Best Unrestricted Grants for Nonprofits in Pennsylvania

South Dakota Community Foundation

As a statewide community foundation, we work with donors, nonprofits and community leaders to strengthen philanthropy in South Dakota every day.

Scholarships

At South Dakota Community Foundation (SDCF), we proudly manage more than 350 scholarship funds in partnership with generous donors who are committed to supporting students. These scholarships offer countless opportunities to help ease the financial burden of continuing their education.

South Dakota Highway Superintendents Association

To provide financial support to charitable and nonprofit purposes at the recommendation of the donor.

South Dakota Community Foundation

As a statewide community foundation, we work with donors, nonprofits and community leaders to strengthen philanthropy in South Dakota every day.

Scholarships

At South Dakota Community Foundation (SDCF), we proudly manage more than 350 scholarship funds in partnership with generous donors who are committed to supporting students. These scholarships offer countless opportunities to help ease the financial burden of continuing their education.

Witzleben Scholarship

To provide financial support to high school graduate(s) residing on the Standing Rock Reservation in South Dakota and North Dakota

The Witzleben twins are proud to be descendants of people who lived on the land now known as the Standing Rock Reservation. Their father, Camillus Witzleben, was born in South Dakota to parents who both worked in education. He became a medical doctor and later taught at the University of Pennsylvania Medical School. Camillus inherited land on the Standing Rock Reservation from his father, and he passed it on to his daughters, including the twins. Through the establishment of this scholarship, the sisters aim to support a resident of the Standing Rock Reservation in pursuing their education. This scholarship is a way to honor their ancestors and celebrate their own native heritage.

The Washington Red Raspberry Commission offers research grants to support the advancement of red raspberry cultivation. These grants focus on innovative farming practices, pest management, and cultivar development, aimed at enhancing grower productivity and sustainability. Proposals are evaluated based on their potential impact on the industry, with an emphasis on practical applications. The commission invites researchers from various backgrounds to contribute, ensuring a diverse range of solutions for the challenges faced by raspberry growers.

The Small Instruments and Modern Equipment program invites shared-use biomedical research facilities to apply for funding to purchase small instruments or scientific equipment. These resources, which may include core facilities and biorepositories, aim to enhance operational efficiency and support the use of innovative technologies. Funding is specifically targeted for instruments that produce outputs beyond traditional digital data, excluding highly specialized or building-level infrastructure equipment.

The Regional Excellence for Access to Comprehensive Care for Hemophilia Networks (REACH Networks) aims to enhance access to coordinated, evidence-based care for individuals with hemophilia and related disorders. This initiative will broaden access to comprehensive care, implement quality improvement projects, and provide ongoing training and education for Hemophilia Treatment Center staff. The focus is on improving best practices for comprehensive, collaborative care, including effective lifespan transitions for patients.

The Bee Grant Program, offered by the Whole Kids Foundation, supports K-12 schools and non-profits in enhancing or establishing bee programs with live bees. The Traditional Bee Grant provides up to $1,500 or equipment for new initiatives, while the Renewal Bee Grant offers $500 to previously funded projects. Eligible applicants must ensure strong support from their organization and have a knowledgeable beekeeper as a mentor. This initiative emphasizes bee education and conservation, fostering awareness among students.

The BJA FY 2026 Edward Byrne Memorial Justice Assistance Grant (JAG) Program offers formula funding to support local governments in enhancing public safety. This grant aids in hiring personnel, purchasing essential equipment, and providing training and technical assistance to address crime and safety challenges. Applicants are encouraged to verify their eligibility for direct JAG funding from BJA before submitting their applications. The deadline for full applications is October 16, 2026, at 8:59 p.m. ET.

The Marion B. Sewer Distinguished Scholarship for Undergraduates provides $2,000 to support students pursuing biochemistry and molecular biology, especially those from diverse backgrounds. Eligible applicants must be U.S. citizens or residents, enrolled full-time in accredited institutions, and members of ASBMB. This scholarship aims to enhance diversity in the biomedical workforce and encourage ongoing engagement in scientific activities. Applications are open to all qualified candidates, with a focus on underrepresented groups.

Lois Roth Foundation

The Lois Roth Foundation honors the life and work of Lois Wersba Roth. Since 1987, it has sought to promote and encourage dialogue across national, linguistic and cultural boundaries, with an emphasis on the humanities, arts and social sciences. Foundation programs are conducted in collaboration with a range of partners and focused on three domains: Fulbright & Academic Collaborations, Cultural Diplomacy, and Literature & Translation.

Cultural Diplomacy

In recollection of Lois Roth’s efforts to promote cross‐cultural understanding and cooperation as a US Foreign Service Officer, the Roth Foundation partners with the Bureau of Educational and Cultural Affairs (ECA) (US State Department), to provide the department’s four awards honoring excellence in the field of cultural and educational diplomacy.

The types of qualities displayed by recipients of Roth Foundation cultural diplomacy awards include:

• Cross‐cultural sensitivity and understanding for all—regardless of age, race, religion, color, sex, national origin or disability—and the courage and intellectual integrity to bring alternate facts and opinions into open conversation
• Ingenuity and imagination in creating projects, programs and products to deepen the contact between foreign intellectuals, artists and professionals and their US counterparts
• Familiarity with global affairs and foreign languages, to deepen substantive discussion between US and foreign intellectuals, scholars and professionals
• Patience, wisdom and generosity in helping new colleagues, both international and US, develop their careers
• Special skill in promoting collaborations between US and foreign institutions and high‐quality exchange opportunities with the civil sector.

Gill Jacot-Guillarmod Award

Established in 2013, Gill Jacot-Guillarmod Award is named in honor of Gillian (Gill) Jacot-Guillarmod, who served for 35 years at the U.S. Mission, then Embassy in South Africa, spanning the apartheid period to the emergence of democracy. The award recognizes mid-career, locally-employed staff members at U.S. embassies and consulates who have made outstanding contributions in educational and cultural diplomacy.

Nomination Process

Every spring, the Department of State’s Bureau of Educational and Cultural Affairs will internally circulate details regarding nominations for the four Lois Roth Foundation Awards. State Department supervisors are invited to submit nominations in all four categories.

Gray for Glioblastoma Society

A 501 (c) 3 created to raise awareness for and funds to support Glioblastoma Multiforme research by accepting donations and donating to cancer care and research facilities. Our organization has gifted over $275,000 to support GBM research projects at renowned cancer centers including The Ty Miller Lab at Case Western Reserve University, Dana Farber Cancer Institute, Children’s Hospital LA/Saban Research Institute and The Preston Robert Tisch Brain Tumor Center at Duke. We accomplish this while simultaneously creating a hopeful and positive space and providing resources and a space of community through our social media and events.

Gray for Glioblastoma Grant

Gray for Glioblastoma Society (GFG) is dedicated to funding projects that advance glioblastoma (GBM) research and move the needle forward in care and quality of life. We invite proposals that align with our mission and demonstrate meaningful impact in the GBM space.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Naval Mobile Construction Battalion 25 Memorial Scholarship

Provides financial assistance for children (who are seeking post-secondary education) of members who have died while actively serving with NMCB 25. 

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Negaunee Environmental Scholarship Fund

Provides financial assistance for students who attend Negaunee Public Schools and are pursuing a career in an environmental related field, or as the Foundation may determine. 

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

Learning from Abroad to Reimagine Health Knowledge Systems for Equity and Wellbeing Grant

The Robert Wood Johnson Foundation (RWJF) is committed to dismantling structural racism and eliminating barriers to health equity by working alongside communities, practitioners, and institutions. One way we support this mission is by investing in the knowledge of historically marginalized communities and deepening the relationships that build community power, evidence, and systems of change. Another way we do this is by looking beyond the U.S. borders. The Global Ideas for U.S. Solutions team looks abroad for ideas to improve health equity, justice, and wellbeing in the U.S.  

This funding opportunity invites organizations to learn and produce solutions to build a more inclusive and equitable health knowledge system, inspired by other countries that have faced or are currently facing similar health equity challenges. It allows organizations to learn from efforts outside of the U.S. to reimagine and rebuild the health knowledge system in ways that can withstand systemic threats while advancing health equity and wellbeing for the future. Among many other characteristics yet to be identified, our learnings to date suggest that the following contribute to this reimagined version of the health knowledge system:  

• The experience of people most affected by health inequities is centered in the generation of data and evidence and in policymaking;
• Health is more than the absence of disease. It is about individual and collective healing and wellbeing;
• Mis- and disinformation are eliminated and public trust in science and evidence is restored;
• History, culture, and language are preserved and protected, and ecological and biomedical sciences are braided with Indigenous, traditional, holistic, and community frameworks; and
• Cross-sector approaches and global learning networks break down siloes and allow for more effective and equitable solutions. They leverage lessons from resistance movements and connect artists, researchers, public health, and civil society.

The purpose of this CFP is to support organizations in pursuing action-oriented projects that leverage learning from outside the U.S. to create a more durable and equitable health knowledge system in the U.S. These efforts will advance health equity, justice, and wellbeing through community-driven knowledge generation, preservation, and narrative. Together, these actions lay the foundation for a more inclusive, equitable, and resilient health knowledge system in times of crisis and beyond. 

Total Awards

Type of Award: Awards will be structured as grants and will be made to organizations, not to individuals.

• Number of Awards: Up to 15 awards will be funded.  
• Amount of Award: Awards will be up to $500,000 each. Please request only what is necessary to allow us to fund as many recipients as possible. We expect larger awards to correspond with more distributed funding (e.g., multiple people’s salaries or multiple activities). See more information on RWJF budget categories and allowable costs here.  
• Award Duration: Awards will be up to 36 months.  

The Ted & Shannon Skokos Foundation Grant, established in 2008, supports nonprofit organizations in arts, education, humanity, and faith. It prioritizes visionary leadership, community impact, sustainability, organizational strength, and collaboration. The foundation seeks to fund eligible 501(c)(3) nonprofits that align with its mission and positively influence communities, particularly in Dallas, Texas, and Arkansas, where the founders have personal connections.

The Craig H. Neilsen Foundation's Psychosocial Research Postdoctoral Fellowship supports early-career researchers in spinal cord injury (SCI) psychosocial studies. It aims to enhance professional interest and training in this vital field, focusing on areas such as caregiving, employment, and technology access. The fellowship offers mentored training, covering salary and up to $35,000 for non-personnel costs over two years, ensuring comprehensive support for fellows to advance their careers.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Marquette Senior High School Class of 1977 Scholarship Fund 

Provides scholarships to MSHS graduating students who best represent the character, ideals and drive of the Class of 1977. The recipient shall use the scholarship to pursue a college degree or vocational education program of their choice. 

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

Real World Evidence on clinical outcomes with Aztreonam-Avibactam (ATM-AVI)

This RFP invites research proposals aimed at assessing clinical outcomes associated with the use of Aztreonam-Avibactam (ATM-AVI) in real world clinical settings.

In scope are adult patients with suspected or documented infections due to aerobic gram negative organisms. Eg. CRE-MBL, Stenotrophomonas maltophilia, treated with ATM-AVI.

Geographic Scope

Countries where ATM-AVI is available (ex-US) and used in clinical practice at the time of RFP release, including but not limited to parts of EU, the United Kingdom, the Middle East, and selected Asia-Pacific markets. Proposals from institutions already participating in Pfizer-sponsored or funded, overlapping ATM-AVI RWE study may be considered out of scope. Proposals involving studies on patients that have received ATM-AVI via pre-approval or pre-launch expanded access routes may be considered out of scope

Project Types and Area of Interest

Potential applicants are requested to submit research proposals to study the below outcomes following treatment with ATM-AVI for adult patients with suspected or documented infections with aerobic gram negative organisms e.g. CRE-MBL, S. maltophilia.

• Clinical effectiveness with ATM-AVI
• Safety outcomes with ATM-AVI
• Microbiological outcomes with ATM-AVI
• Health Economic outcomes with ATM-AVI (in addition to any of the above)

Proposals may include data from special populations such as – immunocompromised (solid organ transplant or haemato-oncological patients)

Funding Range and Project Length

• Individual projects requesting up to $50,000 USD will be considered. The total budget for this RFP is $ 250,000 USD
• Maximum project length is 12 months

The Gibson Foundation, now known as Gibson Gives, is dedicated to enhancing lives through music by supporting 501(c)(3) organizations. Their mission is to inspire and amplify the power of music through guitars for all generations. With a commitment to music education and wellness, Gibson Gives is making a positive impact worldwide, ensuring that music continues to shape the lives of musicians and enrich communities. Donations are reviewed monthly, requiring a minimum of four weeks for processing.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Lowell A. Larson Scholarship

Provides scholarships to MSHS graduating students pursuing secondary education in the trades including, but not limited to construction, welding, automotive, hvac, etc.

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The Edwards Lifesciences Foundation Grants program aims to improve the health of underserved communities by supporting initiatives focused on education, screening, and treatment of cardiovascular disease. The Foundation seeks to enhance care access for patients, promote awareness of heart health, and foster community engagement through volunteer opportunities. By 2025, the goal is to positively impact the lives of 2.5 million patients affected by structural heart issues. The program emphasizes collaboration and innovation in healthcare.

The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.

The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.

Jacquie Porter Scholarship for Aspiring Early Childhood Teachers in Austin ISD

Aspirations of becoming an early childhood educator.

Awards

• (1) $5,000.00

The Petfinder Emergency Medical Grant assists Petfinder members in providing urgent medical care for pets in need. Grants range from $100 to $1,000 and are awarded monthly until funds are depleted. Eligible expenses cover various emergency treatments, with a focus on saving one pet's life or improving its quality of life. Applicants must be active Petfinder members and agree to share their stories on social media, promoting both the grant and the pets they help.