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Best Operating Grants for Nonprofits in Pennsylvania

Find the perfect Operating grants for nonprofits in Pennsylvania on Instrumentl. 10,000+ Operating grants for nonprofits in Pennsylvania in the United States.

10,000+

Available grants

$2.66B

Total funding

$5K

Median grant

10,000+ grants
$2.66B total
$5K median

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10,273 Results based on applied filters

Alliance for Innovation on Maternal Health (AIM) Capacity Program

Health Resources and Services Administration
Federal Government
American Samoa, Guam +4 more
Up to US $230,000
The Alliance for Innovation on Maternal Health (AIM) Capacity Program aims to enhance the capacity of state, territorial, and Tribal entities in the U.S. to implement and sustain AIM Patient Safety Bundles. By promoting evidence-based maternal safety practices, the program strives to improve the quality of maternity care, enhance maternal health outcomes, and significantly reduce preventable maternal mortality and severe morbidity.
Maternal And Perinatal Health Patient Safety

Identifying the Effects of GLP-1 Medications Among Individuals with Cardiovascular, Kidney and Metabolic Disease

American Heart Association
Association/Society
United States
Up to US $300,000
The American Heart Association is inviting proposals for research on the effects of GLP-1 and GIP agonists in individuals with cardiovascular, kidney, and metabolic diseases. This initiative aims to explore how these medications can alleviate the CKM burden. Researchers with expertise in causal inference, machine learning, and cardiovascular research are encouraged to apply, particularly those working in multidisciplinary teams and leveraging various data sources.
Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases Kidney Diseases

Grief Reach: Changemaker Supported Community Expansion Cycle - up to $110,000

National Alliance for Children's Grief (NACG)
Private
United States
Up to US $110,000
The Grief Reach: Changemaker Supported Community Expansion Cycle offers up to $110,000 to enhance community programs for grieving children. Organizations are encouraged to innovate and expand their services to better meet community needs. The initiative, in partnership with the Judi’s House/JAG Institute, emphasizes training and resources for effective program evaluation over a three-year period, culminating in impactful community expansion projects.
Children’s Mental Health Mental Health & Psychiatric Diseases Family Services +1 more

Patrice Faye Cohen Memorial Scholarship Award

Jewish Community Foundation
Private
United States
Unspecified amount
The Patrice Faye Cohen Memorial Scholarship Award supports high school women from Southern New Jersey who are pursuing college education with a focus on entrepreneurship. Established in memory of Patrice Faye Cohen, a successful business owner, this scholarship aims to empower women to achieve their entrepreneurial dreams. Eligible candidates must demonstrate a commitment to their studies and entrepreneurial aspirations, with financial support available for tuition and related expenses.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

21st Century Museum Professionals Program (2027)

Institute of Museum and Library Services
Federal Government
American Samoa, Guam +7 more
US $100,000 - US $500,000
The 21st Century Museum Professionals (21MP) Program, funded by the Institute of Museum and Library Services, aims to enhance career pathways and professional networks in the museum sector. This initiative focuses on developing current museum staff, recruiting new professionals, and fostering partnerships that promote effective workforce training. By emphasizing peer learning and alternative career pathways, the program seeks to create a robust and diverse museum workforce across the nation.
Education - Higher Education Workforce Preparation & Job Readiness Museums & Cultural Institutions +1 more

NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional) (357230)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $3,500,000
The NHLBI SBIR Phase IIB Bridge Awards aim to accelerate the commercialization of innovative technologies targeting heart, lung, blood, and sleep disorders. This funding supports small businesses in later-stage research and development, bridging the gap between SBIR Phase II awards and commercialization. Projects must align with NHLBI's mission and demonstrate potential for clinical relevance, emphasizing partnerships with investors to secure necessary funding for regulatory approval.
Medical Technology, Devices, and Equipment Cardiovascular Diseases & Systems Hematological Systems +2 more

Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $130,000
The Mentored Career Development Award (K01) from the NIH aims to diversify the biomedical research workforce by supporting candidates from underrepresented backgrounds. It provides mentoring and training in research independence, focusing on cardiovascular, pulmonary, hematologic diseases, and sleep disorders. Eligible institutions can guide faculty members in special studies, but applicants should not lead their own clinical trials. This initiative promotes diversity and enhances research capability in health disparities populations.
Cardiovascular Diseases & Systems Hematological Systems Respiratory Diseases & Systems +2 more

Elizabeth Pastor Ashland University Music Education Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Elizabeth Pastor Ashland University Music Education Scholarship supports music students at Ashland University, honoring the legacy of Elizabeth Pastor, a renowned pianist and educator. This scholarship aims to assist students pursuing a music-related career, reflecting Pastor's belief in the transformative power of art. Established through her estate plan, it embodies her commitment to fostering musical talent and enriching the community through education and the arts.
Education - Higher Education Academic Scholarship Programs Music Education +2 more

Community Care Corps RFP

Community Care Corps
Federal Government
United States
US $30,000 - US $200,000

Request for Proposals

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

Senior Services Caregiver Support / Respite Care Disability Care & Services +1 more

Joest, Brian H. Memorial Scholarship

Noble County Community Foundation
Private
United States
US $1,000

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story – Joest, Brian H. Memorial Fund

Brian Henry Joest was born in Lagrange, Indiana in 1957. He grew up on the Atwood family farm that was settled by his ancestors in the mid-1800s. Now a historical Hoosier Homestead, the Atwood Farm provided him with all the outdoor activities possible for a farm boy in northern Indiana. Brian’s love of nature and the outdoors continued throughout his life. After high school, he attended Glen Oaks Community College and then Purdue University, where he earned a Bachelor of Science degree in Agricultural Economics

For decades, Brian went on annual backcountry camping and canoeing trips across the US and Canada. He paddled some of the most beautiful rivers in North America. He took a road trip to remote northern Alaska. He camped out on an active volcano in Guatemala. He explored most of the US National Parks. In his later years, his travels were less rustic but still adventurous as he and his wife, Cindy, checked off many items on his bucket list. They traveled to Paris, Rome, Florence, the Amalfi Coast of Italy, Ireland, and all around the US and Canada.

Brian began his professional career with management positions at Many Glacier Hotel at Glacier National Park in Montana; the Grand Hotel on Mackinac Island, Michigan; the Mountain View Grand Resort in New Hampshire; and Copper Mountain Ski Resort in Colorado. He also worked for Marriott Corporation where he opened new hotels across the Midwest.

Upon the birth of his first child, Brian moved his young family back to Lagrange County so his children could grow up on the Atwood Farm near their family. Brian worked for Life Care Center of Lagrange, was a substitute teacher for the Lakeland School District, and worked for fifteen years for East Noble School Corporation, most recently as an Instructional Assistant for high school students with special needs.

Brian enjoyed doing things for other people and took so much joy in their happiness. His career choices reflected his servant’s heart. He loved working in the hospitality industry and being able to make someone else’s vacation more memorable. He helped the patients and their families at Life Care Center. He spent years making a difference for students in our local schools.

Brian experienced first-hand the unique challenges faced by the families of individuals with special needs. He was a father, stepfather, and step-grandfather to children with different disabilities. He understood the difficulties of navigating support systems and knew there are gaps in these systems that result in unmet needs. At the end of his life, while he was fighting cancer, Brian dreamed of being able to return to the classroom to help special needs students. This was not to be. In 2022, his family created this fund in his honor with the intent of continuing his dream to help improve the lives of individuals with special needs.

Kinesiology & Sports Medicine Speech Rehabilitation Physical Therapy +4 more

Basic Needs and Income Creation

Bank Of America Charitable Foundation Inc
Private
Abbeville County, South Carolina, Ada County, Idaho +198 more
Unspecified amount
The Bank of America Charitable Foundation focuses on improving economic mobility and social progress through partnerships with nonprofits. It prioritizes basic needs, income creation, stable housing, and community empowerment. By supporting vulnerable populations, the foundation aims to enable individuals to achieve their goals and contribute positively to their communities. The foundation emphasizes sustainable progress, ensuring that all community members have access to essential resources and opportunities for growth.
Basic Human Needs Economic Services & Development Employment Services +2 more

CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed) (356935)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $300,000
The CCRP Initiative invites applications for basic research on chemical threats affecting the nervous system, including chemical warfare agents and toxic industrial chemicals. This funding aims to elucidate toxicity mechanisms, explore new toxic exposure manifestations, and identify targets for therapeutic development. Proposals should generate data relevant to understanding these toxic threats, with applications due by 5 PM local time. Optional Letters of Intent are encouraged 30 days prior to the proposal deadline.
Neuroscience Environmental Chemistry & Toxicology Neurological Diseases & Disorders

Guidelines to Develop Best-In-Class Maintenance Strategies for Vertical Assets RFP

Water Research Foundation
Private
Countries
Up to US $250,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5415 - Guidelines to Develop Best-In-Class Maintenance Strategies for Vertical Assets

Grant Information

  • Develop a clear understanding of the background and benefits associated with implementing well-rounded maintenance strategies for vertical assets.
  • Develop a structured approach to identify and implement best-in-class maintenance strategies for vertical assets that improve reliability, increase asset availability, reduce unplanned work and emergency shutdowns, support the transition from reactive to proactive maintenance, and minimize total lifecycle cost.
  • Apply leading practices such as Reliability Centered Maintenance (RCM) and cutting-edge technologies and analytics to vertical assets.
Water Resource Management

Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed) (348960)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $400,000
This funding opportunity aims to support Early Stage Investigators (ESIs) in conducting preclinical HIV/AIDS research using Nonhuman Primate (NHP) models. Eligible applicants must have at least two years of postdoctoral experience and be within ten years of their terminal degree. The initiative aligns with the NIH Strategic Plan for HIV and HIV-Related Research, targeting the reduction of HIV incidence, development of therapies, and advancement in research areas related to HIV.
HIV / AIDS

Trail Accelerator Grants- Spring Cycle Planning and Design

International Mountain Bicycling Association
Private
United States
US $10,000 - US $30,000
The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.
Trail Creation & Maintenance Biking Pedestrian & Bike-Friendly Infrastructure

Florence Merriam Bailey Award

American Ornithological Society
Association/Society
United States
US $1,500
The Florence Merriam Bailey Award, presented by the American Ornithological Society, honors outstanding articles published by early career members in AOS journals within the last two years. Awarded annually, it includes a $1,500 cash prize to the lead author. Papers recognized alternate between the journals 'Ornithology' and 'Ornithological Applications'. Nominees must adhere to high ethical standards as outlined in the AOS Code of Conduct.
Ornithology

TERF Research Grants

Thoroughbred Education and Research Foundation
Association/Society
United States
Unspecified amount
The Thoroughbred Education and Research Foundation (TERF) offers grants to support thoroughbred health, welfare, and education. Focused on enhancing equine research and safety in racing, TERF prioritizes funding for scholarships, educational programs, and veterinary medicine. Eligible applicants must be recognized 501(c)(3) organizations, with a commitment to transparency in reporting. This initiative aims to significantly impact the thoroughbred industry by fostering improved care and understanding of these horses, contributing to their overall welfare.
Mammalogy

TERF Education Grants

Thoroughbred Education and Research Foundation
Association/Society
United States
Unspecified amount
The Thoroughbred Education and Research Foundation (TERF) offers grants to support education and research related to Thoroughbred horses. The foundation prioritizes funding for scholarships, educational programs, and equine research aimed at promoting thoroughbred health and welfare. Eligible applicants include qualified 501(c)(3) organizations, while those previously funded must submit reports before applying again. Notably, TERF does not provide funds for facilities caring for unwanted horses or cover overhead costs for grants.
Mammalogy

AOS-Sponsored Student Memberships

American Ornithological Society
Association/Society
Countries
Unspecified amount
The AOS-Sponsored Student Memberships provide one year of free membership to students globally interested in ornithology. Awardees gain full access to AOS membership benefits and are encouraged to participate in various opportunities, including the annual meeting and travel grants. This initiative aims to foster the next generation of ornithologists by supporting their academic and professional growth while upholding high ethical standards aligned with the AOS Code of Conduct.
Ornithology

ASTRO-LUNGevity Residents / Fellows in Radiation Oncology Seed Grant

LUNGevity Foundation Inc
Private
United States
Up to US $50,000
The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to enhance the research careers of residents and fellows focused on radiation oncology, specifically benefiting lung cancer patients. This initiative supports basic, translational, and clinical research endeavors. With a maximum award amount of $50,000 for one year, it provides essential funding to foster innovative projects that can lead to significant advancements in lung cancer treatment.
Cancer / Oncology Lung Cancer Biomedical Imaging

Stem Cell Grants: Travel Award

Cornell University- Society for the Humanities
Association/Society
United States
Up to US $1,200
The Stem Cell Grants: Travel Award supports students, postdocs, and faculty attending scientific conferences and workshops related to stem cell research. Up to $1,200 is available for each application, with a maximum of two applications per PI lab each calendar year. Priority is given to those presenting at stem cell meetings and workshops. All applications must be submitted at least one week before travel to ensure funding consideration.
Bioengineering Synthetic Biology Cell Biology +4 more

Duquesne Light - Traditional Grants

Duquesne Light Company
Private
Allegheny County, Pennsylvania, Beaver County, Pennsylvania
Unspecified amount

About Us

For more than 100 years, Duquesne Light Company has provided safe and reliable electric service to communities in southwestern Pennsylvania. Today, our core values of safety, integrity, dependability, equity and community enable us to serve more than 600,000 customers in two counties, including the city of Pittsburgh. We are committed to safely powering our customers’ lives while playing a leading role in our region’s clean energy transition. Our vision is to create a larger-than-light, clean energy future for all by delivering exceptional results today and boldly harnessing opportunities for tomorrow. In doing so, we can ensure a cleaner, healthier and more equitable community for generations to come.

Charitable Giving at Duquesne Light

Our Charitable Giving Grants Program is designed to help communities most affected by the rising cost of living—especially those burdened by high energy expenses. By prioritizing funding for nonprofit organizations helping individuals and families meet their basic needs and access high quality workforce development opportunities, we aim to reduce financial strain and promote long-term economic stability for residents across our service area.

Funding Priorities

By funding Basic Needs, we support access to essentials like food, housing, childcare, and transportation, along with wraparound services and crisis interventions—helping families achieve stability and reduce financial strain.

Through Workforce Development, we invest in training and career pathways that lead to family-sustaining wages and long-term job security, empowering individuals to overcome economic challenges and build a more resilient future.

Grantmaking

Traditional Grants

Duquesne Light’s Traditional Grants program provides funding to nonprofit organizations with annual operating budgets over $500,000 that are working to improve the quality of life for residents within our service territory. Grants support programs aligned with one of two focus areas: Basic Needs and Workforce Development.

Basic Human Needs Workforce Preparation & Job Readiness Career / College Preparation +1 more

Celine Wyatt Memorial Scholarship

Muskingum County Community Foundation
Corporate
United States
Unspecified amount
The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.
Education - High School Education - Higher Education Women & Girl Services +3 more

Helen M. Heitmann Young Scholar Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Helen M. Heitmann Young Scholar Award, presented by SHAPE America, honors young professionals who have made significant contributions to research in curriculum and instruction within health and physical education. Eligible candidates must be current SHAPE America members and have 3 to 6 years of experience post-doctorate. This award emphasizes active involvement and scholarship in the field, encouraging innovative research that enhances educational practices for preK-12 students.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

Curriculum and Instruction Honor Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Curriculum and Instruction Honor Award, presented by SHAPE America, recognizes outstanding contributions to health and physical education curriculum research. This prestigious award highlights the importance of effective instructional practices that prepare students for active and healthy lives. Award recipients are selected based on their scholarship in health education and physical education, demonstrating commitment to excellence since the organization's founding in 1885. SHAPE America advocates for quality education and promotes the well-being of preK-12 students across the United States.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

F26AS00071 Cooperative Endangered Species Conservation Fund: Habitat Conservation Plan Land Acquisition Grants

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $26,000,000
The Cooperative Endangered Species Conservation Fund supports habitat conservation through land acquisition grants. Established in 1997, this program aims to minimize conflicts between listed species conservation and land use. The U.S. Fish and Wildlife Service provides matching grants to state agencies for projects that ensure the long-term protection of habitats. By acquiring land or conservation easements, this initiative facilitates species recovery and helps prevent future listings under the Endangered Species Act, enhancing overall ecosystem health.
Environmental Conservation Habitat & Ecosystem Restoration Land / Habitat Conservation

Operating Grants for Nonprofits in Pennsylvania Highlights

Looking for operating grants for nonprofits in Pennsylvania?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Pennsylvania recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Pennsylvania

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

300+ Operating grants for nonprofits in Pennsylvania grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

100+ Operating grants for nonprofits in Pennsylvania over $25K in average grant size

88 Operating grants for nonprofits in Pennsylvania over $50K in average grant size

45 Operating grants for nonprofits in Pennsylvania supporting general operating expenses

300+ Operating grants for nonprofits in Pennsylvania supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

1,000+ Grants on Instrumentl focused on Education - K through 12

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Pennsylvania?

Most grants are due in the second quarter.

Q1
27.0%
Q2
28.4%
Q3
23.4%
Q4
21.2%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Pennsylvania?

Grants are most commonly $28,750.

$500 $500 Min.
$28,750 $28.8 K Median
$465,890 $465.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Pennsylvania?

Grants are most commonly $120,832.

$120,832

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Pennsylvania year over year?

In 2024, funders in Pennsylvania awarded a total of 114,767 grants.

2022 101,760

2023 105,380

2024 114,767

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Pennsylvania given out in Pennsylvania, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in Pennsylvania changing over time?

Funding has increased by 39.90%.

2022 $9,486,595,381

2023 $9,869,112,363
4.03%

2024 $13,806,751,647
39.90%

Pennsylvania Counties That Receive the Most Funding

How does grant funding vary by county?

Montgomery County, Philadelphia County, and Allegheny County receive the most funding.

County Total Grant Funding in 2024
Montgomery County $11,058,341,664
Philadelphia County $2,487,099,923
Allegheny County $1,915,534,930
Chester County $846,675,579
Centre County $563,407,306