Best Grants for 501(c)(3) in Pennsylvania

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Mellon Foundation's Economic Development Grant Program aims to address economic disparities in Pittsburgh and southwestern Pennsylvania by enhancing workforce skills and creating job opportunities. The program focuses on talent development, workforce systems, and community building, advocating for innovative education and training that aligns with future job markets. It seeks proposals that promote 21st-century skills, foster entrepreneurship, and support underrepresented groups, ultimately driving economic independence and community vitality.

The Marilyn Lichtman Foundation supports non-profit organizations that align with its mission of aiding those in need, preserving wildlife, and assisting American armed forces and veterans. Grant applications must comply with Section 501(c)(3) of the IRS code and the foundation's specific guidelines. However, applications from for-profit organizations, political entities, government bodies, and individuals are not accepted. The foundation aims to make a meaningful impact in the community.

The Connelly Foundation Grant, established in 1955, aims to create access and opportunities for those in need, particularly in the Philadelphia area. Focused on education, human services, and cultural initiatives, it supports nonprofits that enhance Catholic education, address essential needs, and promote civic engagement. The Foundation seeks to partner with organizations demonstrating effective leadership and sustainable practices, while avoiding direct grants to individuals or funding for advocacy and charter schools.

Ted Gacomis Scholarship for Civil Engineering

Mission Statement

Ted Gacomis worked with several civil engineering firms in Chester County. For thirty plus years, he was part of Edward B. Walsh (EBW) & Associates, based in Exton, PA, where he became a Partner and Vice President. The EBW family and the many County township officials with whom he worked were a very important part of his life.

Ted offered his engineering skills to many organizations as a volunteer, including Habitat for Humanity and Operation Honduras, the latter holding a very special place in his heart as he volunteered there for more than twelve years.

Ted was more than a Civil Engineer; it was very important to him to mentor and support future generations of young men and women in his profession. He offered his time and knowledge freely and was never too busy to answer a question. Along with this “teaching” came, of course, the jokes and sense of humor he loved to share.

He was born in Kingston, PA and graduated from Wyoming Valley West High School. He then attended the Pennsylvania State University to study Civil Engineering, which was followed by receiving his engineering license. Prior to joining EBW, Ted’s first professional employment was with the Pennsylvania Department of Transportation, where he continued his learning, including that of adding to his repertoire of practical jokes. Ted loved to have fun with his co-workers and friends.

A gentleman, scholar, true friend, and a humble man, Ted would be so pleased to be honored with a scholarship bearing his name that would help a young person know what it means to be a person of integrity, compassion and hard work pursuing a degree in civil engineering.

Because Ted was a dear mentor to many, Howell Engineering, a full service civil engineering/land surveying/environmental firm, located in West Chester, PA, will provide, in addition to the scholarship, a summer internship complete with a mentoring opportunity. Engineering interns would be exposed to all facets of civil engineering design and the latest AutoCAD design software as well as drone technology. Howell performs civil site design engineering and land surveying for a wide variety of clients including residential, commercial and industrial real estate developers.

Guidelines

The Ted Gacomis Scholarship for Civil Engineering awards a scholarship of $1,000 to one high school senior, who will pursue a degree in civil engineering and to offer an internship at a local engineering firm.

The Just Born Corporate Giving Grant Program aims to enhance the well-being of children and families in need by supporting initiatives in arts, education, health, and community development. The program focuses on opportunities that benefit underserved populations, emphasizing diverse leadership and community engagement. Grants prioritize projects that promote cultural enrichment, educational access, and essential health services, ultimately fostering a collaborative and inclusive environment for all. Through strategic partnerships, Just Born Quality Confections is committed to making a meaningful impact in its local communities.

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

CommonSpirit Health offers the Community Health Improvement Grant to enhance health equity and service systems for underserved populations. Through collaborative efforts with 501(c)(3) organizations, this initiative provides financial support for essential health projects. Grant amounts range from $19,500 for small grants to $150,000 for standard grants, varying by hospital. Participating hospitals include those under Catholic Health Initiatives and Dignity Health, aimed at addressing significant community health needs.

The DCNR Circuit Rider Grant offers funding to support the hiring of full-time staff for regional park, recreation, and conservation initiatives. Eligible applicants include county and municipal governments, as well as multi-municipal agencies. Grant funding covers salaries and approved training expenses, decreasing over four years from 100% in the first year to 25% in the fourth year. This program enhances local capacity for effective recreation and conservation management.

The Alston Beech Foundation Grant supports nonprofit organizations with clear, identifiable needs in the North Central Philadelphia area. Grants are available for strategic planning, program expansion, organizational capacity building, and initiatives focused on education, arts, and community safety. Eligible organizations must be 501(c)(3) certified, operational for at least two years, and comply with specific income and employment criteria. Applications are limited to one per organization annually, promoting sustainable community development.

Pennsylvania Department of Labor & Industry

The Department of Labor & Industry (L&I) employs more than 5,000 workers in 200 offices statewide. Established in 1913, the department originally inspected the working conditions in factories around the state. Over time, the department's responsibilities expanded.

L&I administers benefits to unemployed individuals, oversees the administration of workers' compensation benefits to individuals with job-related injuries, and provides vocational rehabilitation to individuals with disabilities. The department prepares job seekers for the global workforce through employment and job training services for adult, youth, older workers, and dislocated workers. In addition, L&I enforces various laws and safety standards in the workplace and administers the commonwealth's programs for community service by young Pennsylvanians. L&I also promotes economic development and an improved business climate through a variety of initiatives and programs to help Pennsylvania's workforce remain world-class and globally competitive.

Pennsylvania’s Workforce Professionals in Digital Infrastructure (WPDI)

The Pennsylvania Department of Labor & Industry (L&I) announces the availability of approximately $2 million in funding through the Workforce Professionals in Digital Infrastructure (WPDI) Grant. One grant will be awarded through a competitive process. L&I developed this grant opportunity as part of a broader, collaborative framework to align workforce strategies with both regional economic development goals and statewide priorities. The WPDI Grant is designed to support the development of a comprehensive investment plan focused on building regional capacity and creating industry-led solutions to ensure Pennsylvanians have the appropriate skills and experiences essential to the construction, power, supply and operations of Pennsylvania’s digital infrastructure—particularly in the data center sector.

Training and workforce strategies funded through this grant will be data-informed and guided by labor market insights. The goal is to ensure that the resulting employment opportunities are high-quality—offering strong wages, benefits, career advancement potential, and alignment with industry standards for worker protections and long-term stability—including those commonly associated with union-covered roles. The selected awardee will create a regional response team of dedicated partners with the expertise, experience and capacity to jointly address the in-demand workforce needs of a data center located in Salem Township, Luzerne County.

The FirstBank Charitable Foundation (FBCF) is a 501(c)(3) nonprofit established in 2008, focused on supporting charitable organizations in New Jersey, Pennsylvania, and Florida. With over a million dollars awarded, FBCF aims to enhance community well-being through partnerships in health, housing, and education. Nonprofits aligning with FBCF's mission and demonstrating significant service impact are encouraged to apply for grants, fostering a stronger fabric within their neighborhoods.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The William Penn Foundation's Arts and Culture Programming aims to enhance access to diverse high-quality arts experiences for all Philadelphians. With a focus on inclusivity and equity, this initiative invites proposals for projects that address historic inequities in arts access and engage communities through performances and exhibitions. Organizations with less than $750,000 in annual expenses are encouraged to apply for funding to support innovative and welcoming arts initiatives that enrich the cultural landscape through 2035.

The Chester County Community Foundation offers funding through its Field of Interest and Donor Advised Funds, supporting nonprofits in various sectors such as arts, education, and health. Grants range from $500 to $7,500, with proposals accepted year-round. Eligibility requires nonprofits to be based in Chester County and have budgets of $500,000 or less. The foundation aims to enhance the effectiveness of local organizations through capacity-building initiatives.

About Northeast SARE

The Northeast Sustainable Agriculture Research and Education (SARE) Program offers grants and education to farmers, educators, service providers, researchers and others to address key issues affecting the sustainability of agriculture throughout our region.

The program serves Connecticut, Delaware, Massachusetts, Maryland, Maine, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, West Virginia, and Washington, D.C. The program is administered by Northeast SARE's host institution, the University of Vermont.

Farming Community Grant Program

The Northeast SARE Farming Community Grant applies social science research and education projects that strengthen farming and food systems at the community level.

These projects explore innovative approaches to improving the health and sustainability of agricultural communities in the Northeast. This program supports projects that are grounded in community partnerships and informed by the lived experiences of farmers. It encourages collaboration among farmers, service providers, researchers, and nonprofit organizations to co-create solutions that are responsive to local needs and scalable across the region.

This program encourages innovative solutions to challenges in farming and food systems in the Northeast USA, including but not limited to the areas of: Marketing and business; Crop production; Raising livestock; Aquaculture; Economic and social sustainability; Ecological knowledge; Projects related to climate and/or bioenergy work that provide direct or indirect benefits to farmers,ranchers, and private foresters; and more.

Technical Assistance Program

Applicants and grantees of the Farming Community Grant Program are eligible for Technical Assistance (TA) provided by Northeast SARE’s Technical Assistance Providers.

Funding: This grant is reimbursement based; you must spend money to receive the grant funds.

The John Crain Kunkel Foundation Grant supports initiatives that enhance the quality of life for individuals in Pennsylvania. Focused on charitable, educational, and scientific purposes, the foundation prioritizes projects in Dauphin, Cumberland, Lebanon, Perry, and Juniata Counties. Grants may extend to organizations outside Pennsylvania that benefit communities within the state. Applications are accepted from January 1st to September 1st, with specific eligibility requirements including proof of tax-exempt status.

Endowment Act - CACs/DVSOs Grant Program

Overview:

Act 1 of 2013, better known as the “Endowment Act,” directs PCCD to distribute $48 million in National Collegiate Athletic Association (NCAA) monetary penalties levied on the Pennsylvania State University (PSU) to the victims of child sexual abuse in the Commonwealth.

Act 1 states: “Unless otherwise expressly stated in the agreement, the funds may only be used within the Commonwealth for the benefit of the residents of this Commonwealth and on any of the following:

• Programs or projects preventing child sexual abuse and/or assisting the victims of child sexual abuse.
• Multidisciplinary Investigative Teams established under 23 Pa.C.S. (relating to domestic relations).
• Child Advocacy Centers.
• Victim service organizations that provide services to children subjected to sexual abuse.
• Training of persons who are mandated by law to report child sexual abuse or to treat victims of child sexual abuse.”

The Pennsylvania Commission on Crime and Delinquency (PCCD) is now accepting applications for funding under the Endowment Act, specifically for Categories 3 (Child Advocacy Centers (CACs)) and 4 (Direct Victim Service Organizations that provide services to children subjected to sexual abuse (DVSOs)). 

Funding Availability:

A total of $3,000,000 in state Endowment Act Categories 3 (CACs) & 4 (DVSOs) funds is being announced to support this initiative. PCCD expects to fund 30 grants with budgets not to exceed $100,000 over the 2-year project period.

Applicant agencies may submit only ONE application under this funding announcement. Due to the competitive nature of these funds, PCCD is not able to provide guidance to applicants on which category they should select.

At the direction of the Child Advocacy Center Advisory Committee (CACAC), at least $1.5 million of the funding (50% of the total released) is to be reserved for Category 3 (CACs) applicants. Should the amount requested under Category 3 exceed 50% of the requested funding, then the amount awarded under each category will be dependent on the percentage of the total dollar amount requested under each category. For example, if 60% of the funding is requested under Category 3 (CACs), and 40% of the funding is requested under Category 4 (DVSOs), then $1,800,000 (60% of available funding) would be allocated to support CAC applicants and $1,200,000 (40% of available funding) would be allocated to support DVSO applicants.

PCCD is not liable for costs incurred prior to the official start date of the award. 

The Sewage Facilities Grant Program, established under Act 13 of 2012, utilizes funds from the Marcellus Legacy Fund to support compliance with the Pennsylvania Sewage Facilities Act. This program aims to cover costs associated with the necessary planning work under Act 537, facilitating effective sewage management across the state.

The Gordon Kirkland Lifetime Achievement Award, awarded biennially by the Pennsylvania Chapter of The Wildlife Society, honors mid-career or later professionals for their exceptional contributions to wildlife ecology and conservation in Pennsylvania. This peer-nominated award recognizes individuals for their achievements and dedication through wildlife-inspired artwork, emphasizing their impact on conservation efforts. Support letters are crucial in the nomination process, highlighting candidates’ academic, professional, and community engagement in wildlife-related initiatives.

The National Coastal Resilience Fund (NCRF) aims to protect coastal communities through nature-based solutions, enhancing habitats while addressing the growing threats of climate change. Established in 2018, the fund focuses on restoring vital ecosystems like marshes and reefs to mitigate flooding impacts. With rising sea levels and increasing storm intensity, NCRF invests in community-led projects that foster resilience, ensuring both people and wildlife can adapt to changing environmental conditions.

The Waste Management Charitable Contributions Program supports initiatives that enhance environmental stewardship, sustainability education, and community vitality. With a commitment to civic pride and economic development, the program prioritizes organizations that address local needs and promote sustainable practices. Eligible applicants include 501(c)(3) organizations that focus on public purposes, while ineligible requests include funding for operating costs and individual fundraising events. This initiative fosters a collaborative approach to community betterment.

The Stimulating Hematology Investigation: New Endeavors (SHINE) program aims to enhance nonmalignant hematology research aligned with the goals of the NIDDK, NIA, and NHLBI. It invites R01 grant applications focused on innovative and early translational hematology topics, fostering growth in this critical research area. Key deadlines for applications span from February 2025 to October 2027, allowing for both standard and renewal submissions.

The Ritton Family Foundation, along with Par Mar Stores, offers the Par Mar Stores Scholarship Program to support students pursuing higher education. This initiative awards multiple scholarships annually to eligible high school seniors and undergraduate students residing in Pennsylvania, Ohio, West Virginia, Maryland, or Kentucky. Recipients are chosen based on academic achievement, community involvement, and financial need, with opportunities for reapplication each year.

The Asian Cultural Council's Individual Fellowship provides artists, scholars, and arts professionals from Asia and the United States with opportunities for self-directed cultural exchange and research in unfamiliar regions. This program supports activities such as interviews, workshops, and archival research, fostering cultural immersion and collaboration. With a funding limit of $35,000, the fellowship encourages innovative proposals that enhance creative perspectives and relationships among peers, while also ensuring strong eligibility criteria for applicants.

The DCNR Community and Watershed Forestry Program offers financial support to enhance forest buffers, convert lawns, and plant urban trees. Grants start at $50,000, covering up to 80% of project costs, with local matching funds required. Eligible applicants include counties, municipalities, nonprofits, and other organizations committed to conservation efforts. This initiative aims to strengthen community forestry practices, contributing to environmental sustainability and improved local ecosystems.

The Dairy Farm Improvement & Modernization Grant supports dairy farmers in enhancing their operations for sustainable success. This funding aids in modernizing outdated systems and implementing innovative solutions that improve farm viability, milk quality, and worker conditions while addressing climate impacts. Eligible applicants include dairy farmers, cooperatives, and service providers across Northeast states. Awards range from $15,000 to $100,000, requiring a 25% match contribution.