Best Smith County Grants for Nonprofits in Mississippi

The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of biological processes driven by somatic mutations in human tissues through innovative technology development. Since its inception in 2023, the program has produced multi-omic datasets from human tissues representing all germ layers. The NIH is now advancing to Stage 2, focusing on collaborative efforts to refine and implement validated technologies for somatic mutation detection and functional interpretation, promoting rigorous and cost-effective methodologies.

The Cancer Prevention and Control Programs aim to eliminate cancer through collaborative efforts among state, territorial, and tribal organizations. Funded by the CDC, this program supports initiatives such as breast and cervical cancer screening, cancer control planning, and cancer surveillance. By fostering partnerships and community involvement, the program seeks to improve health outcomes and achieve the mission of 'All People Free of Cancer.' This comprehensive approach ensures that resources are effectively coordinated to address the cancer burden in communities.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.

The BJA FY 2026 Students, Teachers, and Officers Preventing (STOP) School Violence Program aims to enhance school safety by funding initiatives that train staff and students, develop threat assessment teams, and implement technology solutions like anonymous reporting systems. This program supports effective strategies to identify and mitigate risks of school violence, ensuring students have the tools necessary to foster a secure learning environment while adhering to the guidelines set forth by the STOP School Violence Act.

The State Biomonitoring Cooperative Agreement aims to enhance public health laboratories' ability to conduct biomonitoring and assess human exposure to environmental chemicals. This funding opportunity emphasizes community investigations, state-level studies, and emerging chemicals not covered in the National Exposure Report. By improving laboratory capacity and fostering collaboration, the initiative seeks to identify harmful exposures and evaluate intervention effectiveness over a three-year period.

The National Institute of Neurological Disorders and Stroke (NINDS) is collaborating with other NIH institutes to enhance rigor and replicability in biomedical and behavioral research. This initiative aims to support projects focused on assessing the impact of improved research practices, developing frameworks for study selection, and measuring the generalizability of findings. Currently, applications are not being solicited, allowing researchers time to prepare collaborative proposals.

Strategic Multi-Modal Investment Funds

Recognizing the significance Multi-Modal infrastructure has on the State’s economy and its importance to the citizens for jobs and the transportation of goods and services, the Mississippi Legislature established the Strategic Multi-Modal Investments Fund (SMIF) during the 2023 Regular Session. The SMIF was established to increase the capacity for the movement of freight and increase economic activity at the airports, ports and railroads located in this state and to support long-term economic growth in the state. The legislature provided the necessary authority to initially fund the program up to $30 million.

In continuation of the program, the 2026 Legislative Session earmarked $10 million of Capital Expense funds received by MDOT. In accordance with Miss. Code Ann. § 65-1-901 and rules and regulations established by the Department, MDOT will administer the Strategic Multi-Modal Investments Fund for necessary investments and repairs to airports, ports, and railroads in the state.

In accordance with the legislation, the following goals have been established:

• Goal 1 – Fund projects that increase the capacity for freight movement in the State.
• Goal 2 – Fund projects that increase economic activity at the ports, airports and railroads within the State.
• Goal 3 – Fund projects that support long-term economic growth in the State.

Multi-Modal Transportation Improvement Program

The Multi-Modal Transportation Improvement Program (MTIP) is administered by the Mississippi Department of Transportation for the improvement of airports, ports, railroads, and transit systems in the state.

Airport, port, and rail projects must be related to capital improvements or the rehabilitation of basic infrastructure and outside of the normal operating budget. Transit projects include capital and certain other expenses that meet FTA eligibility requirements. Projects cannot be for routine maintenance or administrative or operational expenses.

The John H. Prescott Marine Mammal Rescue Assistance Grant supports the recovery and care of sick or injured marine mammals through federal assistance to the U.S. National Marine Mammal Stranding and Entanglement Response Networks. Eligible applicants must provide a Prescott Letter of Eligibility, confirming their participation in the network. This program aims to enhance marine mammal health monitoring and response capabilities across the country, ensuring timely and effective interventions for stranded marine life.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR) Competitive Grants Program aims to enhance the capacity of state and local government crime laboratories for processing DNA samples. This program focuses on using DNA technology to improve forensic efficiency and implement Rapid DNA in booking stations. It targets jurisdictions with operational challenges, ensuring fair access to funding. Eligible agencies can apply for both competitive and formula CEBR funding.

The National Institute of Neurological Disorders and Stroke (NINDS) aims to enhance research on Amyotrophic Lateral Sclerosis (ALS) through intermediate patient population expanded access protocols. These protocols will provide investigational drugs to ALS patients while collecting vital data to inform future treatments and care strategies. This initiative seeks to better understand the disease's biomarkers, patient experiences, and the overall impact of investigational therapies, fostering advancements in ALS research and care.

American Cancer Society

The mission of the American Cancer Society is to improve the lives of people with cancer and their families through advocacy, research, and patient support, to ensure everyone has an opportunity to prevent, detect, treat, and survive cancer.

ACS Research Priority Areas

The American Cancer Society (ACS) has identified these 6 areas to categorize and track the research we fund to help advance our mission. Applicants (except Institutional Research Grants and Professor grants) are asked to select at least 1 of these research areas that aligns with their proposal:

• Etiology (causes of cancer)
• Obesity/Healthy Eating and Active Living (HEAL)
• Screening and Diagnosis
• Treatment
• Survivorship
• Health Equity Across the Cancer Continuum

Research Scholar Grants

Research Scholar Grants (RSG) provide support for independent, self-directed researchers.

Applicants' institutions must provide space and other resources customary for independent investigators.

Grant proposals are investigator-initiated and may pursue questions across the cancer research continuum, as long as they fit within an American Cancer Society (ACS) priority research area.

These grants typically contribute to the cost of salaries, consumable supplies, and other miscellaneous items required in the research. 

Research Scholar Grants are funded up to $215,000 per year (direct costs), plus 10% allowable indirect costs, with a project period up to four years.

Rural Provider Technology Grant Program

Rural Provider Technology Grant Program is part of the HTAM Initiative. The Health Technology Advancement & Modernization Initiative (HTAM) is Mississippi’s effort to modernize the technology that supports rural healthcare—so providers can deliver safer, faster, and more coordinated care.

RTG Goal

Provide funding to entities to support necessary enhancements to technology hardware and software, including but not limited to digital and smart tools, ambient listening technologies, automated systems, and resources to support onboarding to the statewide health information exchange. Eligible improvements may also include broader technology upgrades, cybersecurity and data integrity enhancements, cybersecurity awareness programs, development of security protocols or policies, training, integration and implementation costs associated with technology changes and the acquisition of related equipment needed to address identified gaps or unmet needs within a provider’s technology ecosystem. Technology investments are targeted at increasing or improving service capacity, securing and protecting data, and supporting long-term operational sustainability.

Program Objectives

All grant projects funded under this Notice of Funding Opportunity (NOFO) must align with at least one of the program objectives listed below:

• Foster the use of innovative technologies that promote efficient care delivery, enhance data security, and expand access to digital health tools for rural facilities, providers, and patients. This could include the modernization of technology, expanding digital tools, and improved interoperability.
• Improve interoperability and data connectivity by facilitating onboarding, integration, and enable participation in the statewide health information exchange to improve data sharing, care coordination, and continuity of care.
• Strengthen core technology infrastructure by enabling participating facilities to modernize and stabilize essential technology hardware and software systems to support safe, efficient, and high-quality care delivery.
• Enhance cybersecurity by funding targeted upgrades that protect patient data, ensure data integrity, mitigate operational risk, and support compliance with applicable privacy and security requirements.
• Improving financial and operational sustainability to reduce closures and keep care local. This could include optimizing revenue cycle, leveraging data analytics, alignment with current and future care delivery models, and upgrading facilities.

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.

The Deployed Warfighter Protection FY27 program aims to safeguard military personnel from disease-carrying arthropods, including ticks and mosquitoes. It seeks innovative research to develop new insecticides, improve existing formulations, and enhance personal protection technologies. The initiative also focuses on effective pesticide application equipment, addressing both current and emerging arthropod threats. This program is crucial for maintaining the health and safety of deployed military forces.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.

The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR)—Formula Grants Program aims to support states and local governments in enhancing their DNA analysis capabilities. By providing funding for existing crime laboratories, this initiative seeks to increase the processing capacity for DNA samples, thereby reducing the backlog in forensic DNA analysis and ensuring timely entry into the Combined DNA Index System (CODIS). Applications are due by November 5, 2026.

The BJA FY 2026 Adult Treatment Court Program aims to enhance Adult Treatment Court operations, focusing on preventing overdoses and reducing substance use among high-risk adults in the criminal justice system. The program integrates judicial supervision, substance use disorder treatment, and recovery support services to improve outcomes for participants. This funding opportunity from the U.S. Department of Justice highlights the commitment to public safety and addressing critical issues like the opioid crisis.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA) aims to enhance the capacity of grantees through dedicated training. It addresses critical operational issues related to overdose responses, targeting illicit opioids and stimulants. The program underscores the U.S. Department of Justice's commitment to public safety, law enforcement support, and the fight against substance misuse. Applications are due by November 9, 2026.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

The BJA FY 2026 Veterans Treatment Court Program aims to enhance operations for veterans in the criminal justice system, focusing on reducing substance use, including opioids and alcohol. It integrates treatment for substance use and mental health disorders within a judicial framework, targeting high-risk veterans. This initiative not only addresses public safety concerns but also aims to provide necessary support and resources for veterans dealing with issues like PTSD and traumatic brain injury, fostering rehabilitation and recovery.

The OJJDP FY 2026 Juvenile Drug Treatment Court Program aims to enhance juvenile drug treatment courts (JDTCs) across the U.S. by supporting states, local courts, and Tribal governments. This initiative focuses on improving outcomes for youth dealing with substance use disorders or co-occurring mental health issues. The program underscores the commitment of the Office of Justice Programs to strengthen community safety and provide vital resources for effective intervention and support.