Best Large Grants for Nonprofit Organizations in Oregon

The Jackson Foundation, established by Maria C. Jackson, provides funding for charitable, educational, and welfare-related projects primarily within Oregon. Governed by trustees, it aims to enhance public welfare in Portland and statewide. The Foundation does not support individual grants or private businesses and typically limits funding to one grant per organization annually. It considers projects of broader appeal outside the Portland area, ensuring that its contributions effectively promote community welfare.

National Coastal Wetlands Conservation Grants

The National Coastal Wetlands Conservation Grants Program annually provides grants of up to $1 million to coastal and Great Lakes states, as well as U.S. territories to protect, restore and enhance coastal wetland ecosystems and associated uplands. The Program is funded by revenues collected from excise taxes on sport fishing equipment, electric motors and sonar, import duties on fishing tackle, yachts and pleasure craft, a portion of the gasoline tax attributable to motorboats and small engines, and interest on the fund, under the authority of the Dingell-Johnson Sport Fish Restoration Act of 1950.

Eligible projects include the acquisition of real property interest in coastal lands or waters and the restoration, enhancement, or management of coastal wetlands ecosystems.

OWEB Coastal Wetlands Grants

The U.S. Fish and Wildlife Service (USFWS) National Coastal Wetlands Conservation Grant Program (NCWCGP) was established to acquire, restore, and enhance wetlands in coastal states through competitive matching grants to state agencies. The primary goal of the NCWCGP is the long‐term conservation of coastal wetland ecosystems. Only legislatively approved state agencies may submit applications to the NCWCGP. Since 2013, OWEB has been an approved agency. OWEB serves as the official grantee of the federal award and makes the federal funds available to local conservation and restoration partners through sub-grants. All sub-grants are subject to the Rules and guidelines of OWEB’s grant programs.

Eligible Projects

All projects must ensure long-term conservation.

Eligible projects under the NCWCGP include:

• Acquisition of a real property interest (permanent conservation easement or fee title) in coastal lands or coastal wetlands ecosystems from willing sellers, and/or
• Restoration, enhancement, or management of coastal wetlands ecosystems.

Restoration Grants

OWEB issues a solicitation for Coastal Wetlands Restoration Grant applications in the spring of each year.

The Rose Grant is a competitive funding opportunity aimed at supporting Oregon-based nonprofits with operating budgets over $250,000. Grants typically range from $25,000 to $35,000 annually, with possible awards between $10,000 and $75,000. Organizations are encouraged to demonstrate a commitment to diversity and financial readiness. The grant application is shared with the Daffodil Grant program, and funding decisions are expected within 3-4 months after the application period closes.

The Zinnia Grant is a competitive funding opportunity aimed at making a significant impact in Oregon organizations. It typically awards between $250,000 and $350,000 annually for a three-year term. Eligible applicants must have an operating budget over $1M and a proven track record of previous grants. This grant emphasizes a commitment to equity and is designed to streamline the application process for organizations aligned with the foundation's mission.

The Reser Family Foundation's Midsize Grant Program supports organizations in Oregon with annual budgets over $1.2 million. Grants range from $12,500 to $50,000 and prioritize innovative projects in Education, Health, Arts, and Environment. Eligible applicants must be established 501(c)(3) organizations for over three years and demonstrate community impact. Applications require a letter of support and collaboration with funding partners. The foundation does not fund organizations involved in active litigation or one-time events.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Planning and Demonstration Grants

Planning and Demonstration Grant Eligibility Requirements

Eligible activities for a Planning and Demonstration Grant include: develop a new Action Plan, conduct supplemental safety planning to update an existing Action Plan, or carry out safety demonstration activities to inform the development of or update to an Action Plan.

These activities may be bundled in any combination, provided that the requirements in this Notice are met. DOT encourages complementary but distinct activities, including but not limited to safety demonstration activities that will help inform the development of an Action Plan. Any applicant that meets the eligibility requirements may apply for a Planning and Demonstration Grant to develop an Action Plan. 

• Expected number of awards: 400 to 700

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Implementation Grants

Implementation Grants fund projects and strategies identified in an Action Plan that address roadway safety problems. Implementation Grants may also fund supplemental planning and demonstration activities, as well as project-level planning, design, and development activities for projects and strategies identified in an Action Plan (e.g., project-level 21 National Environmental Policy Act (NEPA) compliance, associated environmental review activities, permits and approvals, construction design, etc.). 

• Expected number of awards: 40 to 70

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

Cambia Health Foundation seeks to improve health care through focused investments in the health care workforce. They aim to expand, diversify, and train professionals to address behavioral health provider shortages. By enhancing both paid and unpaid workforce sectors, Cambia fosters wellness, reduces stigma, and promotes collaborative care models. Their commitment to health equity reflects in their strategic areas of investment, ensuring everyone has the opportunity for better health outcomes.

Oregon Health Authority

The Oregon Health Authority is at the forefront of lowering and containing costs, improving quality and increasing access to health care in order to improve the lifelong health of people in Oregon.

Mission: Ensuring all people and communities can achieve optimum physical, mental, and social well-being through partnerships, prevention, and access to quality, affordable health care. OHA will transform the health care system in Oregon by: improving the lifelong health of people in Oregon, increasing the quality, reliability, and availability of care for all people in Oregon and lowering or containing the cost of care so it's affordable to everyone.

Regional Source Water Collaborative Project Grant

The Drinking Water Source Protection Fund (DWSPF) is designed for the protection of drinking water sources. Drinking water sources include watersheds above a public water supply surface water intake and/or the delineated portion of the aquifer supplying water to public water supply wells or springs. 

Regional Source Water Collaborative Project grants are being piloted by the agencies to strengthen public water system regional ties and cooperation on source water protection and therefore improve source water resiliency across Oregon. The grants are intended to support projects that reduce risks and foster coordination among public water systems using groundwater and surface water sources. Each grant must dedicate funds to projects within source areas serving smaller water systems (serving fewer than 3,300) that are located inside a larger water system’s (or collaborative’s) drinking water source area(s). Eligible projects must involve at least three smaller water system partners and provide protection benefits to multiple water systems involved in the project. The expectation is that roughly half of the project expenses will be directed at the smaller water systems’ drinking water source areas that are Official Partners to the project. This initiative aims to foster regional coordination and improve source water protection for underserved communities. 

Oregon Health Authority

The Oregon Health Authority is at the forefront of lowering and containing costs, improving quality and increasing access to health care in order to improve the lifelong health of people in Oregon.

Mission: Ensuring all people and communities can achieve optimum physical, mental, and social well-being through partnerships, prevention, and access to quality, affordable health care. OHA will transform the health care system in Oregon by: improving the lifelong health of people in Oregon, increasing the quality, reliability, and availability of care for all people in Oregon and lowering or containing the cost of care so it's affordable to everyone.

Land Acquisition (Conservation) Planning Grant

The Drinking Water Source Protection Fund (DWSPF) is designed for the protection of drinking water sources. Drinking water sources include watersheds above a public water supply surface water intake and/or the delineated portion of the aquifer supplying water to public water supply wells or springs. 

Land Acquisition (Conservation) Planning grants are for conservation purposes directed at the preservation of land to protect, restore, or enhance sources of drinking water serving eligible public water systems. Eligible conservation planning projects can include any studies or activities that involve or are related to assessing legal and/or financial feasibility of purchasing land, easements, or similar projects within an identified drinking water source area. 

Oregon Health Authority

The Oregon Health Authority is at the forefront of lowering and containing costs, improving quality and increasing access to health care in order to improve the lifelong health of people in Oregon.

Mission: Ensuring all people and communities can achieve optimum physical, mental, and social well-being through partnerships, prevention, and access to quality, affordable health care. OHA will transform the health care system in Oregon by: improving the lifelong health of people in Oregon, increasing the quality, reliability, and availability of care for all people in Oregon and lowering or containing the cost of care so it's affordable to everyone.

Traditional Drinking Water Source Protection Grant

The Drinking Water Source Protection Fund (DWSPF) is designed for the protection of drinking water sources. Drinking water sources include watersheds above a public water supply surface water intake and/or the delineated portion of the aquifer supplying water to public water supply wells or springs. 

Traditional Drinking Water Source Protection grants are for projects that promote reducing risks associated within a drinking water source area or the refinement of a drinking water source area. Projects can involve one or more eligible public water systems that are equal partners in the project. 

The Sabbatical Research and Education Grant, offered by Western SARE, enables faculty worldwide to collaborate with farmers and researchers in the Western U.S. This program focuses on conducting innovative research and educational outreach in underserved regions, with an emphasis on unexplored topics. Grants up to $75,000 are available for projects spanning one year, promoting agricultural sustainability and community involvement.

The Formula Grants for Rural Areas program, managed by the Oregon Department of Transportation, enhances public transportation in rural communities with populations under 50,000. It funds operations, capital projects, and planning efforts, distributing funds every two years based on a formula that considers base amount, passenger trips, and service miles. Eligible recipients include local governments and non-profits dedicated to improving mobility management and transit services in these underserved areas.

The AmeriCorps Oregon Planning Grants offer funding to assist organizations in developing new AmeriCorps programs that tackle community challenges. These cost-reimbursement grants provide essential resources for planning and capacity building. Successful applicants receive training and technical assistance from OregonServes, enhancing their ability to implement compliant programs. By completing the planning grant, organizations will be better positioned to apply for fully-funded AmeriCorps grants in the future. Applications are accepted year-round with a final deadline of December 29.

The Oregon Community Foundation's Community Grants Program provides vital funding to nonprofits addressing pressing community needs across Oregon. With a commitment to equitable access, the program supports innovative solutions that foster connection and belonging among diverse populations. The initiative prioritizes funding for new and expanding projects, capacity-building, and small capital improvements, empowering organizations to create lasting impact. This responsive approach has been shaped by local voices and aims to enhance community resilience and address systemic inequities.

The Daffodil Grant is a highly competitive grant program aimed at supporting impactful organizations in Oregon. With funding typically ranging from $100,000 to $125,000 per year, it provides opportunities for multi-year commitments. Eligible applicants must demonstrate a commitment to diversity, equity, and inclusion, as well as financial stability. This program prioritizes organizations aligned with its mission and values, ensuring meaningful investments in the community. Applications are assessed rigorously, with funding decisions expected within 3-4 months.

The Slave 2 Nothing Foundation supports 501(c)(3) organizations addressing human trafficking and substance abuse in states with In-N-Out Burger locations. Their mission is to empower individuals to overcome enslavement by providing essential resources and support. The foundation follows a rigorous vetting process for grant applications, emphasizing the importance of impactful solutions and community engagement. They encourage eligible nonprofits to apply annually, promoting sustainable support for vital services aimed at healing and freedom.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

Wayne D Kuni And Joan E Kuni Foundation

Wayne and Joan Kuni were known for their quiet yet profound commitment to community service. Their philanthropy touched countless individuals throughout the Pacific Northwest and included financial support and hands-on volunteer efforts to support medical, educational and human services organizations. Both had their own unique approach to service and a commitment to long-term impact that resonates today through the work of the Kuni Foundation.

We advance the promise of human potential by investing in cancer research and accelerating the inclusion of individuals experiencing intellectual and developmental disabilities (IDD).

Discovery Grants for Cancer Research: Advancing Innovation

We embrace cancer research that takes a bold, collaborative and equity-focused approach, and we consider risk a necessity. We also recognize the importance of research that continues to refine and improve existing approaches. Discovery Grants fund both early and established cancer research in the quest for improved detection, treatment and outcomes.

Discovery Grants funding can be utilized for:

• Research that builds a greater understanding of cancer development and growth
• Research on the cusp of the “next stage” including early research or late-stage research ready for clinical trial
• Research activities seeking to reduce disparities by targeting improved access, treatment and outcomes for marginalized communities
• Research that identifies and dismantles barriers to underserved communities to increase the diversity of clinical participants, population cohorts, and clinical samples
• Research focused on rare forms of cancer or cancer research that is traditionally under-resourced and has seen little development in a decade or more

Projects that demonstrate collaboration and data sharing across a range of institutions and/or disciplines are highly encouraged. However, the principal investigator(s) must be located in Washington or Oregon.

The 2026 Carceral Systems Organizing Grant seeks to support organizations working to eradicate carceral systems, create alternative justice solutions, or pursue system reform by addressing systemic criminalization that disproportionately targets Black, Indigenous and people of color (BIPOC) and low-income/poor communities across our five-state region.

We define carceral systems organizing broadly to include all systems that criminalize people’s lives based on race, poverty, gender, immigration status and/or disability. Examples include but are not limited to: 

• Abolition, transformative justice, and alternatives to incarceration
• Ending racial profiling and police brutality
• 'Addressing racial inequities in drug laws
• Child welfare, foster care, child protective services
• Youth incarceration and the school-to-prison pipeline
• Detention and deportation of immigrant communities
• Homeless encampment sweeps and criminalization of survival needs
• Re-entry organizing by and for folks who were recently incarcerated

Oregon Parks and Recreation Department

The mission of the Oregon Parks and Recreation Department (OPRD) is to provide and protect outstanding natural, scenic, cultural, historic and recreational sites for the enjoyment and education of present and future generations. Its vision is to take the long view to protect Oregon's special places and provide the greatest experience while creating stable future funding.

The department was created as a branch of the Highway Department in 1921. The 1989 Legislature created a separate Parks and Recreation Department, effective in 1990. State park user fees, Oregon Lottery dollars, and recreation vehicle license fees are the main fund sources for department activities.

Recreational Trails Program

The Recreational Trails Program (RTP) is a federally funded grant program administered by the Oregon Parks and Recreation Department. Since 1993, Oregon has funded over 500 projects with RTP funds to develop, improve, or expand motorized and non-motorized trails and their facilities.

• Eligible projects include:
  • Construction of new trails
  • Major rehabilitation of existing trails
  • Development or improvement of trailhead or other support facilities
  • Acquisition of land or easements for the purpose of trail development
  • Safety and education projects

CommonSpirit Health offers the Community Health Improvement Grant to enhance health equity and service systems for underserved populations. Through collaborative efforts with 501(c)(3) organizations, this initiative provides financial support for essential health projects. Grant amounts range from $19,500 for small grants to $150,000 for standard grants, varying by hospital. Participating hospitals include those under Catholic Health Initiatives and Dignity Health, aimed at addressing significant community health needs.

The Conservation Partners Grant Program, funded by the National Fish and Wildlife Foundation, supports private landowners in implementing regenerative agriculture and conservation practices. By awarding competitive grants, the program facilitates technical assistance for developing management plans and best practices, enabling landowners to maximize the ecological benefits of their lands. This initiative is crucial for enhancing fish and wildlife habitats, addressing pressing conservation issues, and promoting sustainable land stewardship across the United States.

The Community Grants Program - Spring Cycle, led by The Oregon Community Foundation, aims to empower small rural and culturally responsive organizations across Oregon. With a commitment to philanthropy, this initiative focuses on fostering impactful community change. The 2026 Spring Cycle invites eligible organizations to apply, ensuring their missions align with the program's goals. For those not fitting this cycle, a second opportunity will be available later in 2026, promoting inclusivity in funding.

The Trail Blazers LIVE Grant, presented by Avangrid Renewables, aims to empower organizations in Oregon and SW Washington that connect youth to environmental education and employment. With grants of up to $25,000 annually, and potential additional funding for a total of $50,000, this initiative supports efforts to engage historically underserved communities in sustainability and environmental stewardship. Eligible organizations are encouraged to apply and contribute to a greener future.

Out of School Time

Oregon Community Foundation (OCF) has identified out-of-school time as an opportunity to combat socioeconomic, geographic, and racial inequities in student success. Research has shown that quality out-of-school time programs that have a robust SEL focus can support positive youth development and increase engagement with school, thus improving attendance, boosting academic performance, and increasing the likelihood of high school graduation and post-secondary attainment. 

OCF seeks proposals from out-of-school time programs in Oregon that wish to participate in a three-year, highly structured SEL program quality improvement Learning Community. Interested organizations should already be familiar with continuous program quality processes and wish to deepen their SEL program quality.   Programs must serve youth from low-income families, youth of color and/or youth from under-resourced rural communities.