Best Unrestricted Grants for Nonprofits in North Carolina

The OJJDP FY 2026 Expanding Youth Access to Community-Based Treatment program aims to enhance support for youth facing substance use and mental health challenges. This funding opportunity focuses on community-based treatment initiatives that cater to youths with substance use disorders (SUD) and co-occurring mental health conditions. By fostering cross-system strategies, the program seeks to improve outcomes for at-risk youth and reduce recidivism through better access to necessary treatment services.

The PERF: Infrastructure/Registry Research Grant focuses on developing new multicenter infrastructures or enhancing existing programs in pediatric neurology. It aims to advance clinical research, particularly in pediatric epilepsy, supporting projects that train and mentor young investigators. The grant offers up to $300,000 for a duration of three years, with an emphasis on mentorship for both senior and early-stage investigators, ensuring the growth of expertise in the field.

The Great Lakes Bay Community Resource Association Scholarship, founded in May 2023, aims to enhance health outcomes and educational opportunities for underserved individuals. With a focus on human medical-related fields, this scholarship supports students pursuing careers in nursing, psychology, and more. Beneficiaries will engage with professional mentors and gain hands-on experience in community health initiatives. The scholarship reflects a commitment to addressing healthcare disparities and empowering future professionals in the medical field.

The Abbvie Parkinson’s Disease Grant aims to enhance the understanding and management of subcutaneous infusion therapies for advanced Parkinson’s disease. As these therapies become more prevalent, it is crucial for Movement Disorder Specialists and General Neurologists to develop confidence in identifying, mitigating, and managing infusion site events. This grant seeks to provide essential education and resources to support safe and effective treatment options for patients experiencing motor fluctuations.

The NIDCD Research Fellowship for Audiologists provides clinical audiologists enrolled in Ph.D. programs with essential research training. This initiative encourages the integration of clinical and translational research, fostering strong research foundations vital for advancing audiology and hearing healthcare. Although applications are not currently being solicited, the program aims to prepare potential candidates for meaningful collaborations and impactful research projects in the biomedical, behavioral, or clinical sciences.

The BJA FY 2026 Residential Substance Abuse Treatment for State Prisoners Formula Grants Program aims to enhance the capacity of state, local, and tribal governments in providing residential substance use disorder treatment for incarcerated individuals. This funding opportunity supports evidence-based treatment, aids in reintegration into society, and promotes continuity of care through community-based recovery services, ultimately improving outcomes for those with substance use and co-occurring mental health disorders.

The NIJ FY 2026 Research on Gender Dysphoria and Violent Crime funding opportunity aims to support crucial research exploring the connections between gender dysphoria and violent behavior. This initiative seeks to fill gaps in empirical evidence, focusing on aspects such as prevalence rates of violent crime, post-conviction analyses, and the impact of comorbidities on violence. Researchers are encouraged to conduct retrospective data analyses to better understand these complex relationships and inform future treatment and intervention strategies.

The FY26 Reconstructive Transplant Research Program Concept Award encourages innovative research addressing critical issues in reconstructive transplantation. It supports groundbreaking concepts and untested theories, emphasizing creativity and relevance to specific focus areas. Notably, preliminary data presentation is prohibited, yet applications must demonstrate potential for interpretable results. Early-career investigators are particularly encouraged to apply, fostering new talent in this vital research field.

The Summit Credit Union Grant emphasizes charitable giving through partnerships that support equity, financial wellbeing, and women's empowerment. Committed to reducing inequities, the credit union seeks nonprofit organizations that align with these pillars to foster community growth. Eligibility criteria include being a 501(c)(3) nonprofit serving specific areas and submitting an online application. However, funding is not available for individuals, religious or political organizations, or any entities that discriminate based on various identities.

The Japan-U.S. Friendship Commission (JUSFC) is a federal agency established in 1975 to enhance U.S.-Japan relations through educational and cultural exchanges. JUSFC supports various initiatives in arts, education, and global challenges, focusing on fostering partnerships between U.S. and Japanese organizations. The Commission aims to facilitate dynamic people-to-people exchanges, ensuring a robust understanding between the nations and promoting collaborative projects that enrich both societies.

The Chrysalis Fund, managed by the Entomological Society of America, supports K-12 educators in fostering youth interest in insect science. Grants can cover various project expenses, including supplies and travel costs. Funding levels include micro-grants (under $500), regular grants ($500-$999), and large grants ($1,000-$2,500). This initiative encourages innovative educational programs that engage students with entomology, enhancing their learning experience and promoting science education.

The Mary Lou and Dwight Pitman Scholarship supports area public high school students in Sangamon County, excluding Springfield and Chatham districts, who have siblings planning to attend college. Established through the Sangamon County Foundation in 1924, this scholarship honors the legacy of community leaders and aims to empower the next generation by aiding students' educational pursuits. Eligible applicants include graduating high school seniors and current college students who are direct descendants of U.S. Service Members.

The John Edelman Scholarship supports student veterans pursuing careers in mental health counseling, offering five scholarships of $10,000 each. This initiative, funded by Student Veterans of America, emphasizes the importance of mental health support for veterans. Eligible candidates must be enrolled as full-time students in the 2025-2026 academic year and maintain strong academic performance. The scholarship aims to reward exceptional achievement and encourage further study in disciplines that promote mental well-being.

The Winston-Salem Foundation's Women's Fund Grants focus on enhancing economic security for women and girls in Forsyth County, where less than 7% of philanthropic funding targets their needs. This initiative aims to address systemic barriers, improve educational and health outcomes, and foster overall well-being. With the program's priorities including support for organizations led by women of color and those actively involving their community, the Women's Fund is dedicated to building an inclusive economy and empowering marginalized voices.

About Us

For more than eight decades, this principle has remained at the heart of UNCF, enabling us to raise more than $6 billion and help more than 550,000 students and counting not just attend college, but thrive, graduate and become leaders.

We do this in three ways: By awarding more than 11,000 students scholarships, worth more than $62 million, each year. By providing financial support to 37 historically Black colleges and universities (HBCUs). And by serving as the nation’s leading advocate for the importance of minority education and community engagement.

This three-pronged approach is powerful: Since our founding in 1944, we’ve helped to more than double the number of minorities attending college. The six-year graduation rate for UNCF African American scholarship recipients is 70%. This is 11% higher than the national average and 31% higher than the national average for all African Americans.

Thelma M. Shafran Endowed Scholarship

The John Taylor Babbitt Foundation offers grants to support nonprofit organizations in preventing sudden cardiac death through initiatives such as acquiring AEDs and providing CPR training. Applications are accepted on a rolling basis and should include a detailed estimate of funding needs and commitments. The foundation emphasizes timely use of funds and adherence to safety regulations, ensuring a positive impact on diverse populations, including student athletes and vulnerable groups.

The Mark Mayden Scholarship, established in 2006 by the Community Foundation of Dickinson County, honors the legacy of Mark Mayden, a devoted supporter of agribusiness. This $700 scholarship aims to assist hardworking students from Dickinson County in pursuing technical or vocational education, fostering opportunities for future generations. By rewarding initiative and talent, the scholarship reflects Mark's belief in the transformative power of education and hard work, ensuring that deserving students have the support they need to succeed.

The McKnight Brain Research Foundation Innovator Awards aim to support innovative research in cognitive aging and memory loss, offering two 3-year grants of $750,000 each. Targeted at early-career investigators, the program encourages high-risk, high-gain proposals that explore clinical translational research and the biological mechanisms of cognitive aging. By fostering emerging scientific leaders, the initiative seeks to advance transformative discoveries in this critical area of aging research, enhancing understanding and treatment of age-related cognitive decline.

The Loren Engel Memorial FFA Scholarship, established by Margaret Engle in 2005, honors Loren Engel’s dedication to agriculture and leadership. This $300 scholarship is available for graduating high school students from Dickinson County who have served as FFA chapter officers, demonstrating commitment to agricultural education. The Community Foundation of Dickinson County aims to support local students pursuing technical or vocational education, ensuring future generations can thrive in their community.

The Get Out and Get Active Grant by the Anxiety & Depression Initiative supports innovative projects that promote the mental health benefits of physical activity. This funding aims to reduce anxiety and depression through community fitness programs and educational campaigns, emphasizing the intersection of physical activity and mental health. Eligible applicants include nonprofits and academic institutions in the U.S. seeking to enhance well-being and integrate active lifestyles for individuals living with mental illness.

The MCSF Career & Technical Education Scholarship supports children of Marines pursuing non-degree certificate programs. It offers financial assistance to eligible applicants based on need, helping cover tuition, fees, and associated educational costs. With a minimum GPA requirement of 2.00 and a family income cap of $123,000, this scholarship ensures that all qualifying students have access to vocational training at accredited institutions. Applications are accepted year-round, providing flexibility for students.

The Undergraduate Development Program Advisor Travel Award, hosted by the Society of Toxicology, enables faculty advisors to attend the Undergraduate Development Program from March 21-23, 2026. This initiative aims to familiarize advisors with toxicology and encourage them to guide students toward careers in biomedical sciences. Recipients of the award will participate in educational sessions, networking opportunities, and receive support for travel-related expenses, fostering diversity and innovation within the field.

Albert Smith Conservation Scholarship

Albert A. Smith was born in Omer, Mich., in 1913. He began his education in a one room schoolhouse near Omer and successfully completed his first three grades in the first year of school. Upon graduation from Flint Northern High School at age 15, he went on to receive an undergraduate degree from the University of Michigan and thereafter a law degree in 1939. In the mid-1950s, he opened a law office in Saginaw that later became the law firm of Smith Bovill, P.C.

Mr. Smith’s love of the law was matched by his interest in the outdoors, and in particular his beloved Ruffed Grouse. He used his rolling farm and woods to entertain his friends, clients and courtroom adversaries. He was a consummate host to anyone who shared his love for the hunt.

Al was generous with his time and resources. He supported and served on the boards of his favorite charities and civic groups, including the Salvation Army, the Ruffed Grouse Society where he served as national president, the Samaritan Center and First Congregational Church. In 1976, he was recognized for his outstanding conservation work when he received the Wildlife Conservationist of the Year Award from the Michigan United Conservation Clubs.

The Ohio Children’s Foundation Grant aims to enhance the lives of at-risk children and families through funding for early childhood education programs. With nearly $1 million awarded in grants over three years, the Foundation supports initiatives that promote school readiness, advocate for public policies, and provide resources for parents. Prioritizing children aged 0-5, the Foundation seeks innovative programs that address early brain development and minimize toxic stress, ensuring a brighter future for vulnerable families.

The Ken and Eileen Gross Memorial Scholarship, established by friends of the couple, supports Saginaw County high school seniors pursuing a teaching degree. With a focus on fostering education, this scholarship honors Ken, a dedicated educator, and Eileen, a successful property manager. Eligible students must demonstrate a minimum 3.0 GPA and financial need, ensuring that those committed to teaching can pursue their aspirations. Awards typically range from $500 to $4,000, empowering the next generation of educators.

Implementing Germline and Somatic Testing for Precision Medicine in Community-Based Prostate Cancer Care 

The intent of this Request for Proposal (RFP) is to invite organizations to submit applications to host a 2.5-to-3 hour medical education program at or nearby the organization, to be led by 1-2 Visiting Professors (VPs) with expertise matched to the organization’s unmet educational and pragmatic needs related to integrating and acting on germline and somatic (tumor and/or ctDNA) testing for patients with prostate cancer. Following the education program, organizations will implement their action plan to incorporate, increase, or improve the use of guideline-concordant germline and somatic testing to improve prostate cancer patient care.

The total budget for the RFP is $250,000 USD, with plans to support 5-7 organizations. Individual project budgets should not exceed $50,000 USD.

The Numotion Foundation Grants aim to enhance the lives of individuals with mobility disabilities by supporting IRS-designated 501(c)(3) nonprofit organizations. By fostering partnerships with various charities, including national and local organizations, the foundation raises awareness and funds for necessary research and support services. Contributions are made for each new wheelchair sold, ensuring a coordinated approach to charitable giving while prioritizing programs that specifically assist those with mobility-related challenges.