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Best Operating Grants for Nonprofits in Pennsylvania

Find the perfect Operating grants for nonprofits in Pennsylvania on Instrumentl. 10,000+ Operating grants for nonprofits in Pennsylvania in the United States.

10,000+

Available grants

$2.66B

Total funding

$5K

Median grant

10,000+ grants
$2.66B total
$5K median

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10,281 Results based on applied filters

Never Let Go Fund

Emporia Community Foundation
Private
United States
Up to US $2,000

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Never Let Go Fund

The purpose of the Never Let Go Fund is to provide funds to qualified individuals to cover expenses related to the treatment of childhood cancer. Grant requests will be considered for children under the age of 18.

Health Care Access & Delivery Cancer / Oncology Children’s Health & Pediatrics +1 more

AAAAI Special Recognition Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Special Recognition Award honors individuals who significantly contribute to the allergy and immunology community. Offered by the American Academy of Allergy, Asthma & Immunology, this prestigious award recognizes outstanding efforts in advancing care and research in the field, promoting optimal patient outcomes. The AAAAI, with over 7,000 members worldwide, is a leading authority in allergy and immunology, dedicated to enhancing the knowledge and practice of these critical health areas.
Immune System Diseases Allergies & Allergic Diseases Vaccines & Immunizations

Life Comes From It (LCFI) Grants

Tides Foundation
Private
United States
Unspecified amount
The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.
Indigenous Sovereignty & Rights Minority Services Racial / Ethnic Justice & Rights +1 more

OREF/Musculoskeletal Transplant Foundation Research Grant Prgram

Orthopaedic Research and Education Foundation
Private
United States
US $100,000
The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.
Human Genome & Genetics Cell Biology Synthetic Biology +4 more

Goodnow Fund Grants

Goodnow Fund
Private
United States
Unspecified amount
The Goodnow Fund is a family foundation that provides approximately $1.5 million in grants annually to nonprofit organizations. Focused on supporting vulnerable children, Alzheimer's research, educational opportunities for low-income students, and environmental improvement, the Fund primarily aids organizations in Fairfield County, Connecticut. It identifies potential grantees directly and does not accept unsolicited proposals. For more information, organizations can contact the Fund's Executive Director.
Dementia & Alzheimer’s Disease Child Welfare Services Environment +1 more

Members 1st Charitable Foundation Grant

Members 1 St Charitable Foundation
Private
Adams County, Pennsylvania, Berks County, Pennsylvania +8 more
Up to US $10,000
The Members 1st Charitable Foundation Grant supports local grassroots organizations in South Central and Northeastern Pennsylvania, aiming to enhance their strength, health, and financial stability. Grants up to $10,000 are available each cycle, with a focus on initiatives in art, culture, education, financial literacy, health, wellness, and veterans' services. Organizations must be 501(c)(3) tax-exempt and demonstrate good financial standing to qualify for funding.
Diversity, Equity & Inclusion Educational Access & Equity Arts / Culture Access & Participation +3 more

Celine Wyatt Memorial Scholarship

Muskingum County Community Foundation
Corporate
United States
Unspecified amount
The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.
Education - High School Education - Higher Education Women & Girl Services +3 more

AHRF Discovery Grants

American Hearing Research Foundation
Private
United States
Up to US $50,000
The AHRF Discovery Grants support innovative research on hearing and balance disorders, offering up to $50,000 for one year. Targeting early-career investigators, these grants aim to generate preliminary data for larger funding applications. Special consideration is given to projects exploring Meniere's disease and sudden hearing loss. Grants cover direct research costs, excluding principal investigator salaries and indirect expenses. The initiative strives to fund promising studies that can advance our understanding of auditory and vestibular health.
Hearing Disorders & Audiology Meniere’s Disease

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) (362945)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.
HIV / AIDS

SAF National Awards Program: Award in Forest Science

Society of American Foresters (SAF)
Association/Society
United States
More than US $1,000
The SAF National Awards Program recognizes excellence in forestry through various awards, including the Award in Forest Science. This award acknowledges significant research contributions in quantitative, economic, managerial, and social sciences, promoting advancements in forestry. Recipients receive a $1,000 honorarium, a complimentary SAF convention registration, and travel expense support. Established in 1996, this award highlights the importance of innovative research that impacts both national and international forestry practices.
Forestry

Improved Drug Susceptibility Testing (DST) for Mycobacteria

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.
Infectious & Parasitic Diseases Tuberculosis Drug-Resistant Bacteria

SAF National Awards Program: Barrington Moore Memorial Award in Biological Science

Society of American Foresters (SAF)
Association/Society
United States
More than US $1,000
The SAF National Awards Program recognizes excellence in forestry through various awards, including the Barrington Moore Memorial Award in Biological Science. This award honors individuals for significant contributions to biological research that advances forestry practices. It includes a $1,000 honorarium, convention registration, and travel support. The award celebrates leaders in forest ecology, soil science, and other related fields, promoting innovation and collaboration in forestry research.
Forestry

Alliance for Innovation on Maternal Health (AIM) Capacity Program

Health Resources and Services Administration
Federal Government
American Samoa, Guam +4 more
Up to US $230,000
The Alliance for Innovation on Maternal Health (AIM) Capacity Program aims to enhance the capacity of state, territorial, and Tribal entities in the U.S. to implement and sustain AIM Patient Safety Bundles. By promoting evidence-based maternal safety practices, the program strives to improve the quality of maternity care, enhance maternal health outcomes, and significantly reduce preventable maternal mortality and severe morbidity.
Maternal And Perinatal Health Patient Safety

SAF National Awards Program: Technology Transfer Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $1,000
The SAF National Awards Program honors exceptional contributions to forestry through various awards, including the Technology Transfer Award. This award recognizes significant achievements in technology transfer, ensuring vital technical information reaches those involved in forestry management. It includes a $1,000 honorarium and other benefits presented at the SAF national convention. Nominees must be active members of the Society of American Foresters and demonstrate leadership and impact in their field.
Forestry

Holloway Family Foundation Grant

Graham and Carolyn Holloway Family Foundation
Private
United States
Unspecified amount
The Holloway Family Foundation, established in North Central Texas, aims to enhance community quality of life regardless of race, gender, or religion. Their mission focuses on financial security, creative expression for under-resourced youth, and mentorship for personal development. The foundation supports organizations that provide workforce training, artistic opportunities for children, and guidance for youth in need. By fostering individual growth and economic stability, they empower families and strengthen communities, staying true to the founders' core values and personal experiences.
Tutoring & Mentoring Workforce Preparation & Job Readiness Youth Involvement in the Arts

Joseph O. & Geraldine C. Waymire Nursing Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Joseph O. & Geraldine C. Waymire Nursing Scholarship, established by the Waymire family, supports students pursuing nursing careers. It is open to high school seniors from accredited Marion County institutions and those enrolled in nursing programs at various educational levels. Funds can be used for tuition, fees, and other educational expenses. The scholarship aims to foster a diverse nursing workforce, reflecting the mission of the Central Indiana Community Foundation to enhance community opportunities.
Education - High School Academic Scholarship Programs College Success / Persistence +2 more

Joest, Brian H. Memorial Scholarship

Noble County Community Foundation
Private
United States
US $1,000

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story – Joest, Brian H. Memorial Fund

Brian Henry Joest was born in Lagrange, Indiana in 1957. He grew up on the Atwood family farm that was settled by his ancestors in the mid-1800s. Now a historical Hoosier Homestead, the Atwood Farm provided him with all the outdoor activities possible for a farm boy in northern Indiana. Brian’s love of nature and the outdoors continued throughout his life. After high school, he attended Glen Oaks Community College and then Purdue University, where he earned a Bachelor of Science degree in Agricultural Economics

For decades, Brian went on annual backcountry camping and canoeing trips across the US and Canada. He paddled some of the most beautiful rivers in North America. He took a road trip to remote northern Alaska. He camped out on an active volcano in Guatemala. He explored most of the US National Parks. In his later years, his travels were less rustic but still adventurous as he and his wife, Cindy, checked off many items on his bucket list. They traveled to Paris, Rome, Florence, the Amalfi Coast of Italy, Ireland, and all around the US and Canada.

Brian began his professional career with management positions at Many Glacier Hotel at Glacier National Park in Montana; the Grand Hotel on Mackinac Island, Michigan; the Mountain View Grand Resort in New Hampshire; and Copper Mountain Ski Resort in Colorado. He also worked for Marriott Corporation where he opened new hotels across the Midwest.

Upon the birth of his first child, Brian moved his young family back to Lagrange County so his children could grow up on the Atwood Farm near their family. Brian worked for Life Care Center of Lagrange, was a substitute teacher for the Lakeland School District, and worked for fifteen years for East Noble School Corporation, most recently as an Instructional Assistant for high school students with special needs.

Brian enjoyed doing things for other people and took so much joy in their happiness. His career choices reflected his servant’s heart. He loved working in the hospitality industry and being able to make someone else’s vacation more memorable. He helped the patients and their families at Life Care Center. He spent years making a difference for students in our local schools.

Brian experienced first-hand the unique challenges faced by the families of individuals with special needs. He was a father, stepfather, and step-grandfather to children with different disabilities. He understood the difficulties of navigating support systems and knew there are gaps in these systems that result in unmet needs. At the end of his life, while he was fighting cancer, Brian dreamed of being able to return to the classroom to help special needs students. This was not to be. In 2022, his family created this fund in his honor with the intent of continuing his dream to help improve the lives of individuals with special needs.

Kinesiology & Sports Medicine Speech Rehabilitation Physical Therapy +4 more

Wild Animal Initiative: Seed Grants

Wild Animal Initiative
Private
Afghanistan, Albania +189 more
Up to US $30,000
The Wild Animal Initiative offers Seed Grants to support innovative projects in wild animal welfare research. These grants aim to facilitate early-career researchers and established scientists in testing new techniques and approaches that incorporate welfare assessments into ecological studies. The program emphasizes cost-effective solutions, focusing on improving the welfare of wild animals. Successful proposals will explore diverse themes such as wild fish welfare and near-term welfare interventions to address urgent animal welfare challenges.
Wildlife Health Ichthyology (Fish)

Incyte: Healthcare-related Charitable Contributions, Sponsorship and Membership Requests

Incyte Corporation
Corporate
United States
Unspecified amount
Incyte Corporation invites organizations to submit membership requests aimed at enhancing healthcare access for patients and advocates. As a biopharmaceutical leader, Incyte supports initiatives that align with its mission to improve patient lives through grants and contributions. Eligible entities include medical schools, associations, non-profits, and advocacy groups. Requests should comply with Incyte's regulatory standards and be submitted at least 60 days prior to the required decision date.
Cancer / Oncology Diseases & Conditions Nursing +2 more

F26AS00071 Cooperative Endangered Species Conservation Fund: Habitat Conservation Plan Land Acquisition Grants

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $26,000,000
The Cooperative Endangered Species Conservation Fund supports habitat conservation through land acquisition grants. Established in 1997, this program aims to minimize conflicts between listed species conservation and land use. The U.S. Fish and Wildlife Service provides matching grants to state agencies for projects that ensure the long-term protection of habitats. By acquiring land or conservation easements, this initiative facilitates species recovery and helps prevent future listings under the Endangered Species Act, enhancing overall ecosystem health.
Environmental Conservation Habitat & Ecosystem Restoration Land / Habitat Conservation

F26AS00105 National Fish Passage Program

Fish and Wildlife Service
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The National Fish Passage Program (NFPP) offers vital assistance for removing barriers to aquatic life, enhancing safety, and promoting local economies. By investing in projects like culvert replacements and floodplain restorations, the program not only supports native fish populations but also delivers significant economic benefits, estimated at $1.5 million for every $1 million invested. With a recent allocation of $15 million, including $5 million for specific restoration initiatives, NFPP continues to advance aquatic connectivity nationwide.
Habitat & Ecosystem Restoration Ichthyology (Fish) Fish Conservation

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund B)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty in digestive disease research. This award aims to support independent careers in pancreatic cancer research by protecting a significant portion of the recipient's time for research activities. Eligible applicants must hold an MD, PhD, or equivalent and work at a North American institution, with AGA membership required. Strong encouragement is given to underrepresented groups.
Pancreatic Cancer

SAF National Awards Program: Employer Leadership Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The SAF National Awards Program recognizes outstanding contributions to forestry through various awards, including the Employer Leadership Award. This award honors employers who significantly support SAF members' professional engagement. Recipients receive a $500 honorarium, complimentary convention registration, and travel expense support. The program aims to celebrate the achievements of individuals and organizations in promoting sustainable forestry practices and enhancing professional development, ultimately driving excellence in natural resource management.
Forestry

SAF National Awards Program: Outstanding Local Unit Achievement Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The SAF National Awards Program celebrates outstanding contributions to forestry through various awards, including the Outstanding Local Unit Achievement Award. This award recognizes local units for their sustained leadership or special projects that benefit the Society of American Foresters and the forestry profession. Each awarded unit receives a $500 honorarium, complimentary convention registration, and funding for travel expenses, ensuring recognition and support for their impactful efforts in forestry.
Forestry

Trail Accelerator Grants- Spring Cycle Planning and Design

International Mountain Bicycling Association
Private
United States
US $10,000 - US $30,000
The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.
Trail Creation & Maintenance Biking Pedestrian & Bike-Friendly Infrastructure

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund A)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty focused on independent research in pancreatic cancer. This award aims to protect at least 50% of the recipient's time for research activities. Eligible applicants must hold an MD or PhD and be classified as early-career. The award encourages physician-scientists and underrepresented groups in biomedical research to apply, supporting innovative research that can lead to significant advancements in understanding pancreatic cancer.
Pancreatic Cancer

Greenawalt Foundation Skilled Trades Program Grant

Greenawalt Foundation
Private
United States
Unspecified amount

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

  • Skilled Trades Training Support
  • Pre-Apprenticeship or Apprenticeship Programs
  • Youth Career Exploration Camps
Vocational & Trade Education Apprenticeship & Internship Programs Youth Development & Leadership +1 more

Operating Grants for Nonprofits in Pennsylvania Highlights

Looking for operating grants for nonprofits in Pennsylvania?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Pennsylvania recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Pennsylvania

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

300+ Operating grants for nonprofits in Pennsylvania grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

100+ Operating grants for nonprofits in Pennsylvania over $25K in average grant size

88 Operating grants for nonprofits in Pennsylvania over $50K in average grant size

45 Operating grants for nonprofits in Pennsylvania supporting general operating expenses

300+ Operating grants for nonprofits in Pennsylvania supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

1,000+ Grants on Instrumentl focused on Education - K through 12

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Pennsylvania?

Most grants are due in the second quarter.

Q1
27.0%
Q2
28.4%
Q3
23.4%
Q4
21.2%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Pennsylvania?

Grants are most commonly $28,750.

$500 $500 Min.
$28,750 $28.8 K Median
$465,890 $465.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Pennsylvania?

Grants are most commonly $120,832.

$120,832

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Pennsylvania year over year?

In 2024, funders in Pennsylvania awarded a total of 114,767 grants.

2022 101,760

2023 105,380

2024 114,767

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Pennsylvania given out in Pennsylvania, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in Pennsylvania changing over time?

Funding has increased by 39.90%.

2022 $9,486,595,381

2023 $9,869,112,363
4.03%

2024 $13,806,751,647
39.90%

Pennsylvania Counties That Receive the Most Funding

How does grant funding vary by county?

Montgomery County, Philadelphia County, and Allegheny County receive the most funding.

County Total Grant Funding in 2024
Montgomery County $11,058,341,664
Philadelphia County $2,487,099,923
Allegheny County $1,915,534,930
Chester County $846,675,579
Centre County $563,407,306