the importance of timely applications to secure funding and advance mental health research initiatives.
Biology Health & Medicine Medical Education & Professional Training +1 more

Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) (357550)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This initiative aims to support research interventions targeting disparities in liver diseases and liver cancer among underserved populations in the U.S. It encourages innovative approaches to reduce health inequities and improve health outcomes. The funding opportunity is available through various deadlines for both standard and renewal applications, promoting multi-level strategies to address these critical health issues effectively.
Cancer / Oncology Liver Disease Health Disparities & Social Determinants of Health

Alzheimer's Disease Research Grants

BrightFocus Foundation
Corporate
United States
US $200,000 - US $300,000
BrightFocus Foundation offers Alzheimer's Disease Research Grants to support innovative research aimed at understanding, preventing, and treating Alzheimer's disease. These grants encourage applications from diverse backgrounds, fostering creativity in scientific research. The program includes Standard Awards for early investigators with a maximum funding of $300,000 for three years and Postdoctoral Fellowship Awards for young researchers at $200,000 for two years, promoting the development of independent research careers.
Dementia & Alzheimer’s Disease

NCAA Jim McKay Graduate Scholarship

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $10,000
The NCAA Jim McKay Graduate Scholarship honors the legacy of journalist Jim McKay by awarding a one-time $10,000 scholarship to one male and one female student-athlete annually. Eligible candidates must have a minimum GPA of 3.5, demonstrate integrity, and show interest in sports communication. There is no limit to the number of nominations from institutions, highlighting the NCAA's commitment to supporting student-athletes in their academic and professional pursuits.
Sports & Athletics News Media & Communications Journalism

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) (357490)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.
Food Safety Drug Safety

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) (357492)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,050,000
The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.
Food Safety Drug Safety

Unrestricted Grants for Nonprofits in North Carolina Highlights

Looking for unrestricted grants for nonprofits in North Carolina?


Read more about each grant below or start your 14-day free trial to see all unrestricted grants for nonprofits in North Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Unrestricted Grants for Nonprofits in North Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Unrestricted grants for nonprofits in North Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

70 Unrestricted grants for nonprofits in North Carolina over $25K in average grant size

51 Unrestricted grants for nonprofits in North Carolina over $50K in average grant size

35 Unrestricted grants for nonprofits in North Carolina supporting general operating expenses

200+ Unrestricted grants for nonprofits in North Carolina supporting programs / projects

1,000+ Grants on Instrumentl focused on Environment

2,000+ Grants on Instrumentl focused on Community Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Unrestricted grants for Nonprofits in North Carolina?

Most grants are due in the first quarter.

Q1
30.4%
Q2
22.4%
Q3
26.2%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Unrestricted Grants for Nonprofits in North Carolina?

Grants are most commonly $17,500.

$500 $500 Min.
$17,500 $17.5 K Median
$477,452 $477.5 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for North Carolina?

Grants are most commonly $131,121.

$131,121

Total Number of Grants

What's the total number of grants in Unrestricted Grants for Nonprofits in North Carolina year over year?

In 2024, funders in North Carolina awarded a total of 70,602 grants.

2022 63,850

2023 62,335

2024 70,602

Top Grant Focus Areas

Among all the Unrestricted Grants for Nonprofits in North Carolina given out in North Carolina, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Unrestricted Grants for Nonprofits in North Carolina changing over time?

Funding has increased by 15.49%.

2022 $7,927,620,616

2023 $7,987,830,464
0.76%

2024 $9,224,796,270
15.49%

North Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Durham County, Orange County, and Mecklenburg County receive the most funding.

County Total Grant Funding in 2024
Durham County $2,942,551,198
Orange County $2,549,339,233
Mecklenburg County $1,468,677,341
Wake County $1,122,908,782
Buncombe County $444,853,701

Related Grants in North Carolina

Browse Other Nonprofit Operations & Capacity Grants in North Carolina

Browse Grants For Nearby Locations

Browse Grants by Major US Cities within North Carolina