Best Operating Grants for Nonprofits in Pennsylvania

Accreditation Sustainability Learning Community RFA

The Association of State and Territorial Health Officials (ASTHO), through the Public Health Infrastructure Grant (PHIG), is currently accepting applications for participation in a learning lab that will foster health department capacity to build a sustainable public health accreditation culture within their agencies. This opportunity is open to applicants from direct PHIG awardees at the state-, big city-, and county-level.

The We Are Moving The Needle Scholarship supports women, trans, and non-binary creators in the music industry by offering two full scholarships for a masterclass with GRAMMY-nominated producer Alissia in Paris. This initiative aims to empower underrepresented voices through education and mentorship, fostering a more inclusive music industry. Participants will engage in hands-on workshops designed to enhance their production skills and gain insights from a leading industry professional, contributing to lasting cultural change.

The Houston Marathon Foundation Grant supports running-related programs and initiatives, especially those that promote health and fitness in the greater Houston area. Organizations can submit unsolicited Letters of Inquiry, which must be pre-approved before submission. The Foundation prioritizes funding for programs that demonstrate fiscal responsibility and operational integrity, and applications are reviewed quarterly. Additionally, programs aiding elite athlete development outside Houston may also be considered.

Scholarships are available to graduating high school seniors. Applications are accepted from mid-November until mid-March. Scholarship award recipients will be announced at the high school awards ceremony. 

Montrose Area Chamber of Commerce Pauline MacNeal Memorial Scholarship

Established to honor past Chamber member Mrs. Pauline MacNeal. Provides college tuition assistance to graduating seniors from the high schools in Susquehanna County, as well as home schooled or cyber schooled students, who reside in Susquehanna County and will major in a business related field.

The Never Lose Hoop Fund, established by JC and Joni Hulls, provides grants to support families affected by cancer. The fund aims to enhance the quality of life for children and their families through shared experiences, such as family camps and outdoor activities. Grants are available for those currently battling cancer or who have lost an immediate family member to cancer within the last two years. This initiative helps families create lasting memories and find joy during difficult times.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Biochemical and Molecular Characterization of Marstacimab and TFPI Pathways 

This competitive grant encompasses research aimed at elucidating molecular and cellular mechanisms underlying marstacimab-TFPI interactions, including but not limited to differential expression of tissue factor and TFPI in various tissues, binding kinetics, and other biochemical properties. Projects should seek to advance foundational understanding of these interactions through innovative approaches in biochemistry, molecular biology, and related disciplines.

Project Types and Area of Interest

Projects that will be considered for Pfizer support will focus on basic science and fundamental biological understanding of Tissue Factor Pathway Inhibitor (TFPI), anti-TFPI Monoclonal Antibodies, and marstacimab. The areas of interest may include (but are not limited to):

• Basic biology of TFPI including interactions among key regulatory proteins in the intrinsic and/or extrinsic clotting cascades (e.g. Protein S being a co-factor for both Protein C and TFPI).
• Impact of differential TFPI expression within tissues and the role of various TFPI pools/isoforms in the regulation of coagulation.
• Pharmacology resulting from concomitant therapies added to anti-TFPI

The Patient Directed Investigation Grant by the Dermatology Foundation supports translational studies aimed at improving patient care in various dermatological fields. With an annual funding of $25,000, it fosters the career development of early-stage clinical investigators. Eligible applicants include those who have completed U.S. dermatology residency training and are not funded by other sources. The grant encourages diverse applicants, particularly from minority backgrounds, to contribute to vital health issues affecting underserved populations.

The Capacity Building for Global, Regional, and National Immunization Programs aims to enhance immunization efforts in key countries, focusing on the prevention and control of vaccine-preventable diseases like polio and measles. By strengthening immunization services and surveillance systems, the program will better address emerging health threats and reach under-immunized populations. Additionally, it will support sustainable practices through National Immunization Technical Advisory Groups and manage the National Stop Transmission of Polio program in Pakistan.

The Majestic Realty Foundation, established in 2002, champions active philanthropy by addressing critical community needs across eight regions in the U.S. Focused on youth, education, health, family support, and violence prevention, the Foundation fosters sustainable community development. Through initiatives like the Los Angeles Youth Leadership Council, it empowers young leaders while encouraging employee volunteerism. By partnering with local nonprofits, the Foundation strengthens community ties, ensuring lasting impact against challenges such as homelessness and youth violence.

The Robert Mapplethorpe Foundation, established in 1988, supports photography programs at museums and public institutions. It promotes photography's recognition alongside other art forms and contributes to HIV/AIDS medical research. Notably, it has funded major galleries and initiatives, donating significant collections to renowned museums. The Foundation aids curators in developing photography exhibitions and provides financial support for acquisitions, exhibitions, and publications, ensuring Mapplethorpe's artistic legacy endures.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Project Types and Area of Interest

Potential applicants are encouraged to identify and address preclinical/basic science data generation for TFPI modulation/rebalancing in their local setting. This may include:

• Rare bleeding disorders which arise from deficiencies in different clotting factors or pathway components but converge on a common functional endpoint which is an impaired thrombin generation (e.g., Factor II, Factor V, Factor VII, Factor X and Factor XI deficiencies, as well as von Willebrand disease).
• Other diseases such as Glanzmann's thrombasthenia (GT) that have a distinct pathophysiological mechanism.
• Other rare bleeding disorders whose mechanisms are not well understood (e.g., Bleeding Disorder of Unknown Cause, BDUC).

The Conservation Service Corps Grants, funded by Great Outdoors Colorado, support outdoor recreation and natural resource projects by hiring youth and veterans through conservation service corps. Annually, $1.5 million is allocated for these initiatives, enabling crews to tackle various projects like trail maintenance, invasive species mitigation, and wildlife habitat improvement. This program not only enhances natural resources but also provides job training and leadership skills to over 1,700 young participants each year.

The CDC has announced funding for FY 2027 to enhance state capacity in alcohol epidemiology and prevent excessive alcohol use through the NOFO CDC-RFA-DP-27-0072. This initiative aims to equip states with essential tools and knowledge for effective public health measures against excessive alcohol use, a major preventable cause of death in the U.S. The program will also provide expert technical assistance and training on effective prevention strategies over a 5-year performance period.

The Esther Ann McFarland Fellowship, awarded by the Historical Society of Pennsylvania, supports advanced research in its extensive collections, focusing on 17th-century Pennsylvania, especially New Sweden, or African American history. This fellowship includes a one-month residency in Philadelphia and a stipend of $3,000. It is designed for advanced, postdoctoral, and dissertation research, allowing scholars to explore diverse historical topics, including the contributions of early Swedish settlers and the impact of African American communities.

The Whole Foods Market Store Giving Program supports local communities by providing financial assistance to 501(c)(3) nonprofit organizations that focus on food access and environmental stewardship. This biannual program allows eligible organizations to apply via the Community Engagement Portal, although not all requests can be fulfilled due to high demand. Priority is given to those without recent funding, promoting sustainable community engagement.

The Pittsburgh Foundation Economic Mobility Grants aim to enhance access to post-secondary education for low-income families. By prioritizing initiatives that support college readiness, admissions navigation, and non-traditional students, the foundation seeks to empower communities. Grants typically range from $10,000 to $150,000 over one to two years, focusing on programmatic and policy-level interventions to foster economic mobility and address historical inequities in education.

The MultiState Conservation Grant Program provides vital funding for wildlife and sport fish restoration projects, as well as initiatives aimed at recruitment, retention, and reactivation (R3) of outdoor enthusiasts. These grants address priority needs identified by the Association of Fish and Wildlife Agencies, supporting collaborative efforts among states to enhance conservation efforts. Eligible projects may include research, education, and public outreach, promoting sustainable use of natural resources and fostering community engagement in conservation.

The OJJDP FY 2026 Second Chance Act Youth Reentry Program aims to provide critical support for moderate- to high-risk youth transitioning back into their communities after confinement. This funding opportunity encourages collaboration among state agencies, local governments, Tribes, and community organizations to deliver comprehensive reentry services and assist youth in overcoming challenges related to recidivism. Applications are due by November 9, 2026, at 8:59 p.m. ET.

The CART Fund Grant supports innovative Alzheimer’s Disease research projects in the U.S. with funding up to $500,000 for a two-year period. It invites full-time faculty from public and private institutions to submit Letters of Intent, emphasizing novel concepts that advance biomedical knowledge. Selected finalists will be invited to apply for standard grants. The initiative aims to foster groundbreaking research initiatives lacking extensive preliminary data, ensuring a focus on projects with transformative potential.

The Laine - Casey Laine Armed Services Scholarship, established to honor Lieutenant Casey Laine Swakon, supports students from the Coastal Bend area who have participated in JROTC or are part of ROTC programs. Eligible candidates include high school seniors, current college students, and veterans. Applicants must maintain a minimum GPA of 2.5 and complete at least 12 credit hours per semester, ensuring they are well-prepared for their academic pursuits.

The Arthritis National Research Foundation (ANRF) offers grants for research focused on Psoriatic Arthritis (PsA). With funding of up to $125,000 over two years, the ANRF encourages innovative projects that reveal the underlying mechanisms of PsA. Eligibility includes M.D. or Ph.D. qualifications and affiliation with a U.S. nonprofit research institution. Preference is given to senior post-doctoral researchers transitioning to independent status and new assistant professors. Applications without a Co-PI or those who have previously received ANRF funding will not be accepted.

This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.

Oncology Nursing Foundation

The mission of the Oncology Nursing Foundation is to support cancer nursing excellence.

Since 1981, the Oncology Nursing Foundation(ONF), through generous contributions from individuals and institutions, has provided more than $33 million in funding to support oncology nursing education, research and leadership development. This funding has translated to career development awards, academic scholarships, research grants, a myriad of specialized educational initiatives, as well as nurse resiliency support. The Foundation’s activities have played a critical role in improving patient care and advancing the oncology nursing profession.

Radiation Oncology Certified Nurse (ROCN™) Exam Scholarship

Recipients receive funding to cover the ONCC ROCN™ Certification exam fee.

Purpose

To support registered oncology nurses who specialize in providing care for adult or pediatric patients with cancer undergoing radiation therapy by providing funding support to cover the ROCN™ Certification exam fee. 

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The Terry Baucom Bluegrass Education Grant, established by the IBMA Foundation, honors the legacy of renowned bluegrass musician Terry Baucom. This grant supports musicians of all ages by providing funds for lessons, educational materials, and workshops. With awards beginning in January 2025, each grant can reach up to $500. Financial need is considered but not mandatory. This initiative aims to foster talent and ensure accessibility to bluegrass music education for a diverse range of applicants.

Thomas E. and Marian L. Overby Scholarship

Amount

• $1000
• Active
• Renewable

This scholarship is to provide financial support for an individual pursuing a degree in the field of nursing. The scholarship recipient shall be under the age of 50 seeking education beyond the high school level to become a nurse or certified nursing assistant.

This grant aims to enhance cooperation and regulatory standards among animal food safety programs by funding national feed associations. It promotes inter-agency collaboration, strengthens state regulatory frameworks, and supports the Animal Feed Regulatory Program Standards (AFRPS). By leveraging resources and aligning with federal and state initiatives, the program seeks to improve animal food safety and ensure comprehensive surveillance and protection.