Best Large Grants for Nonprofit Organizations in Northern Mariana Islands

The Waste Management Charitable Contributions Program supports initiatives that enhance environmental stewardship, sustainability education, and community vitality. With a commitment to civic pride and economic development, the program prioritizes organizations that address local needs and promote sustainable practices. Eligible applicants include 501(c)(3) organizations that focus on public purposes, while ineligible requests include funding for operating costs and individual fundraising events. This initiative fosters a collaborative approach to community betterment.

The BRAIN Initiative's BBQS Program aims to revolutionize the study of brain function by facilitating high-resolution tracking of complex behaviors alongside neural activity. This transformative research opportunity seeks to develop innovative tools for minimally intrusive measurements of various biobehavioral functions while accounting for environmental variables. Emphasizing transdisciplinary collaboration, it focuses on creating new analytical frameworks that model neurobehavioral function as dynamic systems influenced by an organism's surroundings, thereby advancing our understanding of behavior at the organismal level.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.

The NIA Research and Entrepreneurial Development Immersion (REDI) program aims to enhance entrepreneurial education for graduate students and early-career scientists in aging and Alzheimer's research. This initiative prepares trainees for diverse career paths beyond traditional research, focusing on vital skills such as scientific communication, intellectual property, and market needs assessment. Through innovation-focused applications, the REDI program seeks to increase the number of Ph.D.-trained scientists ready for various career opportunities in translational sciences and entrepreneurship.

The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) aims to create a secure, scalable cloud platform for genetic data related to Alzheimer’s disease. This initiative will enhance data accessibility, promote interoperability, and support rigorous research practices. By facilitating collaboration and providing robust analytical tools, the platform will maximize the scientific impact of AD/ADRD research, aligning with NIH goals for transparent and reproducible science, while addressing recommendations for broad access to high-value datasets.

The U.S. Wildland Fire Service Joint Fire Science Program (JFSP) invites proposals for regional fire science exchanges across nine designated regions in the U.S. This initiative aims to promote the sharing of fire science knowledge and practices over a two-year period. Eligible applicants can focus on regions including Alaska, Appalachians, Great Basin, North Atlantic, Northern Rockies, Northwest, Oak Woodlands, Pacific Islands, and Southwest. Proposals must be specific to one region.

The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.

The FY26 Parkinson’s Research Program Investigator-Initiated Research Award supports innovative, multidisciplinary research projects aimed at advancing the understanding and treatment of Parkinson’s disease. The award encourages collaboration among multiple principal investigators, requiring preliminary data and allowing clinical trials to enhance research outcomes. This initiative is vital for fostering impactful discoveries within the four specified focus areas of the program, ultimately improving patient care and management.

The NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32) supports rigorous biomedical research training and dissertation research for doctoral candidates in clinical, behavioral, or biomedical sciences. Funded by the NIH, this fellowship aims to enhance research capabilities and knowledge in the field of audiology. Key deadlines for applications include April 8, August 8, and December 8 for the years 2025 to 2027, ensuring timely opportunities for aspiring researchers.

The FY26 Parkinson’s Research Program (PRP) Early Investigator Research Award supports early-career researchers in Parkinson’s disease (PD) research. It offers two funding levels: Level 1 for fellows requiring a Mentor and Level 2 for independent investigators. The PI must show potential in PD research, with Level 1 emphasizing mentorship and Level 2 needing preliminary data. Research must align with one of the four FY26 PRP Focus Areas, excluding clinical trials.

The CERF: Artist Get Ready Grant offers up to $1,000 to craft artists for safeguarding their studios and preparing for emergencies. Priority is given to underrepresented artists, including BIPOC and folk/traditional artists. Eligible activities encompass studio safety upgrades and disaster readiness. Applicants must be 18 years or older, residing in the U.S. for two years, and not have received this grant in the previous year. Funds must be used within six months, with outcomes documented for CERF+.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.

The Craft Artists Emergency Relief Grant provides $3,000 to U.S.-based individual craft artists aged 18 and older who are facing recent, unforeseen emergencies. Established by the Craft Emergency Relief Fund (CERF+) in 1985, this grant aims to empower artists during critical times, allowing them to use the funds as needed for recovery. Applications are accepted on a rolling basis, ensuring timely support for artists in distress.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

The Trans Justice Funding Project (TJFP) provides grants to grassroots trans-led organizations in the U.S. and territories, focusing on those with budgets under $250,000. TJFP supports initiatives that address varying needs within trans communities, including health, legal aid, and mutual aid projects. The organization prioritizes groups led by trans people of color and emphasizes the importance of centering marginalized voices in the fight for trans justice.

The KUH P30 Resource Core Center funding opportunity invites applications for centers aimed at enhancing research in Kidney, Urology, and Hematology diseases. These centers will provide essential resources, including data and tools, to the research community, fostering collaboration through a national network with the Center Coordinating Hub. This initiative by the National Institutes of Health aims to drive innovative research and shared expertise for improved health outcomes.

The NEI Collaborative Clinical Vision Research program aims to support innovative clinical trials focused on chronic eye diseases. This funding opportunity encourages multifaceted research addressing the causes, treatment, and rehabilitation of vision conditions, ensuring comprehensive oversight by the NIH. The program includes components like Chair's Grant and Coordinating Centers, fostering collaboration among researchers to enhance public health outcomes related to vision.

The KUH U24 Center Coordinating Hub aims to foster collaboration among funded Centers within the NIDDK/KUHN mission. This initiative encourages the development and sharing of vital research resources, including data, reagents, and expertise, with the broader scientific community. By creating a national network, the program enhances research capabilities and promotes innovative solutions in kidney, urology, and hematology diseases.

The Fiscal Year 2026 Flood Mitigation Assistance program aims to enhance flood mitigation funding delivery, focusing on the needs of disaster survivors. This federal initiative, managed by FEMA, provides essential funds to states, territories, and local governments to mitigate flood risks and reduce repetitive damage to properties insured under the National Flood Insurance Program. The program supports various activities designed to lower the financial exposure of the NFIP while promoting community resilience against flooding.

The Cancer Health Equity Research Centers (CHERCs) initiative by the American Cancer Society aims to address health disparities by supporting research focused on social determinants affecting cancer care. This program encourages innovative projects that engage communities, enhance access, and improve outcomes across diverse populations. By fostering collaborations and promoting multidisciplinary approaches, CHERCs strive to create equitable cancer prevention and treatment solutions, ensuring that all individuals have fair opportunities for cancer care and survivorship.

The NIDDK Multi-Purpose Resource-Related Research Centers Cooperative Agreement (U2C) invites applications to enhance research capabilities in areas such as obesity and diabetes. These centers provide specialized services, including technical support and data coordination, primarily to clients at other institutions lacking necessary expertise. This initiative aims to bolster high-impact research through collaboration and experiential training, addressing critical health challenges aligned with NIDDK's mission.

The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.

The DoW Bone Marrow Failure Idea Development Award supports innovative, high-impact research aimed at understanding and curing bone marrow failure diseases. This grant is available to both Established Investigators and Early-Career Investigators, with no preliminary data required for applications. Reviewers assess proposals based on specific criteria tailored to the investigator's career stage. The focus is on achieving interpretable results that contribute significantly to the field.

The National Institute of Dental and Craniofacial Research (NIDCR) is set to announce a funding opportunity for clinical trials and observational studies within its Dental Primary Care Practice-Based Research Network (PBRN). This initiative aims to enhance the integration of oral and medical health by facilitating research conducted in dental practices. While applications are not currently being accepted, this notice serves to encourage collaborations that will lead to impactful projects in whole-person health.

The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.