Best Unrestricted Grants for Nonprofits in Pennsylvania

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

LSW Architects Legacy Scholarship

The LSW Architects Legacy Scholarship Fund was established in honor of LSW Architects' founding leaders and their ability to imagine and build in creative space. 

Number and Size of Awards:

The number and size of awards may vary and are determined by the selection committee. Minimum award amount is $2,500.

Number of Awards: 4

Total Amount Awarded: $10,000

About Levitt

The Levitt Family Foundation exists to strengthen the social fabric of America. We partner with communities to activate underused outdoor spaces, creating welcoming, inclusive destinations where the power of free, live music brings people together and invigorates community life.

Festival Grants

The Levitt Foundation is offering grants of up to $5,000 to U.S.-based 501(c)(3) nonprofits presenting free outdoor music festivals in 2026. 

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

The BioMarin Medical Education Grant offers funding for educational activities aimed at enhancing the knowledge and skills of healthcare professionals. Eligible applicants include accredited providers, medical associations, and patient advocacy groups. The grant focuses on supporting initiatives related to rare diseases, ensuring timely access to treatments and education. Applications are accepted year-round, but a minimum of 60 days is required for review prior to events. This commitment underscores BioMarin's dedication to improving patient care and advancing medical knowledge.

The Greenpoint Foundation Grant aims to enhance community life by supporting organizations that focus on agriculture, food security, education, and community enhancement. Established in 2022, the Foundation accepts grant applications year-round for both general operating budgets and specific projects. Priority is given to 501(c)(3) organizations and local government entities, while faith-based programs are considered on a case-by-case basis. Grant recipients must submit impact reports to ensure continued support.

The Parkinson Family Foundation Grant supports organizations focusing on Food & Water, Faith & Evangelism, and Health & Humanitarian Efforts. Applications are open year-round, with grants ranging from $1,000 to $5,000; larger requests are typically declined. Eligible applicants include schools, state governments, and 501(c)(3) nonprofits. The Foundation emphasizes selectivity and prioritizes organizations with established relationships and those promoting American ideals like freedom and justice.

The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.

The Culpeper Rotary Foundation Scholarship supports residents of Culpeper County pursuing a four-year degree. With a $1,000 award renewable for four years, applicants must demonstrate financial need and maintain a GPA of 2.5 or higher. The Northern Piedmont Community Foundation manages the scholarship application process, emphasizing community involvement. This initiative reflects NPCF's commitment to enhancing educational opportunities in the region, ensuring that local students have the support they need to succeed in their academic pursuits.

The Howe Foundation, established by Thomas E. Howe in Clark County, Nevada, supports U.S. charitable organizations focused on education, medical advancements, and game hunters associations. Grants are administered by Wells Fargo Bank, with applications reviewed annually in September. Eligible organizations must be 501(c)(3) exempt under the Internal Revenue Code, ensuring support for meaningful community initiatives.

The UPMC Body Contouring Fellowship Program addresses the increasing need for body contouring post-bariatric surgery, a growing field in plastic surgery. This one-year clinical fellowship offers comprehensive mentorship in preoperative evaluation, treatment planning, and postoperative management for patients experiencing skin laxity after significant weight loss. Trainees will engage with an interdisciplinary weight loss team and gain hands-on experience through weekly outpatient clinics and formal conferences, preparing them for advanced practice in this vital area of healthcare.

The Rural Arts Initiative Grant Program, established by the Laura Jane Musser Fund, aims to support nonprofit arts organizations in rural communities. The program encourages access to the arts through scholarships, community engagement, and innovative activities. Priority is given to organizations located in areas with populations under 20,000, ensuring that artistic opportunities are available to both adults and children. Applications are accepted for one year of funding, with potential for up to three consecutive years.

Powering Economic Opportunity Fund

Converting America's economic transformation into lasting earnings gains for workers — by backing the employer-side job designs and workplace practices that a durable payer will carry forward.

Across the United States, the modernization of energy systems, physical infrastructure, and advanced manufacturing is creating sustained demand for skilled workers — electricians, welders, energy technicians, construction managers, and industrial specialists — even as the broader labor market has slowed. The Bureau of Labor Statistics projects that energy-related occupations will be among the fastest-growing through 2034, and critical trades face significant shortages as experienced workers retire. 

Geopolitical uncertainty and conflicts only accelerate these trends and the need to focus on energy security. At the same time, AI-driven disruption continues to displace entry-level knowledge roles, creating a strong and underserved candidate pool for durable trade pathways.

Investments are expanding access to skilled trades training, but a critical gap remains between funding workforce programs and achieving lasting employment outcomes. Too many workers complete training without staying in quality jobs, and too few investments address the employer practices that improve retention, advancement and long-term earnings.

As part of our multiyear partnership with Families and Workers Fund, GitLab Foundation is pleased to announce a $4M open call for the Powering Economic Opportunity Fund — flexible grants of up to $500,000 supporting organizations that partner directly with employers, unions and industry to strengthen work-based learning, improve job quality and connect workers to durable, living-wage careers. Round 2 invests in employer-side practice change — the job designs and workplace practices that help workers stay, advance, and build careers — and in the durable financing that sustains those practices after the grant ends.

The NCAA Postgraduate Scholarship for Winter Sports awards up to 126 scholarships of $10,000 annually to outstanding student-athletes who excel both academically and athletically. Eligible candidates are in their final year of NCAA competition and must have a minimum GPA of 3.2. The scholarships are available for men and women in various winter sports and are intended for use in accredited graduate programs, emphasizing the importance of academic achievement and community involvement.

The U.S. Hillman Prize for Broadcast Journalism, awarded by the Sidney Hillman Foundation, recognizes outstanding journalism that serves the common good. Open to global journalists, the contest honors work accessible to U.S. audiences, with no entry limits per outlet. Winners receive a $5,000 honorarium and a certificate at a ceremony in New York City. This prestigious award highlights impactful stories across various media platforms, emphasizing the importance of journalism in addressing social issues.

The Jennie K. Scaife Charitable Foundation Grant focuses on enhancing family support, women's and children's health, and animal welfare. It aims to fund programs that promote beneficial human-animal interactions and early intervention in addiction prevention. Eligible organizations must have a valid 501(c)(3) designation. Grants align with at least one of the foundation's focus areas, ensuring impactful contributions to community welfare and well-being.

The Robert L. Johnson Memorial Research Grant, offered by the Midwest Aquatic Plant Management Society, supports graduate students in aquatic plant management with grants of up to $10,000. This initiative promotes research that advances the management of aquatic ecosystems and fosters educational opportunities. Recipients are required to present their findings at the annual conference, contributing to the society's mission of sustainable aquatic resource management and ecological preservation.

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

Gropper Clement Legacy Scholarship

To provide financial support to graduates of Huron, James Valley Christian, Kadoka and Miller High Schools.

The Zonta Club of Greater Sandusky High School STEM Scholarship Fund provides financial support to female high school seniors from Erie, Huron, or Ottawa County, Ohio, who plan to pursue a degree in STEM or medical fields at accredited institutions. Established by the Zonta Club, this scholarship aims to empower young women to contribute positively to their communities by facilitating access to higher education opportunities. Since its inception, it has fostered academic growth and leadership among recipients.

The Susan E. Kraus/Robert W. Gill Fund, managed by the Berks County Community Foundation, provides financial support to adults who previously lived in foster care in Berks County. Grants, capped at $1,000 per year, are aimed at assisting individuals with transitional housing costs and educational expenses, helping them achieve stability and independence as they transition to adulthood.

The Seymour Siegel Youth Achievement Award, offered by the Jewish Community Foundation, provides financial support for high school students pursuing post-secondary education or vocational training. Open to applicants of the Jewish faith, this award prioritizes those from single-parent households, orphans, or foster children. Interested candidates must submit a personal narrative detailing their qualifications. The foundation, established in 1979, is a leading community resource in South Jersey, managing over $35 million in assets.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

The Rotary Works Foundation Grant supports charitable projects primarily focused on children, youth, and families, emphasizing active Rotarian involvement. Grants range from $500 to $5,000, awarded prior to events. Eligible applicants include 501(c)(3) or 501(c)(1) organizations. Preference is given to projects engaging Rotarians. The application deadline is the 2nd Wednesday of each month, and all grantees must report outcomes post-project.

This grant aims to enhance global polio eradication efforts through innovative modeling approaches. It focuses on developing effective strategies for cVDPV2 outbreak response and optimizing surveillance following global WPV eradication. The initiative also seeks to build a skilled public health workforce in statistical and mathematical modeling, assess economic impacts of response strategies, and foster capacity among students to address polio and other vaccine-preventable diseases.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Patient Care Fund

The NAFC Patient Care Fund supports direct patient services that expand immediate access to care. This funding is designed to help NAFC members meet urgent patient needs by supporting clinical supplies, expanded services, contracted providers, transportation assistance, medication access, and other direct care resources.

The ECMC Foundation focuses on eliminating equity gaps in postsecondary education by 2040 through strategic grantmaking and investments. They support organizations aiming to remove barriers to completion, build institutional capacity, and transform the postsecondary ecosystem. Eligible entities include nonprofit organizations, government entities, and postsecondary institutions. However, funding is not available for personal scholarships, political activities, or projects outside the U.S. that do not align with the Foundation's mission of diversity and inclusion.